CDK9
Encyclopedia
CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase
associated with P-TEFb
.
CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.
with Cyclin K
, Cyclin T2, RELA
, Cyclin T1, Retinoblastoma protein
, Androgen receptor
, SKP1A
, MYBL2
, CDC34
and SUPT5H
.
Cyclin-dependent kinase
thumb|350px|Schematic of the cell cycle. outer ring: I=[[Interphase]], M=[[Mitosis]]; inner ring: M=Mitosis; G1=[[G1 phase|Gap phase 1]]; S=[[S phase|Synthesis]]; G2=[[G2 phase|Gap phase 2]]...
associated with P-TEFb
P-TEFb
Positive Transcription Elongation Factor b is the key factor regulating eukaryotic mRNA transcription at the level of elongation.It is a cyclin dependent kinase, composed of Cdk9 and in humans one of three cyclins, T1, T2, or K....
.
CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.
Interactions
CDK9 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Cyclin K
Cyclin K
Cyclin-K is a protein that in humans is encoded by the CCNK gene.-Further reading:...
, Cyclin T2, RELA
RELA
Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...
, Cyclin T1, Retinoblastoma protein
Retinoblastoma protein
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in the majority types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide...
, Androgen receptor
Androgen receptor
The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...
, SKP1A
SKP1A
S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins , such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins...
, MYBL2
MYBL2
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.-Interactions:MYBL2 has been shown to interact with Retinoblastoma-like protein 1, Cyclin A1, EP300, CREB-binding protein, CDK9, Cyclin-dependent kinase inhibitor 1C and PARP1.-Further reading:...
, CDC34
CDC34
Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.-Interactions:CDC34 has been shown to interact with CSNK2B, BTRC and CDK9.-Further reading:...
and SUPT5H
SUPT5H
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.-Interactions:SUPT5H has been shown to interact with Cyclin-dependent kinase 7, PIN1, CDK9, HTATSF1, POLR2A, PRMT1 and Protein arginine methyltransferase 5....
.