Haplotypes groups	DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB3
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB3*01
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB3*02
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB3*03
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. having diverged from DRB1 approximately 4 million years ago.

DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

Alleles

DR52 recognition of some DRB3* alleles

DRB3*	DR52	?	Sample
allele	%	%	size (N)
0101	95		62
0102	99		1
0201	99		2
0202	95		100
0203	95		1
0301	95		36

Associated diseases

DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis,

DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis,

DRB3*0101:DRB1*0301 is linked to Lofgren's syndrome

DRB3*0202 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, acute necrotizing encephalopathy

DRB3*0301 is weakly associated with anti-cardiolipin antibodies in SLE

DRB3*0301:DRB1*1302 may be associated with Crohn's diseaes

DRB1 linkage

HLA-DRB3 is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR3

HLA-DR3

HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease....

 - DRB1*03

HLA-DR5

HLA-DR5

HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:...

 -

• HLA-DR11
  HLA-DR11
  HLA-DR11 is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.-Serology:...
  
   - DRB1*11
• HLA-DR12
  HLA-DR12
  HLA-DR12 is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.-Serology:...
  
   - DRB1*12

HLA-DR6

HLA-DR6

HLA-DR6 is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.-Serology:DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7....

 -

• HLA-DR13
  HLA-DR13
  HLA-DR13 is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.-Alleles:...
  
   - DRB1*13
• HLA-DR14
  HLA-DR14
  HLA-DR14 is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.-Alleles:...
  
  - DRB1*14