1681 Charles II grants a land charter to William Penn for the area that will later become Pennsylvania.
1682 Philadelphia, Pennsylvania is founded.
1683 William Penn signs a friendship treaty with Lenni Lenape Indians in Pennsylvania.
1754 French and Indian War: in the first engagement of the war, Virginia militia under 22-year-old Lieutenant Colonel George Washington defeat a French reconnaissance party in the Battle of Jumonville Glen in what is now Fayette County in southwestern Pennsylvania.
1775 The first abolition society in North America is established. The Society for the Relief of Free Negroes Unlawfully Held in Bondage is organized in Philadelphia, Pennsylvania by Benjamin Franklin and Benjamin Rush.
1782 Gnadenhütten massacre: Ninety-six Native Americans in Gnadenhutten, Ohio, who had converted to Christianity are killed by Pennsylvania militiamen in retaliation for raids carried out by other Indians.
1817 Opening of the first private mental health hospital in the United States, the Asylum for the Relief of Persons Deprived of the Use of Their Reason (now Friends Hospital) in Philadelphia, Pennsylvania.
1851 Saint Joseph's University is founded in Philadelphia, Pennsylvania.
1878 John Kehoe, the last of the Molly Maguires is executed in Pennsylvania.
1987 Pennsylvania politician R. Budd Dwyer shoots and kills himself at a press conference on live national television, leading to debates on boundaries in journalism.
1991 Senator John Heinz of Pennsylvania and six others are killed when a helicopter collides with their plane over an elementary school in Merion, Pennsylvania.