This is an overview about the chapter IV (also called chapter E) of the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD

ICD

The International Statistical Classification of Diseases and Related Health Problems is a medical classification that provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or disease...

-10). This chapter is about Endocrine, nutritional and metabolic diseases.

The ICD-10 is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization

World Health Organization

The World Health Organization is a specialized agency of the United Nations that acts as a coordinating authority on international public health. Established on 7 April 1948, with headquarters in Geneva, Switzerland, the agency inherited the mandate and resources of its predecessor, the Health...

 (WHO). The code set allows more than 155,000 different codes and permits tracking of many new diagnoses and procedures, a significant expansion on the 17,000 codes available in ICD-9.

(E00–E07) Thyroid gland / Thyroid hormone

• Congenital iodine-deficiency syndrome
• Iodine-deficiency-related thyroid
  Thyroid
  The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
  
   disorders and allied conditions
  • Iodine-deficiency-related diffuse (endemic) goitre
    Endemic goitre
    Endemic goitre is a type of goitre that is associatedwith dietary iodine deficiency.Some inland areas where soil and water lacks in iodine compounds and consumption of marine foods is low are known for higher incidence of goitre. In such areas goitre is said to be "endemic".This type of goitre is...
    
    
  • Iodine-deficiency-related multinodular (endemic) goitre
    Endemic goitre
    Endemic goitre is a type of goitre that is associatedwith dietary iodine deficiency.Some inland areas where soil and water lacks in iodine compounds and consumption of marine foods is low are known for higher incidence of goitre. In such areas goitre is said to be "endemic".This type of goitre is...
    
    
  • Iodine-deficiency-related (endemic) goitre, unspecified
    Endemic goitre
    Endemic goitre is a type of goitre that is associatedwith dietary iodine deficiency.Some inland areas where soil and water lacks in iodine compounds and consumption of marine foods is low are known for higher incidence of goitre. In such areas goitre is said to be "endemic".This type of goitre is...
    
    
  • Other iodine-deficiency-related thyroid
    Thyroid
    The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
    
     disorders and allied condition
• Subclinical iodine-deficiency hypothyroidism
  Hypothyroidism
  Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
  
  
• Other hypothyroidism
  Hypothyroidism
  Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
  
  
  • Congenital hypothyroidism
    Congenital hypothyroidism
    Congenital hypothyroidism is a condition of thyroid hormone deficiency present at birth. Approximately 1 in 4000 newborn infants has a severe deficiency of thyroid function, while even more have mild or partial degrees. If untreated for several months after birth, severe congenital hypothyroidism...
    
     with diffuse goitre
  • Congenital hypothyroidism
    Congenital hypothyroidism
    Congenital hypothyroidism is a condition of thyroid hormone deficiency present at birth. Approximately 1 in 4000 newborn infants has a severe deficiency of thyroid function, while even more have mild or partial degrees. If untreated for several months after birth, severe congenital hypothyroidism...
    
     without goitre
    Goitre
    A goitre or goiter , is a swelling in the thyroid gland, which can lead to a swelling of the neck or larynx...
    
    
  • Hypothyroidism
    Hypothyroidism
    Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
    
     due to medicaments and other exogenous
    Exogenous
    Exogenous refers to an action or object coming from outside a system. It is the opposite of endogenous, something generated from within the system....
    
     substances
  • Postinfectious hypothyroidism
    Hypothyroidism
    Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
    
    
  • Atrophy
    Atrophy
    Atrophy is the partial or complete wasting away of a part of the body. Causes of atrophy include mutations , poor nourishment, poor circulation, loss of hormonal support, loss of nerve supply to the target organ, disuse or lack of exercise or disease intrinsic to the tissue itself...
    
     of thyroid
    Thyroid
    The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
    
     (acquired)
  • Myxoedema coma
• Other nontoxic goitre
  Goitre
  A goitre or goiter , is a swelling in the thyroid gland, which can lead to a swelling of the neck or larynx...
  
  
• Thyrotoxicosis (hyperthyroidism
  Hyperthyroidism
  Hyperthyroidism is the term for overactive tissue within the thyroid gland causing an overproduction of thyroid hormones . Hyperthyroidism is thus a cause of thyrotoxicosis, the clinical condition of increased thyroid hormones in the blood. Hyperthyroidism and thyrotoxicosis are not synonymous...
  
  )
  • Thyrotoxicosis with diffuse goitre
    • Graves' disease
      Graves' disease
      Graves' disease is an autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones...
      
      
  • Thyrotoxicosis with toxic single thyroid nodule
  • Thyrotoxicosis with toxic multinodular goitre
    Toxic multinodular goitre
    Toxic multinodular goitre is a form of hyperthyroidism - where there is excess production of thyroid hormones. It is characterized by functionally autonomous nodules...
    
    
  • Thyrotoxicosis from ectopic thyroid tissue
  • Thyrotoxicosis factitia
    Thyrotoxicosis factitia
    Thyrotoxicosis factitia refers to a condition of thyrotoxicosis caused by the ingestion of exogenous thyroid hormone. It can be the result of mistaken ingestion of excess drug, such as levothyroxine, or as a symptom of Munchausen syndrome. It is an uncommon form of hyperthyroidism.References:*...
    
    
  • Thyroid crisis or storm
  • Other thyrotoxicosis
  • Thyrotoxicosis, unspecified
• Thyroiditis
  Thyroiditis
  Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
  
  
  • Acute thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    
  • Subacute thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    
    • De Quervain's thyroiditis
      De Quervain's thyroiditis
      de Quervain's thyroiditis, can also be known as subacute granulomatous thyroiditis or Giant Cell Thyroiditis. Males and females of all ages are affected...
      
      
  • Chronic
    Chronic (medicine)
    A chronic disease is a disease or other human health condition that is persistent or long-lasting in nature. The term chronic is usually applied when the course of the disease lasts for more than three months. Common chronic diseases include asthma, cancer, diabetes and HIV/AIDS.In medicine, the...
    
     thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
     with transient thyrotoxicosis
  • Autoimmune thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    
    • Hashimoto's thyroiditis
      Hashimoto's thyroiditis
      Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is gradually destroyed by a variety of cell- and antibody-mediated immune processes. It was the first disease to be recognized as an autoimmune disease...
      
      
  • Drug-induced thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    
  • Other chronic
    Chronic (medicine)
    A chronic disease is a disease or other human health condition that is persistent or long-lasting in nature. The term chronic is usually applied when the course of the disease lasts for more than three months. Common chronic diseases include asthma, cancer, diabetes and HIV/AIDS.In medicine, the...
    
     thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    
    • Riedel's thyroiditis
      Riedel's thyroiditis
      Riedel's thyroiditis, also called Riedel's struma is a chronic form of thyroiditis.It is believed to be a form of autoimmune thyroiditis.-Pathophysiology:...
      
      
  • Thyroiditis
    Thyroiditis
    Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.-Classification:...
    
    , unspecified
• Other disorders of thyroid
  Thyroid
  The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
  
  
  • Hypersecretion of calcitonin
  • Dyshormogenetic goitre
  • Other specified disorders of thyroid
    Thyroid
    The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
    
    
    • Sick-euthyroid syndrome
  • Disorder of thyroid
    Thyroid
    The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
    
    , unspecified

(E10–E14) Diabetes mellitus

• Note: the following conditions are subtypes of each code from E10-14:
  • (E1x.0) Diabetic coma
    Diabetic coma
    Diabetic coma is a reversible form of coma found in people with diabetes mellitus. It is a medical emergency.Three different types of diabetic coma are identified:#Severe diabetic hypoglycemia...
    
    
  • (E1x.1) Diabetic ketoacidosis
    Diabetic ketoacidosis
    Diabetic ketoacidosis is a potentially life-threatening complication in patients with diabetes mellitus. It happens predominantly in those with type 1 diabetes, but it can occur in those with type 2 diabetes under certain circumstances...
    
    
  • (E1x.2) Diabetic nephropathy
    Diabetic nephropathy
    Diabetic nephropathy , also known as Kimmelstiel-Wilson syndrome, or nodular diabetic glomerulosclerosis and intercapillary glomerulonephritis, is a progressive kidney disease caused by angiopathy of capillaries in the kidney glomeruli. It is characterized by nephrotic syndrome and diffuse...
    
    
  • (E1x.3) Diabetic retinopathy
    Diabetic retinopathy
    Diabetic retinopathy is retinopathy caused by complications of diabetes mellitus, which can eventually lead to blindness....
    
    
  • (E1x.4) Diabetic neuropathy
    Diabetic neuropathy
    Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves in addition to macrovascular conditions that can culminate in diabetic neuropathy...
    
    
  • (E1x.5) Diabetic angiopathy
    Diabetic angiopathy
    Diabetic angiopathy is a form of angiopathy associated with diabetes mellitus. While not exclusive, the two most common forms are Diabetic retinopathy and Diabetic nephropathy, whose pathophysiologies are largely identical.-Pathophysiology:...
    
    
  • (E1x.6) Diabetic arthropathy
• Insulin-dependent diabetes mellitus
  Insulin-dependent diabetes mellitus
  Insulin-dependent diabetes mellitus is a medical term that describes diabetes mellitus that requires insulin therapy to avoid ketoacidosis...
  
  
• Non-insulin-dependent diabetes mellitus
• Malnutrition
  Malnutrition
  Malnutrition is the condition that results from taking an unbalanced diet in which certain nutrients are lacking, in excess , or in the wrong proportions....
  
  -related diabetes mellitus
  Diabetes mellitus
  Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
  
  
• Other specified diabetes mellitus
  Diabetes mellitus
  Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
  
  
• Unspecified diabetes mellitus
  Diabetes mellitus
  Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
  
  

(E15–E16) Other disorders of glucose regulation and pancreatic internal secretion

• Nondiabetic hypoglycaemic coma
  • • Drug-induced insulin coma in nondiabetic
    • Hyperinsulinism
      Hyperinsulinism
      Hyperinsulinism refers to an above normal level of insulin in the blood of a person or animal. Normal insulin secretion and blood levels are closely related to the level of glucose in the blood, so that a given level of insulin can be normal for one blood glucose level but low or high for another...
      
       with hypoglycaemic coma
    • Hypoglycaemic coma NOS
• Other disorders of pancreatic internal secretion
  • Drug-induced hypoglycaemia without coma
    Coma
    In medicine, a coma is a state of unconsciousness, lasting more than 6 hours in which a person cannot be awakened, fails to respond normally to painful stimuli, light or sound, lacks a normal sleep-wake cycle and does not initiate voluntary actions. A person in a state of coma is described as...
    
