TNIK
Encyclopedia
TRAF2 and NCK-interacting protein kinase is an enzyme
that in humans is encoded by the TNIK gene
.
domain and a C-terminal GCK domain that serves a regulatory function.
, although the significance is unclear.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the TNIK gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinaseKinase
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases...
domain and a C-terminal GCK domain that serves a regulatory function.
Interactions
TNIK has been shown to interact with KIAA0090KIAA0090
KIAA0090 is a human gene coding for a protein of unknown function. KIAA0090 has two aliases OTTHUMP00000002581 and RP1-43E13.1. The gene codes for multiple transcript variants which can localize to different subcellular compartments. KIAA0090 interacts with multiple effector proteins...
, although the significance is unclear.