Dog health
Encyclopedia
Dog
The domestic dog is a domesticated form of the gray wolf, a member of the Canidae family of the order Carnivora. The term is used for both feral and pet varieties. The dog may have been the first animal to be domesticated, and has been the most widely kept working, hunting, and companion animal in...
s is a well studied area in veterinary medicine
Veterinary medicine
Veterinary Medicine is the branch of science that deals with the prevention, diagnosis and treatment of disease, disorder and injury in non-human animals...
.
Infectious disease
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...
s that affect dogs are important not only from a veterinary standpoint, but also because of the risk to public health
Public health
Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals" . It is concerned with threats to health based on population health...
; an example of this is rabies
Rabies
Rabies is a viral disease that causes acute encephalitis in warm-blooded animals. It is zoonotic , most commonly by a bite from an infected animal. For a human, rabies is almost invariably fatal if post-exposure prophylaxis is not administered prior to the onset of severe symptoms...
. Genetic disorder
Genetic disorder
A genetic disorder is an illness caused by abnormalities in genes or chromosomes, especially a condition that is present from before birth. Most genetic disorders are quite rare and affect one person in every several thousands or millions....
s also affect dogs, often due to selective breeding
Selective breeding
Selective breeding is the process of breeding plants and animals for particular genetic traits. Typically, strains that are selectively bred are domesticated, and the breeding is sometimes done by a professional breeder. Bred animals are known as breeds, while bred plants are known as varieties,...
to produce individual dog breed
Dog breed
Dog breeds are groups of closely related and visibly similar domestic dogs, which are all of the subspecies Canis lupus familiaris, having characteristic traits that are selected and maintained by humans, bred from a known foundation stock....
s. Due to the popularity of both commercial and homemade dog food
Dog food
Dog food refers to food specifically intended for consumption by dogs. Though technically omnivorous, dogs exhibit a natural carnivorous bias, have sharp, pointy teeth, and have short gastrointestinal tracts better suited for the consumption of meat...
s, nutrition
Nutrition
Nutrition is the provision, to cells and organisms, of the materials necessary to support life. Many common health problems can be prevented or alleviated with a healthy diet....
is also a heavily-studied subject.
Diseases
- For a complete list, see List of dog diseases
Some diseases and other health problems are common to both humans and dogs; others are unique to dogs and other animals. Dogs are susceptible to various diseases; similarly to humans, they can have diabetes, epilepsy
Epilepsy
Epilepsy is a common chronic neurological disorder characterized by seizures. These seizures are transient signs and/or symptoms of abnormal, excessive or hypersynchronous neuronal activity in the brain.About 50 million people worldwide have epilepsy, and nearly two out of every three new cases...
, cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
, or arthritis
Arthritis
Arthritis is a form of joint disorder that involves inflammation of one or more joints....
.
Infectious diseases
An infectious diseaseInfectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...
is caused by the presence of organisms such as virus
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...
es, bacteria
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...
, fungi, or parasites (either animal
Animal
Animals are a major group of multicellular, eukaryotic organisms of the kingdom Animalia or Metazoa. Their body plan eventually becomes fixed as they develop, although some undergo a process of metamorphosis later on in their life. Most animals are motile, meaning they can move spontaneously and...
ian or protozoa
Protozoa
Protozoa are a diverse group of single-cells eukaryotic organisms, many of which are motile. Throughout history, protozoa have been defined as single-cell protists with animal-like behavior, e.g., movement...
n). Most of these diseases are spread directly from dog to dog, while others require a vector such as a tick
Tick
Ticks are small arachnids in the order Ixodida, along with mites, constitute the subclass Acarina. Ticks are ectoparasites , living by hematophagy on the blood of mammals, birds, and sometimes reptiles and amphibians...
or mosquito
Mosquito
Mosquitoes are members of a family of nematocerid flies: the Culicidae . The word Mosquito is from the Spanish and Portuguese for little fly...
. Certain infectious diseases are a concern from a public health
Public health
Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals" . It is concerned with threats to health based on population health...
standpoint because they are zoonoses
Zoonosis
A zoonosis or zoonoseis any infectious disease that can be transmitted from non-human animals to humans or from humans to non-human animals . In a study of 1415 pathogens known to affect humans, 61% were zoonotic...
(transmittable to humans).
Rabies
Rabies
Rabies is a viral disease that causes acute encephalitis in warm-blooded animals. It is zoonotic , most commonly by a bite from an infected animal. For a human, rabies is almost invariably fatal if post-exposure prophylaxis is not administered prior to the onset of severe symptoms...
is a viral disease commonly associated with dogs, although in recent years canine rabies has been practically eliminated in North America
North America
North America is a continent wholly within the Northern Hemisphere and almost wholly within the Western Hemisphere. It is also considered a northern subcontinent of the Americas...
and Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...
due to extensive and often mandatory vaccination
Vaccination
Vaccination is the administration of antigenic material to stimulate the immune system of an individual to develop adaptive immunity to a disease. Vaccines can prevent or ameliorate the effects of infection by many pathogens...
requirements. However it is still a significant problem in Africa
Africa
Africa is the world's second largest and second most populous continent, after Asia. At about 30.2 million km² including adjacent islands, it covers 6% of the Earth's total surface area and 20.4% of the total land area...
, the Middle East
Middle East
The Middle East is a region that encompasses Western Asia and Northern Africa. It is often used as a synonym for Near East, in opposition to Far East...
, Latin America
Latin America
Latin America is a region of the Americas where Romance languages – particularly Spanish and Portuguese, and variably French – are primarily spoken. Latin America has an area of approximately 21,069,500 km² , almost 3.9% of the Earth's surface or 14.1% of its land surface area...
, and Asia
Asia
Asia is the world's largest and most populous continent, located primarily in the eastern and northern hemispheres. It covers 8.7% of the Earth's total surface area and with approximately 3.879 billion people, it hosts 60% of the world's current human population...
. Dogs are considered to be the main reservoir
Natural reservoir
Natural reservoir or nidus, refers to the long-term host of the pathogen of an infectious disease. It is often the case that hosts do not get the disease carried by the pathogen or it is carried as a subclinical infection and so asymptomatic and non-lethal...
for rabies in developing countries
Developing country
A developing country, also known as a less-developed country, is a nation with a low level of material well-being. Since no single definition of the term developing country is recognized internationally, the levels of development may vary widely within so-called developing countries...
. Areas that are rabies-free, (usually islands) such as Britain, Ireland
Ireland
Ireland is an island to the northwest of continental Europe. It is the third-largest island in Europe and the twentieth-largest island on Earth...
, Australia
Australia
Australia , officially the Commonwealth of Australia, is a country in the Southern Hemisphere comprising the mainland of the Australian continent, the island of Tasmania, and numerous smaller islands in the Indian and Pacific Oceans. It is the world's sixth-largest country by total area...
, New Zealand
New Zealand
New Zealand is an island country in the south-western Pacific Ocean comprising two main landmasses and numerous smaller islands. The country is situated some east of Australia across the Tasman Sea, and roughly south of the Pacific island nations of New Caledonia, Fiji, and Tonga...
, Hong Kong SAR and the American state of Hawaii
Hawaii
Hawaii is the newest of the 50 U.S. states , and is the only U.S. state made up entirely of islands. It is the northernmost island group in Polynesia, occupying most of an archipelago in the central Pacific Ocean, southwest of the continental United States, southeast of Japan, and northeast of...
have strict quarantine
Quarantine
Quarantine is compulsory isolation, typically to contain the spread of something considered dangerous, often but not always disease. The word comes from the Italian quarantena, meaning forty-day period....
laws to keep their territories rabies-free. These require long periods of isolation and observation of imported animals, which makes them unattractive places to move with a pet unless the pet is quite young. Areas that are not rabies-free usually require that dogs (and often cats) be vaccinated against rabies.
Historically, rabies has long been linked to dogs. The earliest mention of rabies is in the Codex of Eshnunna
Eshnunna
Eshnunna was an ancient Sumerian city and city-state in central Mesopotamia. Although situated in the Diyala Valley north-east of Sumer proper, the city nonetheless belonged securely within the Sumerian cultural milieu.The tutelary deity of the city was Tishpak .- History :Occupied from the Jemdet...
(ca. 1930 BC
20th century BC
The 20th century BC is a century which lasted from the year 2000 BC to 1901 BC.-Events:* 2000 BC: Arrival of the ancestors of the Latins in Italy.* 2000 BC: Town of Mantua was presumably founded.* 2000 BC: Stonehenge is believed to have been completed....
) (written prior to the Code of Hammurabi
Code of Hammurabi
The Code of Hammurabi is a well-preserved Babylonian law code, dating to ca. 1780 BC . It is one of the oldest deciphered writings of significant length in the world. The sixth Babylonian king, Hammurabi, enacted the code, and partial copies exist on a human-sized stone stele and various clay...
), which dictates that the owner of a dog showing symptoms of rabies should take preventative measure against bites. If a person was bitten by a rabid dog and later died, the owner was fined heavily. The sacred animal of the Babylonia
Babylonia
Babylonia was an ancient cultural region in central-southern Mesopotamia , with Babylon as its capital. Babylonia emerged as a major power when Hammurabi Babylonia was an ancient cultural region in central-southern Mesopotamia (present-day Iraq), with Babylon as its capital. Babylonia emerged as...
n goddess of health Gula
Gula
Nintinugga was a Babylonian goddess of healing, the consort of Ninurta. She is identical with another goddess, known as Bau, though it would seem that the two were originally independent....
or Ninisina
Ninsun
In Sumerian mythology, Ninsun or Ninsuna is a goddess, best known as the mother of the legendary hero Gilgamesh, and as the tutelary goddess of Gudea of Lagash. Her parents are the deities Anu and Uras.-Myths:...
was the dog; if a person insulted a dog, Gula caused that dog to bite the person and inflict them with rabies. In the 1800s the infectious nature of rabies was first demonstrated by taking the saliva from a rabid dog and injecting it into another animal.
Rabies in dogs is a fatal disease transmitted by the bite of an infected mammal
Mammal
Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...
, such as a cat
Cat
The cat , also known as the domestic cat or housecat to distinguish it from other felids and felines, is a small, usually furry, domesticated, carnivorous mammal that is valued by humans for its companionship and for its ability to hunt vermin and household pests...
, raccoon
Raccoon
Procyon is a genus of nocturnal mammals, comprising three species commonly known as raccoons, in the family Procyonidae. The most familiar species, the common raccoon , is often known simply as "the" raccoon, as the two other raccoon species in the genus are native only to the tropics and are...
, bat
Bat
Bats are mammals of the order Chiroptera "hand" and pteron "wing") whose forelimbs form webbed wings, making them the only mammals naturally capable of true and sustained flight. By contrast, other mammals said to fly, such as flying squirrels, gliding possums, and colugos, glide rather than fly,...
, or another dog. Animals with rabies suffer deterioration of the brain and tend to behave bizarrely and often aggressively, increasing the chances that they will bite another animal or a person and transmit the disease. Three stages of rabies are recognized in dogs and other animals. The first stage is a one to three day period characterized by behavioral changes and is known as the prodromal stage
Prodrome
In medicine, a prodrome is an early symptom that might indicate the start of a disease before specific symptoms occur. It is derived from the Greek word prodromos or precursor...
. The second stage is the excitative stage, which lasts three to four days. It is this stage that is often known as furious rabies due to the tendency of the affected dog to be hyperreactive to external stimuli and bite at anything near. The third stage is the paralytic stage and is caused by damage to motor neuron
Motor neuron
In vertebrates, the term motor neuron classically applies to neurons located in the central nervous system that project their axons outside the CNS and directly or indirectly control muscles...
s. Incoordination is seen due to rear limb paralysis
Paralysis
Paralysis is loss of muscle function for one or more muscles. Paralysis can be accompanied by a loss of feeling in the affected area if there is sensory damage as well as motor. A study conducted by the Christopher & Dana Reeve Foundation, suggests that about 1 in 50 people have been diagnosed...
and drooling and difficulty swallowing is caused by paralysis of facial and throat muscles. Death is usually caused by respiratory arrest
Respiratory arrest
Respiratory arrest is the cessation of breathing. It is a medical emergency and it usually is related to or coincides with a cardiac arrest. Causes include opiate overdose, head injury, anaesthesia, tetanus, or drowning...
.
A person or dog bitten by an unknown dog (or other animal) should always be treated without waiting for symptoms, given the potentially fatal consequences of a rabid biter: there have been very few cases of someone surviving rabies when treatment was not begun until after symptoms appeared. Depending on local laws, dogs that are showing neurological signs at the time of the bite are euthanized
Animal euthanasia
Animal euthanasia is the act of putting to death painlessly or allowing to die, as by withholding extreme medical measures, an animal suffering from an incurable, especially a painful, disease or condition. Euthanasia methods are designed to cause minimal pain and distress...
in order to have their brain tested for rabies. Unvaccinated healthy dogs need to be confined for ten days from the time of the bite (at home or at a veterinarian depending on local law). If the dog is not showing signs of rabies at the end of ten days, then the bitten person could not have been exposed to rabies. Dogs, cats, and ferrets can have the rabies virus in their saliva
Saliva
Saliva , referred to in various contexts as spit, spittle, drivel, drool, or slobber, is the watery substance produced in the mouths of humans and most other animals. Saliva is a component of oral fluid. In mammals, saliva is produced in and secreted from the three pairs of major salivary glands,...
several days before showing symptoms. Ten day confinement does not apply to other species. A dog or cat bitten by a wild animal in an area known to have rabies should be confined for six months, because it can take that long for symptoms to start. This is an incentive to dog-owners to vaccinate their dogs even if they feel the risk of their dog contracting rabies is low, since vaccination will eliminate the need for their dog to be euthanized or impounded should it bite anyone or be suspected of biting anyone.