    
  • Other hypoglycaemia
    • Functional nonhyperinsulinaemic hypoglycaemia
    • Hyperinsulinism
      Hyperinsulinism
      Hyperinsulinism refers to an above normal level of insulin in the blood of a person or animal. Normal insulin secretion and blood levels are closely related to the level of glucose in the blood, so that a given level of insulin can be normal for one blood glucose level but low or high for another...
      
      : NOS
    • Hyperinsulinism
      Hyperinsulinism
      Hyperinsulinism refers to an above normal level of insulin in the blood of a person or animal. Normal insulin secretion and blood levels are closely related to the level of glucose in the blood, so that a given level of insulin can be normal for one blood glucose level but low or high for another...
      
      : functional
    • Hyperplasia of pancreatic islet beta cells NOS
    • Posthypoglycaemic coma encephalopathy
  • Hypoglycaemia, unspecified
  • Increased secretion of glucagon
    Glucagon
    Glucagon, a hormone secreted by the pancreas, raises blood glucose levels. Its effect is opposite that of insulin, which lowers blood glucose levels. The pancreas releases glucagon when blood sugar levels fall too low. Glucagon causes the liver to convert stored glycogen into glucose, which is...
    
    
  • Abnormal secretion of gastrin
    Gastrin
    In humans, gastrin is a peptide hormone that stimulates secretion of gastric acid by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the antrum of the stomach, duodenum, and the pancreas...
    
    
    • Hypergastrinaemia
    • Zollinger-Ellison syndrome
      Zollinger-Ellison syndrome
      Zollinger–Ellison syndrome is a triad of gastric acid hypersecretion, severe peptic ulceration, and non-beta cell islet tumor of pancreas . In this syndrome increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often the cause is a tumor of...
      
      
  • Other specified disorders of pancreatic internal secretion
  • Disorder of pancreatic internal secretion, unspecified

(E20–E21) Parathyroid gland / PTH

• Hypoparathyroidism
  Hypoparathyroidism
  Hypoparathyroidism is decreased function of the parathyroid glands with under production of parathyroid hormone. This can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany , and several other symptoms...
  
  
  • Idiopathic
    Idiopathic
    Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios + πάθος, pathos , it means approximately "a disease of its own kind". It is technically a term from nosology, the classification of disease...
    
     hypoparathyroidism
    Hypoparathyroidism
    Hypoparathyroidism is decreased function of the parathyroid glands with under production of parathyroid hormone. This can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany , and several other symptoms...
    
    
  • Pseudohypoparathyroidism
    Pseudohypoparathyroidism
    Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone. Patients have a low serum calcium and high phosphate, but the parathyroid hormone level is actually appropriately high...
    
    
• Hyperparathyroidism
  Hyperparathyroidism
  Hyperparathyroidism is overactivity of the parathyroid glands resulting in excess production of parathyroid hormone . The parathyroid hormone regulates calcium and phosphate levels and helps to maintain these levels...
  
   and other disorders of parathyroid gland
  Parathyroid gland
  The parathyroid glands are small endocrine glands in the neck that produce parathyroid hormone. Humans usually have four parathyroid glands, which are usually located on the rear surface of the thyroid gland, or, in rare cases, within the thyroid gland itself or in the chest...
  
  
  • Primary hyperparathyroidism
    Primary hyperparathyroidism
    Primary hyperparathyroidism causes hypercalcemia through the excessive secretion of parathyroid hormone , usually by an adenoma of the parathyroid glands.-Epidemiology:...
    
    
  • Secondary hyperparathyroidism
    Secondary hyperparathyroidism
    Secondary hyperparathyroidism refers to the excessive secretion of parathyroid hormone by the parathyroid glands in response to hypocalcemia and associated hypertrophy of the glands. This disorder is especially seen in patients with chronic renal failure...
    
    , not elsewhere classified

(E22–E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

• Hyperfunction of pituitary gland
  Pituitary gland
  In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g , in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity covered by a dural fold...
  
  
  • Acromegaly
    Acromegaly
    Acromegaly is a syndrome that results when the anterior pituitary gland produces excess growth hormone after epiphyseal plate closure at puberty...
    
     and pituitary gigantism
  • Hyperprolactinaemia
    Hyperprolactinaemia
    Hyperprolactinaemia or hyperprolactinemia is the presence of abnormally-high levels of prolactin in the blood. Normal levels are less than 500 mIU/L for women, and less than 450 mIU/L for men....
    
    
  • Syndrome of inappropriate secretion of antidiuretic hormone
    • Central precocious puberty
      Precocious puberty
      As a medical term, precocious puberty describes puberty occurring at an unusually early age. In most of these children, the process is normal in every respect except the unusually early age, and simply represents a variation of normal development. In a minority of children, the early development is...
      
      
• Hypofunction and other disorders of pituitary gland
  Pituitary gland
  In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g , in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity covered by a dural fold...
  
  
  • Hypopituitarism
    Hypopituitarism
    Hypopituitarism is the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain...
    
    
    • Fertile eunuch syndrome
    • Hypogonadotropic hypogonadism
    • Idiopathic growth hormone deficiency
    • Isolated deficiency of gonadotropin
      Gonadotropin
      Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates. This is a family of proteins, which include the mammalian hormones follitropin , lutropin , placental chorionic gonadotropins hCG and eCG and chorionic gonadotropin , as well as at least two...
      
      
    • Isolated deficiency of growth hormone
      Growth hormone
      Growth hormone is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior...
      
      
    • Isolated deficiency of pituitary hormone
    • Kallmann's syndrome
    • Lorain-Levi short stature
    • Necrosis
      Necrosis
      Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...
      
       of pituitary gland
      Pituitary gland
      In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g , in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity covered by a dural fold...
      
       (postpartum)
    • Panhypopituitarism
    • Pituitary cachexia
      Cachexia
      Cachexia or wasting syndrome is loss of weight, muscle atrophy, fatigue, weakness, and significant loss of appetite in someone who is not actively trying to lose weight...
      
      
    • Pituitary insufficiency NOS
    • Pituitary short stature
      Short stature
      Short stature refers to a height of a human being which is below expected. Shortness is a vague term without a precise definition and with significant relativity to context...
      
      
    • Sheehan's syndrome
      Sheehan's syndrome
      Sheehan syndrome, also known as Simmonds' syndrome or postpartum hypopituitarism or postpartum pituitary necrosis, is hypopituitarism , caused by necrosis due to blood loss and hypovolemic shock during and after childbirth...
      
      
    • Simmonds' disease
  • Drug-induced
    Medication
    A pharmaceutical drug, also referred to as medicine, medication or medicament, can be loosely defined as any chemical substance intended for use in the medical diagnosis, cure, treatment, or prevention of disease.- Classification :...
    
     hypopituitarism
    Hypopituitarism
    Hypopituitarism is the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain...
    
    
  • Diabetes insipidus
    Diabetes insipidus
    Diabetes insipidus is a condition characterized by excessive thirst and excretion of large amounts of severely diluted urine, with reduction of fluid intake having no effect on the concentration of the urine. There are several different types of DI, each with a different cause...
    
    
  • Hypothalamic dysfunction, not elsewhere classified
  • Other disorders of pituitary gland
    Pituitary gland
    In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g , in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity covered by a dural fold...
    
    
    • Abscess of pituitary
    • Adiposogenital dystrophy
      Adiposogenital Dystrophy
      Adiposogenital dystrophy is a condition which may be caused by secondary hypogonadism originating from decreased levels in GnRH. Low levels of GnRH has been associated with defects of the feeding centers of the hypothalamus, leading to an increase consumption of food and thus caloric...
      
      
  • Disorder of pituitary gland
    Pituitary gland
    In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g , in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity covered by a dural fold...
    
    , unspecified

(E24–E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

• Cushing's syndrome
  Cushing's syndrome
  Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...
  
  
  • Pituitary-dependent Cushing's disease
  • Nelson's syndrome
    Nelson's syndrome
    Nelson's syndrome is the rapid enlargement of a pituitary adenoma that occurs after the removal of both adrenal glands.-Pathophysiology:Removal of both adrenal glands, or bilateral adrenalectomy, is an operation for Cushing's syndrome...
    
    
  • Ectopic ACTH syndrome
  • Alcohol
    Alcohol
    In chemistry, an alcohol is an organic compound in which the hydroxy functional group is bound to a carbon atom. In particular, this carbon center should be saturated, having single bonds to three other atoms....
    
    -induced pseudo-Cushing's syndrome
    Pseudo-Cushing's syndrome
    Pseudo-Cushing's syndrome is a medical condition in which patients display the signs, symptoms, and abnormal hormone levels seen in Cushing's syndrome...
    
    
  • Other Cushing's syndrome
    Cushing's syndrome
    Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...
    
    
  • Cushing's syndrome
    Cushing's syndrome
    Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...
    
    , unspecified
• Adrenogenital disorders
  • Congenital adrenogenital disorders associated with enzyme deficiency
    • Congenital adrenal hyperplasia
      Congenital adrenal hyperplasia
      Congenital adrenal hyperplasia refers to any of several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the biochemical steps of production of cortisol from cholesterol by the adrenal glands ....
      
      
      • Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
        Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
        Congenital adrenal hyperplasia due to 21-hydroxylase deficiency , in all its forms, accounts for over 95% of diagnosed cases of congenital adrenal hyperplasia, and "CAH" in most contexts refers to 21-hydroxylase deficiency...
        
        
• Hyperaldosteronism
  Hyperaldosteronism
  Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood.-Types:...
  
  
  • Primary hyperaldosteronism
    • Conn's syndrome
      Conn's syndrome
      Primary aldosteronism, also known as primary hyperaldosteronism, is characterized by the overproduction of the mineralocorticoid hormone aldosterone by the adrenal glands., when not a result of excessive renin secretion. Aldosterone causes increase in sodium and water retention and potassium...
      
      
    • Primary aldosteronism due to adrenal hyperplasia (bilateral)
  • Secondary hyperaldosteronism
  • Other hyperaldosteronism
    Hyperaldosteronism
    Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood.-Types:...
    
