There are many conditions of or affecting the human Hematologic system

Circulatory system

The circulatory system is an organ system that passes nutrients , gases, hormones, blood cells, etc...

 — the Biological system

Biological system

In biology, a biological system is a group of organs that work together to perform a certain task. Common systems, such as those present in mammals and other animals, seen in human anatomy, are those such as the circulatory system, the respiratory system, the nervous system, etc.A group of systems...

 that includes plasma

Blood plasma

Blood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...

, platelet

Platelet

Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is normally just 5 to 9 days...

s, leukocytes, and erythrocytes, the major components of blood and the bone marrow

Bone marrow

Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...

.

Anemias

An anemia is a decrease in number of red blood cell

Red blood cell

Red blood cells are the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen to the body tissues via the blood flow through the circulatory system...

s (RBCs) or less than the normal quantity of hemoglobin

Hemoglobin

Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...

 in the blood. However; it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency.

Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis

Hemolysis

Hemolysis —from the Greek meaning "blood" and meaning a "loosing", "setting free" or "releasing"—is the rupturing of erythrocytes and the release of their contents into surrounding fluid...

) or deficient red blood cell production (ineffective hematopoiesis). Based on 2005-2006 estimates, the Centers for Disease Control and Prevention

Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention are a United States federal agency under the Department of Health and Human Services headquartered in Druid Hills, unincorporated DeKalb County, Georgia, in Greater Atlanta...

, has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis.

Nutritional anemias

A nutritional anemia refers to a type of anemia that can be directly attributed to either a nutritional disorder or a nutritional deficiency.

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Iron deficiency anemia Iron deficiency anemia Iron-deficiency anemia is a common anemia that occurs when iron loss occurs, and/or the dietary intake or absorption of iron is insufficient...
Iron deficiency anemia (or iron deficiency anaemia) is a common anemia that occurs when iron loss (often from intestinal bleeding or menses) occurs, and/or the dietary intake or absorption of iron Iron Iron is a chemical element with the symbol Fe and atomic number 26. It is a metal in the first transition series. It is the most common element forming the planet Earth as a whole, forming much of Earth's outer and inner core. It is the fourth most common element in the Earth's crust...  is insufficient. In such a state, hemoglobin, which contains iron, cannot be formed.
Plummer-Vinson syndrome Plummer-Vinson syndrome Plummer–Vinson syndrome , also called Paterson–Brown–Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia , glossitis, and iron deficiency anemia...
Plummer-Vinson syndrome (PVS), also called Paterson-Brown-Kelly syndrome or sideropenic dysphagia presents as a triad of dysphagia Dysphagia Dysphagia is the medical term for the symptom of difficulty in swallowing. Although classified under "symptoms and signs" in ICD-10, the term is sometimes used as a condition in its own right. Sufferers are sometimes unaware of their dysphagia....  (due to esophageal webs), glossitis Glossitis Glossitis is inflammation of the tongue. It causes the tongue to swell and change color. Finger-like projections on the surface of the tongue may be lost, causing the tongue to appear smooth.... , and iron deficiency anemia Iron deficiency anemia Iron-deficiency anemia is a common anemia that occurs when iron loss occurs, and/or the dietary intake or absorption of iron is insufficient... . It most usually occurs in postmenopausal women.
Vitamin B12 deficiency anemia Vitamin B12 Vitamin B12, vitamin B12 or vitamin B-12, also called cobalamin, is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins...
Vitamin B12 deficiency anemia occurs when a "lower-than-normal" amount of the vitamin B12 is available within the body, leading to a decreased production of healthy red blood cells.
Vitamin B12 deficiency anemia due to intrinsic factor deficiency Vitamin B12 deficiency Vitamin B12 deficiency or hypocobalaminemia is a low blood level of vitamin B12, it can cause permanent damage to nervous tissue as a long term effect. Vitamin B12 was discovered from its relationship to the disease pernicious anemia, which is an autoimmune disease that destroys parietal cells in...
vitamin B12 deficiency is caused by a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency
Pernicious anemia Pernicious anemia Pernicious anemia is one of many types of the larger family of megaloblastic anemias...
Pernicious anemia (also known as Macrocytic achylic anemia, Congenital pernicious anemia, Juvenile pernicious anemia, and Vitamin B12 deficiency) is one of many types of the larger family of megaloblastic anemia Megaloblastic anemia Megaloblastic anemia is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis stage... s. It is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Pernicious anemia is the result of inadequate production of the protein intrinsic factor Intrinsic factor Intrinsic factor also known as gastric intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the small intestine...  needed by the body to absorb vitamin B 12, causing a reduction of new red blood cells.
Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria Vitamin B12 Vitamin B12, vitamin B12 or vitamin B-12, also called cobalamin, is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins...
Vitamin B 12 deficiency anemia due to selective vitamin B 12 malabsorption with proteinuria (also known as Imerslund-Gräsbeck syndrome) is a rare autosomal recessive disorder which requires the indefinite administration of Vitamin B12 injections.
Megaloblastic hereditary anemia Megaloblastic anemia Megaloblastic anemia is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis stage...	, ,
Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis DNA synthesis DNA synthesis commonly refers to:*DNA replication - DNA biosynthesis *Polymerase chain reaction - enzymatic DNA synthesis *Oligonucleotide synthesis - chemical synthesis of nucleic acids...  in red blood cell production.
Transcobalamin II deficiency
Transcobalamin II deficiency (TCII) (also known as hereditary transcobalamin II deficiency) is a rare autosomal recessive disorder that results in neurological dysfunction. Transcobalamin II are a type of carrier protein Carrier protein Carrier proteins are proteins involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane. Carrier proteins are integral membrane proteins; that is they exist within and span the membrane across which they transport substances. The... s which bind with plasma vitamin B12 (cobalamin) in the production of red blood cells.
Folate-deficiency anemia Folate deficiency Folate deficiency is a lack of folic acid in the diet and the signs are often subtle. Folate deficiency anemia is the medical name given for the condition. -Symptoms:Loss of appetite, and weight loss can occur...
Folate-deficiency anemia (also known as dietary folate-deficiency anemia) is a condition that develops when the body does not have the adequate supply of folic acid Folic acid Folic acid and folate , as well as pteroyl-L-glutamic acid, pteroyl-L-glutamate, and pteroylmonoglutamic acid are forms of the water-soluble vitamin B9...  available that is needed for the production of new healthy blood cells.
Nutritional megaloblastic anemia	, ,		D000749
Nutritional Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis DNA synthesis DNA synthesis commonly refers to:*DNA replication - DNA biosynthesis *Polymerase chain reaction - enzymatic DNA synthesis *Oligonucleotide synthesis - chemical synthesis of nucleic acids...  in red blood cell production.
Drug-induced folate deficiency anemia Folate deficiency Folate deficiency is a lack of folic acid in the diet and the signs are often subtle. Folate deficiency anemia is the medical name given for the condition. -Symptoms:Loss of appetite, and weight loss can occur...
Protein deficiency anemia
Protein deficiency anemia is an anemia that results from an inadequate intake of dietary protein.
Scurvy Scurvy Scurvy is a disease resulting from a deficiency of vitamin C, which is required for the synthesis of collagen in humans. The chemical name for vitamin C, ascorbic acid, is derived from the Latin name of scurvy, scorbutus, which also provides the adjective scorbutic...
Scurvy is a disease resulting from a deficiency of vitamin C, which is required for the synthesis of collagen in humans.

