Haemodialysis-associated amyloidosis
Encyclopedia
Haemodialysis-associated amyloidosis is a form of amyloidosis
associated with chronic renal failure
.
, a serum protein, in the blood. It accumulates because it is unable to cross the dialysis filter.
Amyloidosis
In medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
associated with chronic renal failure
Chronic renal failure
Chronic kidney disease , also known as chronic renal disease, is a progressive loss in renal function over a period of months or years. The symptoms of worsening kidney function are unspecific, and might include feeling generally unwell and experiencing a reduced appetite...
.
Presentation
Long-term haemodialysis results in a gradual accumulation of β2 microglobulinBeta-2 microglobulin
β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells . In humans, the β2 microglobulin protein is encoded by the B2M gene.-Structure and function:...
, a serum protein, in the blood. It accumulates because it is unable to cross the dialysis filter.