    
    • Bartter's syndrome
  • Hyperaldosteronism
    Hyperaldosteronism
    Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood.-Types:...
    
    , unspecified
• Other disorders of adrenal gland
  Adrenal gland
  In mammals, the adrenal glands are endocrine glands that sit atop the kidneys; in humans, the right suprarenal gland is triangular shaped, while the left suprarenal gland is semilunar shaped...
  
  
  • Other adrenocortical overactivity
  • Primary adrenocortical insufficiency
    • Addison's disease
      Addison's disease
      Addison’s disease is a rare, chronic endocrine disorder in which the adrenal glands do not produce sufficient steroid hormones...
      
      
  • Addisonian crisis
  • Drug-induced
    Medication
    A pharmaceutical drug, also referred to as medicine, medication or medicament, can be loosely defined as any chemical substance intended for use in the medical diagnosis, cure, treatment, or prevention of disease.- Classification :...
    
     adrenocortical insufficiency
  • Other and unspecified adrenocortical insufficiency
    • Hypoaldosteronism
      Hypoaldosteronism
      In medicine , hypoaldosteronism refers to decreased levels of the hormone aldosterone.The term "isolated hypoaldosteronism" is used to describe lowered aldosterone without corresponding changes in cortisol...
      
      
    • Adrenocortical insufficiency NOS
  • Adrenomedullary hyperfunction

(E28–E30) Gonads / Estrogen, androgens, testosterone, etc.

• Ovarian dysfunction
  • Estrogen
    Estrogen
    Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...
    
     excess
  • Androgen
    Androgen
    Androgen, also called androgenic hormone or testoid, is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors...
    
     excess
  • Polycystic ovarian syndrome
  • Primary ovarian failure
    • Premature menopause NOS
• Testicular dysfunction
  • Testicular hyperfunction
  • Testicular hypofunction
    • 5-Alpha-reductase deficiency
      5-alpha-reductase deficiency
      5-Alpha-reductase deficiency is an autosomal recessive intersex condition caused by a mutation of the 5-alpha reductase type 2 gene.-Normal function:...
      
       (with male pseudohermaphroditism
      Pseudohermaphroditism
      Pseudohermaphroditism, or pseudo-hermaphroditism, is the condition in which an organism is born with secondary sex characteristics or a phenotype that is different from what would be expected on the basis of the gonadal tissue ....
      
      )
    • Testicular hypogonadism NOS
• Disorders of puberty
  Puberty
  Puberty is the process of physical changes by which a child's body matures into an adult body capable of reproduction, as initiated by hormonal signals from the brain to the gonads; the ovaries in a girl, the testes in a boy...
  
  , not elsewhere classified
  • Delayed puberty
    Delayed puberty
    Puberty is described as delayed puberty with exceptions when an organism has passed the usual age of onset of puberty with no physical or hormonal signs that it is beginning. Puberty may be delayed for several years and still occur normally, in which case it is considered constitutional delay, a...
    
    
  • Precocious puberty
    Precocious puberty
    As a medical term, precocious puberty describes puberty occurring at an unusually early age. In most of these children, the process is normal in every respect except the unusually early age, and simply represents a variation of normal development. In a minority of children, the early development is...
    
    
  • Other disorders of puberty
    Puberty
    Puberty is the process of physical changes by which a child's body matures into an adult body capable of reproduction, as initiated by hormonal signals from the brain to the gonads; the ovaries in a girl, the testes in a boy...
    
    
    • Premature thelarche
      Thelarche
      Thelarche is the onset of secondary breast development, usually occurring at the beginning of puberty in girls. Its etymology is from Greek θηλή [tʰelḗ], “nipple” and ἀρχή [arkʰḗ], “beginning, onset”. Thelarche is usually noticed as a firm, tender lump directly under the centre of the nipple...
      
      

(E31–E35) Other

• Polyglandular dysfunction
  • Autoimmune polyglandular failure
    • Schmidt's syndrome
  • Polyglandular hyperfunction
• Diseases of thymus
  Thymus
  The thymus is a specialized organ of the immune system. The thymus produces and "educates" T-lymphocytes , which are critical cells of the adaptive immune system....
  
  
  • Persistent hyperplasia of thymus
    • Hypertrophy of thymus
  • Abscess of thymus
• Other endocrine disorders
  • Carcinoid syndrome
    Carcinoid syndrome
    Carcinoid syndrome refers to the array of symptoms that occur secondary to carcinoid tumors. The syndrome includes flushing and diarrhea, and, less frequently, heart failure and bronchoconstriction...
    
    
  • Other hypersecretion of intestinal hormones
  • Ectopic hormone secretion, not elsewhere classified
  • Short stature
    Short stature
    Short stature refers to a height of a human being which is below expected. Shortness is a vague term without a precise definition and with significant relativity to context...
    
    , not elsewhere classified
    • NOS
    • constitutional
    • Laron-type
      Laron syndrome
      Laron syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an insensitivity to growth hormone , caused by a variant of the growth hormone receptor. It causes short stature and a resistance to diabetes and cancer....
      
      
    • psychosocial
      Psychogenic dwarfism
      Psychosocial short stature or psychosocial dwarfism, sometimes called psychogenic or stress dwarfism or the eponymous Kaspar Hauser syndrome, is a growth disorder that is observed between the ages of 2 and 15, caused by extreme emotional deprivation or stress.The symptoms include decreased growth...
      
      
  • Constitutional tall stature
    • Constitutional gigantism
      Gigantism
      Gigantism, also known as giantism , is a condition characterized by excessive growth and height significantly above average...
      
      
  • Androgen resistance syndrome
    • Reifenstein's syndrome
  • Other specified endocrine disorders
    • Progeria
      Progeria
      Progeria is an extremely rare genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. The word progeria comes from the Greek words "pro" , meaning "before", and "géras" , meaning "old age"...
      
      
• Disorders of endocrine glands
  Endocrine glands
  Endocrine glands are glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct. The main endocrine glands include the pituitary gland, pancreas, ovaries, testes, thyroid gland, and adrenal glands. The hypothalamus is a neuroendocrine...
  
   in diseases classified elsewhere
  • Disorders of thyroid gland in diseases classified elsewhere
  • Disorders of adrenal glands in diseases classified elsewhere
  • Disorders of other endocrine glands
    Endocrine glands
    Endocrine glands are glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct. The main endocrine glands include the pituitary gland, pancreas, ovaries, testes, thyroid gland, and adrenal glands. The hypothalamus is a neuroendocrine...
    
     in diseases classified elsewhere

(E40–E46) Malnutrition

• Kwashiorkor
  Kwashiorkor
  Kwashiorkor is an acute form of childhood protein-energy malnutrition characterized by edema, irritability, anorexia, ulcerating dermatoses, and an enlarged liver with fatty infiltrates. The presence of edema caused by poor nutrition defines kwashiorkor...
  
  
• Nutritional marasmus
  Marasmus
  Marasmus is a form of severe protein-energy malnutrition characterized by energy deficiency.A child with marasmus looks emaciated. Body weight may be reduced to less than 80% of the average weight that corresponds to the height . Marasmus occurrence increases prior to age 1, whereas kwashiorkor...
  
  
• Marasmic kwashiorkor
  Kwashiorkor
  Kwashiorkor is an acute form of childhood protein-energy malnutrition characterized by edema, irritability, anorexia, ulcerating dermatoses, and an enlarged liver with fatty infiltrates. The presence of edema caused by poor nutrition defines kwashiorkor...
  
  
• Unspecified severe protein-energy malnutrition
  Protein-energy malnutrition
  Protein-energy malnutrition refers to a form of malnutrition where there is inadequate protein intake.Types include:* Kwashiorkor...
  
  
• Protein-energy malnutrition
  Protein-energy malnutrition
  Protein-energy malnutrition refers to a form of malnutrition where there is inadequate protein intake.Types include:* Kwashiorkor...
  
   of moderate and mild degree
• Retarded development following protein-energy malnutrition
  Protein-energy malnutrition
  Protein-energy malnutrition refers to a form of malnutrition where there is inadequate protein intake.Types include:* Kwashiorkor...
  
  
• Unspecified protein-energy malnutrition
  Protein-energy malnutrition
  Protein-energy malnutrition refers to a form of malnutrition where there is inadequate protein intake.Types include:* Kwashiorkor...
  
  

(E50–E64) Other nutritional deficiencies

• Vitamin A
  Vitamin A
  Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
  
   deficiency
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with conjunctival xerosis
    Xerosis
    Xerosis cutis is the medical term for dry skin.It can have many different causes, including general dehydration, atopic dermatitis, Vitamin A deficiency, and maybe diabetes. Treatment is primarily symptomatic. "Xero", meaning dry or dehydrated, "osis" usually referring to a medical disease or...
    
    
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with Bitot's spot and conjunctival xerosis
    Xerosis
    Xerosis cutis is the medical term for dry skin.It can have many different causes, including general dehydration, atopic dermatitis, Vitamin A deficiency, and maybe diabetes. Treatment is primarily symptomatic. "Xero", meaning dry or dehydrated, "osis" usually referring to a medical disease or...
    
    
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with corneal xerosis
    Xerosis
    Xerosis cutis is the medical term for dry skin.It can have many different causes, including general dehydration, atopic dermatitis, Vitamin A deficiency, and maybe diabetes. Treatment is primarily symptomatic. "Xero", meaning dry or dehydrated, "osis" usually referring to a medical disease or...
    
    
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with corneal ulcer
    Corneal ulcer
    A corneal ulcer, or ulcerative keratitis, is an inflammatory condition of the cornea involving loss of its outer layer. It is very common in dogs and is sometimes seen in cats...
    
    ation and xerosis
    Xerosis
    Xerosis cutis is the medical term for dry skin.It can have many different causes, including general dehydration, atopic dermatitis, Vitamin A deficiency, and maybe diabetes. Treatment is primarily symptomatic. "Xero", meaning dry or dehydrated, "osis" usually referring to a medical disease or...
    
    
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with keratomalacia
    Keratomalacia
    Keratomalacia is an eye disorder that leads to a dry cornea. One of its major causes is Vitamin A deficiency. When xerophthalmia persists for a long time, it results in keratomalacia. There is degradation of corneal epithelium which may also get vascularised. Later corneal opacities develop...
    