Other viral diseases
Other canine viral diseases of note include parvovirus, distemper, infectious canine hepatitis, herpesvirus, and influenza.
Canine parvovirus
Canine parvovirus
Canine parvovirus type 2 is a contagious virus mainly affecting dogs. The disease is highly contagious and is spread from dog to dog by direct or indirect contact with their feces. It can be especially severe in puppies that are not protected by maternal antibodies or vaccination. It has two...
(caused by canine parvovirus
Parvovirus
Parvovirus, often truncated to "parvo", is both the common name in English casually applied to all the viruses in the Parvoviridae taxonomic family, and also the taxonomic name of the Parvovirus genus within the Parvoviridae family...
type 2, canine parvovirus type 1 is also known as canine minute virus
Canine minute virus
Canine minute virus is a type of virus of the family Parvoviridae that infects dogs. It is most similar to bovine parvovirus in its protein structure and DNA. A virus causing respiratory disease in humans has been called human bocavirus due to its similarity to both these viruses...
) causes a highly contagious gastrointestinal infection that is especially severe in puppies. It is spread through contact with infected feces. The virus attacks rapidly dividing cells, notably those in the lymph node
Lymph node
A lymph node is a small ball or an oval-shaped organ of the immune system, distributed widely throughout the body including the armpit and stomach/gut and linked by lymphatic vessels. Lymph nodes are garrisons of B, T, and other immune cells. Lymph nodes are found all through the body, and act as...
s, intestinal crypt
Crypts of Lieberkühn
In histology, an intestinal crypt is a gland found in the epithelial lining of the small intestine and colon...
s, and the bone marrow
Bone marrow
Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...
. There is depletion of lymphocyte
Lymphocyte
A lymphocyte is a type of white blood cell in the vertebrate immune system.Under the microscope, lymphocytes can be divided into large lymphocytes and small lymphocytes. Large granular lymphocytes include natural killer cells...
s in lymph nodes and necrosis
Necrosis
Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...
and destruction of the intestinal crypts. Symptoms and signs include vomiting, bloody diarrhea, depression, severe dehydration, fever, and low white blood cell
White blood cell
White blood cells, or leukocytes , are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a...
counts. Although there is no specific treatment for the canine parvovirus, aggressive intravenous fluid therapy
Intravenous therapy
Intravenous therapy or IV therapy is the infusion of liquid substances directly into a vein. The word intravenous simply means "within a vein". Therapies administered intravenously are often called specialty pharmaceuticals...
and antibiotics for dogs with secondary bacterial infections is usually required.
Canine distemper
Canine distemper
Canine distemper is a viral disease that affects animals in the families Canidae, Mustelidae, Mephitidae, Hyaenidae, Ailuridae, Procyonidae, Pinnipedia, some Viverridae and Felidae...
, caused by a paramyxovirus
Paramyxovirus
Paramyxoviruses are viruses of the Paramyxoviridae family of the Mononegavirales order; they are negative-sense single-stranded RNA viruses responsible for a number of human and animal diseases.-Genera:*Subfamily Paramyxovirinae**Genus Avulavirus Paramyxoviruses (from Greek para-, beyond, -myxo-,...
similar to the cause of measles
Measles
Measles, also known as rubeola or morbilli, is an infection of the respiratory system caused by a virus, specifically a paramyxovirus of the genus Morbillivirus. Morbilliviruses, like other paramyxoviruses, are enveloped, single-stranded, negative-sense RNA viruses...
, is a highly contagious disease that affects the respiratory, gastrointestinal, and central nervous systems. It is spread through either direct contact with respiratory excretions, through the air, or on fomite
Fomite
A fomite is any inanimate object or substance capable of carrying infectious organisms and hence transferring them from one individual to another. A fomite can be anything...
s (inanimate objects such as clothing). Symptoms and signs include discharge from the eye or nose, coughing, difficulty breathing, vomiting, diarrhea, depression, seizures, and paralysis. Similar to canine parvovirus, treatment is supportive.
Infectious canine hepatitis
Infectious canine hepatitis
Infectious canine hepatitis is an acute liver infection in dogs caused by canine adenovirus type-1 . CAV-1 also causes disease in wolves, coyotes, and bears, and encephalitis in foxes. The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs. It is contracted...
is caused by canine adenovirus type 1. The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs. It causes a liver infection and a bleeding disorder. Signs and symptoms include fever, depression, loss of appetite, coughing, tender abdomen, and spontaneous hemorrhages. Treatment is symptomatic.
Canine herpesvirus
Canine herpesvirus
Canine herpesvirus ' is a virus of the family Herpesviridae which most importantly causes a fatal hemorrhagic disease in puppies less than two to three weeks old. It is known to exist in the United States, Canada, Australia, Japan, England and Germany...
is a virus of the family Herpesviridae
Herpesviridae
The Herpesviridae are a large family of DNA viruses that cause diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word herpein , referring to the latent, recurring infections typical of this group of viruses...
which most importantly causes a fatal hemorrhagic disease in puppies less than two to three weeks old. It is transmitted to puppies in the birth canal and by contact with infected oral and nasal secretions from the mother or other infected dogs, but it is not spread through the air. Signs and symptoms include depression, nasal discharge, and weakness. The inability of very young puppies to mount a febrile response seems to be a significant contributing factor to the high mortality rate in this age dog - it can reach 80 percent. In adult dogs, canine herpesvirus can cause abortion
Miscarriage
Miscarriage or spontaneous abortion is the spontaneous end of a pregnancy at a stage where the embryo or fetus is incapable of surviving independently, generally defined in humans at prior to 20 weeks of gestation...
.
Canine influenza
Canine influenza
Canine influenza is influenza occurring in canines. Canine influenza is caused by varieties of Influenzavirus A, such as equine influenza virus H3N8, which in 2004 was discovered to cause disease in dogs. Because of the lack of previous exposure to this virus, dogs have no natural immunity to...
usually refers to infection with equine influenza virus H3N8
H3N8
H3N8 is a subtype of the species Influenza A virus that is endemic in birds, horses and dogs.-Introduction:Equine influenza is a highly contagious respiratorydisease of horses and related animals such as donkeys,...
. This virus was found to infect dogs in 2004, and the disease was very contagious due to the dog's lack of natural immunity
Immunity (medical)
Immunity is a biological term that describes a state of having sufficient biological defenses to avoid infection, disease, or other unwanted biological invasion. Immunity involves both specific and non-specific components. The non-specific components act either as barriers or as eliminators of wide...
. Signs and symptoms include cough and nasal discharge, and in more severe cases fever and pneumonia
Pneumonia
Pneumonia is an inflammatory condition of the lung—especially affecting the microscopic air sacs —associated with fever, chest symptoms, and a lack of air space on a chest X-ray. Pneumonia is typically caused by an infection but there are a number of other causes...
. Canine influenza has a high morbidity but a low mortality
Mortality rate
Mortality rate is a measure of the number of deaths in a population, scaled to the size of that population, per unit time...
.
Bacterial diseases
Opportunistic infection
An opportunistic infection is an infection caused by pathogens, particularly opportunistic pathogens—those that take advantage of certain situations—such as bacterial, viral, fungal or protozoan infections that usually do not cause disease in a healthy host, one with a healthy immune system...
s secondary to decreased resistance (often the result of viral infections), or secondary to other conditions (pyoderma
Pyoderma
Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart impetigo, furuncle, carbuncle, tropical ulcer, etc. Autoimmune conditions include pyoderma gangrenosum...
secondary to skin allergies or pyometra
Pyometra
Pyometra is a disease of the uterus most commonly seen in female dogs, but also seen in female cats , rabbits, ferrets, rats and guinea pigs. Pyometra is an important disease to be aware of for any dog owner because of the sudden nature of the disease and the deadly consequences if left untreated...
secondary to cystic endometrial hyperplasia). These examples are not considered infectious diseases because they do not satisfy Koch's postulates
Koch's postulates
Koch's postulates are four criteria designed to establish a causal relationship between a causative microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884 and refined and published by Koch in 1890...
- for example Staphylococcus intermedius, a commonly isolated bacteria from skin infections in dogs, would not cause pyoderma when introduced to a healthy dog. In all likelihood that type of bacteria is already present on the skin of a healthy dog.
There are some bacteria that are contagious from dog to dog. The most notable of these are Bordetella bronchiseptica
Bordetella bronchiseptica
Bordetella bronchiseptica is a small, gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious bronchitis, but rarely infects humans. Closely related to B. pertussis—the obligate human pathogen that causes pertussis or whooping cough—B...
, one of the causes of kennel cough
Kennel cough
Kennel cough is a highly contagious canine illness characterized by inflammation of the upper respiratory system. It can be caused by viral infections such as canine distemper, canine adenovirus, canine parainfluenza virus, or canine respiratory coronavirus, or bacterial infections such as...
, Leptospira
Leptospira
Leptospira is a genus of spirochaete bacteria, including a small number of pathogenic and saprophytic species...
sp, which cause leptospirosis
Leptospirosis
Leptospirosis is caused by infection with bacteria of the genus Leptospira, and affects humans as well as other mammals, birds, amphibians, and reptiles.The...
, and Brucella canis, cause of brucellosis
Brucellosis
Brucellosis, also called Bang's disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever, Mediterranean fever, rock fever, or undulant fever, is a highly contagious zoonosis caused by ingestion of unsterilized milk or meat from infected animals or close contact with their secretions...
in dogs. There are also common tick-borne bacterial diseases, including Lyme disease
Lyme disease
Lyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...
, ehrlichiosis, and Rocky Mountain spotted fever
Rocky Mountain spotted fever
Rocky Mountain spotted fever is the most lethal and most frequently reported rickettsial illness in the United States. It has been diagnosed throughout the Americas. Some synonyms for Rocky Mountain spotted fever in other countries include “tick typhus,” “Tobia fever” , “São Paulo fever” or “febre...
.
Leptospirosis is a zoonotic disease caused by bacteria of the genus Leptospira. Humans and dogs become infected through contact with water, food, or soil containing urine from infected animals. This may happen by swallowing contaminated food or water or through skin contact, especially with mucosal surfaces, such as the eyes or nose, or with broken skin. In dogs, transmission most commonly occurs by drinking puddle, pond, or ditch water contaminated by urine from infected wildlife such as squirrel
Squirrel
Squirrels belong to a large family of small or medium-sized rodents called the Sciuridae. The family includes tree squirrels, ground squirrels, chipmunks, marmots , flying squirrels, and prairie dogs. Squirrels are indigenous to the Americas, Eurasia, and Africa and have been introduced to Australia...
s or raccoon
Raccoon
Procyon is a genus of nocturnal mammals, comprising three species commonly known as raccoons, in the family Procyonidae. The most familiar species, the common raccoon , is often known simply as "the" raccoon, as the two other raccoon species in the genus are native only to the tropics and are...
s. The liver and kidney are most commonly damaged by leptospirosis. Vasculitis
Vasculitis
Vasculitis refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis...
can occur, causing edema
Edema
Edema or oedema ; both words from the Greek , oídēma "swelling"), formerly known as dropsy or hydropsy, is an abnormal accumulation of fluid beneath the skin or in one or more cavities of the body that produces swelling...
and potentially disseminated intravascular coagulation
Disseminated intravascular coagulation
Disseminated intravascular coagulation , also known as disseminated intravascular coagulopathy or consumptive coagulopathy, is a pathological activation of coagulation mechanisms that happens in response to a variety of diseases. DIC leads to the formation of small blood clots inside the blood...
(DIC). Myocarditis
Myocarditis
Myocarditis is inflammation of heart muscle . It resembles a heart attack but coronary arteries are not blocked.Myocarditis is most often due to infection by common viruses, such as parvovirus B19, less commonly non-viral pathogens such as Borrelia burgdorferi or Trypanosoma cruzi, or as a...
, pericarditis
Pericarditis
Pericarditis is an inflammation of the pericardium . A characteristic chest pain is often present.The causes of pericarditis are varied, including viral infections of the pericardium, idiopathic causes, uremic pericarditis, bacterial infections of the precardium Pericarditis is an inflammation of...
, meningitis
Meningitis
Meningitis is inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation may be caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs...
, and uveitis
Uveitis
Uveitis specifically refers to inflammation of the middle layer of the eye, termed the "uvea" but in common usage may refer to any inflammatory process involving the interior of the eye....
are also possible sequelae.
Sexually transmitted disease
Sexually transmitted disease , also known as a sexually transmitted infection or venereal disease , is an illness that has a significant probability of transmission between humans by means of human sexual behavior, including vaginal intercourse, oral sex, and anal sex...
, but can also be spread through contact with aborted fetuses. The most common sign is abortion during the last trimester or stillbirth
Stillbirth
A stillbirth occurs when a fetus has died in the uterus. The Australian definition specifies that fetal death is termed a stillbirth after 20 weeks gestation or the fetus weighs more than . Once the fetus has died the mother still has contractions and remains undelivered. The term is often used in...
. Other symptoms include inflammation of the intervertebral disc
Intervertebral disc
Intervertebral discs lie between adjacent vertebrae in the spine. Each disc forms a cartilaginous joint to allow slight movement of the vertebrae, and acts as a ligament to hold the vertebrae together.-Structure:...
and eye (uveitis
Uveitis
Uveitis specifically refers to inflammation of the middle layer of the eye, termed the "uvea" but in common usage may refer to any inflammatory process involving the interior of the eye....
), and inflammation of the testicle (orchitis
Orchitis
Orchitis or orchiditis is a condition of the testes involving inflammation. It can also involve swelling and frequent infection.-Symptoms:Symptoms of orchitis are similar to those of testicular torsion...
