HLA-C
Encyclopedia
HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6, which encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Cw*02
Cw*03
Cw*04
Cw*05
Cw*06
Cw*08
Cw*1202 to *1215
Cw*1402 to *1405
Cw*1501 to *1511
Cw*1601 to *1606
Cw*1701 to *1703
Cw*1801 and *1802
Cw7-B7 (Western Eurasia, South Africa)
Cw7-B8 (Western Eurasia)
Cw1-B46 (China, Indochina)
Cw5-B44 (Western Eurasia)
with KIR2DL1
. and with various members of the Leukocyte immunoglobulin-like receptor
family, particularly the activating receptors LILRA1 and LILRA3
HLA-C is a locus on chromosome 6, which encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Nomenclature
Cw*01- Cw1 Serotype: Cw*0102 and Cw*0109
- Cw11 ?
- Cw*0104 to *0108
Cw*02
- Cw2 Serotype: Cw*0202 and *0208
- Cw*0203 to *0207, and 0209
Cw*03
- Cw9 Serotype: Cw*0303
- Cw10 Serotype: Cw*0302, *0304, and *0306
- Cw3 Serotype: Cw*0307
- Cw*0305 and 0308
Cw*04
- Cw4 Serotype: Cw*0401, *0407, and *0410
Cw*05
- Cw5 Serotype: Cw*0501 and *0502
- Cw*0503 to *506 and *0508 to *0510
Cw*06
- Cw6 Serotype: Cw*0602 and *0605
- Cw6*0603, *0604 and *0606 to *0611
- Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
- Cw*0707 to *0711, *0713, *0715, and *0717 to *0729
Cw*08
- Cw8 Serotype: Cw*0801, *0802 and *0803
- Cw*805 to *0812
Cw*1202 to *1215
Cw*1402 to *1405
Cw*1501 to *1511
Cw*1601 to *1606
Cw*1701 to *1703
Cw*1801 and *1802
Common Haplotype
Cw4-B35 (Western Africa to Native Americans)Cw7-B7 (Western Eurasia, South Africa)
Cw7-B8 (Western Eurasia)
Cw1-B46 (China, Indochina)
Cw5-B44 (Western Eurasia)
Interactions
HLA-C has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with KIR2DL1
KIR2DL1
Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.-Further reading:...
. and with various members of the Leukocyte immunoglobulin-like receptor
Leukocyte immunoglobulin-like receptors
The leukocyte immunoglobulin-like receptors are a family of receptors possessing extracellular immunoglobulin domains.They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells...
family, particularly the activating receptors LILRA1 and LILRA3
LILRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3 also known as CD85 antigen-like family member E , immunoglobulin-like transcript 6 , and leukocyte immunoglobulin-like receptor 4 is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on...