ARAF
Encyclopedia
Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme
that in humans is encoded by the ARAF gene
. A-Raf is a member of the Raf kinase
family of serine/threonine-specific protein kinase
s.
with:
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the ARAF gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. A-Raf is a member of the Raf kinase
Raf kinase
Raf kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a Raf kinase-related oncogene that enhances fibrosarcoma induction...
family of serine/threonine-specific protein kinase
Serine/threonine-specific protein kinase
Serine/threonine protein kinases phosphorylate the OH group of serine or threonine .At least 125 of the 500+ human protein kinases are serine/threonine kinases .-Regulation:...
s.
Interactions
ARAF has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with:
- EFEMP1EFEMP1EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene.-Further reading:...
, - MAP2K2MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.- Function :The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in...
, - PRPF6PRPF6Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.-Interactions:PRPF6 has been shown to interact with TXNL4B, ARAF and Androgen receptor.-External links:*...
, - RRASRRASRas-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.-Interactions:RRAS has been shown to interact with RASSF5, NCK1, Bcl-2, ARAF and RALGDS.-Further reading:...
, - TIMM44TIMM44Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.-Further reading:...
, and - TH1LTH1LNegative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.-Interactions:TH1L has been shown to interact with RDBP, ARAF and Cofactor of BRCA1.-Further reading:...
.