Haplotypes groups	DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1201
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1202
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1203
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1306
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR12(DR12) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

 that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5

HLA-DR5

HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:...

 serotype group which also contains the similar HLA-DR11

HLA-DR11

HLA-DR11 is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.-Serology:...

 antigens.

Serology

DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles

DRB1*	DR12	DR5	DR11	Sample
allele	%	%	%	size (N)
1201	83	4	2	893
1202	89			162
1203	>50			3
1206	>50			2

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common
on the West Pacific Rim and particularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus

Lichen sclerosus

Lichen sclerosus is an uncommon disease of unknown cause that results in white patches on the skin, which may cause scarring on and around genital skin....

, and undifferentiated spondyloarthritis.

DRB1*1201 is associated with iritis

Iritis

Iritis is a form of anterior uveitis and refers to the inflammation of the iris of the eye.-Types:There are two main types of iritis: acute and chronic. They differ in numerous ways....

 in juvenile arthritis,primary antiphospholipid syndrome

Antiphospholipid syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome , often also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids that provokes blood clots in both arteries and veins as well as pregnancy-related complications such as...

, tiopronin

Tiopronin

Tiopronin is a prescription thiol drug used to control the rate of cystine precipitation and excretion in the disease cystinuria. Due to the rarity of the disorder, tioronin falls under the classification of an orphan drug.-Uses:...

 intolerance in rheumatoid arthritis

Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...

, adult chronic articular Still's disease

Still's disease

Still's disease can refer to:* Juvenile idiopathic arthritis* Adult-onset Still's disease...

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population.

Extended linkage

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease

Coeliac disease

Coeliac disease , is an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward...

DRB1*1201:DRB3*01/03: colorectal cancer

Colorectal cancer

Colorectal cancer, commonly known as bowel cancer, is a cancer caused by uncontrolled cell growth , in the colon, rectum, or vermiform appendix. Colorectal cancer is clinically distinct from anal cancer, which affects the anus....

Genetic Linkage

Serotypes	DRA	DRB1		DR11(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DR52 HLA-DR52 HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...	*0101	*1201	*0101
*0101	*1202	*0201
*0101	*1202	*0202
*0101	*1202	*0301
Serotypes	DRB1	DQA1	DQB1
DR12(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DQ7 HLA-DQ7 HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....  (7.5, 3 HLA-DQ3 HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2... )	*1201	*0505	*0301
	*1202	*0505	*0301
DR12(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DQ7 HLA-DQ7 HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....  (7.3, 3 HLA-DQ3 HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2... )	*1201	*0303	*0301
DR12(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DQ7 HLA-DQ7 HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....  (7.4, 3 HLA-DQ3 HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2... )	*1201	*0401	*0301
DR12(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DQ7 HLA-DQ7 HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....  (7.6, 3 HLA-DQ3 HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2... )	*1201	*0601	*0301
Serotypes	HLA-A HLA-A HLA-A are a group of human leukocyte antigens that are encoded by the HLA-A locus on human chromosome 6p. The HLA genes constitute a large subset of the Major histocompatibility complex of humans. HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the...	HLA-C HLA-C HLA-C belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane...	HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...	| DRB1
A31(19)-Cw10-B51(5)-DR12(5)	*3101	*0304	*5101	*1202
A11-Cw9-B75(15)-DR12(5)	*1101	*0303	*1502	*1202
A2-Cw10-B13-DR12(5)	*0201	*0304	*1301	*1202

HLA-DR12 is genetically linked to DR52 and HLA-DQ7

HLA-DQ7

HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....

serotypes.