The protein kinase domain is a structurally conserved

Conserved sequence

In biology, conserved sequences are similar or identical sequences that occur within nucleic acid sequences , protein sequences, protein structures or polymeric carbohydrates across species or within different molecules produced by the same organism...

 protein domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

 containing the catalytic function of protein kinase

Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...

s. Protein kinases are a group of enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

s that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases.

Protein kinases possess a catalytic subunit which transfers the gamma phosphate from nucleoside triphosphates (often ATP

Adenosine triphosphate

Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...

) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. These enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific

Serine/threonine-specific protein kinase

Serine/threonine protein kinases phosphorylate the OH group of serine or threonine .At least 125 of the 500+ human protein kinases are serine/threonine kinases .-Regulation:...

 and tyrosine specific

Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....

.

Function

Protein kinase

Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...

 function has been evolutionarily conserved from Escherichia coli

Escherichia coli

Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...

to Homo sapiens. Protein kinases play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins.

Structure

The catalytic subunits of protein kinases are highly conserved, and several structures have been solved, leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases.

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme.

Examples

The following is a list of human proteins containing the protein kinase domain:

AAK1

AAK1

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene...

; ABL1; ABL2

ABL2

Tyrosine-protein kinase ABL2 also known as Abelson-related gene is an enzyme that in humans is encoded by the ABL2 gene.- Function :...

; ACVR1

ACVR1

Activin A receptor, type I also known as ALK-2 is a protein which in humans is encoded by the ACVR1 gene.- Function :...

; ACVR1B

ACVR1B

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.ACVR1B or ALK-4 acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3...

; ACVR1C

ACVR1C

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules...

; ACVR2A

ACVR2A

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.ACVR2A is an activin type 2 receptor.-Interactions:ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B.-Further reading:...

; ACVR2B

ACVR2B

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.-Interactions:ACVR2B has been shown to interact with SYNJ2BP and ACVR1B.-Further reading:...

; ACVRL1

ACVRL1

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene.ACVRL1 is a receptor in the TGF beta signaling pathway.It is also known as "activin receptor-like kinase 1", or "ALK1".-Further reading:...

; ADCK1; ADCK2; ADCK3; ADCK4; ADCK5; ADRBK1;
ADRBK2; AKT1

AKT1

RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. Multiple alternatively spliced transcript variants have been found for this gene.- Function :...

; AKT2

AKT2

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.-Interactions:AKT2 has been shown to interact with TCL1A, APPL1, SH3RF1 and CHUK.-Further reading:...

; AKT3

AKT3

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.-Interactions:AKT3 has been shown to interact with Protein kinase Mζ.-Further reading:...

; ALPK1

ALPK1

Alpha-protein kinase 1 is an enzyme that in humans is encoded by the ALPK1 gene.-Further reading:...

; ALPK2; ALPK3; STRADB

ALS2CR2

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.-Further reading:...

; CDK15; AMHR2; ANKK1

ANKK1

The ANKK1 gene is a member of an extensive family of proteins involved in signal transduction pathways. This gene contains a single nucleotide polymorphism that causes an amino acid substitution within the 11th of 12 ankyrin repeats of ANKK1...

;
ARAF

ARAF

Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.-Interactions:...

; ATM

Ataxia telangiectasia mutated

Ataxia telangiectasia mutated is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis...

; ATR

Ataxia telangiectasia and Rad3 related

Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein or FRAP-related protein 1 is an enzyme that in humans is encoded by the ATR gene...

; AURKA; AURKB; AURKC

AURKC

Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.-Further reading:...

; AXL

AXL receptor tyrosine kinase

Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.-Interactions:AXL receptor tyrosine kinase has been shown to interact with TENC1.-Further reading:...

; BCKDK

BCKDK

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial is an enzyme that in humans is encoded by the BCKDK gene.-Further reading:...

; BLK

BLK (gene)

Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene.-Interactions:The tyrosine-protein kinase BLK has been shown to interact with UBE3A.-Further reading:...

; BMP2K

BMP2K

BMP-2-inducible protein kinase is an enzyme that in humans is encoded by the BMP2K gene.-Further reading:...

; BMPR1A

BMPR1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 .- Function :...

; BMPR1B

BMPR1B

Bone morphogenetic protein receptor type-1B also known as CDw293 is a protein that in humans is encoded by the BMPR1B gene.- Function :...

; BMPR2

BMPR2

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling...

; BMX

BMX (gene)

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.-Interactions:BMX has been shown to interact with PAK1, PTK2, PTPN21 and RUFY1.-Further reading:...

;
BRAF

BRAF (gene)

Serine/threonine-protein kinase B-Raf or simply B-Raf, also known as proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog B1, is a protein that in humans is encoded by the BRAF gene...

; BRSK1

BRSK1

BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene....

; BRSK2

BRSK2

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.-Further reading:...

; BTK

Bruton's tyrosine kinase

Bruton's tyrosine kinase is a type of kinase enzyme implicated in the primary immunodeficiency disease X-linked agammaglobulinemia . Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor...

; BUB1

BUB1

Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 is an enzyme that in humans is encoded by the BUB1 gene....

; C21orf7

C21orf7

Chromosome 21 open reading frame 7, also known as C21orf7, is a human gene located on chromosome 21. It is a coding gene.-Interactions:C21orf7 has been shown to interact with GPS2.-Further reading:...

; CALM1; CALM2

CALM2

Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene.- Further reading :...

; CALM3

CALM3

Calmodulin is a protein that in humans is encoded by the CALM3 gene.-Further reading:...

