Haplotypes groups	DQA*01:DRB1*1101 to DQA*01:DRB1*1111
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1101
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1102
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1103
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1104
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1105
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1106
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR11 (DR11) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5

HLA-DR5

HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:...

 serotype group which also contains the similar HLA-DR12

HLA-DR12

HLA-DR12 is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.-Serology:...

 antigens.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 alleles

DRB1*	DR11	DR5	DR12	Sample
allele	%	%	%	size (N)
1101	92	5		3474
1102	89	3		430
1103	89	4		397
1104	87	4		2119
1105	75			4
1106	20	73		15
1107	>50			1
1108	>50			2
1109	80	20		5

The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157

By serotype

DR11 is associated with grape anaphylaxis

Anaphylaxis

Anaphylaxis is defined as "a serious allergic reaction that is rapid in onset and may cause death". It typically results in a number of symptoms including throat swelling, an itchy rash, and low blood pressure...

, well-differentiated thyroid cancer

Thyroid cancer

Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid adenoma, or it can be a malignant neoplasm , such as papillary, follicular, medullary or anaplastic thyroid cancer. Most patients are 25 to 65 years of age when first diagnosed; women are more affected...

, low antibody production in Hepatitis C

Hepatitis C

Hepatitis C is an infectious disease primarily affecting the liver, caused by the hepatitis C virus . The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years...

.

By allele(s)

DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody

DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma, cervical cancer risk (HPV?)

DRB1*1102: Tiopronin intolerance in rheumatoid arthritis

DRB1*1104: pauciarticular juvenile rheumatoid arthritis

By haplotype

DR11 is an identifyer for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease.
DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease.

DRB1*1101:DQA1*0505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus, mite sensitive asthma

DRB1*1102:DQA1*0505:DQB1*0301 haplotype is associated with hepatitis B virus persistence

Genetic Linkage

Serotypes	DRA	DRB1		DR11(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DR52 HLA-DR52 HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...	*0101	*1101	*02
*0101	*1102	*02
*0101	*1103	*02
*0101	*1104	*02
Serotypes	DRB1	DQA1	DQB1
DR11(5 HLA-DR5 HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:... )-DQ7 HLA-DQ7 HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....  (7.5, 3 HLA-DQ3 HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2... )	*1101	*0505	*0301
	*1102	*0505	*0301
	*1103	*0505	*0301
	*1104	*0505	*0301
Serotypes	HLA-A HLA-A HLA-A are a group of human leukocyte antigens that are encoded by the HLA-A locus on human chromosome 6p. The HLA genes constitute a large subset of the Major histocompatibility complex of humans. HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the...	HLA-C HLA-C HLA-C belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane...	HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...	| DRB1
A2-Cw7-B18-DR11	*0201	*0701	*1801	*1104
A24(9)-Cw4-B35-DR11	*2402	*0401	*3501	*1101
A24(9)-Cw14(BL)-B51(5)-DR11	*2402	*1402	*5101	*1104

HLA-DR11 is genetically linked to HLA-DR52

HLA-DR52

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...

 and HLA-DQ7

HLA-DQ7

HLA-DQ7 is an HLA-DQ serotype that recognizes the common HLA DRB1*0301 and the less common HLA DRB1*0304 gene products. DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9....

(3

HLA-DQ3

HLA-DQ3 is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3 a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2...

) serotypes.
The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.