) and prostate
Prostate
The prostate is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals....
(prostatitis
Prostatitis
Prostatitis is an inflammation of the prostate gland, in men. A prostatitis diagnosis is assigned at 8% of all urologist and 1% of all primary care physician visits in the United States.-Classification:...
) in males.
Tick-borne disease
Tick-borne disease
Tick-borne diseases are diseases or illnesses transmitted by ticks. As the incidence of tick-borne illnesses increases and the geographic areas in which they are found expand, it becomes increasingly important that health professionals be able to distinguish the diverse, and often overlapping,...
s are common in dogs. Lyme disease, or borreliosis, is caused by Borrelia burgdorferi
Borrelia burgdorferi
Borrelia burgdorferi is a species of Gram negative bacteria of the spirochete class of the genus Borrelia. B. burgdorferi is predominant in North America, but also exists in Europe, and is the agent of Lyme disease....
and spread by Ixodes pacificus
Ixodes pacificus
Ixodes pacificus, the Western blacklegged tick, is a species of Ixodes, a parasitic tick found on the western coast of North America. It is the principal vector of Lyme Disease in that region....
on the West coast of the United States and by I. scapularis
Ixodes scapularis
Ixodes scapularis is commonly known as the deer tick or blacklegged tick , and in some parts of the USA as the bear tick. It is a hard-bodied tick of the eastern and northern Midwestern United States...
(deer tick) in the rest of the U.S. Signs and symptoms include fever, joint swelling and pain, lameness, and swelling of the lymph nodes. It has been diagnosed in dogs in all 48 states of the continental U.S. Ehrlichia canis, which causes canine ehrlichiosis, and Rickettsia rickettsii
Rickettsia
Rickettsia is a genus of non-motile, Gram-negative, non-sporeforming, highly pleomorphic bacteria that can present as cocci , rods or thread-like . Being obligate intracellular parasites, the Rickettsia survival depends on entry, growth, and replication within the cytoplasm of eukaryotic host cells...
, which causes Rocky Mountain spotted fever, are both spread by the American dog tick, Dermacentor variabilis
Dermacentor variabilis
Dermacentor variabilis, also known as the American dog tick, is a species of tick that is known to carry bacteria responsible for several diseases in humans, including Rocky Mountain spotted fever and tularemia . It is one of the most well-known hard ticks.Though D...
, and the brown dog tick, Rhipicephalus sanguineous.
Fungal diseases
One of the most common fungalFungus
A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...
diseases in dogs is ringworm, or dermatophytosis, an infection of the skin, hair, or nails. There are three fungal species that cause ringworm in dogs. About 70 percent of infections are caused by Microsporum
Microsporum
Microsporum is a genus of fungi that causes tinea capitis, tinea corpus, ringworm, and other dermatophytoses. Microsporum forms both macroconidia and microconidia on short conidiophores...
canis, 20 percent by M. gypseum, and 10 percent by Trichophyton
Trichophyton
The fungus genus Trichophyton is characterized by the development of both smooth-walled macro- and microconidia. Macroconidia are mostly borne laterally directly on the hyphae or on short pedicels, and are thin- or thick-walled, clavate to fusiform, and range from 4 to 8 by 8 to 50 um in size....
mentagrophytes. Signs include hair loss and scaling of the skin. Treatment for localized ringworm is not always necessary as the disease is self-limiting, but the cliinical course can be shortened by using topical miconazole
Miconazole
Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes...
or clotrimazole
Clotrimazole
Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections such as vaginal yeast infections, oral thrush, and ringworm...
. Generalized infections, most commonly seen in immunocompromised
Immunodeficiency
Immunodeficiency is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency may also decrease cancer immunosurveillance. Most cases of immunodeficiency are acquired but some people are born with defects in their immune system,...
dogs, can be treated with oral antifungal drug
Antifungal drug
An antifungal medication is a medication used to treat fungal infections such as athlete's foot, ringworm, candidiasis , serious systemic infections such as cryptococcal meningitis, and others...
s such as griseofulvin
Griseofulvin
Griseofulvin is an antifungal drug that is administered orally. It is used both in animals and in humans, to treat fungal infections of the skin and nails...
or itraconazole
Itraconazole
Itraconazole , invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections. The drug may be given orally or intravenously.-Medical uses:...
. Infection can spread to humans.
Blastomycosis
Blastomycosis is a fungal infection caused by the organism Blastomyces dermatitidis...
, caused by Blastomyces
Blastomyces
Blastomyces is a fungal genus responsible for the medical condition blastomycosis.The most well known species of the genus is Blastomyces dermatitidis. B. dermatitidis is a dimorphic fungal pathogen, found primarily in the Mid-West and Northern United States and Canada...
dermatitidis, is a fungal disease that affects both dogs and humans, although it is only rarely zoonotic. It is found mainly in the United States in the Mississippi River
Mississippi River
The Mississippi River is the largest river system in North America. Flowing entirely in the United States, this river rises in western Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains...
and Great Lakes
Great Lakes
The Great Lakes are a collection of freshwater lakes located in northeastern North America, on the Canada – United States border. Consisting of Lakes Superior, Michigan, Huron, Erie, and Ontario, they form the largest group of freshwater lakes on Earth by total surface, coming in second by volume...
areas. Signs include weight loss, cough, fever, enlarged lymph nodes, draining skin lesions, blindness, and lameness. Because dogs are ten times more likely to become infected from the environment than humans, they are considered to be sentinels for the disease.
Histoplasmosis
Histoplasmosis
Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary greatly, but the disease primarily affects the lungs...
, caused by Histoplasma capsulatum, is a disease with a worldwide distribution. In the United States it is mainly found in the Mississippi and Ohio River
Ohio River
The Ohio River is the largest tributary, by volume, of the Mississippi River. At the confluence, the Ohio is even bigger than the Mississippi and, thus, is hydrologically the main stream of the whole river system, including the Allegheny River further upstream...
areas, most commonly in bird and bat feces. Signs include weight loss, cough, fever, enlarged lymph nodes, and gastrointestinal symptoms. Coccidioidomycosis
Coccidioidomycosis
Coccidioidomycosis is a fungal disease caused by Coccidioides immitis or C. posadasii. It is endemic in certain parts of Arizona, California, Nevada, New Mexico, Texas, Utah and northwestern Mexico.C...
, caused by Coccidioides immitis
Coccidioides immitis
Coccidioides immitis is a pathogenic fungus that resides in the soil in certain parts of the southwestern United States, northern Mexico, and a few other areas in the Western Hemisphere....
, is found in arid
Arid
A region is said to be arid when it is characterized by a severe lack of available water, to the extent of hindering or even preventing the growth and development of plant and animal life...
and semi-arid
Semi-arid
A semi-arid climate or steppe climate describes climatic regions that receive precipitation below potential evapotranspiration, but not extremely...
regions of Central
Central America
Central America is the central geographic region of the Americas. It is the southernmost, isthmian portion of the North American continent, which connects with South America on the southeast. When considered part of the unified continental model, it is considered a subcontinent...
and South America
South America
South America is a continent situated in the Western Hemisphere, mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere. The continent is also considered a subcontinent of the Americas. It is bordered on the west by the Pacific Ocean and on the north and east...
, Mexico
Mexico
The United Mexican States , commonly known as Mexico , is a federal constitutional republic in North America. It is bordered on the north by the United States; on the south and west by the Pacific Ocean; on the southeast by Guatemala, Belize, and the Caribbean Sea; and on the east by the Gulf of...
, and southwestern United States. Signs include weight loss, fever, cough, enlarged lymph nodes, and lameness.
External parasites
- FleaFleaFlea is the common name for insects of the order Siphonaptera which are wingless insects with mouthparts adapted for piercing skin and sucking blood...
s and tickTickTicks are small arachnids in the order Ixodida, along with mites, constitute the subclass Acarina. Ticks are ectoparasites , living by hematophagy on the blood of mammals, birds, and sometimes reptiles and amphibians...
s of various species can be acquired and brought home by a dog, where they can multiply and attack humans (and vice versa). This is particularly important, now that tick-borne Lyme DiseaseLyme diseaseLyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...
has become endemicEndemic (epidemiology)In epidemiology, an infection is said to be endemic in a population when that infection is maintained in the population without the need for external inputs. For example, chickenpox is endemic in the UK, but malaria is not...
throughout a large area, in addition to other similar diseases such as Rocky Mountain Spotted FeverRocky Mountain spotted feverRocky Mountain spotted fever is the most lethal and most frequently reported rickettsial illness in the United States. It has been diagnosed throughout the Americas. Some synonyms for Rocky Mountain spotted fever in other countries include “tick typhus,” “Tobia fever” , “São Paulo fever” or “febre...
. Although dogs do not seem to be as susceptible to such diseases as humans, similar rickettsiaRickettsiaRickettsia is a genus of non-motile, Gram-negative, non-sporeforming, highly pleomorphic bacteria that can present as cocci , rods or thread-like . Being obligate intracellular parasites, the Rickettsia survival depends on entry, growth, and replication within the cytoplasm of eukaryotic host cells...
l diseases have been spread by dogs to humans through such mechanisms as a dog killing an infected rabbit, then shaking itself off in the house near enough to its owners to fatally infect most of the family. - FleaFleaFlea is the common name for insects of the order Siphonaptera which are wingless insects with mouthparts adapted for piercing skin and sucking blood...
s and tickTickTicks are small arachnids in the order Ixodida, along with mites, constitute the subclass Acarina. Ticks are ectoparasites , living by hematophagy on the blood of mammals, birds, and sometimes reptiles and amphibians...
s are common parasites for which there are many effective preventive measures. - Various miteMiteMites, along with ticks, are small arthropods belonging to the subclass Acari and the class Arachnida. The scientific discipline devoted to the study of ticks and mites is called acarology.-Diversity and systematics:...
s cause skin problems such as mangeMangeMange is the common name for a class of persistent contagious skin diseases caused by parasitic mites. Since mites also infect plants, birds, and reptiles, the term "mange," suggesting poor condition of the hairy coat due to the infection, is sometimes reserved only for pathological...
.
Internal parasites
- ParasitesParasitismParasitism is a type of symbiotic relationship between organisms of different species where one organism, the parasite, benefits at the expense of the other, the host. Traditionally parasite referred to organisms with lifestages that needed more than one host . These are now called macroparasites...
, particularly intestinal worms such as hookwormHookwormThe hookworm is a parasitic nematode that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human. Two species of hookworms commonly infect humans, Ancylostoma duodenale and Necator americanus. A. duodenale predominates in the Middle East, North Africa, India...
s, tapeworms and roundwormAscaris lumbricoidesAscaris lumbricoides is the giant roundworm of humans, belonging to the phylum Nematoda. An ascarid nematode, it is responsible for the disease ascariasis in humans, and it is the largest and most common parasitic worm in humans. One-sixth of the human population is estimated to be infected by this...
s, can be transmitted in a dog's fecesFecesFeces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
. Some tapeworms have fleaFleaFlea is the common name for insects of the order Siphonaptera which are wingless insects with mouthparts adapted for piercing skin and sucking blood...
s as intermediate hosts: the worm egg must be consumed by a flea to hatch, then the infected flea must be ingested (usually by the dog while grooming itself, but occasionally by a human through various means) for the adult worm to establish itself in the intestines. The worm's eggs then pass through the intestines and adhere to the nether regions of the dog, and the cycle begins again. - Intestinal wormWormThe term worm refers to an obsolete taxon used by Carolus Linnaeus and Jean-Baptiste Lamarck for all non-arthropod invertebrate animals, and stems from the Old English word wyrm. Currently it is used to describe many different distantly-related animals that typically have a long cylindrical...
s cause varying degrees of discomfort. - HeartwormHeartwormHeartworm is a parasitic roundworm that is spread from host to host through the bites of mosquitoes. The heartworm is a type of filaria, a small thread-like worm. The definitive host is the dog but it can also infect cats, wolves, coyotes, foxes and other animals, such as ferrets, sea lions and...
is a dog parasitoidParasitoidA parasitoid is an organism that spends a significant portion of its life history attached to or within a single host organism in a relationship that is in essence parasitic; unlike a true parasite, however, it ultimately sterilises or kills, and sometimes consumes, the host...
. It is hard to eliminate and can be fatal; prevention, however, is easily achieved using medication.- As the name suggests, an infected mosquito injects a larva into the dog's skin, where it migrates to the circulatory systemCirculatory systemThe circulatory system is an organ system that passes nutrients , gases, hormones, blood cells, etc...
and takes up residence in the pulmonary arteriesPulmonary arteryThe pulmonary arteries carry deoxygenated blood from the heart to the lungs. They are the only arteries that carry deoxygenated blood....
and heartHeartThe heart is a myogenic muscular organ found in all animals with a circulatory system , that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions...
, growing and reproducing to an alarming degree. The effects on the dog are quite predictable, cardiac failure over a year or two, leading to death. Treatment of an infected dog is difficult, involving an attempt to poison the healthy worm with arsenicArsenicArsenic is a chemical element with the symbol As, atomic number 33 and relative atomic mass 74.92. Arsenic occurs in many minerals, usually in conjunction with sulfur and metals, and also as a pure elemental crystal. It was first documented by Albertus Magnus in 1250.Arsenic is a metalloid...
compounds without killing the weakened dog, and frequently does not succeed. Prevention is much the better course, via heartworm prophylactics which contain a compound which kills the larvae immediately upon infection without harming the dog. Often they are available combined with other parasite preventives.