; CAMK1

CAMK1

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.-Further reading:...

; CAMK1D; CAMK1G;
CAMK2A

CAMK2A

Calcium/calmodulin-dependent protein kinase type II alpha chain is an enzyme that in humans is encoded by the CAMK2A gene.-Interactions:CAMK2A has been shown to interact with Actinin alpha 4, DLG1 and CDK5R1.-Further reading:...

; CAMK2B

CAMK2B

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.-Interactions:CAMK2B has been shown to interact with Actinin alpha 4.-Further reading:...

; CAMK2D

CAMK2D

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.-Further reading:...

; CAMK2G

CAMK2G

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.-Further reading:...

; CAMK4

CAMK4

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.-Further reading:...

; CAMKK1

CAMKK1

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.-Further reading:...

; CAMKK2

CAMKK2

Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the CAMKK2 gene.-Function:The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca++/calmodulin-dependent protein kinase subfamily...

; CAMKV;
CASK

CASK

Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 , calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.-Genomics:This gene is located on the short arm of...

; CDK20; CDK1; CDK11B

CDC2L1

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.-Interactions:CDC2L1 has been shown to interact with Cyclin D3.-Further reading:...

; CDK11A

CDC2L2

PITSLRE serine/threonine-protein kinase CDC2L2 is an enzyme that in humans is encoded by the CDC2L2 gene.-Further reading:...

; CDK13

CDC2L5

Cell division cycle 2-like protein kinase 5 is an enzyme that in humans is encoded by the CDC2L5 gene.-Further reading:...

; CDK19; CDC42BPA

CDC42BPA

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.-Further reading:...

;
CDC42BPB; CDC42BPG; CDC7; CDK10; CDK2

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...

; CDK3; CDK4; CDK5;
CDK6; CDK7; CDK8; CDK9

CDK9

CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase associated with P-TEFb.CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle...

; CDK12

CRKRS

Cell division cycle 2-related protein kinase 7 is an enzyme that in humans is encoded by the CRKRS gene.-Further reading:...

; CDK14

PFTK1

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.-Further reading:...

; CDK16

PCTK1

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene.-Further reading:...

; CDK17

PCTK2

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the PCTK2 gene.-Further reading:...

; CDK18

PCTK3

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.-Further reading:...

; CDKL1; CDKL2

CDKL2

Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.-Further reading:...

; CDKL3; CDKL4; CDKL5

CDKL5

CDKL5 is a gene that provides instructions for making a protein called cyclin-dependent kinase-like 5 also known as serine/threonine kinase 9 that is essential for normal brain development. Although little is known about the protein's function, it may play a role in regulating the activity of...

;
CHEK1

CHEK1

Serine/threonine-protein kinase Chk1 is an enzyme that in humans is encoded by the CHEK1 gene.Chk1 is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor...

; CHEK2

CHEK2

CHEK2 is the official symbol for the human gene CHK2 checkpoint homolog. It is located on the long arm of chromosome 22.-Function:The protein encoded by this gene, CHK2 a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest.In response to DNA damage and...

; CHUK

CHUK

Inhibitor of nuclear factor kappa-B kinase subunit alpha also known as IKK1 or conserved helix-loop-helix ubiquitous kinase is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription...

; CIT

CIT (gene)

Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene.-Interactions:CIT has been shown to interact with RHOB and RHOA.-Further reading:...

; CKB

Creatine kinase

Creatine kinase , also known as creatine phosphokinase or phospho-creatine kinase , is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and consumes adenosine triphosphate to create phosphocreatine and adenosine diphosphate...

; CKM

Creatine kinase

Creatine kinase , also known as creatine phosphokinase or phospho-creatine kinase , is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and consumes adenosine triphosphate to create phosphocreatine and adenosine diphosphate...

; CLK1

CLK1

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.-Further reading:...

; CLK2

CLK2

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.-Further reading:...

; CLK3;
CLK4; CSF1R; CSK

C-src tyrosine kinase

C-src tyrosine kinase, also known as CSK, is a human protein and gene. It includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase, which acts as a negative regulatory site...

; CSNK1A1

CSNK1A1

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.-Interactions:Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1 and AXIN1.-Further reading:...

; CSNK1A1L; CSNK1D

CSNK1D

Casein kinase I isoform delta is an enzyme that in humans is encoded by the CSNK1D gene.-Interactions:CSNK1D has been shown to interact with Gap junction protein, alpha 1.-Further reading:...

; CSNK1E

CSNK1E

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.-Interactions:CSNK1E has been shown to interact with PER1 and AXIN1.-References:...

; CSNK1G1; CSNK1G2;
CSNK1G3; CSNK2A1

CSNK2A1

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.-Interactions:Casein kinase 2, alpha 1 has been shown to interact with CHEK1, FGF1, CDC25B, CREB-binding protein, Activating transcription factor 2, C-Fos, MAPK14, RELA, PIN1, PLEKHO1, CSNK2B, PTEN, ATF1,...

; CSNK2A2

CSNK2A2

Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A2 gene.-Interactions:CSNK2A2 has been shown to interact with CSNK2B, FGF1, PTEN, RELA, ATF1, Nucleolin, CREB binding protein, Activating transcription factor 2, PIN1, C-jun and C-Fos.-Further reading:...

; DAPK1

DAPK1

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.-Further reading:...

; DAPK2

DAPK2

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.-Further reading:...

; DAPK3

DAPK3

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.-Interactions:DAPK3 has been shown to interact with PAWR and Death associated protein 6.-Further reading:...