Haemolytic, Aplastic and other anemias

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Acanthocytosis
Acanthocytosis (also known as Abetalipoproteinemia, Apolipoprotein B deficiency, and Bassen-Kornzweig syndrome) is a rare, genetically inherited, autosomal recessive condition that causes the inability to fully digest dietary fats in the intestines. The gene responsible for this condition is the microsomal triglyceride transfer protein gene.
Acute posthemorrhagic anemia Acute posthemorrhagic anemia Acute posthemorrhagic anemia or acute blood loss anemia is a condition in which a person quickly loses a large volume of circulating hemoglobin. Acute blood loss is usually associated with an incident of trauma or a severe injury resulting in a large loss of blood. It can also occur during or after...
Acute posthemorrhagic anemia (also known as acute blood loss anemia) is a condition in which a person quickly loses a large volume of circulating hemoglobin. Acute blood loss is usually associated with an incident of trauma or a severe injury resulting in a large loss of blood. It can also occur during or after a surgical procedure.
Alpha-thalassemia Alpha-thalassemia Alpha-thalassemia is a form of thalassemia involving the genes HBA1 and HBA2. Alpha-thalassemia is due to impaired production of 1,2,3, or 4 alpha globin chains, leading to a relative excess of beta globin chains...		, ,
Alpha-thalassemia (α-thalassemia) is a form of thalassemia Thalassemia Thalassemia is an inherited autosomal recessive blood disease that originated in the Mediterranean region. In thalassemia the genetic defect, which could be either mutation or deletion, results in reduced rate of synthesis or no synthesis of one of the globin chains that make up hemoglobin...  involving the genes HBA1 HBA1 Hemoglobin, alpha 1, also known as HBA1, is a human gene encoding the hemoglobin protein.-Interactions:Hemoglobin, alpha 1 has been shown to interact with HBB. Interactions between the N-terminal amino groups of the alpha-subunits and the C-terminal histidine of the β-subunits participate in ion...   and HBA2 HBA2 Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.- Function :The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2... . It is condition that causes a reduction of hemoglobin production. There are two types of Alpha-thalassemia named hemoglobin Bart hydrops fetalis syndrome (also known as Hb Bart syndrome) and HbH disease.
Anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...	-
Anemia is a general medical term used to describe a number of conditions that result in a decrease in the number of red blood cell Red blood cell Red blood cells are the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen to the body tissues via the blood flow through the circulatory system... s (RBCs) or less than the normal quantity of hemoglobin Hemoglobin Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...  in the blood.
Anemia of chronic disease Anemia of chronic disease Anemia of chronic disease, also referred to as anemia of inflammatory response is a form of anemia seen in chronic illness, e.g. from chronic infection, chronic immune activation, or malignancy...
Anemia of chronic disease (ACD) (also known as anemia of inflammatory response) is a condition where the body converts iron into unused ferrin, causing a drop in hemoglobin production, and as a result; decreased red blood cell production and count. This is caused by a natural defense mechanism initiated by an inflammatory response in response to the underlying chronic disease.
Anemia in Kidney Disease and Dialysis
Anemia in Kidney Disease and Dialysis results from the diseased kidney's inability to produce enough of the hormone erythropoietin. Erythropoietin is used to stimulate an adequate production of red blood cells from the bone marrow.
Anemia of prematurity Anemia of prematurity Anemia of prematurity refers to a form of anemia affecting preterm infants with decreased hematocrit.-Pathophysiology:Preterm infants are often anemic and typically experience heavy blood losses from frequent laboratory testing in the first few weeks of life...
Anemia of prematurity refers to a form of anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...  affecting preterm infants with decreased hematocrit Hematocrit The hematocrit or packed cell volume or erythrocyte volume fraction is the percentage of the concentration of red blood cells in blood. It is normally about 45% for men and 40% for women... .
Aplastic anemia Aplastic anemia Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish blood cells. The condition, per its name, involves both aplasia and anemia...	-
Aplastic anemia is a condition where bone marrow does not produce sufficient new cell Cell (biology) The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos.... s to replenish blood cells.
Autoimmune hemolytic anemia Autoimmune hemolytic anemia Autoimmune hemolytic anemia occurs when antibodies directed against the person's own red blood cells cause the RBCs to burst , leading to insufficient plasma concentration. The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in serious cases...	-
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia Hemolytic anemia Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels or elsewhere in the human body . It has numerous possible causes, ranging from relatively harmless to life-threatening...  where the body's immune system attacks its own red blood cells (RBCs), leading to their destruction (hemolysis Hemolysis Hemolysis —from the Greek meaning "blood" and meaning a "loosing", "setting free" or "releasing"—is the rupturing of erythrocytes and the release of their contents into surrounding fluid... ). Types of AIHA include Warm autoimmune hemolytic anemia Warm autoimmune hemolytic anemia Warm Antibody Autoimmune Hemolytic Anemia is the most common of the autoimmune hemolytic diseases. About half of the cases are idiopathic, with the other half attributable to a predisposing condition or medications being taken.-Pathophysiology:... , Cold agglutinin disease, and Paroxysmal cold hemoglobinuria Paroxysmal cold hemoglobinuria Paroxysmal cold hemoglobinuria is a disease of humans that is characterized by the sudden presence of hemoglobin in the urine , typically after exposure to cold temperatures.... .
Beta-thalassemia Beta-thalassemia Beta-thalassemias are a group of inherited blood disorders caused by reduced or absent synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated...
Beta-thalassemia (β-thalassemia) is an autosomal dominant blood condition that results in the reduction of hemoglobin production. The cause for the disorder is related to a genetic mutation of the HBB gene. This gene is responsible for providing the instructions to produce beta-globin; one of the major components of hemoglobin. The two classification types of beta thalassemia are thalassemia major (also known as Cooley's anemia) and thalassemia intermedia.
Diamond-Blackfan anemia Diamond-Blackfan anemia Diamond–Blackfan anemia , also known as Blackfan–Diamond anemia and Inherited erythroblastopenia, is a congenital erythroid aplasia that usually presents in infancy. DBA patients have low red blood cell counts . The rest of their blood cells are normal...
Diamond–Blackfan anemia (DBA), (also known as Blackfan–Diamond anemia and Inherited erythroblastopenia) is a congenital erythroid aplasia Aplasia Aplasia is defined in general as "defective development or congenital absence of an organ or tissue." In the field of hematology, the term refers to "incomplete, retarded, or defective development, or cessation of the usual regenerative process."-Examples:*Acquired pure red cell aplasia*Aplasia...  that usually presents in infancy.
Congenital dyserythropoietic anemia Congenital dyserythropoietic anemia Congenital dyserythropoietic anemia is a rare blood disorder, similar to the thalassemias. CDA is one of many types of anemia, characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells in the body and a less than normal quantity of hemoglobin in...