    
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with night blindness
  • Vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency with xerophthalmic scars of cornea
    Cornea
    The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Together with the lens, the cornea refracts light, with the cornea accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is...
    
    
  • Other ocular manifestations of vitamin A
    Vitamin A
    Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...
    
     deficiency
    • Xerophthalmia
      Xerophthalmia
      Xerophthalmia is a medical condition in which the eye fails to produce tears. It may be caused by a deficiency in vitamin A and is sometimes used to describe that lack, although there may be other causes....
      
       NOS
• Thiamine
  Thiamine
  Thiamine or thiamin or vitamin B1 , named as the "thio-vitamine" is a water-soluble vitamin of the B complex. First named aneurin for the detrimental neurological effects if not present in the diet, it was eventually assigned the generic descriptor name vitamin B1. Its phosphate derivatives are...
  
   deficiency
  • Beriberi
    Beriberi
    Beriberi is a nervous system ailment caused by a thiamine deficiency in the diet. Thiamine is involved in the breakdown of energy molecules such as glucose and is also found on the membranes of neurons...
    
    
  • Wernicke's encephalopathy
    Wernicke's encephalopathy
    Wernicke encephalopathy is a syndrome characterised by ataxia, ophthalmoplegia, confusion, and impairment of short-term memory.It is caused by lesions in the medial thalamic nuclei, mammillary bodies, periaqueductal and periventricular brainstem nuclei, and superior cerebellar vermis, often...
    
    
• Niacin
  Niacin
  "Niacin" redirects here. For the neo-fusion band, see Niacin .Niacin is an organic compound with the formula and, depending on the definition used, one of the forty to eighty essential human nutrients.Niacin is one of five vitamins associated with a pandemic deficiency disease: niacin deficiency...
  
   deficiency (pellagra
  Pellagra
  Pellagra is a vitamin deficiency disease most commonly caused by a chronic lack of niacin in the diet. It can be caused by decreased intake of niacin or tryptophan, and possibly by excessive intake of leucine. It may also result from alterations in protein metabolism in disorders such as carcinoid...
  
  )
• Deficiency of other B group vitamins
  • Riboflavin
    Riboflavin
    Riboflavin, also known as vitamin B2 or additive E101, is an easily absorbed micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, vitamin B2 is required for a...
    
     deficiency
    • Ariboflavinosis
      Ariboflavinosis
      Ariboflavinosis is the medical condition caused by deficiency of riboflavin . Ariboflavinosis is most often seen in association with protein-energy malnutrition, and also in cases of alcoholism....
      
      
  • Pyridoxine
    Pyridoxine
    Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'.-Chemistry:...
    
     deficiency
  • Deficiency of other specified B group vitamins
• Ascorbic acid
  Ascorbic acid
  Ascorbic acid is a naturally occurring organic compound with antioxidant properties. It is a white solid, but impure samples can appear yellowish. It dissolves well in water to give mildly acidic solutions. Ascorbic acid is one form of vitamin C. The name is derived from a- and scorbutus , the...
  
   deficiency
  • Scurvy
    Scurvy
    Scurvy is a disease resulting from a deficiency of vitamin C, which is required for the synthesis of collagen in humans. The chemical name for vitamin C, ascorbic acid, is derived from the Latin name of scurvy, scorbutus, which also provides the adjective scorbutic...
    
    
• Vitamin D deficiency
  • Rickets
    Rickets
    Rickets is a softening of bones in children due to deficiency or impaired metabolism of vitamin D, magnesium , phosphorus or calcium, potentially leading to fractures and deformity. Rickets is among the most frequent childhood diseases in many developing countries...
    
    , active
• Other vitamin
  Vitamin
  A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. In other words, an organic chemical compound is called a vitamin when it cannot be synthesized in sufficient quantities by an organism, and must be obtained from the diet. Thus, the term is conditional both on...
  
   deficiencies
  • Deficiency of vitamin E
    Vitamin E
    Vitamin E is used to refer to a group of fat-soluble compounds that include both tocopherols and tocotrienols. There are many different forms of vitamin E, of which γ-tocopherol is the most common in the North American diet. γ-Tocopherol can be found in corn oil, soybean oil, margarine and dressings...
    
    
  • Deficiency of vitamin K
    Vitamin K
    Vitamin K is a group of structurally similar, fat soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone derivatives...
    
    
• Dietary calcium deficiency
  Hypocalcaemia
  In medicine, hypocalcaemia is the presence of low serum calcium levels in the blood, usually taken as less than 2.1 mmol/L or 9 mg/dl or an ionized calcium level of less than 1.1 mmol/L or 4.5 mg/dL. It is a type of electrolyte disturbance...
  
  
• Dietary selenium deficiency
  Selenium deficiency
  Selenium deficiency is relatively rare in healthy well-nourished individuals. Few cases have been reported.-Causes:It can occur in patients with severely compromised intestinal function, those undergoing total parenteral nutrition, those who have had gastrointestinal bypass surgery, and also on...
  
  
• Dietary zinc deficiency
  Zinc deficiency
  Zinc deficiency is insufficient zinc to meet the needs of biological organisms. It can occur in both plants and animals. Zinc deficient soil is soil in which there is insufficient zinc to allow plants to grow normally.-Description:...
  
  
• Deficiency of other nutrient
  Nutrient
  A nutrient is a chemical that an organism needs to live and grow or a substance used in an organism's metabolism which must be taken in from its environment. They are used to build and repair tissues, regulate body processes and are converted to and used as energy...
  
   elements
  • Iron deficiency
    Iron deficiency (medicine)
    Iron deficiency is one of the most common of the nutritional deficiencies. Iron is present in all cells in the human body, and has several vital functions...
    
    
  • Magnesium deficiency
    Magnesium deficiency
    Magnesium deficiency is a detrimental plant disorder that occurs most often in strongly acidic, light, sandy soils, where magnesium can be easily leached away. Magnesium is an essential macronutrient found from 0.2-0.4% dry matter and is necessary for normal plant growth...
    
    
  • Manganese deficiency
    Manganese deficiency (medicine)
    Manganese deficiency in humans results in a number of medical problems. Manganese is a vital element of nutrition in very small quantities...
    
    
  • Chromium deficiency
    Chromium deficiency
    Chromium deficiency is a disorder that results from an insufficient dietary intake of chromium. Whether or not such a deficiency ever occurs in people eating a normal diet is debated, and clear cases of deficiency have only been observed in hospital patients who were fed defined liquid diets...
    
    
  • Molybdenum deficiency
    Molybdenum deficiency
    Molybdenum deficiency refers to the clinical consequences of inadequate supplies of molybdenum in the diet.The amount of molybdenum required is relatively small, and molybdenum deficiency usually doesn't occur in natural settings. However, it can occur in individuals receiving parenteral nutrition....
    
    
  • Vanadium deficiency
• Other nutritional deficiencies
  • Essential fatty acid
    Essential fatty acid
    Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them...
    
     (EFA) deficiency
• Sequelae of malnutrition
  Malnutrition
  Malnutrition is the condition that results from taking an unbalanced diet in which certain nutrients are lacking, in excess , or in the wrong proportions....
  
   and other nutritional deficiencies

(E65–E68) Obesity and other hyperalimentation

• Localized adiposity
  • Fat pad
    Fat pad
    A fat pad is a mass of closely packed fat cells surrounded by fibrous tissue septa. They may be extensively supplied with capillaries and nerve endings.Examples are:* Intraarticular fat pads. These are also covered by a layer of synovial cells...
    
    
• Obesity
  Obesity
  Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
  
  
  • Obesity due to excess calories
  • Drug-induced obesity
  • Extreme obesity with alveolar hypoventilation
    • Pickwickian syndrome
      Pickwickian syndrome
      Obesity hypoventilation syndrome is a condition in which severely overweight people fail to breathe rapidly enough or deeply enough, resulting in low blood oxygen levels and high blood carbon dioxide levels...
      
      
  • Other obesity
    Obesity
    Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
    
    
    • Morbid obesity
  • Obesity
    Obesity
    Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
    
    , unspecified
• Other hyperalimentation
  Hyperalimentation
  Hyperalimentation refers to a state where quantities of food consumed are greater than appropriate. It includes overeating, as well as other routes of administration such as in parenteral nutrition....
  
  
  • Hypervitaminosis A
    Hypervitaminosis A
    Hypervitaminosis A refers to the effects of excessive vitamin A intake.-Presentation:Effects include* Birth defects* Liver problems* Reduced bone mineral density that may result in osteoporosis* Coarse bone growths...
    
    
  • Hypercarotenaemia
  • Megavitamin-B 6 syndrome
  • Hypervitaminosis D
    Hypervitaminosis D
    Hypervitaminosis D is a state of vitamin D toxicity.The recommended daily allowance is 400 IU per day. Overdose has been observed at 1925 µg/d...
    
    
• Sequelae of hyperalimentation
  Hyperalimentation
  Hyperalimentation refers to a state where quantities of food consumed are greater than appropriate. It includes overeating, as well as other routes of administration such as in parenteral nutrition....
  
  

(E70–E72) Amino-acids

• Disorders of aromatic amino-acid metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
  
  • Classical phenylketonuria
    Phenylketonuria
    Phenylketonuria is an autosomal recessive metabolic genetic disorder characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase , rendering it nonfunctional. This enzyme is necessary to metabolize the amino acid phenylalanine to the amino acid tyrosine...
    
    
  • Other hyperphenylalaninaemias
  • Disorders of tyrosine
    Tyrosine
    Tyrosine or 4-hydroxyphenylalanine, is one of the 22 amino acids that are used by cells to synthesize proteins. Its codons are UAC and UAU. It is a non-essential amino acid with a polar side group...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Alkaptonuria
      Alkaptonuria
      Alkaptonuria is a rare inherited genetic disorder of phenylalanine and tyrosine metabolism. This is an autosomal recessive condition that is due to a defect in the enzyme homogentisate 1,2-dioxygenase , which participates in the degradation of tyrosine...
      
       (ILDS E70.210)
    • Ochronosis
      Ochronosis
      Ochronosis is the syndrome caused by the accumulation of homogentisic acid in connective tissues. The phenomenon was first described by Rudolf Virchow in 1865. The condition was named after the yellowish discoloration of the tissue seen on microscopic examination...
      