; DCLK1

DCLK1

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.-Further reading:...

;
DCLK2; DCLK3; DDR1

DDR1

For the older type of computer memory, see DDR SDRAM.Discoidin domain receptor family, member 1, also known as DDR1 or CD167a , is a human gene.-Further reading:...

; DDR2

DDR2 (gene)

Discoidin domain receptor family, member 2, also known as DDR2 or CD167b , is a human gene.-Interactions:DDR2 has been shown to interact with SHC1.-Further reading:...

; DMPK

Myotonic dystrophy protein kinase

Myotonin-protein kinase also known as myotonic dystrophy protein kinase or dystrophia myotonica protein kinase is an enzyme that in humans is encoded by the DMPK gene.- Function :...

; DYRK1A

DYRK1A

Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region...

; DYRK1B

DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.- Function :DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The...

; DYRK2

DYRK2

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is an enzyme that in humans is encoded by the DYRK2 gene.-Further reading:...

; DYRK3

DYRK3

Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.-Further reading:...

; DYRK4;
EGFR

Epidermal growth factor receptor

The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands...

; EIF2AK1

EIF2AK1

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.-Further reading:...

; EIF2AK2; EIF2AK3

EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3 is an enzyme that in humans is encoded by the EIF2AK3 gene. Patients with mutations in this gene develop Wolcott-Rallison syndrome.-Interactions:...

; EIF2AK4

EIF2AK4

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.-Further reading:...

; ELK1

ELK1

E twenty-six -like transcription factor 1, also known as Elk1, functions as a transcription activator. It is classified as a ternary complex factor , a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences...

; EPHA1

EPHA1

EPH receptor A1 is a protein that in humans is encoded by the EPHA1 gene.-Further reading:...

; EPHA2; EPHA3

EPHA3

EPH receptor A3 is a protein that in humans is encoded by the EPHA3 gene.-Interactions:EPH receptor A3 has been shown to interact with EFNB2 and EFNA5.-Further reading:...

; EPHA4; EPHA5

EPHA5

EPH receptor A5 is a protein that in humans is encoded by the EPHA5 gene.-Further reading:...

; EPHA6

EPHA6

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.-Further reading:...

; EPHA7

EPHA7

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.-Further reading:...

; EPHA8

EPHA8

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.-Further reading:...

; EPHB1; EPHB2; EPHB3

EPHB3

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.-Interactions:EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.-Further reading:...

; EPHB4; ERBB2; ERBB3

ERBB3

Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene.It is thought that ERBB3, when activated, becomes a substrate for dimerization and subsequent phosphorylation by ERBB1, ERBB2 and ERBB4....

; ERBB4

ERBB4

Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized....

; ERN1

ERN1

Serine/threonine-protein kinase/endoribonuclease IRE1 is an enzyme that in humans is encoded by the ERN1 gene.-Interactions:ERN1 has been shown to interact with Heat shock protein 90kDa alpha , member A1.-Further reading:...

; ERN2; FER

FER (gene)

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.-Interactions:FER has been shown to interact with TMF1 and Cortactin.-Further reading:...

; FES

Feline sarcoma oncogene

Proto-oncogene tyrosine-protein kinase Fes/Fps is an enzyme that in humans is encoded by the FES gene.-Interactions:Feline sarcoma oncogene has been shown to interact with BCAR1 and BCR gene.-Further reading:...

; FGFR1; FGFR2; FGFR3

FGFR3

Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 .-Structure and function:-Disease linkage:...

; FGFR4; FGR

FGR (gene)

Gardner-Rasheed feline sarcoma viral oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.- Function :This gene is a member of the Src family of protein tyrosine kinases...

; FLT1

FLT1

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.-Interactions:FLT1 has been shown to interact with PLCG1 and Vascular endothelial growth factor B.-Further reading:...

; FLT3; FLT4

FLT4

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic...

; FYN

FYN

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth...

; GAK

GAK (protein)

Cyclin G-associated kinase is a serine/threonine kinase that in humans is encoded by the GAK gene.- Function :In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases , whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that...

; GRK1; GRK4

GRK4

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.-Further reading:...

;
GRK5

GRK5

G protein-coupled receptor kinase 5 is an enzyme that in humans is encoded by the GRK5 gene.-Further reading:...

; GRK6

GRK6

G protein-coupled receptor kinase 6 is an enzyme that in humans is encoded by the GRK6 gene.-Further reading:...

; GRK7; GSK3A

GSK3A

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' and implicated in the control of several regulatory proteins including glycogen synthase and...

; GSK3B

GSK3B

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.- Function :Glycogen synthase kinase-3 is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms,...

; GUCY2C; GUCY2D

GUCY2D

GUCY2D is a guanylate cyclase associated with type 1 Leber's congenital amaurosis.-References:...

; GUCY2E; GUCY2F;
HCK

HCK

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.-Interactions:HCK has been shown to interact with BCR gene, ELMO1, Cbl gene, RAS p21 protein activator 1, RASA3, Granulocyte colony-stimulating factor receptor, ADAM15 and RAPGEF1.-Further reading:...

; HIPK1

HIPK1

Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.-Further reading:...

; HIPK2

HIPK2

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.-Interactions:HIPK2 has been shown to interact with SKI protein, Death associated protein 6, P53, CREB binding protein, Mothers against decapentaplegic homolog 1, TP53INP1 and RANBP9.-Further reading:...

; HIPK3

HIPK3

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.-Further reading:...

; HIPK4; HUNK; ICK

ICK (gene)

Serine/threonine-protein kinase ICK is an enzyme that in humans is encoded by the ICK gene.-Further reading:...