Congenital dyserythropoietic anemia (CDA) is a generically inherited autosomal recessive (types I and II) or autosomal dominant (type III) blood disorder that effects the normal maturation process of red blood cell production. Mutations to the CDAN1 gene (type I), SEC23B gene (type II), and a currently unknown gene for type III causes a disruption in the normal formation of erythropoiesis Erythropoiesis Erythropoiesis is the process by which red blood cells are produced. It is stimulated by decreased O2 in circulation, which is detected by the kidneys, which then secrete the hormone erythropoietin... , thereby causing a reduction of circulating healthy mature red blood cells.
Drug-induced autoimmune hemolytic anemia Drug-induced autoimmune hemolytic anemia Drug-induced autoimmune hemolytic anemia is a form of hemolytic anemia.Penicillin in high doses can induce immune mediated hemolysis via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells...
Drug-induced autoimmune hemolytic anemia is a type of hemolytic anemia in which a mediated immune response triggers IgG and IgM antibody production in regards to the presence of high doses of penicillin Penicillin Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....  via the hapten Hapten A hapten is a small molecule that can elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself...  mechanism causing the reduction of red blood cells in the spleen.
Drug-induced nonautoimmune hemolytic anemia Drug-induced nonautoimmune hemolytic anemia Drug-induced nonautoimmune hemolytic anemia is a form of hemolytic anemia.Non-immune drug induced hemolysis can occur via oxidative mechanisms. This is particularly likely to occur when there is an enzyme deficiency in the antioxidant defense system of the red blood cells...
Glucose-6-phosphate dehydrogenase deficiency Glucose-6-phosphate dehydrogenase deficiency Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive hereditary disease characterised by abnormally low levels of glucose-6-phosphate dehydrogenase , a metabolic enzyme involved in the pentose phosphate pathway, especially important in red blood cell metabolism. G6PD deficiency is...			D005955
Hemoglobinopathy Hemoglobinopathy Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits. Common hemoglobinopathies include...
Hemoglobinopathy is a kind of gene Gene A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains... tic defect that results in abnormal structure of one of the globin Globin Globins are a related family of proteins, which are thought to share a common ancestor. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members of this family include myoglobin and hemoglobin, which both bind the heme prosthetic group...  chains of the hemoglobin Hemoglobin Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...  molecule. Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits. Hemoglobinopathies imply structural abnormalities in the globin proteins themselves. Hemoglobinopathy variants include sickle-cell disease Sickle-cell disease Sickle-cell disease , or sickle-cell anaemia or drepanocytosis, is an autosomal recessive genetic blood disorder with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various... .
Hemolytic anemia Hemolytic anemia Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels or elsewhere in the human body . It has numerous possible causes, ranging from relatively harmless to life-threatening...	-
Hemolytic anemia (also known as haemolytic anaemia) is an anemia due to hemolysis Hemolysis Hemolysis —from the Greek meaning "blood" and meaning a "loosing", "setting free" or "releasing"—is the rupturing of erythrocytes and the release of their contents into surrounding fluid... , the abnormal breakdown of red blood cells. A number of different mediating factors can cause this condition; either from within the blood cell itself ((intrinsic factors) or outside of the cell (extrinsic factors).
Congenital hemolytic anemia Congenital hemolytic anemia Congenital hemolytic anemia refers to hemolytic anemia which is primarily due to congenital disorders.-Types:Basically classified by causative mechanism , types of congenital hemolytic anemia include:...
Fanconi's anemia			D005199
Fanconi's anemia is a rare genetic autosomal recessive aplastic anemia that involves chromosomes 9q and 20q.
Hereditary spherocytosis Hereditary spherocytosis Hereditary spherocytosis is a genetically-transmitted form of spherocytosis, an auto-hemolytic anemia characterized by the production of red blood cells that are sphere-shaped rather than bi-concave disk shaped , and therefore more prone to hemolysis.-Symptoms:As in non-hereditary spherocytosis,...
Hereditary spherocytosis is a genetically-transmitted (autosomal dominant) form of spherocytosis Spherocytosis Spherocytosis is an auto-hemolytic anemia characterized by the production of red blood cells , or erythrocytes, that are sphere-shaped, rather than bi-concave disk shaped. Spherocytes are found in hereditary spherocytosis and autoimmune hemolytic anemia.It almost always refers to hereditary... , an auto-hemolytic Hemolysis Hemolysis —from the Greek meaning "blood" and meaning a "loosing", "setting free" or "releasing"—is the rupturing of erythrocytes and the release of their contents into surrounding fluid...  anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...  characterized by the production of red blood cells that are sphere-shaped rather than bi-concave disk shaped (Donut-Shaped), and therefore more prone to hemolysis.
Hereditary elliptocytosis Hereditary elliptocytosis Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the sufferer's erythrocytes are elliptical rather than the typical biconcave disc shape. It is one of many red-cell membrane defects. In its severe forms, this disorder...
Hereditary elliptocytosis (HE) (also known as ovalocytosis), is an inherited blood disorder in which an abnormally large number of circulating red blood cells are elliptical or cigar shaped rather than the typical biconcave disc shape. It is caused in part by mutations in the formation of specific Spectrin tetramers Spectrin Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure...  or proteins responsible for giving the red blood cell its shape and elasticity causing continued deformation as the cell matures. Subtypes of this condition include southeast Asian ovalocytosis and spherocytic elliptocytosis.
Hereditary pyropoikilocytosis Hereditary pyropoikilocytosis Hereditary pyropoikilocytosis is an autosomal recessive form of hemolytic anemia characterized by an abnormal sensitivity of red blood cells to heat and erythrocyte morphology similar to that seen in thermal burns. Patients with HPP tend to experience severe haemolysis and anaemia in infancy that...
Hereditary pyropoikilocytosis (HPP) is an autosomal recessive form of hemolytic anemia which typically presents at infancy or early childhood, characterized by abnormal red blood cell morphology including "budding red cells, fragmented red cells, spherocytes, elliptocytes, triangular cells, and other bizarre-shaped red cells."
Acquired hemolytic anemia Acquired hemolytic anemia Acquired hemolytic anemia can be divided into immune and non-immune mediated forms of hemolytic anemia.-Immune:Immune mediated hemolytic anemia *Autoimmune hemolytic anemia**Warm antibody autoimmune hemolytic anemia...
Cold hemagglutinin disease
Cold hemagglutinin disease (also known as cold agglutinin disease and autoimmune anemia due to cold-reactive antibodies)is an autoimmune disease Autoimmune disease Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body actually attacks its own cells. The immune system mistakes some part of the body as a pathogen and attacks it. This may be restricted to...  characterized by the presence of high concentrations of circulating antibodies, usually IgM IGM IGM as an acronym or abbreviation can refer to:* Immunoglobulin M , the primary antibody against A and B antigens on red blood cells* International Grandmaster, a chess ranking* intergalactic medium* Intragroup medium - see: Intracluster medium... , directed against red blood cell Red blood cell Red blood cells are the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen to the body tissues via the blood flow through the circulatory system... s. It is a form of autoimmune hemolytic anemia Autoimmune hemolytic anemia Autoimmune hemolytic anemia occurs when antibodies directed against the person's own red blood cells cause the RBCs to burst , leading to insufficient plasma concentration. The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in serious cases... , specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31°C.