       (ILDS E70.230)
    • Tyrosinaemia
  • Albinism
    Albinism
    Albinism is a congenital disorder characterized by the complete or partial absence of pigment in the skin, hair and eyes due to absence or defect of an enzyme involved in the production of melanin...
    
    
    • Oculocutaneous albinism
      Oculocutaneous albinism
      Oculocutaneous albinism is a form of albinism involving the eyes , skin , and in rare instances, the hair as well.Four types of oculocutaneous albinism have been described, all caused by a disruption of melanin synthesis and all autosomal recessive disorders.Common Albinism requires genes from both...
      
       (ILDS E70.310)
    • Partial albinism (ILDS E70.312)
    • Oculocutaneous albinism
      Oculocutaneous albinism
      Oculocutaneous albinism is a form of albinism involving the eyes , skin , and in rare instances, the hair as well.Four types of oculocutaneous albinism have been described, all caused by a disruption of melanin synthesis and all autosomal recessive disorders.Common Albinism requires genes from both...
      
       type 1 (tyrosinase
      Tyrosinase
      Tyrosinase also known as monophenol monooxygenase is an enzyme that catalyses the oxidation of phenols and is widespread in plants and animals...
      
      -negative) (ILDS E70.314)
    • Oculocutaneous albinism
      Oculocutaneous albinism
      Oculocutaneous albinism is a form of albinism involving the eyes , skin , and in rare instances, the hair as well.Four types of oculocutaneous albinism have been described, all caused by a disruption of melanin synthesis and all autosomal recessive disorders.Common Albinism requires genes from both...
      
       type 2 (tyrosinase
      Tyrosinase
      Tyrosinase also known as monophenol monooxygenase is an enzyme that catalyses the oxidation of phenols and is widespread in plants and animals...
      
       positive) (ILDS E70.314)
    • Albinoidism (ILDS E70.318)
    • Waardenburg's syndrome (ILDS E70.320)
    • Chediak-Higashi syndrome
      Chédiak-Higashi syndrome
      Chédiak–Higashi syndrome is a rare autosomal recessive disorder that arises from a microtubule polymerization defect which leads to a decrease in phagocytosis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism and peripheral neuropathy...
      
       (ILDS E70.340)
    • Piebaldism
      Piebaldism
      Piebaldism is a rare autosomal dominant disorder of melanocyte development. Common characteristics include a congenital white forelock, scattered normal pigmented and hypopigmented macules and a triangular shaped depigmented patch on the forehead....
      
       (ILDS E70.350)
    • Tietz's syndrome (ILDS E70.358)
    • Hermansky-Pudlak syndrome
      Hermansky-Pudlak syndrome
      Hermansky–Pudlak syndrome is a rare autosomal recessive disorder which results in oculocutaneous albinism , bleeding problems due to a platelet abnormality , and storage of an abnormal fat-protein compound .There are eight classic forms of the disorder, based on the genetic mutation...
      
       (ILDS E70.360)
    • Cross syndrome (ILDS E70.380)
  • Other disorders of aromatic amino-acid metabolism
    • Disorders of histidine
      Histidine
      Histidine Histidine, an essential amino acid, has a positively charged imidazole functional group. It is one of the 22 proteinogenic amino acids. Its codons are CAU and CAC. Histidine was first isolated by German physician Albrecht Kossel in 1896. Histidine is an essential amino acid in humans...
      
       metabolism
    • Disorders of tryptophan
      Tryptophan
      Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG...
      
       metabolism
  • Disorder of aromatic amino-acid metabolism, unspecified
• Disorders of branched-chain amino-acid metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
   and fatty-acid metabolism
  • Maple-syrup-urine disease
  • Other disorders of branched-chain amino-acid metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Propionic acidemia
      Propionic acidemia
      Propionic acidemia, also known as propionic aciduria, propionyl-CoA carboxylase deficiency and ketotic glycinemia, is an autosomal recessive metabolic disorder, classified as a branched-chain organic acidemia....
      
      
    • Methylmalonic acidemia
      Methylmalonic acidemia
      Methylmalonic acidemia , also called methylmalonic aciduria, is an autosomal recessive metabolic disorder. It is a classical type of organic acidemia....
      
      
    • Isovaleric acidemia
      Isovaleric acidemia
      Isovaleric acidemia, also called isovaleric aciduria or isovaleric acid CoA dehydrogenase deficiency, is a rare autosomal recessive metabolic disorder which disrupts or prevents normal metabolism of the branched-chain amino acid leucine...
      
      
  • Disorder of branched-chain amino-acid metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    , unspecified
  • Disorders of fatty-acid metabolism
    • Adrenoleukodystrophy
      Adrenoleukodystrophy
      Adrenoleukodystrophy is a rare, inherited disorder that leads to progressive brain damage, failure of the adrenal glands and eventually death. ALD is a disease in a group of genetic disorders called leukodystrophies, whose chief feature is damage to myelin...
      
       (Addison-Schilder)
    • Muscle carnitine palmityltransferase deficiency
• Other disorders of amino-acid metabolism
  • Disorders of amino-acid transport
    Transport
    Transport or transportation is the movement of people, cattle, animals and goods from one location to another. Modes of transport include air, rail, road, water, cable, pipeline, and space. The field can be divided into infrastructure, vehicles, and operations...
    
    
    • Cystinuria
      Cystinuria
      Cystinuria is an inherited autosomal recessive disease that is characterized by the formation of cystine stones in the kidneys, ureter, and bladder.-Signs and symptoms:Cystinuria is a cause of persistent kidney stones...
      
      
    • Cystinosis
      Cystinosis
      Cystinosis is a lysosomal storage disease characterized by the abnormal accumulation of the amino acid cystine. It is a genetic disorder that typically follows an autosomal recessive inheritance pattern. Cystinosis is the most common cause of Fanconi syndrome in the pediatric age group...
      
      
    • Hartnup disease
      Hartnup disease
      Hartnup disease is an autosomal recessive metabolic disorder affecting the absorption of nonpolar amino acids...
      
      
    • Lowe's syndrome
  • Disorders of sulfur-bearing amino-acid metabolism
    • Cystathioninuria
      Cystathioninuria
      Cystathioninuria, also called cystathionase deficiency, is an autosomal recessive metabolic disorder that results in an excess of cystathionine in the urine. It is associated with a congenital dysfunction of the enzyme cystathionase, or acquired deficiency of vitamin B6 which is essential for the...
      
      
    • Homocystinuria
      Homocystinuria
      Homocystinuria, also known as cystathionine beta synthase deficiency or CBS deficiency, is an inherited disorder of the metabolism of the amino acid methionine, often involving cystathionine beta synthase...
      
      
    • Methioninaemia
    • Sulfite oxidase deficiency
  • Disorders of urea cycle
    Urea cycle
    The urea cycle is a cycle of biochemical reactions occurring in many animals that produces urea from ammonia . This cycle was the first metabolic cycle discovered , five years before the discovery of the TCA cycle...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Argininaemia
    • Argininosuccinic aciduria
      Argininosuccinic aciduria
      Argininosuccinic aciduria, also called argininosuccinic acidemia, is an inherited disorder that causes the accumulation of argininosuccinic acid in the blood and urine. Some patients may also have an elevation of ammonia, a toxic chemical, which can affect the nervous system...
      
      
    • Citrullinaemia
    • Hyperammonaemia
  • Disorders of lysine
    Lysine
    Lysine is an α-amino acid with the chemical formula HO2CCH4NH2. It is an essential amino acid, which means that the human body cannot synthesize it. Its codons are AAA and AAG....
    
     and hydroxylysine
    Hydroxylysine
    5-Hydroxylysine is an amino acid with the molecular formula C6H14N2O3. It was first discovered in 1921 by Donald Van Slyke. It is a hydroxy derivative of lysine. It is most widely known as a component of collagen....
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Glutaric aciduria
      Glutaric aciduria
      Glutaric aciduria can refer to:* Glutaric aciduria type 1* Glutaric acidemia type 2...
      
      
    • Hydroxylysinaemia
    • Hyperlysinaemia
    • Lysinuric protein intolerance
      Lysinuric protein intolerance
      Lysinuric protein intolerance , also called hyperdibasic aminoaciduria type 2 or familial protein intolerance, is an autosomal recessive metabolic disorder affecting amino acid transport....
      
      
  • Disorders of ornithine
    Ornithine
    Ornithine is an amino acid that plays a role in the urea cycle.-Role in urea cycle:L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen....
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Ornithinaemia
      Ornithinaemia
      Ornithinaemia is a blood disorder characterized by high levels of ornithine. Also known as hyperornithinemia, it may be associated with psychomotor retardation or epileptic episodes....
      
       (types I, II)
  • Disorders of glycine
    Glycine
    Glycine is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its 'side chain', glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.Glycine is a colourless, sweet-tasting crystalline solid...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Hyperhydroxyprolinaemia
    • Hyperprolinaemia (types I, II)
    • Non-ketotic hyperglycinaemia
    • Sarcosinaemia

(E73–E74) Carbohydrates

• Lactose intolerance
  Lactose intolerance
  Lactose intolerance, also called lactase deficiency or hypolactasia, is the inability to digest and metabolize lactose, a sugar found in milk...
  
  
• Other disorders of carbohydrate metabolism
  Carbohydrate metabolism
  Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown and interconversion of carbohydrates in living organisms....
  
  
  • Glycogen storage disease
    Glycogen storage disease
    Glycogen storage disease is the result of defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. GSD has two classes of cause: genetic and acquired. Genetic GSD is caused by any inborn error of metabolism involved in these processes...
    
    
    • Glycogen storage disease type I
      Glycogen storage disease type I
      Glycogen storage disease type I or von Gierke's disease, is the most common of the glycogen storage diseases. This genetic disease results from deficiency of the enzyme glucose-6-phosphatase. This deficiency impairs the ability of the liver to produce free glucose from glycogen and from...
      
       (von Gierke's disease)
    • Glycogen storage disease type II
      Glycogen storage disease type II
      Glycogen storage disease type II is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme...
      
       (Pompe's disease)
    • Glycogen storage disease type III
      Glycogen storage disease type III
      Glycogen storage disease type III is an autosomal recessive metabolic disorder and inborn error of metabolism characterized by a deficiency in glycogen debranching enzymes....
      