; IGF1R; IGF2R; IKBKB; IKBKE

IKBKE

Inhibitor of nuclear factor kappa-B kinase subunit epsilon is an enzyme that in humans is encoded by the IKBKE gene.-Interactions:IKBKE has been shown to interact with TANK.-Further reading:...

;
ILK

Ilk

Ilk is a village in Szabolcs-Szatmár-Bereg county, in the Northern Great Plain region of eastern Hungary.-Geography:It covers an area of and has a population of 1263 people ....

; INSR; IRAK1

IRAK1

Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.-Interactions:IRAK1 has been shown to interact with Myd88, IKBKG, IKK2, TRAF6, CHUK and Ubiquitin C.-Further reading:...

; IRAK2

IRAK2

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.-Interactions:IRAK2 has been shown to interact with TRAF6 and Myd88.-Further reading:...

; IRAK3

IRAK3

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.-Further reading:...

; IRAK4; ITK

ITK (gene)

IL2-inducible T-cell kinase, also known as ITK, is a protein that in humans is encoded by the ITK gene.- Function :This gene encodes an intracellular tyrosine kinase expressed in T-cells...

; JAK1; JAK2; JAK3; KALRN; KDR

Kinase insert domain receptor

Kinase insert domain receptor also known as vascular endothelial growth factor receptor 2 is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309...

; SIK3

KIAA0999

KIAA0999 protein is a protein that in humans is encoded by the SIK3 gene.-Further reading:...

; KSR2; LATS1

LATS1

Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.It has been associated with the Hippo signaling pathway.-Interactions:LATS1 has been shown to interact with Zyxin and Cdk1.-Further reading:...

;
LATS2

LATS2

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.-Further reading:...

; LIMK1

LIMK1

LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.-Interactions:LIMK1 has been shown to interact with PAK1, YWHAZ, PAK4, Cofilin 1, Neuregulin 1 and Cyclin-dependent kinase inhibitor 1C.-External links:...

; LCK

Lck

Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...

; LIMK2

LIMK2

LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene.-External links:* Info with links in the...

; LRRK1

LRRK1

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.-Further reading:...

; LRRK2

LRRK2

Leucine-rich repeat kinase 2 , also known as dardarin, is an enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family...

; LYN

LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged...

; MAK

MAK (gene)

Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene.-Further reading:...

;
MAP2K1

MAP2K1

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.- Function :The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein kinase kinase...

; MAP2K2

MAP2K2

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.- Function :The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in...

; MAP2K3

MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.-Interactions:MAP2K3 has been shown to interact with TAOK2 and PLCB2.-Further reading:...

; MAP2K4

MAP2K4

Dual specificity mitogen-activated protein kinase kinase 4 is an enzyme that in humans is encoded by the MAP2K4 gene.-Interactions:MAP2K4 has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.-Further reading:...

; MAP2K5

MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.-Upstream:This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms .-Interactions:MAP2K5 has been shown to interact...

; MAP2K6

MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.- Function :...

; MAP2K7

MAP2K7

Mitogen-activated protein kinase kinase 7, also known as MAP2K7, is ahuman gene.-Interactions:MAP2K7 has been shown to interact with GADD45B, MAPK8, MAPK8IP3, MAPK8IP1, MAP3K12, MAP3K2, MAPK8IP2 and DUSP19.-Further reading:...

; MAP3K1

MAP3K1

Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.-Interactions:MAP3K1 has...

;
MAP3K10

MAP3K10

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.-Interactions:MAP3K10 has been shown to interact with NEUROD1, Huntingtin, MAPK8IP1, KIF3A, CDC42 and MAPK8IP2.-Further reading:...

; MAP3K11

MAP3K11

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.-Interactions:MAP3K11 has been shown to interact with MAPK8IP1, CDC42, SH3RF1, MAPK8IP2 and AKT1.-Further reading:...

; MAP3K12

MAP3K12

Mitogen-activated protein kinase kinase kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.-Interactions:MAP3K12 has been shown to interact with MAPK8IP1, MAP2K7 and MAPK8IP2.-Further reading:...

; MAP3K13

MAP3K13

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.-Further reading:...

; MAP3K14

MAP3K14

Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase is an enzyme that in humans is encoded by the MAP3K14 gene.- Function :...

; MAP3K15; MAP3K2

MAP3K2

Mitogen-activated protein kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP3K2 gene.-Interactions:MAP3K2 has been shown to interact with SH2D2A, MAP2K7, MAP2K5, XIAP and MAPK8.-Further reading:...

; MAP3K3

MAP3K3

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene.-Interactions:MAP3K3 has been shown to interact with [SQSTM1/p62], MAP2K5, YWHAE, GAB1 and BRCA1.-Further reading:...

;
MAP3K4

MAP3K4

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.-Interactions:MAP3K4 has been shown to interact with GADD45G, GADD45B and GADD45A.-Further reading:...

; MAP3K5; MAP3K6; MAP3K7

MAP3K7

Mitogen-activated protein kinase kinase kinase 7 is an enzyme that in humans is encoded by the MAP3K7 gene.-Interactions:MAP3K7 has been shown to interact with Mothers against decapentaplegic homolog 6, MAP3K7IP2, MAP3K7IP1, MAP3K7IP3, ASK1, PPM1B, TRAF6, MAP2K6 and CHUK.-Further reading:...

; MAP3K8

MAP3K8

Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.-Interactions:MAP3K8 has been shown to interact with AKT1, CHUK, NFKB2 and NFKB1.-Further reading:...