- As the name suggests, an infected mosquito injects a larva into the dog's skin, where it migrates to the circulatory system
- Hydatidosis is caused by a cestode EchinococcusEchinococcusThe genus Echinococcus includes six species of cyclophyllid tapeworms to date, of the family Taeniidae. Infection with Echinococcus results in hydatid disease, also known as echinococcosis....
. This is usually noticed among dogs, wild dogs, foxes, etc. Due to its importance as a zoonosisZoonosisA zoonosis or zoonoseis any infectious disease that can be transmitted from non-human animals to humans or from humans to non-human animals . In a study of 1415 pathogens known to affect humans, 61% were zoonotic...
, these worms are important to treat. Preventing hydatidosis is an easier task than treating the same. Anthelmintics such as praziquantelPraziquantelPraziquantel is an anthelmintic effective against flatworms. Praziquantel is not licensed for use in humans in the UK; it is, however, available as a veterinary anthelmintic, and is available for use in humans on a named-patient basis....
may help prevent this condition. Prohibition of the feeding of dogs with uncooked offals may be the best prophylactic measure against these tapeworms.
Genetic diseases
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
conditions are a problem in some dogs, particularly purebreeds. For this reason many of the national kennel club
Kennel club
A kennel club is an organization for canine affairs that concerns itself with the breeding, showing and promotion of more than one breed of dog...
s require that dogs with certain genetic illnesses or who are deemed to be carriers cannot be registered. Some of the most common conditions include hip dysplasia, seen in large breed dogs, von Willebrand disease
Von Willebrand disease
von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor , a multimeric protein that is required for...
, a disease that affects platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
s that is inherited in Doberman Pinschers, entropion
Entropion
Entropion is a medical condition in which the eyelid folds inward. It is very uncomfortable, as the eyelashes constantly rub against the cornea. Entropion is usually caused by genetic factors and may be congenital...
, a curling in of the eyelid seen in Shar Pei
Shar Pei
The Shar Pei, or Chinese Shar-Pei, is a breed of dog known for its distinctive features of deep wrinkles and a blue-black tongue. The breed comes from China. The name translates to "sand skin" and refers to the texture of its short, rough coat...
s and many other breeds, progressive retinal atrophy
Progressive retinal atrophy
Progressive retinal atrophy is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, it is characterized by the bilateral degeneration of the retina, causing progressive vision loss culminating in blindness...
, inherited in many breeds, deafness, and epilepsy
Epilepsy in animals
Epilepsy can occur in animals other than humans . It is characterized by recurrent, unprovoked seizures. Canine epilepsy is often genetic. Epilepsy in cats and other pets is rarer, likely because there is no hereditary component to epilepsy in these animals.-Canine epilepsy:In dogs, epilepsy is...
, known to be inherited in Belgian Shepherd Dogs, German Shepherd Dog
German Shepherd Dog
The German Shepherd Dog , also known as an Alsatian or just the German Shepherd, is a breed of large-sized dog that originated in Germany. The German Shepherd is a relatively new breed of dog, with its origin dating to 1899. As part of the Herding Group, the German Shepherd is a working dog...
s, Cocker Spaniels, and St. Bernard
St. Bernard (dog)
The St. Bernard is a breed of very large working dog from the Italian and Swiss Alps, originally bred for rescue. The breed has become famous through tales of alpine rescues, as well as for its large size.-Appearance:The St. Bernard is a large dog...
s.
Subaortic stenosis
Aortic valve stenosis
Aortic valve stenosis is a disease of the heart valves in which the opening of the aortic valve is narrowed. The aortic valve is the valve between the left ventricle of the heart and the aorta, which is the largest artery in the body and carries the entire output of blood.-Pathophysiology:The...
, or SAS, is a genetic ailment that causes a narrowing of the passage of blood between the heart
Heart
The heart is a myogenic muscular organ found in all animals with a circulatory system , that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions...
and the aorta
Aorta
The aorta is the largest artery in the body, originating from the left ventricle of the heart and extending down to the abdomen, where it branches off into two smaller arteries...
. This leads to heart problems and sometimes sudden death. It affects larger breeds such as the Newfoundland Dog and the Golden Retriever
Golden Retriever
The Golden Retriever is a medium-sized breed of dog. They were historically developed as gundogs to retrieve shot waterfowl such as ducks and upland game birds during hunting and shooting parties. As such, they were bred to have a soft mouth to retrieve game undamaged and have an instinctive love...
. In some dogs, such as collie
Collie
The collie is a distinctive type of herding dog, including many related landraces and formal breeds. It originates in Scotland and Northern England. It is a medium-sized, fairly lightly built dog with a pointed snout, and many types have a distinctive white pattern over the shoulders. Collies...
s, the blue merle
Merle (coat colour in dogs)
Merle is a pattern in a dogs coat, though is commonly incorrectly referred to as a color.- Description :Merle can affect all coat colors but the colors most commonly seen that are affected are brown and black, when affected by merle they are usually called liver and blue, though some call liver red...
or harlequin
Great Dane
The Great Dane , also known as German Mastiff or Danish Hound , is a breed of domestic dog known for its giant size...
coloring is actually the heterozygote of a partially recessive
Recessive
In genetics, the term "recessive gene" refers to an allele that causes a phenotype that is only seen in a homozygous genotype and never in a heterozygous genotype. Every person has two copies of every gene on autosomal chromosomes, one from mother and one from father...
gene preventing proper development of the nervous system; therefore, if two such dogs are mated, on the average one quarter of the puppies will have severe genetic defects in their nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...
s and sensory organs ranging from deafness to fatal flaws.
Skin diseases
Atopy
Atopy or atopic syndrome is a predisposition toward developing certain allergic hypersensitivity reactions.Atopy may have a hereditary component, although contact with the allergen must occur before the hypersensitivity reaction can develop ....
, a chronic allergic condition, is thought to affect up to 10 percent of dogs. Other skin diseases related to allergies include hot spots and pyoderma
Pyoderma
Pyoderma means any skin disease that is pyogenic. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart impetigo, furuncle, carbuncle, tropical ulcer, etc. Autoimmune conditions include pyoderma gangrenosum...
, both characterized by secondary bacterial infections, food allergy
Food allergy
A food allergy is an adverse immune response to a food protein. They are distinct from other adverse responses to food, such as food intolerance, pharmacological reactions, and toxin-mediated reactions....
, ear infections
Otitis externa in animals
Otitis externa is an inflammation of the outer ear and ear canal. Animals are commonly prone to ear infection, and this is one of the most common manifestations of allergy in dogs. In dogs, those breeds with floppy ears are more prone, since air flow is limited and a warm, moist environment built...
, and flea allergy dermatitis
Flea allergy dermatitis
Flea allergy dermatitis is an eczematous itchy skin disease of dogs and cats. For both of these domestic species flea allergy dermatitis is the most common cause of skin disease. Affected animals develop allergic reactions to chemicals in flea saliva...
. Canine follicular dysplasia is an inherited disorder of the hair follicle
Hair follicle
A hair follicle is a skin organ that produces hair. Hair production occurs in phases, including a growth phase , and cessation phase , and a rest phase . Stem cells are principally responsible for the production of hair....
s resulting in alopecia
Alopecia
Alopecia means loss of hair from the head or body. Alopecia can mean baldness, a term generally reserved for pattern alopecia or androgenic alopecia. Compulsive pulling of hair can also produce hair loss. Hairstyling routines such as tight ponytails or braids may induce Traction alopecia. Both...
(baldness). Mange
Mange
Mange is the common name for a class of persistent contagious skin diseases caused by parasitic mites. Since mites also infect plants, birds, and reptiles, the term "mange," suggesting poor condition of the hairy coat due to the infection, is sometimes reserved only for pathological...
is an infectious skin disease caused by mite
Mite
Mites, along with ticks, are small arthropods belonging to the subclass Acari and the class Arachnida. The scientific discipline devoted to the study of ticks and mites is called acarology.-Diversity and systematics:...
s. Endocrine diseases such as hypothyroidism
Hypothyroidism
Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
and Cushing's syndrome
Cushing's syndrome
Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...
can also manifest as skin problems like alopecia or recurring bacterial infections. Another class of integumentary malady is hygromas
Hygromas
A hygroma, or a false bursa, is a discrete, fluid-filled sac that can form on the joints of dogs in response to repeated pressure, such as that from sitting on a hard surface...
, a swelling typically on or near the elbow joint.
Orthopedic diseases
Orthopedic diseases in dogs can be developmental, hereditary, traumatic, or degenerative. Because of the active nature of dogs, injuries happen frequently. One of the most common of these is an anterior cruciate ligament injuryAnterior cruciate ligament injury
An injury to the anterior cruciate ligament can be a debilitating musculoskeletal injury to the knee, seen most often in athletes. Non-contact tears and ruptures are the most common causes of ACL injury....
, a condition which often requires surgery. Bone fracture
Bone fracture
A bone fracture is a medical condition in which there is a break in the continuity of the bone...
s are a frequent occurrence in outdoor dogs due to trauma from being hit by cars. Degenerative joint disease
Osteoarthritis
Osteoarthritis also known as degenerative arthritis or degenerative joint disease, is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion...
is common in older dogs and is one of the most likely reasons for prescription of non-steroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal Anti-inflammatory medicines , are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory...
s.
Hereditary orthopedic diseases are mainly found in purebred dogs. Hip dysplasia is a common problem that primarily affects larger breeds. Hip dysplasia is a defect in the shape of the hip joint which can, depending on the degree of hip luxation, be quite painful to the dog as it ages. Over time it often causes arthritis in the hips. Dysplasia
Elbow dysplasia
Elbow dysplasia is a condition involving multiple developmental abnormalities of the elbow-joint in the dog, specifically the growth of cartilage or the structures surrounding it. These abnormalities, known as 'primary lesions', give rise to osteoarthritic processes...
can also occur in the elbow joint. Luxating patella
Luxating patella
Luxating patella is a condition in which the patella, or kneecap, dislocates or moves out of its normal location....
s can be a problem for smaller breeds. It can cause lameness and pain in the hind legs.
Developmental orthopedic diseases include panosteitis
Panosteitis
Panosteitis is a common bone disease in dogs. It manifests with sudden, otherwise unexplained pain and lameness sometimes shifting from leg to leg, usually between 5 and 14 months of age. Signs such as fever and weight loss, and symptoms such as anorexia, and lethargy can also be seen...
and hypertrophic osteodystrophy
Hypertrophic osteodystrophy
Hypertrophic Osteodystrophy is a bone disease that occurs in fast-growing large and giant breed dogs. The disorder is sometimes referred to as metaphyseal osteopathy, and typically first presents between the ages of 2 and 7 months...
. Panosteitis occurs in large and giant breed dogs usually between the age of five and fourteen months and manifests as fever, pain, and shifting leg lameness. Hypertrophic osteodystrophy is also seen in young large and giant breed dogs and is characterized by pain, lameness, fever, and swelling of the long bone metaphysis
Metaphysis
The metaphysis is the wider portion of a long bone adjacent to the epiphyseal plate. It is this part of the bone that grows during childhood; as it grows, it ossifies near the diaphysis and the epiphyses...
.
Tumors and cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
tumor
Tumor
A tumor or tumour is commonly used as a synonym for a neoplasm that appears enlarged in size. Tumor is not synonymous with cancer...
s are seen in dogs. Common benign tumors include lipoma
Lipoma
A lipoma is a benign tumor composed of adipose tissue. It is the most common form of soft tissue tumor. Lipomas are soft to the touch, usually movable, and are generally painless. Many lipomas are small but can enlarge to sizes greater than six centimeters. Lipomas are commonly found in adults...
s, non-viral papilloma
Papilloma
Papilloma refers to a benign epithelial tumor growing exophytically in finger-like fronds. In this context papilla refers to the projection created by the tumor, not a tumor on an already existing papilla . When used without context, it frequently refers to infections caused by human...
s, sebaceous gland
Sebaceous gland
The sebaceous glands are microscopic glands in the skin that secrete an oily/waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals...
adenoma, and perianal gland adenomas.
Frequently seen cancers include lymphoma
Lymphoma in animals
Lymphoma in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract. It is also known as lymphosarcoma.-Lymphoma in...
, melanoma
Melanoma
Melanoma is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye...
, mast cell tumors (which are considered to be potentially malignant, even though they may have benign behavior), and osteosarcoma
Osteosarcoma
Osteosarcoma is an aggressive cancerous neoplasm arising from primitive transformed cells of mesenchymal origin that exhibit osteoblastic differentiation and produce malignant osteoid...
(bone cancer).
Certain breeds are more likely to develop particular tumors, larger ones especially. The Golden Retriever
Golden Retriever
The Golden Retriever is a medium-sized breed of dog. They were historically developed as gundogs to retrieve shot waterfowl such as ducks and upland game birds during hunting and shooting parties. As such, they were bred to have a soft mouth to retrieve game undamaged and have an instinctive love...
is especially susceptible to lymphoma, with a lifetime risk of 1 in 8. Boxer
Boxer (dog)
Developed in Germany, the Boxer is a breed of stocky, medium-sized, short-haired dog. The coat is smooth and fawn or brindled, with or without white markings. Boxers are brachycephalic , and have a square muzzle, mandibular prognathism , very strong jaws and a powerful bite ideal for hanging on to...
s and Pug
Pug
The pug is a "toy" breed of dog with a wrinkly, short-muzzled face, and curled tail. The breed has a fine, glossy coat that comes in a variety of colors, and a compact square body with well-developed muscle. They have been described as multum in parvo , referring to the pug's personality and...
s are prone to multiple mast cell tumors. Scottish Terrier
Scottish Terrier
The Scottish Terrier , popularly called the Scottie, is a breed of dog. Initially one of the highland breeds of Terrier that were grouped under the name of Skye Terrier, it is one of five breeds of terrier that originated in Scotland, the other four being the modern Skye, Cairn, Dandie Dinmont, and...
s have eighteen times the risk of mixed breed dogs to develop transitional cell carcinoma
Transitional cell carcinoma
Transitional cell carcinoma is a type of cancer that typically occurs in the urinary system: the kidney, urinary bladder, and accessory organs. It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus...