      
    • Glycogen storage disease type IV
      Glycogen storage disease type IV
      -Synonyms:It is also known as:-*Glycogenosis type IV,*Glycogen Branching Enzyme Deficiency ,*polyglucosan body disease.*Amylopectinosis-Human pathology:...
      
      
    • Glycogen storage disease type V
      Glycogen storage disease type V
      Glycogen storage disease type V is a metabolic disorder, more specifically a glycogen storage disease, caused by a deficiency of myophosphorylase. Its incidence is reported as 1 in 100,000, approximately the same as glycogen storage disease type I....
      
       (McArdle's disease)
  • Disorders of fructose
    Fructose
    Fructose, or fruit sugar, is a simple monosaccharide found in many plants. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion. Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Essential fructosuria
      Essential fructosuria
      Essential fructosuria, also known as hepatic fructokinase deficiency or ketohexokinase deficiency, is a hereditary metabolic disorder caused by a deficiency in hepatic fructokinase, leading to fructose being excreted in the urine . It is essentially a benign condition, as fructose cannot be broken...
      
      
    • Fructose-1,6-diphosphatase deficiency
    • Hereditary fructose intolerance
  • Disorders of galactose
    Galactose
    Galactose , sometimes abbreviated Gal, is a type of sugar that is less sweet than glucose. It is a C-4 epimer of glucose....
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Galactosaemia
    • Galactokinase deficiency
      Galactokinase deficiency
      Galactokinase deficiency, also known as Galactosemia type 2 or GALK deficiency, is an autosomal recessive metabolic disorder marked by an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase...
      
      
  • Other disorders of intestinal carbohydrate absorption
    • Glucose-galactose malabsorption
      Glucose-galactose malabsorption
      Glucose-galactose malabsorption is a condition in which the cells lining the intestine cannot take in the sugars glucose and galactose, which prevents proper digestion of these molecules and larger molecules made from them....
      
      
    • Sucrase deficiency
  • Disorders of pyruvate metabolism and gluconeogenesis
    Gluconeogenesis
    Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids....
    
    
    • Deficiency of phosphoenolpyruvate carboxykinase
    • Deficiency of pyruvate carboxylase
    • Deficiency of pyruvate dehydrogenase
  • Other specified disorders of carbohydrate metabolism
    • Essential pentosuria
    • Oxalosis
    • Oxaluria
    • Renal glycosuria
      Renal glycosuria
      Renal glycosuria, also known as renal glucosuria, is a rare condition in which the simple sugar glucose is excreted in the urine despite normal or low blood glucose levels. With normal kidney function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in...
      
      
  • Disorder of carbohydrate metabolism
    Carbohydrate metabolism
    Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown and interconversion of carbohydrates in living organisms....
    
    , unspecified

(E75) Lipids

• Disorders of sphingolipid
  Sphingolipid
  Sphingolipids are a class of lipids containing a backbone of sphingoid bases, a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named for the mythological Sphinx because of their enigmatic nature. These compounds play...
  
   metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
   and other lipid storage disorders
  • GM 2 gangliosidosis
    GM 2 gangliosidosis
    GM 2 gangliosidosis can refer to:* Tay-Sachs disease* Sandhoff disease* GM2-gangliosidosis, AB variant...
    
    
    • Sandhoff disease
      Sandhoff disease
      Sandhoff disease, also known as Sandhoff-Jatzkewitz disease, variant 0 of GM2-Gangliosidosis or Hexosaminidase A and B deficiency, is a lysosomal genetic, lipid storage disorder caused by the inherited deficiency to create functional beta-hexosaminidases A and B...
      
      
    • Tay-Sachs disease
      Tay-Sachs disease
      Tay–Sachs disease is an autosomal recessive genetic disorder...
      
      
  • Other gangliosidosis
    Gangliosidosis
    Gangliosidosis is a lipid storage disorder caused by the accumulation of lipids known as gangliosides. There are two distinct genetic causes of the disease. Both are autosomal recessive and affect males and females equally.-See also:...
    
    
    • GM 1
      GM1 gangliosidoses
      The GM1 gangliosidoses are caused by a deficiency of beta-galactosidase, with resulting abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells.-Early infantile GM1:...
      
      
    • GM 3
    • Mucolipidosis IV
  • Other sphingolipidosis
    • Gaucher's disease
      Gaucher's disease
      Gaucher's disease is a genetic disease in which a fatty substance accumulates in cells and certain organs.Gaucher's disease is the most common of the lysosomal storage diseases. It is caused by a hereditary deficiency of the enzyme glucosylceramidase. The enzyme acts on the fatty acid...
      
       (ILDS E75.220)
    • Niemann-Pick disease
      Niemann-Pick disease
      Niemann–Pick disease refers to a group of fatal inherited metabolic disorders that are included in the larger family of lysosomal storage diseases .-Signs and symptoms:Symptoms are related to the organs in which they accumulate...
      
       (ILDS E75.230)
    • Farber's disease (ILDS E75.240)
    • Fabry's disease
      Fabry's disease
      Fabry disease is a rare X-linked recessive lysosomal storage disease, which can cause a wide range of systemic symptoms...
      
       (ILDS E75.250)
  • Sphingolipidosis, unspecified
  • Neuronal ceroid lipofuscinosis
    Neuronal Ceroid Lipofuscinosis
    Neuronal Ceroid Lipofuscinoses is the general name for a family of at least eight genetically separate neurodegenerative disorders that result from excessive accumulation of lipopigments in the body's tissues. These lipopigments are made up of fats and proteins...
    
    
    • Batten disease
      Batten disease
      Batten disease is a rare, fatal autosomal recessive neurodegenerative disorder that begins in childhood...
      
       (Type 3)
    • Bielschowsky-Jansky disease (Type 2)
    • Kufs disease (Type 4)
    • Spielmeyer-Vogt disease (Type 3)
  • Other lipid storage disorders
    • Cerebrotendinous cholesterosis (van Bogaert-Scherer-Epstein)
    • Wolman's disease
  • Lipid storage disorder
    Lipid storage disorder
    Lipid storage disorders are a group of inherited metabolic disorders in which harmful amounts of lipids accumulate in some of the body’s cells and tissues. People with these disorders either do not produce enough of one of the enzymes needed to metabolize lipids or they produce enzymes that do...
    
    , unspecified

(E76–E78) Combinations

• Disorders of glycosaminoglycan
  Glycosaminoglycan
  Glycosaminoglycans or mucopolysaccharides are long unbranched polysaccharides consisting of a repeating disaccharide unit. The repeating unit consists of a hexose or a hexuronic acid, linked to a hexosamine .-Production:Protein cores made in the rough endoplasmic reticulum are posttranslationally...
  
   metabolism
  • Mucopolysaccharidosis
    Mucopolysaccharidosis
    Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans - long chains of sugar carbohydrates in each of our cells that help build bone, cartilage, tendons, corneas, skin and...
    
    , type I
    • Hurler syndrome
      Hurler syndrome
      Hurler syndrome, also known as mucopolysaccharidosis type I , Hurler's disease, also gargoylism, is a genetic disorder that results in the buildup of glycosaminoglycans due to a deficiency of alpha-L iduronidase, an enzyme responsible for the degradation of mucopolysaccharides in lysosomes...
      
      
  • Mucopolysaccharidosis
    Mucopolysaccharidosis
    Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans - long chains of sugar carbohydrates in each of our cells that help build bone, cartilage, tendons, corneas, skin and...
    
    , type II
    • Hunter syndrome
      Hunter syndrome
      Hunter syndrome, or mucopolysaccharidosis Type II, is a lysosomal storage disease caused by a deficient enzyme, iduronate-2-sulfatase . The syndrome is named after physician Charles A. Hunter , who first described it in 1917...
      
      
  • Other mucopolysaccharidoses
    • Sanfilippo syndrome
      Sanfilippo syndrome
      Sanfilippo syndrome, or Mucopolysaccharidosis III is a rare autosomal recessive lysosomal storage disease. It is caused by a deficiency in one of the enzymes needed to break down the glycosaminoglycan heparan sulfate .Although undegraded heparan sulfate is the primary stored substrate,...
      
      
    • Morquio syndrome
      Morquio syndrome
      Morquio's syndrome is an autosomal recessive mucopolysaccharide storage disease , usually inherited. It is a rare type of birth defect with serious consequences...
      
      
• Disorders of glycoprotein
  Glycoprotein
  Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
  
   metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
  
  • Defects in post-translational modification of lysosomal enzymes
    • Mucolipidosis II (I-cell disease
      I-cell disease
      Inclusion-cell disease, also referred to as mucolipidosis II , is part of the lysosomal storage disease family and results from a defective phosphotransferase . This enzyme transfers phosphate to mannose residues on specific proteins, and serves as a marker for them to be targeted to lysosomes...
      
      )
    • Mucolipidosis III (pseudo-Hurler polydystrophy
      Pseudo-Hurler polydystrophy
      Pseudo-Hurler polydystrophy, also referred to as mucolipidosis III , is a lysosomal storage disease closely related to I-cell disease...
      
      )
  • Defects in glycoprotein
    Glycoprotein
    Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
    
     degradation
    Chemical decomposition
    Chemical decomposition, analysis or breakdown is the separation of a chemical compound into elements or simpler compounds. It is sometimes defined as the exact opposite of a chemical synthesis. Chemical decomposition is often an undesired chemical reaction...
    
    
    • Aspartylglucosaminuria
      Aspartylglucosaminuria
      Aspartylglucosaminuria , also called aspartylglycosaminuria, is a rare, autosomal recessive lysosomal storage disorder caused by deficient activity of the enzyme N-aspartyl-beta-glucosaminidase . This enzyme normally cleaves long sugar chains known as oligosaccharides in the lysosome...
      
      
    • Fucosidosis
      Fucosidosis
      Fucosidosis, also called alpha-l-fucosidase deficiency, is a rare autosomal recessive lysosomal storage disease in which the enzyme fucosidase is not properly used in the cells to break down fucose. This enzyme normally cleaves long sugar chains known as oligosaccharides in the lysosome...
      
      
    • Mannosidosis
      Mannosidosis
      Mannosidosis is a deficiency in mannosidase, an enzyme.There are two types:* Alpha-mannosidosis* Beta-mannosidosis...
      