; MAP3K9

MAP3K9

Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene.-Further reading:...

; MAP4K1

MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.. It is also known as HPK1 .-Interactions:...

; MAP4K2

MAP4K2

Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.-Interactions:MAP4K2 has been shown to interact with RAB8A and TRAF2.-Further reading:...

;
MAP4K3; MAP4K4

MAP4K4

Mitogen-activated protein kinase kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP4K4 gene.-Interactions:MAP4K4 has been shown to interact with NCK1 and CD29.-Further reading:...

; MAP4K5

MAP4K5

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.-Interactions:MAP4K5 has been shown to interact with CRKL and TRAF2.-Further reading:...

; MAPK1

MAPK1

Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.- Function :The protein encoded by this gene is a member of the MAP kinase family...

; MAPK10

MAPK10

Mitogen-activated protein kinase 10 is an enzyme that in humans is encoded by the MAPK10 gene.-Interactions:MAPK10 has been shown to interact with MAPK8IP3.-Further reading:...

; MAPK12

MAPK12

Mitogen-activated protein kinase 12 , also known as extracellular signal-regulated kinase 6 or stress-activated protein kinase 3 , is an enzyme that in humans is encoded by the MAPK12 gene.- Function :...

; MAPK13

MAPK13

Mitogen-activated protein kinase 13 , also known as stress-activated protein kinase 4 , is an enzyme that in humans is encoded by the MAPK13 gene.- Function :The protein encoded by this gene is a member of the MAP kinase family...

; MAPK14

MAPK14

Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene.-Interactions:MAPK14 has been shown to interact with Casein kinase 2, alpha 1, RPS6KA4, MAPKAPK2, CDC25B, DUSP1, ZFP36L1, CDC25C, MAPKAPK3, Activating transcription factor 2, MAPK1,...

;
MAPK15

MAPK15

Mitogen-activated protein kinase 15 is an enzyme that in humans is encoded by the MAPK15 gene.-Further reading:...

; MAPK3

MAPK3

Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.-Interactions:MAPK3 has been shown to interact with PTPN7, SPIB, GTF2I, DUSP3, HDAC4, RPS6KA2, MAP2K1, DUSP6 and MAP2K2.-Further reading:...

; MAPK4

MAPK4

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.-Further reading:...

; MAPK6

MAPK6

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.-Further reading:...

; MAPK7

MAPK7

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.- Function :MAPK7 is a member of the MAP kinase family...

; MAPK8

MAPK8

Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAPK8 gene.-Interactions:MAPK8 has been shown to interact with SPIB, DUSP1, Activating transcription factor 2, SH3BP5, GSTP1, MAPK8IP1, MAP2K7, CRK, MAP2K4, DUSP22, Myc, MAP3K2, DUSP10, REL, MAPK8IP3, IRS1, MAP3K1 and...

; MAPK9; MAPKAPK2

MAPKAPK2

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.-Interactions:MAPKAPK2 has been shown to interact with MAPK14, AKT1, PHC2 and SHC1.-Further reading:...

;
MAPKAPK3

MAPKAPK3

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.-Interactions:MAPKAPK3 has been shown to interact with MAPK14 and TCF3.-Further reading:...

; MAPKAPK5

MAPKAPK5

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.-Further reading:...

; MARK1

MARK1

Serine/threonine-protein kinase MARK1 is an enzyme that in humans is encoded by the MARK1 gene.-Further reading:...

; MARK2

MARK2

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.-Further reading:...

; MARK3

MARK3

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.-Interactions:MARK3 has been shown to interact with Stratifin.-Further reading:...

; MARK4

MARK4

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.-Interactions:MARK4 has been shown to interact with USP9X and Ubiquitin C.-Further reading:...

; MAST1

MAST1

Microtubule-associated serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MAST1 gene.-Further reading:...

; MAST2

MAST2

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene. The protein encoded by this gene controls TRAF6 and NF-kappaB activity.-Further reading:...

;
MAST3; MAST4; MASTL

MASTL

Microtubule-associated serine/threonine-protein kinase-like is an enzyme that in humans is encoded by the MASTL gene.-Further reading:...

; MELK

MELK

Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.-Further reading:...

; MERTK

MERTK

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.-External links:*...

; MET

C-MET

c-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor . The hepatocyte growth factor receptor protein possesses tyrosine-kinase activity...

; MINK1

MINK1

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.- Function :Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct...

;
MKNK1

MKNK1

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.-Interactions:MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.-Further reading:...

; MKNK2

MKNK2

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.-Interactions:MKNK2 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.-Further reading:...

; MLKL; MOS

MOS (gene)

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.-Interactions:MOS has been shown to interact with MyoD.-Further reading:...

; MST1R

MST1R

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.-Further reading:...

; MST4; MTOR; MYLK

MYLK

Myosin light chain kinase, smooth muscle also known as kinase-related protein or telokin is an enzyme that in humans is encoded by the MYLK gene.- Function :...

;
MYLK2

MYLK2

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.- Function :This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle....

; MYLK3

MYLK3

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.- Function :Phosphorylation of cardiac myosin heavy chains and light chains by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac...

; MYLK4; NEK1

NEK1

NIMA -related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage to radiation.-Further reading:...

; NEK10; NEK11; NEK2

NEK2

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.-Interactions:NEK2 has been shown to interact with MAPK1 and NDC80.-Further reading:...

;
NEK3

NEK3

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.-Further reading:...

; NEK4; NEK5; LOC100506859; NEK6

NEK6

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.-Further reading:...

; NEK7; NEK8

NEK8

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.- Function :...