Paroxysmal cold hemoglobinuria Paroxysmal cold hemoglobinuria Paroxysmal cold hemoglobinuria is a disease of humans that is characterized by the sudden presence of hemoglobin in the urine , typically after exposure to cold temperatures....
Paroxysmal cold hemoglobinuria (PCH) (also known as Donath-Landsteiner syndrome) is a rare condition characterized by the sudden presence of hemoglobin in the urine (called hemoglobinuria Hemoglobinuria In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. The condition is often associated with hemolytic anemia, in which red blood cells are destroyed, thereby increasing levels of free... ), typically after exposure to cold temperatures.
Hemolytic-uremic syndrome Hemolytic-uremic syndrome Hemolytic-uremic syndrome , abbreviated HUS, is a disease characterized by hemolytic anemia, acute renal failure and a low platelet count . It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of diarrhea caused by E. coli O157:H7, which is acquired as a...
Hemolytic-uremic syndrome (HUS) (also known as haemolytic-uraemic syndrome) is a disease characterized by hemolytic anemia Hemolytic anemia Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells , either in the blood vessels or elsewhere in the human body . It has numerous possible causes, ranging from relatively harmless to life-threatening... , acute renal failure Acute renal failure Acute kidney injury , previously called acute renal failure , is a rapid loss of kidney function. Its causes are numerous and include low blood volume from any cause, exposure to substances harmful to the kidney, and obstruction of the urinary tract...  (uremia Uremia Uremia or uraemia is a term used to loosely describe the illness accompanying kidney failure , in particular the nitrogenous waste products associated with the failure of this organ.... ) and a low platelet Platelet Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is normally just 5 to 9 days...  count (thrombocytopenia Thrombocytopenia Thrombocytopenia is a relative decrease of platelets in blood.A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease... ). It predominantly but not exclusively affects children. Most cases are preceded by an episode of diarrhea Diarrhea Diarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...  caused by E. coli O157:H7 Escherichia coli O157:H7 Escherichia coli O157:H7 is an enterohemorrhagic strain of the bacterium Escherichia coli and a cause of foodborne illness. Infection often leads to hemorrhagic diarrhea, and occasionally to kidney failure, especially in young children and elderly persons... , which is acquired as a foodborne illness Foodborne illness Foodborne illness is any illness resulting from the consumption of contaminated food, pathogenic bacteria, viruses, or parasites that contaminate food, as well as chemical or natural toxins such as poisonous mushrooms.-Causes:Foodborne illness usually arises from improper handling, preparation, or... .
Hereditary persistence of fetal hemoglobin Hereditary persistence of fetal hemoglobin Hereditary persistence of fetal hemoglobin is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.-Causes:This is usually caused by mutations in the...
Hereditary stomatocytosis Hereditary stomatocytosis Hereditary stomatocytosis describes a number of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell 'leaks' sodium and potassium ions.-Pathophysiology:...  > |
Hereditary stomatocytosis describes a number of inherited autosomal dominant human conditions which affect the red blood cell, in which the membrane or outer coating of the cell 'leaks' sodium and potassium ions, causing cell lyses and eventual haemolytic anaemia.
Hexokinase deficiency Hexokinase deficiency Hexokinase deficiency is an anemia-causing condition associated with inadequate hexokinase. Specifically, the HK1 isozyme is involved.-References:...
Hexokinase deficiency (also known as human erythrocyte hexokinase deficiency) is an anemia-causing condition associated with inadequate hexokinase Hexokinase A hexokinase is an enzyme that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. In most tissues and organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product.... .
Hyperanaemia
Hypochromic anemia Hypochromic anemia Hypochromic anemia is a generic term for any type of anemia in which the red blood cells are paler than normal. A normal red blood cell will have an area of pallor in the center of it; in hypochromic cells, this area of central pallor is increased...
Hypochromic anemia is a generic term for any type of anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...  in which the red blood cells (erythrocytes) are paler than normal. This is caused by a proportionally reduced amount of hemoglobin present in relation to the size of the red blood cell.
Ineffective erythropoiesis Ineffective erythropoiesis Ineffective erythropoiesis a kinetic term that describes active erythropoiesis with premature death of red blood cells, a decreased output of RBCs from the bone marrow, and, consequently, anemia....
Ineffective erythropoiesis is an anemia caused by the premature apoptosis Apoptosis Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...  of the body's mature red blood cells and subsequent reduction in an adequate production and full maturation of new healthy red blood cells.
Macrocytic anemia
Megaloblastic anemia Megaloblastic anemia Megaloblastic anemia is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis stage...	, ,
Megaloblastic anemia (or megaloblastic anaemia) is an anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...  of macrocytic classification that results from inhibition of DNA synthesis DNA synthesis DNA synthesis commonly refers to:*DNA replication - DNA biosynthesis *Polymerase chain reaction - enzymatic DNA synthesis *Oligonucleotide synthesis - chemical synthesis of nucleic acids...  in red blood cell production.
Microangiopathic hemolytic anemia Microangiopathic hemolytic anemia In medicine microangiopathic hemolytic anemia is a microangiopathic subgroup of hemolytic anemia caused by factors in the small blood vessels. It is identified by the finding of anemia and schistocytes on microscopy of the blood film.-Presentation:It is referred as Runner's anemia...
Minkowski-Chauffard syndrome Minkowski-Chauffard syndrome Minkowski-Chauffard syndrome is a form of hemolytic anemia.It is named for Oskar Minkowski and Anatole Chauffard....
Myelophthisic anemia
Myelophthisic anemia (also known as myelophthisis) is a severe kind of anemia Anemia Anemia is a decrease in number of red blood cells or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin...  found in some people with diseases that affect the bone marrow Bone marrow Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg... . Myelophythisis refers to the displacement of hemopoietic bone-marrow tissue into the peripheral blood, either by fibrosis Fibrosis Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This is as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue... , tumor Tumor A tumor or tumour is commonly used as a synonym for a neoplasm that appears enlarged in size. Tumor is not synonymous with cancer... s or granuloma Granuloma Granuloma is a medical term for a tiny collection of immune cells known as macrophages. Granulomas form when the immune system attempts to wall off substances that it perceives as foreign but is unable to eliminate. Such substances include infectious organisms such as bacteria and fungi as well as... s.