      
    • Sialidosis
      Sialidosis
      Mucolipidosis type I or sialidosis is an inherited lysosomal storage disease that results from a deficiency of the enzyme sialidase. The lack of this enzyme results in an abnormal accumulation of complex carbohydrates known as mucopolysaccharides, and of fatty substances known as mucolipids...
      
       (mucolipidosis I)
  • Other disorders of glycoprotein metabolism
  • Disorder of glycoprotein metabolism, unspecified
• Disorders of lipoprotein
  Lipoprotein
  A lipoprotein is a biochemical assembly that contains both proteins and lipids water-bound to the proteins. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins...
  
   metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
   and other lipidaemias
  • Pure hypercholesterolaemia
    • Familial hypercholesterolaemia
    • Fredrickson's hyperlipoproteinaemia, type IIa
    • Hyperbetalipoproteinaemia
    • Hyperlipidaemia, group A
    • Low-density-lipoprotein-type (LDL) hyperlipoproteinaemia
  • Pure hyperglyceridaemia
    • Endogenous
      Endogenous
      Endogenous substances are those that originate from within an organism, tissue, or cell. Endogenous retroviruses are caused by ancient infections of germ cells in humans, mammals and other vertebrates...
      
       hyperglyceridaemia
    • Fredrickson's hyperlipoproteinaemia, type IV
    • Hyperlipidaemia, group B
    • Hyperprebetalipoproteinaemia
    • Very-low-density-lipoprotein-type (VLDL) hyperlipoproteinaemia
  • Mixed hyperlipidaemia
    • Broad- or floating-betalipoproteinaemia
    • Fredrickson's hyperlipoproteinaemia, type IIb or III
    • Hyperbetalipoproteinaemia with prebetalipoproteinaemia
    • Hypercholesterolaemia with endogenous
      Endogenous
      Endogenous substances are those that originate from within an organism, tissue, or cell. Endogenous retroviruses are caused by ancient infections of germ cells in humans, mammals and other vertebrates...
      
       hyperglyceridaemia
    • Hyperlipidaemia, group C
    • Tubero-eruptive xanthoma
    • Xanthoma tuberosum
  • Hyperchylomicronaemia
    • Fredrickson's hyperlipoproteinaemia, type I or V
    • Hyperlipidaemia, group D
    • Mixed hyperglyceridaemia
  • Other hyperlipidaemia
    • Familial combined hyperlipidaemia
  • Hyperlipidaemia, unspecified
  • Lipoprotein
    Lipoprotein
    A lipoprotein is a biochemical assembly that contains both proteins and lipids water-bound to the proteins. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins...
    
     deficiency
    • Abetalipoproteinaemia
    • High-density lipoprotein deficiency
    • Hypoalphalipoproteinaemia
    • Hypobetalipoproteinaemia
      Hypobetalipoproteinemia
      Hypobetalipoproteinemia is a disorder consisting of low levels of LDL cholesterol or apolipoprotein B, below the 5th percentile. The patient can have hypobetalipoproteinemia and simultaneously have high levels of HDL cholesterol....
      
       (familial)
    • Lecithin cholesterol acyltransferase deficiency
      Lecithin cholesterol acyltransferase deficiency
      Lecithin cholesterol acyltransferase deficiency is disorder of lipoprotein metabolism.Lecithin cholesterol acyltransferase catalyzes the formation of cholesterol esters in lipoproteins.-Types:The disease has two forms:...
      
      
    • Tangier disease
      Tangier disease
      Tangier disease is a rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein , often referred to as "good cholesterol," in the bloodstream.-Diagnosis:...
      
      

(E79–E90) Other metabolic disorders

• Disorders of purine
  Purine
  A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
  
   and pyrimidine
  Pyrimidine
  Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring...
  
   metabolism
  • Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
  • Lesch-Nyhan syndrome
    Lesch-Nyhan syndrome
    Lesch–Nyhan syndrome , also known as Nyhan's syndrome, Kelley-Seegmiller syndrome and Juvenile gout, is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase , produced by mutations in the HPRT gene located on X chromosome. LNS affects about...
    
    
  • Other disorders of purine
    Purine
    A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
    
     and pyrimidine
    Pyrimidine
    Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Hereditary xanthinuria
      Xanthinuria
      Xanthinuria, also known as xanthine oxidase deficiency, is a rare genetic disorder causing the accumulation of xanthine. It is caused by a deficiency of the enzyme xanthine oxidase.It was first formally characterized in 1954.-Causes:...
      
      
• Disorders of porphyrin
  Porphyrin
  Porphyrins are a group of organic compounds, many naturally occurring. One of the best-known porphyrins is heme, the pigment in red blood cells; heme is a cofactor of the protein hemoglobin. Porphyrins are heterocyclic macrocycles composed of four modified pyrrole subunits interconnected at...
  
   and bilirubin metabolism
  • Hereditary erythropoietic porphyria
    • Erythropoietic protoporphyria
      Erythropoietic protoporphyria
      Erythropoietic protoporphyria is a relatively mild form of porphyria, although very painful, which arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue...
      
       (ILDS E80.010)
    • Erythropoietic porphyria, congenital (ILDS E80.020)
    • Gunther's disease
      Gunther's disease
      Gunther disease, also known as congenital erythropoietic porphyria , uroporphyrinogen III synthase deficiency and UROS deficiency, is a congenital form of erythropoietic porphyria. It is a rare, autosomal recessive metabolic disorder affecting heme, caused by deficiency of the enzyme...
      
       (ILDS (ILDS E80.020)
    • Erythropoietic porphyria
      Erythropoietic porphyria
      Erythropoietic porphyria is a type of porphyria associated with erythropoietic cells. In erythropoietic porphyrias, the enzyme deficiency occurs in the red blood cells.There are three types:...
      
       (ILDS (ILDS E80.030)
    • Erythropoietic coproporphyria (ILDS E80.040)
  • Porphyria cutanea tarda
    Porphyria cutanea tarda
    Porphyria cutanea tarda is the most common subtype of porphyria. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs...
    
    
    • Sporadic porphyria cutanea tarda (ILDS E80.110)
    • Familial porphyria cutanea tarda (ILDS E80.120)
  • Other porphyria
    Porphyria
    Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme bio-synthetic pathway . They are broadly classified as acute porphyrias and cutaneous porphyrias, based on the site of the overproduction and accumulation of the porphyrins...
    
    
    • Acute intermittent porphyria
      Acute intermittent porphyria
      Acute intermittent porphyria is a rare autosomal dominant metabolic disorder affecting the production of heme, the oxygen-binding prosthetic group of hemoglobin. It is characterized by a deficiency of the enzyme porphobilinogen deaminase. Acute intermittent porphyria is the second most common...
      
       (ILDS E80.210)
    • Hereditary coproporphyria
      Hereditary coproporphyria
      Hereditary coproporphyria is a type of acute porphyria that is associated with a deficiency of the enzyme coproporphyrinogen III oxidase....
      
       (ILDS E80.222)
    • Variegate porphyria
      Variegate porphyria
      Variegate porphyria is an autosomal dominant porphyria that can have acute symptoms along with symptoms that affect the skin...
      
       (ILDS E80.230)
    • Chester porphyria (ILDS E80.232)
    • Porphyria, hepatic (ILDS E80.240)
    • Pseudoporphyria
      Pseudoporphyria
      Pseudoporphyria is a bullous photosensitivity that clinically and histologically mimics porphyria cutanea tarda. The difference is that no abnormalities in urine or serum porphyrin is noted on laboratories...
      
       (ILDS E80.250)
    • Toxic porphyria (ILDS  E80.260)
    • Hepatoerythropoietic porphyria
      Hepatoerythropoietic porphyria
      Hepatoerythropoietic porphyria is a very rare form of hepatic porphyria caused by a disorder in both genes which code Uroporphyrinogen III decarboxylase .It has a similar presentation to porphyria cutanea tarda , but with earlier onset...
      
       (ILDS E80.282)
    • Porphyria
      Porphyria
      Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme bio-synthetic pathway . They are broadly classified as acute porphyrias and cutaneous porphyrias, based on the site of the overproduction and accumulation of the porphyrins...
      
      , NOS (ILDS E80.290)
  • Defects of catalase
    Catalase
    Catalase is a common enzyme found in nearly all living organisms that are exposed to oxygen, where it catalyzes the decomposition of hydrogen peroxide to water and oxygen...
    
     and peroxidase
    Peroxidase
    Peroxidases are a large family of enzymes that typically catalyze a reaction of the form:For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides...
    
    
    • Acatalasia
      Acatalasia
      Acatalasia is an autosomal recessive peroxisomal disorder caused by a complete lack of catalase.-Presentation:...
      
       (Takahara)
  • Gilbert's syndrome
    Gilbert's syndrome
    Gilbert's syndrome , often shortened to GS, also called Gilbert-Meulengracht syndrome, is the most common hereditary cause of increased bilirubin and is found in up to 5% of the population...
    
    
  • Crigler-Najjar syndrome
    Crigler-Najjar syndrome
    Crigler-Najjar Syndrome or CNS is a rare disorder affecting the metabolism of bilirubin, a chemical formed from the breakdown of blood. The disorder results in an inherited form of non-hemolytic jaundice, which results in high levels of unconjugated bilirubin and often leads to brain damage in...
    
    
  • Other disorders of bilirubin metabolism
    • Dubin-Johnson syndrome
      Dubin-Johnson syndrome
      Dubin–Johnson syndrome is an autosomal recessive disorder that causes an increase of conjugated bilirubin in the serum without elevation of liver enzymes . This condition is associated with a defect in the ability of hepatocytes to secrete conjugated bilirubin into the bile, and is similar to...
      
      
    • Rotor's syndrome
  • Disorder of bilirubin metabolism, unspecified
• Disorders of mineral
  Mineral
  A mineral is a naturally occurring solid chemical substance formed through biogeochemical processes, having characteristic chemical composition, highly ordered atomic structure, and specific physical properties. By comparison, a rock is an aggregate of minerals and/or mineraloids and does not...
  
   metabolism
  Metabolism
  Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
  
  
  • Disorders of copper
    Copper
    Copper is a chemical element with the symbol Cu and atomic number 29. It is a ductile metal with very high thermal and electrical conductivity. Pure copper is soft and malleable; an exposed surface has a reddish-orange tarnish...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Wilson's disease
      Wilson's disease
      Wilson's disease or hepatolenticular degeneration is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease...
      
