Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor

Receptor tyrosine kinase-like orphan receptor

In the field of molecular biology, receptor tyrosine kinase-like orphan receptors are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR proteins can can modulate Wnt signaling by sequestering Wnt ligands....

 (ROR) family.

Function

The protein encoded by this gene is a receptor tyrosine kinase

Receptor tyrosine kinase

Receptor tyrosine kinases s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins....

 that modulates neurite

Neurite

A neurite refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before...

growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.