Neuroacanthocytosis Neuroacanthocytosis Neuroacanthocytosis is a term that refers to a group of genetically diverse conditions complicated by movement disorders, neurological problems and spiculated red blood cells...			D054546
Neuroacanthocytosis (also known as Levine-Critchley syndrome) are a group of rare, genetic conditions that are characterized by movement disorders and acanthocytosis.
Chorea acanthocytosis Chorea acanthocytosis Chorea-acanthocytosis , is a rare hereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells. It belongs to a group of four diseases characterized under the name Neuroacanthocytosis. When a patient's blood is viewed under a microscope, some of the red...			D054546
Chorea-acanthocytosis (ChAc)(also known as Levine-Critchley syndrome, acanthocytosis with neurologic disorder, neuroacanthocytosis, and choreoacanthocytosis) is a rare hereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells. It belongs to a group of four diseases characterized as neuroacanthocytosis.
Non sideropenic hypochromic anaemia
Normocytic anemia Normocytic Anemia Normocytic anemia is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age, reaching 44 percent in men older than 85 years...
A normocytic anemia is a general term for an anemia with an Mean corpuscular volume Mean corpuscular volume The mean corpuscular volume, or "mean cell volume" , is a measure of the average red blood cell size that is reported as part of a standard complete blood count....  (MCV) of 80-100.
Paroxysmal nocturnal hemoglobinuria Paroxysmal nocturnal hemoglobinuria Paroxysmal nocturnal hemoglobinuria , sometimes referred to as Marchiafava-Micheli syndrome, is a rare, acquired, potentially life-threatening disease of the blood characterised by complement-induced intravascular hemolytic anemia , red urine and thrombosis...
Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired
Pyruvate kinase deficiency Pyruvate kinase deficiency Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency, is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells and causes them to deform into echinocytes on peripheral blood smears.Both autosomal dominant and recessive...
Pyruvate kinase deficiency, also called erythrocyte pyruvate kinase deficiency, is an inherited Heredity Heredity is the passing of traits to offspring . This is the process by which an offspring cell or organism acquires or becomes predisposed to the characteristics of its parent cell or organism. Through heredity, variations exhibited by individuals can accumulate and cause some species to evolve...  metabolic disorder of the enzyme pyruvate kinase Pyruvate kinase Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP.-Reaction:The reaction with pyruvate kinase:...  which affects the survival of red blood cell Red blood cell Red blood cells are the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen to the body tissues via the blood flow through the circulatory system... s and causes them to deform into echinocytes on peripheral blood smears.
Rh deficiency syndrome Rh deficiency syndrome Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition....
Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition.
Sickle-cell disease Sickle-cell disease Sickle-cell disease , or sickle-cell anaemia or drepanocytosis, is an autosomal recessive genetic blood disorder with overdominance, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various...
Sideroblastic anemia Sideroblastic anemia Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells . It may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome, which can evolve into hematological malignancies...	-
Sideroblastic anemia or sideroachrestic anemia is a disease in which the bone marrow produces ringed sideroblasts rather than healthy red blood cell Red blood cell Red blood cells are the most common type of blood cell and the vertebrate organism's principal means of delivering oxygen to the body tissues via the blood flow through the circulatory system... s (erythrocytes). It may be caused either by a genetic disorder Genetic disorder A genetic disorder is an illness caused by abnormalities in genes or chromosomes, especially a condition that is present from before birth. Most genetic disorders are quite rare and affect one person in every several thousands or millions....  or indirectly as part of myelodysplastic syndrome Myelodysplastic syndrome The myelodysplastic syndromes are a diverse collection of hematological medical conditions that involve ineffective production of the myeloid class of blood cells.... .
Southeast Asian ovalocytosis
Southeast Asian ovalocytosis (also known as Stomatocytic ovalocytosis, stomatocytic elliptocytosis, and Melanesian ovalocytosis) is a form of hereditary elliptocytosis Hereditary elliptocytosis Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the sufferer's erythrocytes are elliptical rather than the typical biconcave disc shape. It is one of many red-cell membrane defects. In its severe forms, this disorder...  common in some communities in Malaysia and Papua New Guinea Papua New Guinea Papua New Guinea , officially the Independent State of Papua New Guinea, is a country in Oceania, occupying the eastern half of the island of New Guinea and numerous offshore islands... , as it confers some resistance to cerebral Falciparum Malaria Malaria Malaria is a mosquito-borne infectious disease of humans and other animals caused by eukaryotic protists of the genus Plasmodium. The disease results from the multiplication of Plasmodium parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases... .
Spur cell hemolytic anemia Spur cell hemolytic anemia Spur cell hemolytic anemia is a form of hemolytic anemia that results secondary to severe impaired liver function or cirrhosis. Chronic liver disease impairs the liver's ability to esterificate cholesterol, causing free cholesterol to bind to the red cell membrane, increasing its surface area. This...
Spur cell hemolytic anemia is a form of hemolytic anemia that results when free cholesterol binds to the red blood cell's membrane increasing its surface area, causing later deformities such as rough or thorny projections on the erythrocyte named acanthocytes. This condition is caused by the deceased liver's decreased ability to esterificate cholesterol.
Thalassemia Thalassemia Thalassemia is an inherited autosomal recessive blood disease that originated in the Mediterranean region. In thalassemia the genetic defect, which could be either mutation or deletion, results in reduced rate of synthesis or no synthesis of one of the globin chains that make up hemoglobin...			D013789
Triosephosphate isomerase deficiency Triosephosphate isomerase deficiency Triosephosphate isomerase deficiency is a rare autosomal recessive metabolic disorder which was initially described in 1965.It is a unique glycolytic enzymopathy that is characterized by chronic haemolytic anaemia, cardiomyopathy, susceptibility to infections, severe neurological dysfunction, and,...
Triosephosphate isomerase (TPI) deficiency is a genetically inherited autosomal recessive condition "characterized bychronic hemolytic anemia, cardiomyopathy Cardiomyopathy Cardiomyopathy, which literally means "heart muscle disease," is the deterioration of the function of the myocardium for any reason. People with cardiomyopathy are often at risk of arrhythmia or sudden cardiac death or both. Cardiomyopathy can often go undetected, making it especially dangerous to... , susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early childhood."
Warm autoimmune hemolytic anemia Warm autoimmune hemolytic anemia Warm Antibody Autoimmune Hemolytic Anemia is the most common of the autoimmune hemolytic diseases. About half of the cases are idiopathic, with the other half attributable to a predisposing condition or medications being taken.-Pathophysiology:...
Warm autoimmune hemolytic anemia is an autoimmune hemolytic anemia (AIHA) characterized by formation of antibodies that attack the body's own red blood cells in a destructive immune system response.