; NEK9

NEK9

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.-Interactions:NEK9 has been shown to interact with Structure specific recognition protein 1, NEK6 and Ran .-Further reading:...

; MGC42105;
NLK

NLK

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene.-Further reading:...

; NRK; NTRK1; NTRK2; NTRK3; NUAK1

NUAK1

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 is an enzyme that in humans is encoded by the NUAK1 gene.-Interactions:NUAK1 has been shown to interact with USP9X and Ubiquitin C.-Further reading:...

; NUAK2

NUAK2

NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase is an enzyme that in humans is encoded by the NUAK2 gene.-Further reading:...

; OBSCN

OBSCN

Obscurin is a protein that in humans is encoded by the OBSCN gene.-Interactions:OBSCN has been shown to interact with Titin and ANK1.-Further reading:...

; OXSR1

OXSR1

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.-Further reading:...

;
PAK1

PAK1

Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.-Interactions:PAK1 has been shown to interact with C-Raf, NCK1, LIMK1, RAC1, ARHGEF2, BMX, ARPC1B, DYNLL1, Cyclin-dependent kinase 5, PAK1IP1 and CDC42....

; PAK2

PAK2

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.-Interactions:PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.-External links:* Info with links in the...

; PAK3

PAK3

Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.-External links:* Info with links in the...

; PAK4

PAK4

Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.-Interactions:PAK4 has been shown to interact with CDC42, Integrin, beta 5 and LIMK1.-External links:* Info with links in the...

; PAK6

PAK6

Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene.-Interactions:PAK6 has been shown to interact with Androgen receptor.-Further reading:...

; PAK7

PAK7

Serine/threonine-protein kinase PAK 7 is an enzyme that in humans is encoded by the PAK7 gene.-Further reading:...

; PASK

PASK

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.-Further reading:...

; PBK

PBK (gene)

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.-Further reading:...

;
PDGFRA

PDGFRA

Alpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.-Interactions:PDGFRA has been shown to interact with PDGFRB, PLCG1, Sodium-hydrogen antiporter 3 regulator 1, Cbl gene, CRK, Caveolin 1 and PDGFC.-Further reading:...

; PDGFRB

PDGFRB

Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.-Interactions:PDGFRB has been shown to interact with PTPN11, NCK1, Grb2, Caveolin 1, PDGFRA, Sodium-hydrogen antiporter 3 regulator 1, RAS p21 protein activator 1, CRK, SHC1 and...

; PDIK1L; PDPK1; PHKA1

PHKA1

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene.-External links:*...

; PHKB

PHKB

Phosphorylase b kinase regulatory subunit beta is an enzyme that in humans is encoded by the PHKB gene.-External links:*...

; PHKG1

PHKG1

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKG1 gene.-Further reading:...

;
PHKG2

PHKG2

Phosphorylase b kinase gamma catalytic chain, testis/liver isoform is an enzyme that in humans is encoded by the PHKG2 gene.-External links:*...

; PIK3R4

PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene....

; PIM1

PIM1

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus...

; PIM2

PIM2

PIM2 is a scoring system for rating the severity of medical illness for children, one of several ICU scoring systems. Its name stands for "Paediatric Index of Mortality". It has been designed to provide a predicted mortality for a patient by following a well defined procedure...

; PIM3; PINK1

PINK1

PTEN-induced putative kinase 1 is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.-External links:* -Further reading:...

; PKMYT1

PKMYT1

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.-Interactions:PKMYT1 has been shown to interact with PIN1 and STEAP3.-Further reading:...

; PKN1;
PKN2

PKN2

Serine/threonine-protein kinase N2 is an enzyme that in humans is encoded by the PKN2 gene.-Interactions:PKN2 has been shown to interact with Phosphoinositide-dependent kinase-1, AKT1, NCK1, PTPN13 and RHOA.-Further reading:...

; PKN3; PLK1

PLK1

Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 or serine/threonine-protein kinase 13 , is an enzyme that in humans is encoded by the PLK1 gene.- Structure :...

; PLK2

PLK2

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.-Further reading:...

; PLK3

PLK3

Polo-like kinase 3 , also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.- Function :Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain...

; PLK4

PLK4

Serine/threonine-protein kinase PLK4 is an enzyme that in humans is encoded by the PLK4 gene.-Further reading:...

; PNCK; PRKAA1

PRKAA1

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.-Interactions:Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.-Further reading:...

;
PRKAA2

PRKAA2

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.-Further reading:...

; PRKACA

PRKACA

cAMP-dependent protein kinase catalytic subunit alpha is an enzyme that in humans is encoded by the PRKACA gene.-Interactions:PRKACA has been shown to interact with Phosphoinositide-dependent kinase-1, IQGAP1, KvLQT1 and Ryanodine receptor 2....

; PRKACB

PRKACB

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.-Interactions:PRKACB has been shown to interact with Ryanodine receptor 2 and Low affinity nerve growth factor receptor.-Further reading:...

; PRKACG

PRKACG

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.-Interactions:PRKACG has been shown to interact with Ryanodine receptor 2.-Further reading:...

; PRKCA; PRKCB

PRKCB1

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene..-Interactions:PRKCB1 has been shown to interact with RIPK4, Beta adrenergic receptor kinase, PDLIM5 and GNB2L1.-Further reading:-See also:*Protein kinase C...

; PRKCD

PRKCD

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.- Function :Protein kinase C is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol...

; PRKCE

PRKCE

Protein kinase C epsilon type is an enzyme that in humans is encoded by the PRKCE gene.- Function :Protein kinase C is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol...