, a type of urinary bladder cancer.
Gastrointestinal diseases
Due to the indiscriminate nature of a dog's appetite, gastrointestinal upset is a frequent occurrence in dogs. The most common symptoms are anorexia, vomiting, and diarrhea. Foreign bodyForeign body
A foreign body is any object originating outside the body. In machinery, it can mean any unwanted intruding object.Most references to foreign bodies involve propulsion through natural orifices into hollow organs....
ingestion can lead to acute obstruction of the gastrointestinal tract, a very dangerous condition. Acute pancreatitis
Acute pancreatitis
Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have severe complications and high mortality despite treatment...
can also result from dietary indiscretion.
Bloat and gastric torsion
Breeds with deep, narrow chests, such as the Great DaneGreat Dane
The Great Dane , also known as German Mastiff or Danish Hound , is a breed of domestic dog known for its giant size...
or St. Bernard
St. Bernard (dog)
The St. Bernard is a breed of very large working dog from the Italian and Swiss Alps, originally bred for rescue. The breed has become famous through tales of alpine rescues, as well as for its large size.-Appearance:The St. Bernard is a large dog...
, are susceptible to a syndrome of gastric torsion and bloat
Bloat
Bloat is a medical condition in which the stomach becomes overstretched by excessive gas content. It is also commonly referred to as torsion, gastric torsion, and gastric dilatation-volvulus when the stomach is also twisted. The word bloat is often used as a general term to cover gas distension...
. The stomach
Stomach
The stomach is a muscular, hollow, dilated part of the alimentary canal which functions as an important organ of the digestive tract in some animals, including vertebrates, echinoderms, insects , and molluscs. It is involved in the second phase of digestion, following mastication .The stomach is...
twists on its supporting ligament
Ligament
In anatomy, the term ligament is used to denote any of three types of structures. Most commonly, it refers to fibrous tissue that connects bones to other bones and is also known as articular ligament, articular larua, fibrous ligament, or true ligament.Ligament can also refer to:* Peritoneal...
s, sealing off the exits, and the contents begin to generate gas pressure which is very painful and rapidly causes shock and necrosis
Necrosis
Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...
of large areas of stomach tissue. It can be fatal within a few hours. Dogs who have experienced bloat are very susceptible to recurrences. Treatment involves stabilization and abdominal surgery to tack the dog's stomach down to prevent recurrence (gastropexy
Gastropexy
Gastropexy is a surgical operation in which the stomach is sutured to the abdominal wall....
).
Eye diseases
Cataract
A cataract is a clouding that develops in the crystalline lens of the eye or in its envelope, varying in degree from slight to complete opacity and obstructing the passage of light...
s, canine glaucoma
Canine glaucoma
Glaucoma in dogs refers to a group of diseases that affect the optic nerve and involves a loss of retinal ganglion cells in a characteristic pattern. Raised intraocular pressure is a significant risk factor for developing glaucoma...
, and entropion
Entropion
Entropion is a medical condition in which the eyelid folds inward. It is very uncomfortable, as the eyelashes constantly rub against the cornea. Entropion is usually caused by genetic factors and may be congenital...
are seen in dogs. Canine-specific eye diseases include progressive retinal atrophy
Progressive retinal atrophy
Progressive retinal atrophy is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, it is characterized by the bilateral degeneration of the retina, causing progressive vision loss culminating in blindness...
, Collie eye anomaly
Collie eye anomaly
Collie eye anomaly is a congenital, inherited, bilateral eye disease of dogs involving the retina, choroid, and sclera. It can be a mild disease or cause blindness. CEA is caused by a simple autosomal recessive gene defect...
, sudden acquired retinal degeneration
Sudden acquired retinal degeneration
Sudden acquired retinal degeneration syndrome is a disease in dogs causing sudden blindness. It can occur in any breed, but female dogs may be predisposed...
, and cherry eye
Cherry eye
Cherry eye is the term used to refer to canine nictitans gland prolapse, a common congenital eye defect in various dog breeds where the gland of the third eyelid known as the nictitating membrane prolapses and becomes visible. Commonly affected breeds include the Bulldog, Chihuahua, Cocker...
. Injury to the eye can result in corneal ulcers.
The frequency of bilateral glaucoma with a genetic base in purebred dogs is higher than in any species except humans. Cataracts in dogs either have a genetic base or can also be caused by diabetes
Diabetes in dogs
Diabetes mellitus is a disease in which the beta cells of the endocrine pancreas either stop producing insulin or can no longer produce it in enough quantity for the body's needs. The condition is commonly divided into two types, depending on the origin of the condition: Type 1 diabetes, sometimes...
. Nuclear sclerosis
Nuclear sclerosis
Nuclear sclerosis is an age-related change in the density of the crystalline lens nucleus that occurs in all older animals. It is caused by compression of older lens fibers in the nucleus by new fiber formation. The denser construction of the nucleus causes it to scatter light...
resembles a cataract but is actually a normal age-related change.
Vestibular disease
Elderly dogs are susceptible to an unusual form of intense vertigoVertigo (medical)
Vertigo is a type of dizziness, where there is a feeling of motion when one is stationary. The symptoms are due to a dysfunction of the vestibular system in the inner ear...
, known as old dog vestibular disease, the cause of which is unknown, or idiopathic
Idiopathic
Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios + πάθος, pathos , it means approximately "a disease of its own kind". It is technically a term from nosology, the classification of disease...
. Signs include nausea, difficulty or the complete inability to stand, head tilt, circling, and nystagmus (the movement of the eyes in a repetitive jerking motion, usually horizontal). The signs may improve rapidly or take a few days. While most cases are idiopathic, vestibular signs can also be caused by inner ear disease
Otitis interna
Otitis interna is an inflammation of the inner ear and is usually considered synonymous with labyrinthitis. HolaLabyrinthitis is an inflammation of the inner ear that typically results in severe vertigo lasting for one or more days...
, a brain tumor, or rarely a stroke
Stroke
A stroke, previously known medically as a cerebrovascular accident , is the rapidly developing loss of brain function due to disturbance in the blood supply to the brain. This can be due to ischemia caused by blockage , or a hemorrhage...
. The major risk of idiopathic cases is that the dog is often unable to eat, drink, or go outside to urinate or defecate. These cases must receive supportive therapy of intravenous fluids and nutrition; a light sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
is sometimes administered, as the dog may be very stressed by the experience.
Heart disease
Older, small breeds of dogs are prone to congestive heart failureCongestive heart failure
Heart failure often called congestive heart failure is generally defined as the inability of the heart to supply sufficient blood flow to meet the needs of the body. Heart failure can cause a number of symptoms including shortness of breath, leg swelling, and exercise intolerance. The condition...
due to degeneration of the mitral valve
Mitral valve
The mitral valve is a dual-flap valve in the heart that lies between the left atrium and the left ventricle...
. This condition is known to be inherited in Cavalier King Charles Spaniel
Cavalier King Charles Spaniel
The Cavalier King Charles Spaniel is a small breed of Spaniel-type dog, and is classed as a toy dog by most kennel clubs. It is one of the most popular breeds in the United Kingdom. Since 2000, it has been growing in popularity in the United States. It is a smaller breed of spaniel, and Cavalier...
s. Degenerative valve disease is the most common form of heart disease in dogs. Mitral insufficiency
Mitral regurgitation
Mitral regurgitation , mitral insufficiency or mitral incompetence is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood from the left ventricle, through the mitral valve, and into the left atrium, when...
leads to turbulent blood flow and increased pressure in the left atrium
Left atrium
The left atrium is one of the four chambers in the human heart. It receives oxygenated blood from the pulmonary veins, and pumps it into the left ventricle, via the mitral valve.-Foramen ovale:...
. This causes increased pressure in the pulmonary blood vessels and pulmonary edema
Pulmonary edema
Pulmonary edema , or oedema , is fluid accumulation in the air spaces and parenchyma of the lungs. It leads to impaired gas exchange and may cause respiratory failure...
(a build-up of fluid in the lungs). Decreased output of blood by the left ventricle
Left ventricle
The left ventricle is one of four chambers in the human heart. It receives oxygenated blood from the left atrium via the mitral valve, and pumps it into the aorta via the aortic valve.-Shape:...
causes the body to compensate by increasing sympathetic tone and activating the renin-angiotensin-aldosterone system (RAAS). Increased sympathetic tone leads to increased peripheral vascular resistance and increased heart rate and contractility
Contractility
Myocardial contractility is the intrinsic ability of the heart to contract independent of preload and afterload. Changes in the ability to produce force during contraction result from different degrees of binding between myosin and actin filaments...
of the heart muscle. Chronic elevation of sympathetic tone damages the heart muscle. Activation of the RAAS results in increased retention of water and sodium by the kidneys, vasoconstriction
Vasoconstriction
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, particularly the large arteries, small arterioles and veins. The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in...
, and other effects that result in increased blood volume. It also results in an increase in diastolic pressure and leads to pulmonary edema. Treatment for congestive heart failure has historically focussed on two types of drugs that address these concerns: diuretic
Diuretic
A diuretic provides a means of forced diuresis which elevates the rate of urination. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way.- Medical uses :...
s (especially furosemide
Furosemide
Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix...
), which decrease blood volume, and ACE inhibitor
ACE inhibitor
ACE inhibitors or angiotensin-converting enzyme inhibitors are a group of drugs used primarily for the treatment of hypertension and congestive heart failure...
s, which interrupt the RAAS. Recently, pimobendan
Pimobendan
Pimobendan or pimobendane. It is a calcium sensitizer with positive inotropic and vasodilator effects...
- which increases the force with which the heart muscle contracts, and is also a vasodilator - is being more widely used in the treatment of congestive heart failure
Congestive heart failure
Heart failure often called congestive heart failure is generally defined as the inability of the heart to supply sufficient blood flow to meet the needs of the body. Heart failure can cause a number of symptoms including shortness of breath, leg swelling, and exercise intolerance. The condition...
caused by valvular disease. A major veterinary study, called the QUEST study (QUality of life and Extension of Survival Time), published in September 2008 found that dogs with congestive heart failure receiving pimobendan
Pimobendan
Pimobendan or pimobendane. It is a calcium sensitizer with positive inotropic and vasodilator effects...
plus furosemide
Furosemide
Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix...
had significantly better survival outcomes than those receiving benazepril
Benazepril
Benazepril, brand name Lotensin, is a medication used to treat high blood pressure , congestive heart failure, and chronic renal failure...
(an ACE inhibitor
ACE inhibitor
ACE inhibitors or angiotensin-converting enzyme inhibitors are a group of drugs used primarily for the treatment of hypertension and congestive heart failure...
) plus furosemide
Furosemide
Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix...
. However, ACE inhibitors and pimobendan have different mechanisms of action, and many veterinary cardiologists recommend they be used concurrently.
Cardiomyopathy
Cardiomyopathy
Cardiomyopathy, which literally means "heart muscle disease," is the deterioration of the function of the myocardium for any reason. People with cardiomyopathy are often at risk of arrhythmia or sudden cardiac death or both. Cardiomyopathy can often go undetected, making it especially dangerous to...
, or disease of the heart muscle, is also seen in dogs and is associated with large breeds (the exception being Cocker Spaniels, a medium-sized breed). Dilated cardiomyopathy
Dilated cardiomyopathy
Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot pump blood efficiently. The decreased heart function can affect the lungs, liver, and other body systems....
is seen in Great Danes, Irish Wolfhound
Irish Wolfhound
The Irish wolfhound is a breed of domestic dog , specifically a sighthound. The name originates from its purpose rather than from its appearance...
s, St. Bernards, Dobermann
Dobermann
The Doberman Pinscher or simply Doberman, is a breed of domestic dog originally developed around 1890 by Karl Friedrich Louis Dobermann. Doberman Pinschers are among the most common of pet breeds, and the breed is well known as an intelligent, alert, and loyal companion dog...
s, Boxer
Boxer (dog)
Developed in Germany, the Boxer is a breed of stocky, medium-sized, short-haired dog. The coat is smooth and fawn or brindled, with or without white markings. Boxers are brachycephalic , and have a square muzzle, mandibular prognathism , very strong jaws and a powerful bite ideal for hanging on to...
s, and other large breeds. Dobermanns, in addition to heart muscle failure, are prone to ventricular arrhythmias. Boxer dogs are predisposed to a unique cardiomyopathy with clinical and histological changes analogous to human arrhythmogenic right ventricular cardiomyopathy (ARVC). The disease has been termed “Boxer cardiomyopathy
Boxer cardiomyopathy
Boxer cardiomyopathy is a disease of the myocardium primarily affecting Boxer dogs. It is characterized by the development of ventricular tachyarrhythmias, resulting in syncope and sudden cardiac death...
” or “Boxer ARVC”, and is characterized by development of ventricular tachyarrhythmias. Affected dogs are at risk of syncope and sudden cardiac death. Myocardial failure and congestive heart failure are rare manifestations of this disease.