Blood cancers

A blood cancer or hematological malignancy is a type of malignant cancer that originates, affects, or involves the blood, bone marrow, or lymph nodes. These cancers include leukemias, lymphomas, and myelomas. These particular types of cancers can arise as defected mature cell types that have differentiated from hematopoietic precursor cells (often in the bone marrow) and begin to quickly proliferate through the bloodstream where it can then often infiltrate other organs and tissues. Others can involve the formation of tumors from lymphoblasts from within the lymphoid tissue. Incidences of affected people with a form of blood cancer has been steady increasing over recent years; however, due in part to early detection methods and subsequent advancements in the treatment of the diseases, mortality rates have continued to decrease.

Lymphoma

Lymphoma

Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage...

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Hodgkin lymphoma		5973
Non-Hodgkin lymphoma Non-Hodgkin lymphoma The non-Hodgkin lymphomas are a diverse group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas. Types of NHL vary significantly in their severity, from indolent to very aggressive....	-	9065
The non-Hodgkin lymphomas (NHLs) are a diverse group of blood cancers Hematological malignancy Hematological malignancies are the types of cancer that affect blood, bone marrow, and lymph nodes. As the three are intimately connected through the immune system, a disease affecting one of the three will often affect the others as well: although lymphoma is technically a disease of the lymph...  that include any kind of lymphoma Lymphoma Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage...  except Hodgkin's lymphoma Hodgkin's lymphoma Hodgkin's lymphoma, previously known as Hodgkin's disease, is a type of lymphoma, which is a cancer originating from white blood cells called lymphocytes... s.
Anaplastic large cell lymphoma Anaplastic large cell lymphoma Anaplastic large-cell lymphoma is a type of non-Hodgkin lymphoma that features in the World Health Organisation classification of lymphomas.Its name derives from anaplasia and large-cell lymphoma.-Signs and symptoms:...
Angioimmunoblastic T-cell lymphoma Angioimmunoblastic T-cell lymphoma Angioimmunoblastic T-cell lymphoma is a mature T-cell lymphoma with systemic characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells and high endothelial venules and systemic involvement...
Angioimmunoblastic T-cell lymphoma (AILT) (also known as Angioimmunoblastic lymphadenopathy with dysproteinemia) ) is a mature T-cell lymphoma Lymphoma Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage...  with systemic characterized by a polymorphous lymph node Lymph node A lymph node is a small ball or an oval-shaped organ of the immune system, distributed widely throughout the body including the armpit and stomach/gut and linked by lymphatic vessels. Lymph nodes are garrisons of B, T, and other immune cells. Lymph nodes are found all through the body, and act as...  infiltrate showing a marked increase in follicular dendritic cells Follicular dendritic cells Follicular dendritic cells are cells of the immune system found in lymph follicles of secondary lymphoid organs and tertiary lymphoid organs. They are probably not of hematopoietic origin, though they look similar to true dendritic cells due to their filiform dendritic processes, but are of...  (FDCs) and high endothelial venules High endothelial venules High endothelial venules are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thiner endothelial cells found in regular venules...  (HEVs) and systemic involvement. It is also known as immunoblastic lymphadenopathy (Lukes-Collins Classification) and AILD-type (lymphogranulomatosis X) T-cell lymphoma (Kiel Classification)
Hepatosplenic T-cell lymphoma Hepatosplenic T-cell lymphoma Hepatosplenic T-cell lymphoma is a rare and generally incurable form of lymphoma.- Definition :Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow.- Epidemiology :This...
Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver Liver The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion... , spleen Spleen The spleen is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock... , and bone marrow Bone marrow Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg... . It is a rare and generally incurable form of lymphoma Lymphoma Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage... .
B-cell lymphoma B-cell lymphoma The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are "blood cancers" in the lymph glands. They develop more frequently in older adults and in immunocompromised individuals ....
reticuloendotheliosis
reticulosis
Microglioma
Diffuse large B-cell lymphoma
Follicular lymphoma Follicular lymphoma Follicular lymphoma is the most common of the indolent non-Hodgkin's lymphomas, and the second most common form of non-Hodgkin's lymphomas overall. It is defined as a lymphoma of follicle center B-cells , which has at least a partially follicular pattern...
Follicular Lymphoma also known as (indolent follicular lymphoma) is a type of non-hodgkin's lymphoma that involves both large and small B-cell lymphocytes that spreads from the lymphatic system and into the blood, bone marrow, and internal organs. Approximately 20 to 30 percent of non-hodgkin's lymphomas are diagnosed as follicular lymphoma, with a majority of cases involving those 60 years of age or older.
Mucosa-Associated Lymphatic Tissue lymphoma		31339
Mucosa-Associated Lymphatic Tissue lymphoma (as known as MALT lymphoma and extra-nodal marginal zone lymphoma) is a condition in which lymphatic tissue abnormally presents outside the lymphatic system (extra-nodular) and instead within the mucosa of the gastrointestinal tract Gastrointestinal tract The human gastrointestinal tract refers to the stomach and intestine, and sometimes to all the structures from the mouth to the anus. .... , typically as a lesion in the stomach.
B-cell chronic lymphocytic leukemia		2641
B-cell chronic lymphocytic leukemia (also known as small cell lymphocytic lymphoma) is a blood cancer that involves the B-cell lymphocytes; responsible for the creation of antibodies. Of the two general types of chronic lymphocytic leukemias (the other involving T-cells), B-cell chronic lymphocytic leukemia accounts for approximately 95 percent of the diagnoses.
Mantle cell lymphoma Mantle cell lymphoma Mantle cell lymphoma is one of the rarest of the non-Hodgkin's lymphomas , comprising about 6% of NHL cases. There are only about 15,000 patients presently in the U.S. While it is difficult to treat and seldom considered cured, investigations into better treatments are actively pursued worldwide...
Mantle cell lymphoma (MCL) is a type of B-cell lymphoma an and one of the rarest forms of non-Hodgkin's lymphomas comprising approximately 6% of diagnosed cases.
Burkitt lymphoma		1784
Burkitt lymphoma (also known as Burkitt's tumor, Burkitt lymphoma or malignant lymphoma, Burkitt's type) is a type of B-cell lymphoma that is categorized into one of variant types. These are variants are endemic (occurring in equatorial Africa), sporadic ("non-African"), and immunodeficiency-associated (usually associated with HIV HIV Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive... ).
Mediastinal large B cell lymphoma Mediastinal large B cell lymphoma Mediastinal large B-cell lymphoma is a form of lymphoma involving the mediastinum.Types include:*Primary mediastinal B-cell lymphoma - affects primarily young adults*Diffuse large B cell lymphoma...
Waldenström's macroglobulinemia		14030
Waldenström's macroglobuline (also known as lymphoplasmacytic lymphoma) is a lymphoproliferative disease that involves an abnormal increase of lymphocytes within the bone marrow, creasing disruption of normal red blood cell production.
Nodal marginal zone B cell lymphoma Nodal marginal zone B cell lymphoma Nodal marginal zone B cell lymphoma is a form of marginal-zone lymphoma that can produce colonization of the follicles....
Splenic marginal zone lymphoma Splenic marginal zone lymphoma Splenic marginal zone lymphoma is a lymphoma made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone,...
Splenic marginal zone lymphoma (SMZL) (also known as well-differentiated lymphocytic lymphoma, small lymphocytic lymphoma, and splenic lymphoma with circulating villous lymphocytes) is a lymphoma made up of small B-cells that replace the normal architecture of the white pulp of the spleen Spleen The spleen is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock... . The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone Mantle zone The mantle zone of a lymphatic nodule is an outer ring of small lymphocytes surrounding a germinal center.It is also known as the "corona".It contains transient lymphocytes....  of splenic follicles and erode the marginal zone Marginal zone The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. A marginal zone also exists in lymph nodes.-Composition and markers:It is composed of cells derived... , ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar Hilum (anatomy) In human anatomy, the hilum is a depression or fissure where structures such as blood vessels and nerves enter an organ.-Examples of hila:* Hilum of kidney, admits the renal artery, vein, ureter, and nerves...  lymph nodes are involved along with the peripheral blood.
Intravascular large B-cell lymphoma Intravascular large B-cell lymphoma Intravascular large B-cell lymphoma, abbreviated ILBCL and also referred to as angiotropic large-cell lymphoma, intralymphatic lymphomatosis, intravascular lymphomatosis,, and, less specifically intravascular lymphoma.-Diagnosis:...
Primary effusion lymphoma Primary effusion lymphoma -Causes:It is caused by Kaposi's sarcoma-associated herpesvirus , also known as human herpesvirus 8 .In most cases, the lymphoma cells are also infected with Epstein Barr virus ....		33904
Primary effusion lymphoma is a condition caused by Kaposi's sarcoma-associated herpesvirus Kaposi's sarcoma-associated herpesvirus Kaposi's sarcoma-associated herpesvirus is one of seven currently known human cancer viruses, or oncoviruses. It is also the eighth human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses is HHV-8. Like other herpesviruses, its informal name is used...  (KSHV)
Lymphomatoid granulomatosis Lymphomatoid granulomatosis Lymphomatoid granulomatosis is a neoplastic disease.It is a lymphoproliferative disorder . The word granulomatosis denotes one of its microscopic character, polymorphic lymphoid infiltrates and focal necrosis within it....
Nodular lymphocyte predominant Hodgkin's lymphoma Nodular lymphocyte predominant Hodgkin's lymphoma Nodular lymphocyte predominant Hodgkin's lymphoma is a form of lymphoma.It is no longer classified as a form of classic Hodgkin's lymphoma...

