PAK1
Encyclopedia
Serine/threonine-protein kinase PAK 1 is an enzyme
that in humans is encoded by the PAK1 gene
.
with C-Raf
, NCK1
, LIMK1
, RAC1
, ARHGEF2
, BMX
, ARPC1B
, DYNLL1
, Cyclin-dependent kinase 5
, PAK1IP1
and CDC42
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the PAK1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
PAK1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with C-Raf
C-Raf
RAF proto-oncogene serine/threonine-protein kinase also known as proto-oncogene c-RAF or simply c-Raf is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade...
, NCK1
NCK1
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.-Interactions:NCK1 has been shown to interact with DNM1, EIF2B2, KHDRBS1, Lymphocyte cytosolic protein 2, EPH receptor B1, SOCS7, MINK1, MAP4K1, MAP4K4, Abl gene, WIPF1, RRAS, Wiskott-Aldrich syndrome protein,...
, LIMK1
LIMK1
LIM domain kinase 1 is an enzyme that in humans is encoded by the LIMK1 gene.-Interactions:LIMK1 has been shown to interact with PAK1, YWHAZ, PAK4, Cofilin 1, Neuregulin 1 and Cyclin-dependent kinase inhibitor 1C.-External links:...
, RAC1
RAC1
Ras-related C3 botulinum toxin substrate 1 also known as Rac1 is a protein that in humans is encoded by the RAC1 gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.- Function :Rac1 is...
, ARHGEF2
ARHGEF2
Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.-Further reading:...
, BMX
BMX (gene)
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.-Interactions:BMX has been shown to interact with PAK1, PTK2, PTPN21 and RUFY1.-Further reading:...
, ARPC1B
ARPC1B
Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene.-Further reading:...
, DYNLL1
DYNLL1
Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.-Interactions:DYNLL1 has been shown to interact with DLGAP1, MYO5A, DYNC1I1, BCL2L11, NRF1, IκBα, PAK1, DLG4 and TP53BP1.-Further reading:...
, Cyclin-dependent kinase 5
Cyclin-dependent kinase 5
Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene. The protein encoded by this gene is part of the cyclin-dependent kinase family.-Physiological Role:...
, PAK1IP1
PAK1IP1
p21-activated protein kinase-interacting protein 1 is an enzyme that in humans is encoded by the PAK1IP1 gene.-Further reading:...
and CDC42
CDC42
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...
.
External links
- PAK1 Info with links in the Cell Migration Gateway