;
PRKCG

PRKCG

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.-External Links:* -Further reading:...

; PRKCH

PRKCH

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.-Further reading:...

; PRKCI

PRKCI

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.-Interactions:PRKCI has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase, Centaurin, alpha 1, Phosphoinositide-dependent kinase-1, FRS2, SMG1 , Sequestosome 1 and PARD3.-Further reading:...

; PRKCQ

PRKCQ

Protein kinase C theta type is an enzyme that in humans is encoded by the PRKCQ gene.-Interactions:PRKCQ has been shown to interact with FYN, GLRX3, AKT1 and VAV1.PRKCQ has been shown to phosphorylate CARD11 as part of the NF-κB signaling pathway....

; PRKCZ; PRKD1; PRKD2

PRKD2

Serine/threonine-protein kinase D2 is an enzyme that in humans is encoded by the PRKD2 gene.- Function :The protein encoded by this gene belongs to the protein kinase D family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the...

;
PRKD3

PRKD3

Serine/threonine-protein kinase D3 is an enzyme that in humans is encoded by the PRKD3 gene.-Further reading:...

; PRKG1

PRKG1

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.-Interactions:PRKG1 has been shown to interact with ITPR1, RGS2, TNNT1, MRVI1 and GTF2I.-Further reading:...

; PRKG2; PRKX; LOC389906; PRKY

PRKY

Serine/threonine-protein kinase PRKY is an enzyme that in humans is encoded by the PRKY gene.-Further reading:...

; PRPF4B

PRPF4B

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.-Further reading:...

; PSKH1

PSKH1

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.-Further reading:...

; PSKH2; PTK2

PTK2

PTK2 protein tyrosine kinase 2 , also known as Focal Adhesion Kinase , is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes...

; PTK2B

PTK2B

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.-Protein:-Interactions:PTK2B has been shown to interact with PTPN11, PTPN6, PITPNM1, Gelsolin, Src, GRIN2A, Ewing sarcoma breakpoint region 1, RB1CC1, TGFB1I1, NPHP1, BCAR1, FYN, DLG4, DLG3, DDEF2, Cbl gene, RAS...

; RAF1; RAGE; RET

RET proto-oncogene

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules....

; RIP3; RIPK1

RIPK1

Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.-Interactions:RIPK1 has been shown to interact with CA11, RIPK3, RNF11, Baculoviral IAP repeat-containing protein 3, CFLAR, BIRC2, Caspase 8, RNF216, TNFRSF1A, Sequestosome 1, TRAF2,...

; RIPK2

RIPK2

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.-Further reading:...

; RIPK3

RIPK3

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.-Further reading:...

; RIPK4

RIPK4

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.-Further reading:...

;
ROCK1

ROCK1

Rho-associated, coiled-coil containing protein kinase 1, also known as ROCK1, is a protein serine/threonine kinase, but also denotes the human gene encoding it....

; ROCK2; ROR1

ROR1

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 , is an enzyme that in humans is encoded by the ROR1 gene...

; ROR2

ROR2

Tyrosine-protein kinase transmembrane receptor ROR2 also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It...

; ROS1; RPS6KA1

RPS6KA1

HU-1 redirects here. For the helicopter, see UH-1 Iroquois.Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.-Interactions:RPS6KA1 has been shown to interact with YWHAB, MAPK1, IκBα, TOB1 and TSC2....

; RPS6KA2

RPS6KA2

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.-Interactions:RPS6KA2 has been shown to interact with MAPK3 and MAPK1.-Further reading:...

; RPS6KA3

RPS6KA3

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.- Function :This gene encodes a member of the RSK family of serine/threonine kinases...

;
RPS6KA4

RPS6KA4

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.- Function :This gene encodes a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1...

; RPS6KA5

RPS6KA5

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.-Further reading:...

; RPS6KA6; RPS6KB1; RPS6KB2

RPS6KB2

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.-Further reading:...

; RPS6KC1

RPS6KC1

Ribosomal protein S6 kinase delta-1 is an enzyme that in humans is encoded by the RPS6KC1 gene.-Further reading:...

; RPS6KL1; RYK; SCYL1

SCYL1

SCY1-like 1 , also known as SCYL1, is a human gene which is highly conserved throughout evolution.- Function :This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins...

;
SCYL2

SCYL2

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene.-Further reading:...

; SCYL3

SCYL3

Protein-associating with the carboxyl-terminal domain of ezrin is a protein that in humans is encoded by the SCYL3 gene.-Further reading:...

; SGK1

SGK

Serine/threonine-protein kinase SGK is a kinase subfamily that is currently known as being encoded by SGK1, SGK2, and SGK3 genes.The SGK1 kinase regulates the myo-inositol transporter during osmotic stress....

; LOC100130827; SGK196;
SGK2

SGK2

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.-Further reading:...

; SGK3

SGK3

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.-Further reading:...

; SGK494; SIK1

SNF1LK

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.-Further reading:...

; SIK2

SNF1LK2

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.-Further reading:...

; SLK

SLK (gene)

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.-Interactions:SLK has been shown to interact with PDZK1.-Further reading:...

;
SNRK

SNRK

SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.-Further reading:...

; SPEG

SPEG

SPEG complex locus, also known as SPEG, is a human gene.Mouse Mutant Alleles for Speg Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the Mutant Mouse Embryonic Stem Cell Clones...

; SRC

Src (gene)

Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene.Src is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a...

; SRPK1

SRPK1

Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.-Interactions:SRPK1 has been shown to interact with SNRP70 and ASF/SF2.-Further reading:...