Leukemia

Leukemia

Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
plasma cell leukemia Plasma cell leukemia Plasma cell leukemia , a lymphoproliferative disorder, is a rare cancer involving a subtype of white blood cells called plasma cells. Plasma cell leukemia is one of the most aggressive human neoplasms and constitutes 2% to 4% of all cases of plasma cell disorders...			D007952
Plasma cell leukemia (PCL), a lymphoproliferative disorder, is a rare cancer involving a subtype of white blood cells called plasma cells.
Acute erythraemia and erythroleukaemia
Acute erythremic myelosis
Acute erythroid leukemia
Acute erythroid leukemia (also known as Guglielmo's disease, and acute Di Guglielmo syndrome) is a rare form of acute myeloid leukemia.
Heilmeyer-Schöner disease
Acute megakaryoblastic leukemia Acute megakaryoblastic leukemia Acute megakaryoblastic leukemia is a form of leukemia where a majority of the blasts are megakaryoblastic.It is classified under M7 in the French-American-British classification....			D007947
Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia where megakaryoblast Megakaryoblast A megakaryoblast is a precursor cell to a promegakaryocyte, which in turn becomes a megakaryocyte during haematopoiesis. It is the beginning of the thrombocytic series.... s account for approximately 30% of the nucleated cells within the bone marrow.
Acute megakaryoblastic leukemia Acute megakaryoblastic leukemia Acute megakaryoblastic leukemia is a form of leukemia where a majority of the blasts are megakaryoblastic.It is classified under M7 in the French-American-British classification....
Mast cell leukemia Mast cell leukemia Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation of chronic myeloid leukemia into the more aggressive acute myeloid leukemia. In a small proportion of cases, acute mast cell leukemia may evolve...
Panmyelosis Panmyelosis Panmyelosis is a form of myeloid metaplasia.It is part of the presentation in acute panmyelosis with myelofibrosis....
Acute panmyelosis with myelofibrosis Acute panmyelosis with myelofibrosis Acute panmyelosis with myelofibrosis it is a poorly-defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow...
Acute panmyelosis with myelofibrosis (APMF) is a poorly-defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow Bone marrow Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg... .
Lymphosarcoma cell leukemia
Acute leukaemia of unspecified cell type
Blastic phase chronic myelogenous leukemia Blastic phase chronic myelogenous leukemia Blastic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which more than 30% of the cells in the blood or bone marrow are blast cells immature blood cells). When tiredness, fever, and an enlarged spleen occur during the blastic phase, it is called blast crisis.-...
Blastic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia Chronic myelogenous leukemia Chronic myelogenous leukemia , also known as chronic granulocytic leukemia , is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood...  in which more than 30% of the cells in the blood Blood Blood is a specialized bodily fluid in animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells....  or bone marrow Bone marrow Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...  are blast cells.
Stem cell leukemia
Chronic leukaemia of unspecified cell type
Subacute leukaemia of unspecified cell type
Accelerated phase chronic myelogenous leukemia Accelerated phase chronic myelogenous leukemia Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing. In this phase, 6% to 30% of the cells in the blood and bone marrow are blast cells...
Acute myeloid leukemia Acute myeloid leukemia Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...		203
Acute myeloid leukemia (AML), also known as acute myelogenous leukemia, is a cancer Cancer Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...  of the myeloid Myeloid The term myeloid suggests an origin in the bone marrow or spinal cord, or a resemblance to the marrow or spinal cord.In hematopoiesis, the term "myeloid cell" is used to describe any leukocyte that is not a lymphocyte...  line of blood cells, characterized by the rapid growth of abnormal white blood cell White blood cell White blood cells, or leukocytes , are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a... s that accumulate in the bone marrow Bone marrow Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...  and interfere with the production of normal blood cells Haematopoiesis Haematopoiesis is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells... .
Acute promyelocytic leukemia Acute promyelocytic leukemia Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia , a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t, PML-RARA and variants; FAB subtype M3 and M3 variant.In APL, there is an abnormal accumulation of immature...
Acute basophilic leukemia Acute basophilic leukemia Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation...
Acute eosinophilic leukemia Acute eosinophilic leukemia Acute eosinophilic leukemia is a rare subtype of acute myeloid leukemia with 50 to 80 percent of eosinophilic cells in the blood and marrow. It can arise de novo or may develop in patients having the chronic form of a hypereosinophilic syndrome. Patients with acute eosinophilic leukemia have a...
Acute lymphoblastic leukemia Acute lymphoblastic leukemia Acute lymphoblastic leukemia is a form of leukemia, or cancer of the white blood cells characterized by excess lymphoblasts.Malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. ALL causes damage and death by crowding out normal cells in the bone...
Acute monocytic leukemia Acute monocytic leukemia Acute monocytic leukemia is considered a type of acute myeloid leukemia.-Diagnosis:In order to fulfill World Health Organization criteria for AML-5, a patient must have greater than 20% blasts in the bone marrow, and of these, greater than 80% must be of the monocytic lineage...
Acute myeloblastic leukemia with maturation Acute myeloblastic leukemia with maturation M2 is a subtype of AML .It is also known as "Acute Myeloblastic Leukemia with Maturation".-Cause:This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t...
Acute myeloid dendritic cell leukemia Acute myeloid dendritic cell leukemia Acute myeloid dendritic cell leukemia is an exceedingly rare form of leukemia. This form of leukemia represents only about 0.8% of all cases of acute myeloid leukemia. Dendritic cells function as antigen-presenting cells. They process antigen material and present it on the surface to other cells of...
Adult T-cell leukemia/lymphoma
Aggressive NK-cell leukemia Aggressive NK-cell leukemia Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells and a rapidly declining clinical course....
B-cell prolymphocytic leukemia B-cell prolymphocytic leukemia B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.It can involve deletions from chromosome 11 and chromosome 13....
B-cell chronic lymphocytic leukemia
B-cell leukemia B-cell leukemia B-cell leukemia describes several different types of lymphoid leukemia which affect B cells.Types include :* 9823/3 - B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma* 9826/3 - Acute lymphoblastic leukemia, mature B-cell type...
Chronic myelogenous leukemia Chronic myelogenous leukemia Chronic myelogenous leukemia , also known as chronic granulocytic leukemia , is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood...
Chronic myelomonocytic leukemia Chronic myelomonocytic leukemia Chronic myelomonocytic leukemia is a form of leukemia featuring monocytosis.The categorization of this disease has been controversial. Patients with CMML can present with various clinical features, mimicking either myelodysplastic syndroms or myeloproliferative neoplasms depending upon a patient's...
Chronic neutrophilic leukemia Chronic neutrophilic leukemia Chronic neutrophilic leukemia is a rare myeloproliferative disorder that features a persistent neutrophilia in peripheral blood, myeloid hyperplasia in bone marrow, hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene.-Epidemiology:This is a rare disease,...
Hairy cell leukemia Hairy cell leukemia Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. It is usually classified as a sub-type of chronic lymphoid leukemia...