      
    • Menkes disease
      Menkes disease
      Menkes disease , also called Menkes syndrome, copper transport disease, steely hair disease, kinky hair disease, or Menkes kinky hair syndrome, is a disorder that affects copper levels in the body, leading to copper deficiency...
      
      
  • Disorders of iron metabolism
    • Aceruloplasminemia
      Aceruloplasminemia
      Aceruloplasminemia is an autosomal recessive disorder of iron metabolism characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus....
      
      
    • Hemochromatosis
  • Disorders of zinc
    Zinc
    Zinc , or spelter , is a metallic chemical element; it has the symbol Zn and atomic number 30. It is the first element in group 12 of the periodic table. Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Acrodermatitis enteropathica
      Acrodermatitis enteropathica
      Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc, characterized by periorificial and acral dermatitis, alopecia , and diarrhea....
      
      
  • Disorders of phosphorus
    Phosphorus
    Phosphorus is the chemical element that has the symbol P and atomic number 15. A multivalent nonmetal of the nitrogen group, phosphorus as a mineral is almost always present in its maximally oxidized state, as inorganic phosphate rocks...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Acid phosphatase
      Acid phosphatase
      Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. It is basically a phosphomonoesterase...
      
       deficiency
    • Familial hypophosphataemia
    • Hypophosphatasia
      Hypophosphatasia
      Hypophosphatasia is a rare, and sometimes fatal metabolic bone disease. Clinical symptoms are heterogeneous ranging from the rapidly fatal perinatal variant, with profound skeletal hypomineralization and respiratory compromise to a milder, progressive osteomalacia later in life...
      
      
    • Vitamin-D-resistant osteomalacia
      Osteomalacia
      Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium, or because of overactive resorption of calcium from the bone as a result of hyperparathyroidism...
      
      
    • Vitamin-D-resistant rickets
      Rickets
      Rickets is a softening of bones in children due to deficiency or impaired metabolism of vitamin D, magnesium , phosphorus or calcium, potentially leading to fractures and deformity. Rickets is among the most frequent childhood diseases in many developing countries...
      
      
  • Disorders of magnesium
    Magnesium
    Magnesium is a chemical element with the symbol Mg, atomic number 12, and common oxidation number +2. It is an alkaline earth metal and the eighth most abundant element in the Earth's crust and ninth in the known universe as a whole...
    
     metabolism
    Metabolism
    Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
    
    
    • Hypermagnesemia
      Hypermagnesemia
      Hypermagnesemia is an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood. Usually this results in excess of magnesium in the body....
      
      
    • Hypomagnesemia
      Hypomagnesemia
      Hypomagnesemia is an electrolyte disturbance in which there is an abnormally low level of magnesium in the blood. Usually a serum level less than 0.7 mmol/L is used as reference. The prefix hypo- means low . The middle 'magnes' refers to magnesium...
      
      
  • Disorders of calcium metabolism
    Disorders of calcium metabolism
    Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body....
    
    
    • Familial
      Family
      In human context, a family is a group of people affiliated by consanguinity, affinity, or co-residence. In most societies it is the principal institution for the socialization of children...
      
       hypocalciuric hypercalcaemia
      Hypercalcaemia
      Hypercalcaemia is an elevated calcium level in the blood. . It can be an asymptomatic laboratory finding, but because an elevated calcium level is often indicative of other diseases, a workup should be undertaken if it persists...
      
      
    • Idiopathic
      Idiopathic
      Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios + πάθος, pathos , it means approximately "a disease of its own kind". It is technically a term from nosology, the classification of disease...
      
       hypercalciuria
      Hypercalciuria
      Hypercalciuria or hypercalcinuria is the condition of elevated calcium in the urine. Chronic hypercalcinuria may lead to impairment of renal function, nephrocalcinosis, and renal insufficiency....
      
      
• Cystic fibrosis
  Cystic fibrosis
  Cystic fibrosis is a recessive genetic disease affecting most critically the lungs, and also the pancreas, liver, and intestine...
  
  
• Amyloidosis
  Amyloidosis
  In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
  
  
  • Non-neuropathic heredofamilial amyloidosis
    Amyloidosis
    In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
    
    
    • Familial Mediterranean fever
      Familial Mediterranean fever
      Familial Mediterranean fever is a hereditary inflammatory disorder. FMF is an autoinflammatory disease caused by mutations in MEFV, a gene which encodes a 781–amino acid protein denoted pyrin....
      
      
    • Hereditary amyloid nephropathy
  • Neuropathic heredofamilial amyloidosis
    • Amyloid polyneuropathy (Portuguese)
  • Heredofamilial amyloidosis
    Heredofamilial amyloidosis
    Heredofamilial amyloidosis is an inherited condition that may be characterized by systemic or localized deposition of amyloid in body tissues....
    
    , unspecified
  • Secondary systemic amyloidosis
    Secondary systemic amyloidosis
    Secondary systemic amyloidosis is a condition that involves the adrenal gland, liver, spleen, and kidney as a result of amyloid deposition due to a chronic disease such as Behçet's disease, ulcerative colitis, etc.- See also :* Amyloidosis...
    
    
    • Haemodialysis-associated amyloidosis
      Haemodialysis-associated amyloidosis
      Haemodialysis-associated amyloidosis is a form of amyloidosis associated with chronic renal failure.-Presentation:Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood. It accumulates because it is unable to cross the dialysis filter....
      
      
  • Organ-limited amyloidosis
    Organ-limited amyloidosis
    Organ-limited amyloidosis is a category of amyloidosis where the distribution can be associated primarily with a single organ. It is contrasted to systemic amyloidosis, and it can be caused by several different types of amyloid....
    
    
    • Localized amyloidosis
  • Other amyloidosis
    Amyloidosis
    In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
    
    
  • Amyloidosis
    Amyloidosis
    In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
    
    , unspecified
• Volume depletion
  • Dehydration
    Dehydration
    In physiology and medicine, dehydration is defined as the excessive loss of body fluid. It is literally the removal of water from an object; however, in physiological terms, it entails a deficiency of fluid within an organism...
    
    
  • Hypovolaemia
• Other disorders of fluid
  Fluid
  In physics, a fluid is a substance that continually deforms under an applied shear stress. Fluids are a subset of the phases of matter and include liquids, gases, plasmas and, to some extent, plastic solids....
  
  , electrolyte
  Electrolyte
  In chemistry, an electrolyte is any substance containing free ions that make the substance electrically conductive. The most typical electrolyte is an ionic solution, but molten electrolytes and solid electrolytes are also possible....
  
   and acid-base balance
  • Hyperosmolality and hypernatraemia
  • Hypo-osmolality and hyponatraemia
  • Acidosis
    Acidosis
    Acidosis is an increased acidity in the blood and other body tissue . If not further qualified, it usually refers to acidity of the blood plasma....
    
    
    • Respiratory acidosis
      Respiratory acidosis
      Respiratory acidosis is a medical condition in which decreased ventilation causes increased blood carbon dioxide concentration and decreased pH ....
      
      
    • Metabolic acidosis
      Metabolic acidosis
      In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood pH is low due to increased production of hydrogen by the body or the...
      
      
    • Lactic acidosis
      Lactic acidosis
      Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate, and is considered a distinct form of metabolic acidosis. The condition typically occurs when cells receive too little oxygen , for example...
      
      
  • Alkalosis
    Alkalosis
    Alkalosis refers to a condition reducing hydrogen ion concentration of arterial blood plasma . Generally, alkalosis is said to occur when pH of the blood exceeds 7.45. The opposite condition is acidosis .-Causes:...
    
    
  • Mixed disorder of acid-base balance
  • Hyperkalaemia
  • Hypokalaemia
  • Fluid overload
  • Other disorders of electrolyte
    Electrolyte
    In chemistry, an electrolyte is any substance containing free ions that make the substance electrically conductive. The most typical electrolyte is an ionic solution, but molten electrolytes and solid electrolytes are also possible....
    
     and fluid balance, not elsewhere classified
    • Electrolyte imbalance NOS
    • Hyperchloraemia
    • Hypochloraemia
• Other metabolic disorders
  • Disorders of plasma-protein metabolism, not elsewhere classified
    • Alpha-1-antitrypsin deficiency
    • Bisalbuminaemia
  • Lipodystrophy
    Lipodystrophy
    Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. A more specific term, lipoatrophy is used when describing the loss of fat from one area...
    
    , not elsewhere classified
  • Lipomatosis
    Lipomatosis
    Lipomatosis is a hereditary condition where multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders...
    
    , not elsewhere classified
  • Other specified metabolic disorders
    • Launois-Bensaude adenolipomatosis
    • Trimethylaminuria
      Trimethylaminuria
      Trimethylaminuria , also known as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production of the enzyme Flavin containing monooxygenase 3...
      
      
  • Metabolic disorder, unspecified
• Postprocedural endocrine and metabolic disorders, not elsewhere classified
  • Postprocedural hypothyroidism
    Hypothyroidism
    Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...
    
    
  • Postprocedural hypoinsulinaemia
  • Postprocedural hypoparathyroidism
    Hypoparathyroidism
    Hypoparathyroidism is decreased function of the parathyroid glands with under production of parathyroid hormone. This can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany , and several other symptoms...
    
    
  • Postprocedural hypopituitarism
    Hypopituitarism
    Hypopituitarism is the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain...
    
    
  • Postprocedural ovarian failure
    Failure
    Failure refers to the state or condition of not meeting a desirable or intended objective, and may be viewed as the opposite of success. Product failure ranges from failure to sell the product to fracture of the product, in the worst cases leading to personal injury, the province of forensic...
    
    
  • Postprocedural testicular hypofunction
  • Postprocedural adrenocortical(-medullary
    Adrenal medulla
    The adrenal medulla is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland, consisting of cells that secrete epinephrine , norepinephrine , and a small amount of dopamine in response to...
    
    ) hypofunction
• Nutritional and metabolic disorders in diseases classified elsewhere

See also

• List of ICD-10 codes
• International Statistical Classification of Diseases and Related Health Problems
  ICD
  The International Statistical Classification of Diseases and Related Health Problems is a medical classification that provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or disease...
  
  
• List of ICD-9 codes 240–279: endocrine, nutritional and metabolic diseases, and immunity disorders