Other diseases
Other diseases affecting dogs include endocrineEndocrine system
In physiology, the endocrine system is a system of glands, each of which secretes a type of hormone directly into the bloodstream to regulate the body. The endocrine system is in contrast to the exocrine system, which secretes its chemicals using ducts. It derives from the Greek words "endo"...
diseases, immune-mediated disease
Immune-mediated disease
Immune-mediated diseases are conditions which result from abnormal activity of the body's immune system. The immune system may over-react or start attacking the body . Autoimmune diseases are a subset of immune-mediated diseases....
s, and reproductive diseases. Diabetes mellitus
Diabetes in dogs
Diabetes mellitus is a disease in which the beta cells of the endocrine pancreas either stop producing insulin or can no longer produce it in enough quantity for the body's needs. The condition is commonly divided into two types, depending on the origin of the condition: Type 1 diabetes, sometimes...
, Cushing's syndrome
Cushing's syndrome
Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...
, Addison's disease
Addison's disease
Addison’s disease is a rare, chronic endocrine disorder in which the adrenal glands do not produce sufficient steroid hormones...
, and hypothyroidism
Hypothyroidism
Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
are the most common endocrine diseases. Immune-mediated hemolytic anemia
Autoimmune hemolytic anemia
Autoimmune hemolytic anemia occurs when antibodies directed against the person's own red blood cells cause the RBCs to burst , leading to insufficient plasma concentration. The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in serious cases...
is a devastating disease that causes severe anemia
Anemia
Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...
in dogs through destruction by the immune system. It has been associated with vaccinations and certain drugs, although many cases are idiopathic
Idiopathic
Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios + πάθος, pathos , it means approximately "a disease of its own kind". It is technically a term from nosology, the classification of disease...
. A similar but less severe immune disease is immune-mediated thrombocytopenia
Idiopathic thrombocytopenic purpura
Idiopathic thrombocytopenic purpura is the condition of having an abnormally low platelet count of no known cause . As most incidents of ITP appear to be related to the production of antibodies against platelets, immune thrombocytopenic purpura or immune thrombocytopenia are terms also used to...
, characterized by destruction of platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
s by the immune system. Symptoms include bruising and petechia
Petechia
A petechia is a small red or purple spot on the body, caused by a minor hemorrhage ."Petechiae" refers to one of the three major classes of purpuric skin conditions. Purpuric eruptions are classified by size into three broad categories...
e (pinpoint bruising, often seen in the mouth). Common reproductive diseases include pyometra
Pyometra
Pyometra is a disease of the uterus most commonly seen in female dogs, but also seen in female cats , rabbits, ferrets, rats and guinea pigs. Pyometra is an important disease to be aware of for any dog owner because of the sudden nature of the disease and the deadly consequences if left untreated...
(distension of the uterus
Uterus
The uterus or womb is a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species...
with pus), mammary tumor
Mammary tumor
A mammary tumor is a tumor originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to...
s, and benign prostatic hyperplasia
Benign prostatic hyperplasia
Benign prostatic hyperplasia also known as benign prostatic hypertrophy , benign enlargement of the prostate , and adenofibromyomatous hyperplasia, refers to the increase in size of the prostate....
.
Dangerous foods
Some foods commonly enjoyed by humans are dangerous to dogs:- Dogs love the flavor of chocolateChocolateChocolate is a raw or processed food produced from the seed of the tropical Theobroma cacao tree. Cacao has been cultivated for at least three millennia in Mexico, Central and South America. Its earliest documented use is around 1100 BC...
, but chocolate in sufficient doses is lethally toxic to dogs (and horseHorseThe horse is one of two extant subspecies of Equus ferus, or the wild horse. It is a single-hooved mammal belonging to the taxonomic family Equidae. The horse has evolved over the past 45 to 55 million years from a small multi-toed creature into the large, single-toed animal of today...
s, parrots, and catCatThe cat , also known as the domestic cat or housecat to distinguish it from other felids and felines, is a small, usually furry, domesticated, carnivorous mammal that is valued by humans for its companionship and for its ability to hunt vermin and household pests...
s). Chocolate contains theobromineTheobromineTheobromine , also known as xantheose, is a bitter alkaloid of the cacao plant, with the chemical formula C7H8N4O2. It is found in chocolate, as well as in a number of other foods, including the leaves of the tea plant, and the kola nut...
, a chemical stimulant that, together with caffeineCaffeineCaffeine is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants...
and theophyllineTheophyllineTheophylline, also known as dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as COPD and asthma under a variety of brand names. Because of its numerous side-effects, the drug is now rarely administered for clinical use. As a member of the xanthine family, it...
, belongs to the group of methylxanthine alkaloidAlkaloidAlkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...
s. Dogs are unable to metabolize theobromine effectively. If they eat chocolate, the theobromine can remain in their bloodstreams for up to 20 hours, and these animals may experience fast heart rateTachycardiaTachycardia comes from the Greek words tachys and kardia . Tachycardia typically refers to a heart rate that exceeds the normal range for a resting heart rate...
, hallucinationHallucinationA hallucination, in the broadest sense of the word, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid,...
s, severe diarrheaDiarrheaDiarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...
, epileptic seizures, heart attacksMyocardial infarctionMyocardial infarction or acute myocardial infarction , commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die...
, internal bleedingInternal bleedingInternal bleeding is bleeding occurring inside the body. It can be a serious medical emergency depending on where it occurs , and can potentially cause death and cardiac arrest if proper medical treatment is not received quickly....
, and eventually deathDeathDeath is the permanent termination of the biological functions that sustain a living organism. Phenomena which commonly bring about death include old age, predation, malnutrition, disease, and accidents or trauma resulting in terminal injury....
. A chocolate bar can be sufficient to make a small dog extremely ill or even kill it, depending on the type of chocolate. It would take large quantities of white or milk chocolate to harm a dog, but dark chocolate and baking chocolate can be deadly in small doses. Approximately thirty grams of baking chocolate per kilogram (1/2 ounce per pound) of body weight is enough to be poisonous. In case of accidental intake of chocolate by especially a smaller dog, contact a veterinarianVeterinarianA veterinary physician, colloquially called a vet, shortened from veterinarian or veterinary surgeon , is a professional who treats disease, disorder and injury in animals....
or animal poison control immediately; it is commonly recommended to induce vomiting within two hours of ingestion. If chocolate ingestion is suspected (mostly dark or baking chocolate), hydrogen peroxide can be used to safely induce vomiting, then making a trip to the veterinarian is suggested. Large breeds are less susceptible to chocolate poisoning, but can still die after eating four ounces of chocolate.
-
- Note:Carob treats are often available as dog treats; these are unrelated to chocolate and are safe.
- It has recently been confirmed that grapeGrapeA grape is a non-climacteric fruit, specifically a berry, that grows on the perennial and deciduous woody vines of the genus Vitis. Grapes can be eaten raw or they can be used for making jam, juice, jelly, vinegar, wine, grape seed extracts, raisins, molasses and grape seed oil. Grapes are also...
s and raisinRaisinRaisins are dried grapes. They are produced in many regions of the world. Raisins may be eaten raw or used in cooking, baking and brewing...
s can cause acute kidney failureRenal failureRenal failure or kidney failure describes a medical condition in which the kidneys fail to adequately filter toxins and waste products from the blood...
in dogs (see also grape and raisin toxicity in dogsGrape and raisin toxicity in dogsThe consumption of grapes and raisins presents a potential health threat to dogs. Their toxicity to dogs can cause the animal to develop acute renal failure with anuria...
). The exact mechanism is not known, nor is there any means to determine the susceptibility of an individual dog. While as little as one raisin can be toxic to a susceptible ten pound dog, some other dogs have eaten as much as a pound of grapes or raisins at a time without ill effects. The affected dog usually vomits a few hours after consumption and begins showing signs of renal failure three to five days later. A mycotoxin is suspected to be involved, but one has not been found in grapes or raisins ingested by affected dogs - OnionOnionThe onion , also known as the bulb onion, common onion and garden onion, is the most widely cultivated species of the genus Allium. The genus Allium also contains a number of other species variously referred to as onions and cultivated for food, such as the Japanese bunching onion The onion...
s contain thiosulfateThiosulfateThiosulfate is an oxyanion of sulfur. The prefix thio indicates that thiosulfate ion is a sulfate ion with one oxygen replaced by a sulfur. Thiosulfate occurs naturally and is produced by certain biochemical processes...
which causes hemolytic anemiaHemolytic anemiaHemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels or elsewhere in the human body . It has numerous possible causes, ranging from relatively harmless to life-threatening...
in dogs (and catCatThe cat , also known as the domestic cat or housecat to distinguish it from other felids and felines, is a small, usually furry, domesticated, carnivorous mammal that is valued by humans for its companionship and for its ability to hunt vermin and household pests...
s). Thiosulfate levels are not affected by cooking or processing. Small puppies have died of hemolytic anemia after being fed baby food containing onion powder. Occasional exposure to small amounts is usually not a problem, but continuous exposure to even small amounts can be a serious threat. Also garlicGarlicAllium sativum, commonly known as garlic, is a species in the onion genus, Allium. Its close relatives include the onion, shallot, leek, chive, and rakkyo. Dating back over 6,000 years, garlic is native to central Asia, and has long been a staple in the Mediterranean region, as well as a frequent...
contains thiosulfate, even if to a significantly lesser extent, and it is also known to cause diarrhea and vomiting. Small doses of garlic 5-6 times per week can improve dog health, since garlic is a natural antimicrobialAntimicrobialAn anti-microbial is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or protozoans. Antimicrobial drugs either kill microbes or prevent the growth of microbes...
and helps to prevent heart disease. It is stated that garlic also has repellent effects on fleaFleaFlea is the common name for insects of the order Siphonaptera which are wingless insects with mouthparts adapted for piercing skin and sucking blood...
s and tickTickTicks are small arachnids in the order Ixodida, along with mites, constitute the subclass Acarina. Ticks are ectoparasites , living by hematophagy on the blood of mammals, birds, and sometimes reptiles and amphibians...
s, especially in combination with brewer's or nutritional yeastNutritional yeastNutritional yeast is a deactivated yeast, usually Saccharomyces cerevisiae. The scientific work of Louis Pasteur made it possible to isolate yeast in pure culture form. Nutritional yeast is produced by culturing the yeast with a mixture of sugarcane and beet molasses for a period of 7 days and...
. - Macadamia nuts can cause stiffness, tremors, hyperthermiaHyperthermiaHyperthermia is an elevated body temperature due to failed thermoregulation. Hyperthermia occurs when the body produces or absorbs more heat than it can dissipate...
, and abdominal pain. The exact mechanism is not known. Most dogs recover with supportive care when the source of exposure is removed. - Alcoholic beverageAlcoholic beverageAn alcoholic beverage is a drink containing ethanol, commonly known as alcohol. Alcoholic beverages are divided into three general classes: beers, wines, and spirits. They are legally consumed in most countries, and over 100 countries have laws regulating their production, sale, and consumption...
s pose much the same temptation and hazard to dogs as to humans. A drunk dog displays behavior analogous to that of an intoxicated person. (However, beer presents another problem; see below.) - HopsHopsHops are the female flower clusters , of a hop species, Humulus lupulus. They are used primarily as a flavoring and stability agent in beer, to which they impart a bitter, tangy flavor, though hops are also used for various purposes in other beverages and herbal medicine...
, a plant used in making beerBeerBeer is the world's most widely consumed andprobably oldest alcoholic beverage; it is the third most popular drink overall, after water and tea. It is produced by the brewing and fermentation of sugars, mainly derived from malted cereal grains, most commonly malted barley and malted wheat...
, can cause malignant hyperthermiaMalignant hyperthermiaMalignant hyperthermia or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to certain drugs used for general anesthesia; specifically, the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine...
in dogs, usually with fatal results. Certain breeds, such as GreyhoundGreyhoundThe Greyhound is a breed of sighthound that has been primarily bred for coursing game and racing, and the breed has also recently seen a resurgence in its popularity as a pedigree show dog and family pet. It is a gentle and intelligent breed...
s, seem particularly sensitive to hop toxicity, but hops should be kept away from all dogs. Even small amounts of hops can trigger a potentially deadly reaction, even if the hops are "spent" after use in brewingBrewingBrewing is the production of beer through steeping a starch source in water and then fermenting with yeast. Brewing has taken place since around the 6th millennium BCE, and archeological evidence suggests that this technique was used in ancient Egypt...
. - XylitolXylitolXylitol is a sugar alcohol sweetener used as a naturally occurring sugar substitute. It is found in the fibers of many fruits and vegetables, and can be extracted from various berries, oats, and mushrooms, as well as fibrous material such as corn husks and sugar cane bagasse, and birch...
is a sugar substitute used in chewing gum, chewable vitamins, candy, toothpaste, and other products. Although empirical studies indicate xylitol may be safe for dogs, there have been cases of foods, candies and gums containing xylitol causing toxic or even fatal liver damage in dogs and should be avoided (http://www.aspca.org/site/DocServer/vetm0207f_095-100_.pdf?docID=10462). - Some dogs have food allergies just as humans do; this is particular to the individual dog and not characteristic of the species as a whole. An example is a dog becoming physically ill from salmonSalmonSalmon is the common name for several species of fish in the family Salmonidae. Several other fish in the same family are called trout; the difference is often said to be that salmon migrate and trout are resident, but this distinction does not strictly hold true...
; many humans likewise have seafood allergies. - If dogs eat the pits of fruits such as peaches and apricots or apple seeds, they can get cyanideCyanideA cyanide is a chemical compound that contains the cyano group, -C≡N, which consists of a carbon atom triple-bonded to a nitrogen atom. Cyanides most commonly refer to salts of the anion CN−. Most cyanides are highly toxic....
poisoning due to cyanogenic glycosides. However, the dog has to chew on the pit or seed to release the cyanide. Swallowing them whole will not cause poisoning but may lead to choking. It should be noted that a very large amount of seeds would need to be chewed and swallowed in order to cause problems.