Myeloma

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Multiple myeloma Multiple myeloma Multiple myeloma , also known as plasma cell myeloma or Kahler's disease , is a cancer of plasma cells, a type of white blood cell normally responsible for the production of antibodies...
Kahler's disease
Myelomatosis
solitary myeloma
Plasma cell leukaemia
Plasmacytoma, extramedullary
Malignant plasma cell tumour NOS
Plasmacytoma NOS
Solitary myeloma

Malignant immunoproliferative diseases

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Monoclonal gammopathy Monoclonal gammopathy Monoclonal gammopathy is a synonym for paraproteinemia.- External links :*...
Angiocentric immunoproliferative lesion
Lymphoid granulomatosis
Angioimmunoblastic lymphadenopathy
T-gamma lymphoproliferative disease
Waldenström's macroglobulinaemia
Alpha heavy chain disease
Gamma heavy chain disease
Franklin's disease
Immunoproliferative small intestinal disease
Mediterranean disease
Malignant immunoproliferative disease, unspecified
Immunoproliferative disease NOS

Coagulation, purpura, and other hemorrhagic conditions

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Disseminated intravascular coagulation Disseminated intravascular coagulation Disseminated intravascular coagulation , also known as disseminated intravascular coagulopathy or consumptive coagulopathy, is a pathological activation of coagulation mechanisms that happens in response to a variety of diseases. DIC leads to the formation of small blood clots inside the blood...  (DIC, Defibrination syndrome)
Protein C deficiency Protein C deficiency Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The disease belongs to a group of genetic disorders known as thrombophilias. The prevalence of protein C deficiency has been estimated to about 0.2% to 0.5% of the general population...
Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease Thrombosis Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot to prevent blood loss... .
Protein S deficiency Protein S deficiency Protein S deficiency is a disorder associated with increased risk of venous thrombosis. Protein S, a vitamin K-dependent physiological anticoagulant, acts as a nonenzymatic cofactor to activated protein C in the proteolytic degradation of factor Va and factor VIIIa...
Thrombocytosis Thrombocytosis Thrombocytosis is the presence of high platelet counts in the blood, and can be either primary or reactive...
Idiopathic thrombocytopenic purpura Idiopathic thrombocytopenic purpura Idiopathic thrombocytopenic purpura is the condition of having an abnormally low platelet count of no known cause . As most incidents of ITP appear to be related to the production of antibodies against platelets, immune thrombocytopenic purpura or immune thrombocytopenia are terms also used to...		6673	D016553
Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet Platelet Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes.  The average lifespan of a platelet is normally just 5 to 9 days...  count (thrombocytopenia Thrombocytopenia Thrombocytopenia is a relative decrease of platelets in blood.A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease... ) of no known cause (idiopathic Idiopathic Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios + πάθος, pathos , it means approximately "a disease of its own kind". It is technically a term from nosology, the classification of disease... ).
Recurrent thrombosis Thrombosis Thrombosis is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot to prevent blood loss...
Hemophilia
Hemophilia A
Hemophilia B
Hemophilia C
Von Willebrand disease Von Willebrand disease von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor , a multimeric protein that is required for...
Antiphospholipid syndrome Antiphospholipid syndrome Antiphospholipid syndrome or antiphospholipid antibody syndrome , often also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids that provokes blood clots in both arteries and veins as well as pregnancy-related complications such as...
Thrombocytopenia Thrombocytopenia Thrombocytopenia is a relative decrease of platelets in blood.A normal human platelet count ranges from 150,000 to 450,000 platelets per microliter of blood. These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease...
Glanzmann's thrombasthenia Glanzmann's thrombasthenia Glanzmann's thrombasthenia is an abnormality of platelets. It is an extremely rare coagulopathy , in which the platelets lack glycoprotein IIb/IIIa...
Wiskott-Aldrich syndrome Wiskott-Aldrich syndrome Wiskott–Aldrich syndrome is a rare X-linked recessive disease characterized by eczema, thrombocytopenia , immune deficiency, and bloody diarrhea . It is also sometimes called the eczema-thrombocytopenia-immunodeficiency syndrome in keeping with Aldrich's original description in 1954...

Infection-related

Hematological disorders may be caused by a number of infection-related conditions involving the introduction of microorganisms into the host, such as bacteria

Bacteria

Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...

 and protozoa

Protozoa

Protozoa are a diverse group of single-cells eukaryotic organisms, many of which are motile. Throughout history, protozoa have been defined as single-cell protists with animal-like behavior, e.g., movement...

.

Bacterium-related

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Clostridium infection Clostridium Clostridium is a genus of Gram-positive bacteria, belonging to the Firmicutes. They are obligate anaerobes capable of producing endospores. Individual cells are rod-shaped, which gives them their name, from the Greek kloster or spindle...
Cholera infection Cholera Cholera is an infection of the small intestine that is caused by the bacterium Vibrio cholerae. The main symptoms are profuse watery diarrhea and vomiting. Transmission occurs primarily by drinking or eating water or food that has been contaminated by the diarrhea of an infected person or the feces...
E. coli 0157:H7 infection
Typhoid fever Typhoid fever Typhoid fever, also known as Typhoid, is a common worldwide bacterial disease, transmitted by the ingestion of food or water contaminated with the feces of an infected person, which contain the bacterium Salmonella enterica, serovar Typhi...

Protozoan-related

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Leishmania infection Leishmania Leishmania is a genus of Trypanosomatid protozoa, and is the parasite responsible for the disease leishmaniasis. It is spread through sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. Their primary hosts are vertebrates; Leishmania commonly infects...			*
Malaria infection (Plasmodium infection)
toxoplasmosis Toxoplasmosis Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects most genera of warm-blooded animals, including humans, but the primary host is the felid family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself...

Immunodeficiency with predominantly antibody defects

Condition name	ICD-10 coding number	Diseases Database coding number	Medical Subject Headings
Hereditary hypogammaglobulinemia Hypogammaglobulinemia Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.-Terminology:...
Nonfamilial hypogammaglobulinemia Hypogammaglobulinemia Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.-Terminology:...
Selective deficiency of immunoglobulin A [IgA]
Selective deficiency of immunoglobulin G [IgG] subclasses
Selective deficiency of immunoglobulin M [IgM]
Immunodeficiency with increased immunoglobulin M [IgM]
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
Transient hypogammaglobulinemia of infancy Transient hypogammaglobulinemia of infancy Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth, leading to a reduction in the level of IgG, and also sometimes IgA and IgM...