; SRPK2

SRPK2

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.-Interactions:SRPK2 has been shown to interact with U2AF2 and ASF/SF2.-Further reading:...

; SRPK3; STK10

STK10

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.-Further reading:...

; STK11

STK11

Serine/threonine kinase 11 also known as liver kinase B1 or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.-Expression:...

; STK16

STK16

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.-Further reading:...

;
STK17A; STK17B; STK19

STK19

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.-Further reading:...

; STK24

STK24

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene.-Interactions:STK24 has been shown to interact with PDCD10, TRAF3IP3, STRN3, MOBKL3, STRN, SLMAP, PPP2R1A, CTTNBP2NL, FAM40A and STRN4.-Further reading:...

; STK25

STK25

Serine/threonine-protein kinase 25 is an enzyme that in humans is encoded by the STK25 gene.-Interactions:STK25 has been shown to interact with STRN, PDCD10 and MOBKL3....

; STK3

STK3

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.-Further reading:...

; STK31; STK32A; STK32B;
STK32C; STK33; STK35; STK36

STK36

Serine/threonine-protein kinase 36 is an enzyme that in humans is encoded by the STK36 gene.-Further reading:...

; STK38

STK38

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.-Further reading:...

; STK38L

STK38L

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.-Further reading:...

; STK39

STK39

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.-Further reading:...

; STK4

STK4

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.-Further reading:...

;
STK40

STK40

Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.-Further reading:...

; SYK

Syk

Spleen tyrosine kinase, also known as Syk, is an enyzme which in humans is encoded by the SYK gene.- Function :SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases...

; TAOK1

TAOK1

Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.-Further reading:...

; TAOK2

TAOK2

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.-Interactions:TAOK2 has been shown to interact with MAP2K6 and MAP2K3.-Further reading:...

; TAOK3

TAOK3

Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the TAOK3 gene.-Further reading:...

; TBCK; TBK1; TEC

TEC (gene)

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.-Interactions:TEC has been shown to interact with GNA12, Janus kinase 2, CD117, Suppressor of cytokine signaling 1, ARHGEF12 and DOK1.-Further reading:...

;
TESK1

TESK1

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.-Interactions:TESK1 has been shown to interact with YWHAB and SPRY4.-Further reading:...

; TESK2

TESK2

Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.-Further reading:...

; TGFBR1; TGFBR2; TIE1

TIE1

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.- Function :...

; TIE2; TLK1

TLK1

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.-Interactions:TLK1 has been shown to interact with ASF1B, ASF1A and TLK2.-Further reading:...

; TLK2

TLK2

Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.-Interactions:TLK2 has been shown to interact with TLK1, ASF1B and ASF1A.-Further reading:...

; TNIK

TNIK

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.- Function :Germinal center kinases , such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function.-Interactions:TNIK has been shown to...

; TNK1; TNK2

TNK2

Activated CDC42 kinase 1 is an enzyme that in humans is encoded by the TNK2 gene.-Interactions:TNK2 has been shown to interact with FYN and Grb2.-Further reading:...

;
TSSK1B; TSSK2

TSSK2

Testis-specific serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the TSSK2 gene.-Further reading:...

; TSSK3; TSSK4; TTBK1; TTBK2

TTBK2

TTBK2 is a gene that contains mutations associated with spinocerebellar ataxia.-External Links:*...

; TTK

TTK (gene)

Dual specificity protein kinase TTK is an enzyme that in humans is encoded by the TTK gene.-Further reading:...

; TWF2

TWF2

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.-Further reading:...

;
TXK

TXK

TXK was a range of Crossbar exchanges used by the British Post Office telephone network, subsequently BT, between 1964 and 1994. TXC was used as the designation at first, but this was later changed as TXC sounded too much like TXE the code used for later electronic exchanges...

; TYK2; TYRO3

TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.-Interactions:TYRO3 has been shown to interact with PIK3R1 and GAS6.-Further reading:...

; UHMK1

UHMK1

U2AF homology motif kinase 1, also known as UHMK1, is a protein which in humans is encoded by the UHMK1 gene.-Function:UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown function....

; ULK1

ULK1

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.-Interactions:ULK1 has been shown to interact with GABARAPL2, GABARAP, SYNGAP1 and SDCBP.-Further reading:...

; ULK2

ULK2

Unc-51-like kinase 2 also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene. The gene is located within the Smith-Magenis syndrome region on chromosome 17.- Structure and function :...

;
ULK3; ULK4; VRK1

VRK1

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.-Further reading:...

; VRK2

VRK2

Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.-Further reading:...

; VRK3; WEE1

Wee1

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe . It has a molecular mass of 96 kDa and it is a key regulator of cell cycle progression....

; WEE2; WNK1

WNK1

WNK lysine deficient protein kinase 1, also known as WNK1, is an enzyme which in humans is encoded by the WNK1 gene. The human gene is located on short arm of chromosome 12 .WNK1 is also known as Human Accelerated Region 5...

; WNK2

WNK2

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.-Further reading:...

;
WNK3

WNK3

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.- Function :...

; WNK4

WNK4

Serine/threonine-protein kinase WNK4 also known as WNK lysine deficient protein kinase 4 or WNK4, is an enzyme that in humans is encoded by the WNK4 gene.- Function :The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron...

; YES1

YES1

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.-Interactions:YES1 has been shown to interact with Janus kinase 2, CTNND1, RPL10 and Occludin.-Further reading:...

; ZAK

ZAK

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.- Further reading :...

; ZAP70;