- It has recently been confirmed that grape
- Note:Carob treats are often available as dog treats; these are unrelated to chocolate and are safe.
Green tomatoes should be avoided in a dog's diet because they contain tomatine, which is harmful to dogs. As the tomato ripens and turns red the tomatine disappears, and the tomato become safe for the dog to eat. The tomato plant itself is toxic.
Avocado leaves, bark, skin, or pit are documented to be harmful to animals; cats, dogs, cattle, goats, rabbits, rats, birds, fish, and horses.
Common household substances
Some common household chemicals are particularly dangerous to dogs:- AntifreezeAntifreezeAntifreeze is a freeze preventive used in internal combustion engines and other heat transfer applications, such as HVAC chillers and solar water heaters....
(ethylene glycolEthylene glycolEthylene glycol is an organic compound widely used as an automotive antifreeze and a precursor to polymers. In its pure form, it is an odorless, colorless, syrupy, sweet-tasting liquid...
), due to its sweet taste, poses an extreme danger of poisoning to a dog (or cat) that either drinks from a spill or licks it off its fur. Even a very small amount such as a tablespoon can easily prove fatal. The antifreeze itself is not toxic, but is metabolized via the liver to the toxinToxinA toxin is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded...
s glycolate and oxalateOxalateOxalate , is the dianion with formula C2O42− also written 22−. Either name is often used for derivatives, such as disodium oxalate, 2C2O42−, or an ester of oxalic acid Oxalate (IUPAC: ethanedioate), is the dianion with formula C2O42− also written (COO)22−. Either...
, which cause intoxication and vomiting, metabolic acidosisMetabolic acidosisIn medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low due to increased production of hydrogen by the body or the...
, and finally acute kidney failure leading to seizures and death. By the time symptoms are observed, the kidneys are usually too damaged for the dog to survive so acting quickly is important. Immediate treatments include inducing vomiting by using apomorphineApomorphineApomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes. It is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix...
or dilute hydrogen peroxideHydrogen peroxideHydrogen peroxide is the simplest peroxide and an oxidizer. Hydrogen peroxide is a clear liquid, slightly more viscous than water. In dilute solution, it appears colorless. With its oxidizing properties, hydrogen peroxide is often used as a bleach or cleaning agent...
solution (if this can be done shortly after ingestion), but these merely reduce the amount absorbed – immediate veterinary treatment is still usually imperative due to the high toxicity of the compound. Medical treatments may include fomepizoleFomepizoleFomepizole or 4-methylpyrazole is indicated for use as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. It may be used alone or in combination with hemodialysis...
(preferred treatment) which competes favorably with the toxin in the body, ethanolEthanolEthanol, also called ethyl alcohol, pure alcohol, grain alcohol, or drinking alcohol, is a volatile, flammable, colorless liquid. It is a psychoactive drug and one of the oldest recreational drugs. Best known as the type of alcohol found in alcoholic beverages, it is also used in thermometers, as a...
which competes favorably in the liver long enough to allow excretion to take place, activated charcoal to further reduce uptake of undigested product, and hemodialysisHemodialysisIn medicine, hemodialysis is a method for removing waste products such as creatinine and urea, as well as free water from the blood when the kidneys are in renal failure. Hemodialysis is one of three renal replacement therapies .Hemodialysis can be an outpatient or inpatient therapy...
to remove toxins from the bloodBloodBlood is a specialized bodily fluid in animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells....
. Dogs should not be allowed access to any place in which an antifreeze leak or spill has happened until the spill is completely cleaned out. Some brands of antifreeze contain propylene glycolPropylene glycolPropylene glycol, also called 1,2-propanediol or propane-1,2-diol, is an organic compound with formula C3H8O2 or HO-CH2-CHOH-CH3...
instead of ethylene glycolEthylene glycolEthylene glycol is an organic compound widely used as an automotive antifreeze and a precursor to polymers. In its pure form, it is an odorless, colorless, syrupy, sweet-tasting liquid...
and are marketed as being less harmful or less attractive to animals.
- Mouse and rat poisonRat poisonRodenticides are a category of pest control chemicals intended to kill rodents.Single feed baits are chemicals sufficiently dangerous that the first dose is sufficient to kill....
is commonly found in the house or garage. Dogs readily eat these poisons, which look like small green blocks and are very attractive to them. The poisons work by depleting stores of Vitamin KVitamin KVitamin K is a group of structurally similar, fat soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone derivatives...
in the body, without which blood can not clot properly. Symptoms of poisoning include depression, weakness, difficulty breathing, bruising, and bleeding from any part of the body. These symptoms often take 3 to 4 days to show up. A blood test will show that the blood is not clotting properly. If the poison has only recently been ingested (within 2 to 3 hours), the dog should be given apomorphineApomorphineApomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes. It is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix...
or hydrogen peroxideHydrogen peroxideHydrogen peroxide is the simplest peroxide and an oxidizer. Hydrogen peroxide is a clear liquid, slightly more viscous than water. In dilute solution, it appears colorless. With its oxidizing properties, hydrogen peroxide is often used as a bleach or cleaning agent...
to make it vomit. Activated charcoalActivated carbonActivated carbon, also called activated charcoal, activated coal or carbo activatus, is a form of carbon that has been processed to make it extremely porous and thus to have a very large surface area available for adsorption or chemical reactions.The word activated in the name is sometimes replaced...
can be given to absorb any remaining poison in the gastrointestinal tractGastrointestinal tractThe human gastrointestinal tract refers to the stomach and intestine, and sometimes to all the structures from the mouth to the anus. ....
. Then the dog is given Vitamin K supplementation for 3 to 4 weeks, depending on the type of poison. At the end of treatment, the clotting timeCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
s should be tested again. The prognosisPrognosisPrognosis is a medical term to describe the likely outcome of an illness.When applied to large statistical populations, prognostic estimates can be very accurate: for example the statement "45% of patients with severe septic shock will die within 28 days" can be made with some confidence, because...
is good in these cases. However, if the dog is already showing signs of poisoning, it is too late to try to remove the poison from the body. A whole blood transfusionBlood transfusionBlood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood...
or plasmaBlood plasmaBlood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...
is given to treat the anemiaAnemiaAnemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...
and to try to control bleeding. Vitamin K is also given. The prognosis is poor in these cases.- Mouse and rat poisons containing cholecalciferolCholecalciferolCholecalciferol is a form of vitamin D, also called vitamin D3 or calciol.It is structurally similar to steroids such as testosterone, cholesterol, and cortisol .-Forms:Vitamin D3 has several forms:...
cause hypercalcemiaHypercalcaemiaHypercalcaemia is an elevated calcium level in the blood. . It can be an asymptomatic laboratory finding, but because an elevated calcium level is often indicative of other diseases, a workup should be undertaken if it persists...
and hyperphosphatemiaHyperphosphatemiaHyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood. Often, calcium levels are lowered due to precipitation of phosphate with the calcium in tissues.-Signs and symptoms:...
in dogs. Symptoms include depression, loss of appetite, vomiting blood, weakness, and shock. Treatment is as above for recent exposure. When hypercalcemia occurs (which can take 1 to 2 weeks), treatment is with intravenous fluids (saline), diureticDiureticA diuretic provides a means of forced diuresis which elevates the rate of urination. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way.- Medical uses :...
s, corticosteroidCorticosteroidCorticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte...
s, and calcitoninCalcitoninCalcitonin is a 32-amino acid linear polypeptide hormone that is producedin humans primarily by the parafollicular cells of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium , opposing the effects of parathyroid hormone . Calcitonin has been found...
. Long term prognosis is good once the dog is stabilized.
- Mouse and rat poisons containing cholecalciferol
- ZincZincZinc , or spelter , is a metallic chemical element; it has the symbol Zn and atomic number 30. It is the first element in group 12 of the periodic table. Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2...
toxicity, mostly in the form of the ingestion of US penniesCent (United States coin)The United States one-cent coin, commonly known as a penny, is a unit of currency equaling one one-hundredth of a United States dollar. The cent's symbol is ¢. Its obverse has featured the profile of President Abraham Lincoln since 1909, the centennial of his birth. From 1959 to 2008, the reverse...
minted after 1982, is commonly fatal in dogs where it causes a severe hemolytic anemiaHemolytic anemiaHemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels or elsewhere in the human body . It has numerous possible causes, ranging from relatively harmless to life-threatening...
.
Over-the-counter medications
Poisoning with pain medications is common. AspirinAspirin
Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. It was discovered by Arthur Eichengrun, a chemist with the German company Bayer...
, acetaminophen
Paracetamol
Paracetamol INN , or acetaminophen USAN , is a widely used over-the-counter analgesic and antipyretic . It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies...
(Tylenol
Tylenol
Tylenol is a North American brand of drugs advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, and flu. The active ingredient of its original, flagship product, paracetamol , is marketed as an analgesic and antipyretic...
), ibuprofen
Ibuprofen
Ibuprofen is a nonsteroidal anti-inflammatory drug used for relief of symptoms of arthritis, fever, as an analgesic , especially where there is an inflammatory component, and dysmenorrhea....
(Advil), and naproxen
Naproxen
Naproxen sodium is a nonsteroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as:...
(Aleve) can all cause severe symptoms in dogs, including vomiting blood, diarrhea, and abdominal pain. Specifically, aspirin can cause metabolic acidosis
Metabolic acidosis
In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low due to increased production of hydrogen by the body or the...
, acetaminophen can cause liver disease, ibuprofen can cause kidney disease, and naproxen can cause ulcers
Peptic ulcer
A peptic ulcer, also known as PUD or peptic ulcer disease, is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm...
in the stomach, which can perforate. Treatment depends on the symptoms.
Public health risks
Zoonosis
A zoonosis or zoonoseis any infectious disease that can be transmitted from non-human animals to humans or from humans to non-human animals . In a study of 1415 pathogens known to affect humans, 61% were zoonotic...
. The most well known zoonosis is rabies, a viral infection transmitted through a bite. A common bacterial zoonosis is leptospirosis, transmitted through urine. Some of the most important zoonoses are parasitic. Zoonotic intestinal parasite
Intestinal parasite
Intestinal parasites are parasites that populate the gastro-intestinal tract in humans and other animals. They can live throughout the body, but most prefer the intestinal wall. Means of exposure include: ingestion of undercooked meat, drinking infected water, and skin absorption...
s transmitted through contact with feces include Toxocara canis
Toxocara canis
Toxocara canis is worldwide distributed helminth parasite of dogs and other canids. T. canis are gonochorists, adult worms measure from 9 to 18 cm, are yellow-white in color, and occur in the intestine of the definitive host. In adult dogs, the infection is usually asymptomatic. By the...
(the canine roundworm), which causes toxocariasis
Toxocariasis
-History of discovery:Werner described a parasitic nematode in dogs in 1782 which he named Ascaris canis. Johnston determined that what Werner had described was actually a member of the genus Toxocara established by Stiles in 1905. Fữlleborn speculated that T canis larvae might cause granulomatous...
, visceral larva migrans, and ocular larva migrans
Ocular larva migrans
Ocular larva migrans is the ocular form of the larva migrans syndrome that occurs when toxocara canis larvae invade the eye. They may be associated with visceral larva migrans...
, and hookworm
Hookworm
The hookworm is a parasitic nematode that lives in the small intestine of its host, which may be a mammal such as a dog, cat, or human. Two species of hookworms commonly infect humans, Ancylostoma duodenale and Necator americanus. A. duodenale predominates in the Middle East, North Africa, India...
s, which can cause cutaneous larva migrans
Cutaneous larva migrans
Cutaneous larva migrans is a skin disease in humans, caused by the larvae of various nematode parasites of the hookworm family...
. Zoonotic skin parasites include scabies
Scabies
Scabies , known colloquially as the seven-year itch, is a contagious skin infection that occurs among humans and other animals. It is caused by a tiny and usually not directly visible parasite, the mite Sarcoptes scabiei, which burrows under the host's skin, causing intense allergic itching...
, caused by the mite Sarcoptes scabiei
Sarcoptes scabiei
Sarcoptes scabiei or the itch mite is a parasitic arthropod that burrows into skin and causes scabies. Animals affected include not only human but also wild and domesticated dogs and cats in which it is one cause of mange...
. The most common zoonotic fungal disease is ringworm, caused in this case by Microsporum canis
Microsporum canis
Microsporum canis is an organism that can cause tinea capitis in humans, and simple ringworm in pets. Despite its name, its major reservoir in companion animals is the domestic cat and dog.It is closely related to other dermatophytes....
.
Vaccinations
Depending on the location of the dog, highly recommended vaccines include rabies, canine parvovirus, canine distemper, and infectious canine hepatitis (using canine adenovirus type 2 to avoid reaction). Vaccination for other diseases, including leptospirosis, Lyme disease, Bordetella bronchiseptica, parainfluenza virus, and canine coronavirusCanine coronavirus
Canine coronavirus is a virus of the family Coronaviridae that causes a highly contagious intestinal disease worldwide in dogs. It was discovered in 1971 in Germany during an outbreak in sentry dogs.-Pathology:...
, are used after determining the risk of contact with these pathogens.
Dentistry
Dental diseaseDental disease
Dental diseases may affect the teeth, the gums, or other tissues and parts of the mouth. Dental diseases can cause much more serious problems than a toothache; they can affect our ability to chew, smile, or speak properly. Their severity may range from a simple aphthous ulcer, to a common tooth...
is one of the most common diseases in dogs. Accumulation of plaque
Dental plaque
Dental plaque is a biofilm, usually a pale yellow, that develops naturally on the teeth. Like any biofilm, dental plaque is formed by colonizing bacteria trying to attach themselves to a smooth surface...
and subsequently tartar
Calculus (dental)
In dentistry, calculus or tartar is a form of hardened dental plaque. It is caused by the continual accumulation of minerals from saliva on plaque on the teeth...
leads to gingivitis
Gingivitis
Gingivitis is a term used to describe non-destructive periodontal disease. The most common form of gingivitis is in response to bacterial biofilms adherent to tooth surfaces, termed plaque-induced gingivitis, and is the most common form of periodontal disease...
and then periodontitis (gum disease). Periodontitis leads to loss of the bony attachment of the teeth and tooth loss. Preventive measures include tooth brushing
Tooth brushing
Tooth brushing is the act of cleaning teeth with a toothbrush.Modern medical research has shown that brushing teeth properly can prevent cavities, and periodontal, or gum disease, which causes at least one-third of adult tooth loss. If teeth are not brushed correctly and frequently, it could lead...
, providing an appropriate diet (avoiding tinned and other soft foods and providing dental chew treats) and dental scaling and polishing. Cavities
Dental caries (non-human)
Dental caries, also known as tooth decay, is uncommon among companion animals. Although rarely seen in cats, the incidence of caries in dogs has been estimated at approximately 5%...
are uncommon in dogs.
Nutrition and obesity
Carnivore
A carnivore meaning 'meat eater' is an organism that derives its energy and nutrient requirements from a diet consisting mainly or exclusively of animal tissue, whether through predation or scavenging...
like a dog is not the same as in an omnivorous
Omnivore
Omnivores are species that eat both plants and animals as their primary food source...
human. Wild and feral
Feral
A feral organism is one that has changed from being domesticated to being wild or untamed. In the case of plants it is a movement from cultivated to uncultivated or controlled to volunteer. The introduction of feral animals or plants to their non-native regions, like any introduced species, may...
dogs can usually get all the nutrients needed from a diet of whole prey and raw meat. In addition, the scraps often consist of fat rather than meat protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
, which in excess is no better for dogs than it is for humans. While not all human delicacies are acutely toxic to dogs (see above), many have the same chronically unfortunate results as they do for humans. Lastly, many people overfeed their dogs by giving them table scraps and human food such as ice cream. Dogs will usually eat all the scraps and treats they are fed, which is more than often too much food.
Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
, an increasingly common problem in dogs in Western countries, which can cause numerous health problems just as it does in humans, although dogs are much less susceptible to the common cardiac and arterial consequences of obesity than humans are. According to a study published in the Journal of Veterinary Internal Medicine, the prevalence of obesity in dogs is between 22 and 40 percent.
Additionally, the feeding of table scraps directly from the table (as opposed to taking scraps after the meal, and giving them in the dog's food dish as a treat) can lead to trained begging behavior on the part of the dog, or even encourage the dog to reach up and take food directly from the table (another trained response). These are normally seen as undesirable behavioral traits in a dog.
Obesity can be a sign of other serious ailments such as Cushing's disease
Cushing's disease
Cushing's disease is a cause of Cushing's Syndrome characterised by increased secretion of adrenocorticotropic hormone from the anterior pituitary. This is most often as a result of a pituitary adenoma...
which is characterized by weight gain, appetite increase and lethargy in primarily older dogs.
A modern trend in canine diets is raw feeding
Raw feeding
Raw feeding is the practice of feeding domestic dogs, cats and other animals a diet primarily of uncooked meat, edible bones, and organs.*Supporters of raw feeding believe that the natural diet of raw meat, bones, and organs is superior nutritionally to highly processed commercial pet food...
of whole meats, bones and little filler material.
Vitamins and supplements
It is not yet clearly established if vitamins and supplementsDietary supplement
A dietary supplement, also known as food supplement or nutritional supplement, is a preparation intended to supplement the diet and provide nutrients, such as vitamins, minerals, fiber, fatty acids, or amino acids, that may be missing or may not be consumed in sufficient quantities in a person's diet...
are needed to be administered in dogs. The opinions among the veterinarians are however divided. While some think that vitamins and supplements are necessary and can improve the health of a dog, others believe that they are unnecessary and moreover, may harm the dog. However, according to the U.S. Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...
(FDA), dogs receive the complete and balanced nutritional level just from the commercially processed dog food. Still, pet owners who are giving their dogs homemade food may consider including extra vitamins and supplements into their pet's diet.
It is estimated that nearly a third of the pets (dogs and cats) in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
receive nutritional supplements. This is mainly due to the fact that vitamins are highly recommended in dogs with joint
Joint
A joint is the location at which two or more bones make contact. They are constructed to allow movement and provide mechanical support, and are classified structurally and functionally.-Classification:...
pain as a result of arthritis
Arthritis
Arthritis is a form of joint disorder that involves inflammation of one or more joints....
. According to a study realized in 2006 and published in the Journal of the American Veterinary Medical Association, the most commonly used vitamins are the multivitamins and the fatty acids. The latter improve the shine of a dog's coat by reducing shedding. Probiotics are another type of supplement, VitaHound Lab's supplements are given to dogs with gastrointestinal problems, and antioxidants may be prescribed to fight the effects of aging and the problems that come with it such as cognitive dysfunction.
Veterinarians also state that over doses of vitamins can be harmful in dogs. As an example, calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust...
in excess can cause problems with their bone
Bone
Bones are rigid organs that constitute part of the endoskeleton of vertebrates. They support, and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue is a type of dense connective tissue...
s, especially in the large-breed dogs. Over supplementation of vitamins A and D can cause vitamin toxicity in dogs. Excess vitamin A
Vitamin A
Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
can cause dehydration
Dehydration
In physiology and medicine, dehydration is defined as the excessive loss of body fluid. It is literally the removal of water from an object; however, in physiological terms, it entails a deficiency of fluid within an organism...
, joint pain and can also harm the blood vessels, while too much vitamin D
Vitamin D
Vitamin D is a group of fat-soluble secosteroids. In humans, vitamin D is unique both because it functions as a prohormone and because the body can synthesize it when sun exposure is adequate ....
can cause muscular atrophy, or loss appetite. Whenever a dog owner decides to give his pet vitamins and supplements it is mandatory to first consult a veterinarian. Many veterinarians however recommend that healthy dogs should not receive any vitamins or supplements.
However, some veterinarians recommend dog vitamins in dogs that are under heavy stress
Stress (biology)
Stress is a term in psychology and biology, borrowed from physics and engineering and first used in the biological context in the 1930s, which has in more recent decades become commonly used in popular parlance...
of hard training. Vitamin B12
Vitamin B12
Vitamin B12, vitamin B12 or vitamin B-12, also called cobalamin, is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins...
is considered benefic in these cases, because if given correctly it improves the dog's appetite
Appetite
The appetite is the desire to eat food, felt as hunger. Appetite exists in all higher life-forms, and serves to regulate adequate energy intake to maintain metabolic needs. It is regulated by a close interplay between the digestive tract, adipose tissue and the brain. Decreased desire to eat is...
. Still, dosage should be kept as low as is effective, perhaps beginning with 1-2 cc/ dog / day; with a maximum dose of 4-5 cc/ day. Vitamin C
Vitamin C
Vitamin C or L-ascorbic acid or L-ascorbate is an essential nutrient for humans and certain other animal species. In living organisms ascorbate acts as an antioxidant by protecting the body against oxidative stress...
is thought to help maintaining the well functioning of the immune system
Immune system
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...
and in maintaining a healthy skin. Vitamin E
Vitamin E
Vitamin E is used to refer to a group of fat-soluble compounds that include both tocopherols and tocotrienols. There are many different forms of vitamin E, of which γ-tocopherol is the most common in the North American diet. γ-Tocopherol can be found in corn oil, soybean oil, margarine and dressings...
acts as a mild anti-inflammatory and it also helps maintaining good footpads. It should not be given more than twice a day, 400IU/dog. Other supplements given to dogs are glucosamine
Glucosamine
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is part of the structure of the polysaccharides chitosan and chitin, which compose the exoskeletons of crustaceans and other arthropods, cell walls in fungi and...
and chondroitin. They are intended to increase the viscosity and volume of the joint fluid, called synovium and which acts as a protective mechanism for the joints. A study published in 2007, in The Veterinary Journal shows that a combination of glucosamine and chondroitin is helpful in easing the pain of arthritis dogs.
Good quality supplements should contain at least 8 essential vitamins (Vitamin A, B-complex, D, and E, and B vitamins). The vitamins and minerals should be in correct ration for one's pet and also have a high palatability. It is also important to see from which sources the vitamins and minerals come from.
Dog treats
Dog treats are often given to one's pet as a reward for something they did or just to let them chew on a boneBone
Bones are rigid organs that constitute part of the endoskeleton of vertebrates. They support, and protect the various organs of the body, produce red and white blood cells and store minerals. Bone tissue is a type of dense connective tissue...
and allow for their gums to be worked. Although dog treats carry high benefits for dogs' teeth, they can also be a problem source especially when given excessively. The food treats are usually the ones that cause trouble in dogs.
Food treats can be found all over the Internet, as many dog food and supplements manufacturers produce a wide range of treats intended for dogs. Dog food treats can also be made at home, from basic ingredients that might be found at the grocery store. Many dog owners actually prefer making their own dog treats at home because that way they are making sure their pet's diet is more natural and healthier. Whatsoever, one needs to make sure that the dog food made at home includes all the nutrients and vitamins that a dog needs to be healthy and happy.
Dog treats given excessively can be a cause of obesity
Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
in dogs. The type of food fed has a direct bearing on the tendency of a dog to become overweight. Table scraps, treats, even premium high-energy dog foods can contribute to obesity. Therefore it is highly important to closely monitor the quantity of treats that a dog gets especially when the dog's activity is diminished. Dog treats are more likely to be linked to obesity in old dogs, with reduced activities. On the other hand, active dogs require and use more calories, so dog treats are not a cause of concern in younger and highly active dogs.
Coprophagia
Many dogs have a fondness for eating fecesFeces
Feces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
. Some consume their own or other dogs' feces; others seem to prefer cat feces (which, due to the feline digestive system, are high in protein and consumed by many animals in the wild), and will raid a kitty litter box
Litter box
A litter box, sometimes called a sandbox, sand box, litter tray, litter pan, dirt box, catbox, or cat box, is an indoor feces and urine disposal box for cats that are permitted free roam of a home but who cannot or do not always go outside...
for "treats". This can be unsafe for the dog's health if the animal producing the feces has any diseases or parasites or has recently ingested drugs that might be poisonous.
Spaying and neutering
Spaying (females only) and neutering (both genders but more usually males) refers to the sterilizationNeutering
Neutering, from the Latin neuter , is the removal of an animal's reproductive organ, either all of it or a considerably large part. The process is often used in reference to males whereas spaying is often reserved for females. Colloquially, both terms are often referred to as fixing...
of animals, usually by removal of the male's testicle
Testicle
The testicle is the male gonad in animals. Like the ovaries to which they are homologous, testes are components of both the reproductive system and the endocrine system...
s or the female's ovaries
Ovary
The ovary is an ovum-producing reproductive organ, often found in pairs as part of the vertebrate female reproductive system. Ovaries in anatomically female individuals are analogous to testes in anatomically male individuals, in that they are both gonads and endocrine glands.-Human anatomy:Ovaries...
and uterus
Uterus
The uterus or womb is a major female hormone-responsive reproductive sex organ of most mammals including humans. One end, the cervix, opens into the vagina, while the other is connected to one or both fallopian tubes, depending on the species...
, in order to eliminate the ability to procreate, and reduce sex drive. Neutering has also been known to reduce aggression in male dogs, but has been shown to occasionally increase aggression in female dogs.
Animal control agencies in the United States and the ASPCA advise that dogs not intended for further breeding should be spayed or neutered so that they do not have undesired puppies.
Because of the overpopulation of dogs in some countries, puppies born to strays or as the result of accidental breedings often end up being killed in animal shelters. Spaying and neutering can also decrease the risk of hormone-driven diseases such as mammary cancer, as well as undesired hormone-driven behaviors. However, certain medical problems are more likely after neutering, such as urinary incontinence
Urinary incontinence
Urinary incontinence is any involuntary leakage of urine. It is a common and distressing problem, which may have a profound impact on quality of life. Urinary incontinence almost always results from an underlying treatable medical condition but is under-reported to medical practitioners...
in females and prostate cancer
Prostate cancer
Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...
in males. The hormonal changes involved with sterilization are likely to somewhat change the animal's personality, however, and some object to spaying and neutering as the sterilization could be carried out without the excision of organs.
It is not essential for a female dog to either experience a heat cycle or have puppies before spaying, and likewise, a male dog does not need the experience of mating before neutering.
Female cats and dogs are seven times more likely to develop mammary tumor
Mammary tumor
A mammary tumor is a tumor originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to...
s if they are not spayed before their first heat cycle. The high dietary estrogen content of the average commercial pet food may be contributing factors in the development of mammary cancer, especially when these exogenous sources are added to those normal estrogens produced by the body. Dog food containing soybean
Soybean
The soybean or soya bean is a species of legume native to East Asia, widely grown for its edible bean which has numerous uses...
s or soybean fractions have been found to contain phytoestrogens
Phytoestrogens
Phytoestrogens are plant-derived xenoestrogens functioning as the primary female sex hormone not generated within the endocrine system but consumed by eating phytoestrogonic plants...
in levels that could have biological effects when ingested longterm.
External links
- Encyclopedia of Canine Veterinary Medical Information
- List of substances toxic to dogs from the American Veterinary Medical AssociationAmerican Veterinary Medical AssociationThe American Veterinary Medical Association , founded in 1863, is a not-for-profit association representing more than 81,500 U.S. veterinarians working in private and corporate practice, government, industry, academia, and uniformed services....