Mario Capecchi
Encyclopedia
Mario Renato Capecchi is a city in the Veneto, northern Italy, with approx. 265,000 inhabitants and one of the seven chef-lieus of the region. It is the second largest city municipality in the region and the third of North-Eastern Italy. The metropolitan area of Verona...
, Italy
Italy
Italy , officially the Italian Republic languages]] under the European Charter for Regional or Minority Languages. In each of these, Italy's official name is as follows:;;;;;;;;), is a unitary parliamentary republic in South-Central Europe. To the north it borders France, Switzerland, Austria and...
, 6 October 1937) is an Italian
Italy
Italy , officially the Italian Republic languages]] under the European Charter for Regional or Minority Languages. In each of these, Italy's official name is as follows:;;;;;;;;), is a unitary parliamentary republic in South-Central Europe. To the north it borders France, Switzerland, Austria and...
-born American
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
molecular geneticist
Geneticist
A geneticist is a biologist who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a researcher or lecturer. Some geneticists perform experiments and analyze data to interpret the inheritance of skills. A geneticist is also a Consultant or...
and a co-winner of the 2007 Nobel Prize in Physiology or Medicine
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
for discovering a method for introducing homologous recombination
Homologous recombination
Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA. It is most widely used by cells to accurately repair harmful breaks that occur on both strands of DNA, known as double-strand breaks...
in mice employing embryonic stem cell
Embryonic stem cell
Embryonic stem cells are pluripotent stem cells derived from the inner cell mass of the blastocyst, an early-stage embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells...
s, with Martin Evans
Martin Evans
Sir Martin John Evans FRS is a British scientist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981...
and Oliver Smithies
Oliver Smithies
Oliver Smithies is a British-born American geneticist and Nobel laureate, credited with the invention of gel electrophoresis in 1955, and the simultaneous discovery, with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more...
. He is currently Distinguished Professor of Human Genetics
Human genetics
Human genetics describes the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics,...
and Biology
Biology
Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...
at the University of Utah
University of Utah
The University of Utah, also known as the U or the U of U, is a public, coeducational research university in Salt Lake City, Utah, United States. The university was established in 1850 as the University of Deseret by the General Assembly of the provisional State of Deseret, making it Utah's oldest...
School of Medicine, which he joined in 1973.
Life
Mario Capecchi was born in the ItalianItaly
Italy , officially the Italian Republic languages]] under the European Charter for Regional or Minority Languages. In each of these, Italy's official name is as follows:;;;;;;;;), is a unitary parliamentary republic in South-Central Europe. To the north it borders France, Switzerland, Austria and...
city of Verona
Verona
Verona ; German Bern, Dietrichsbern or Welschbern) is a city in the Veneto, northern Italy, with approx. 265,000 inhabitants and one of the seven chef-lieus of the region. It is the second largest city municipality in the region and the third of North-Eastern Italy. The metropolitan area of Verona...
as the only child of Luciano Capecchi, an Italian airman who would be later reported as missing in action while manning an anti-aircraft gun
Anti-aircraft warfare
NATO defines air defence as "all measures designed to nullify or reduce the effectiveness of hostile air action." They include ground and air based weapon systems, associated sensor systems, command and control arrangements and passive measures. It may be to protect naval, ground and air forces...
in the Western Desert Campaign
Western Desert Campaign
The Western Desert Campaign, also known as the Desert War, was the initial stage of the North African Campaign during the Second World War. The campaign was heavily influenced by the availability of supplies and transport. The ability of the Allied forces, operating from besieged Malta, to...
, and Lucy Ramberg, an American-born daughter of Impressionist painter Lucy Dodd Ramberg and German archaeologist Walter Ramberg. During World War II
World War II
World War II, or the Second World War , was a global conflict lasting from 1939 to 1945, involving most of the world's nations—including all of the great powers—eventually forming two opposing military alliances: the Allies and the Axis...
, his mother was sent to the Dachau concentration camp as punishment for pamphleteering and belonging to an anti-Fascist group. Prior to her arrest she had made contingency plans by selling her belongings and giving the proceeds to a peasant family near Bolzano to provide housing for her only child. However, after one year, the money was exhausted and the family was unable to care for him. At four-and-a-half years old he was left to fend for himself on the streets of northern Italy for the next four years, living in various orphanages and roving through towns with groups of other homeless children.
He almost died of malnutrition. His mother, meanwhile, had been freed from Dachau and began a year-long search for him. She finally found him in a hospital bed in Reggio Emilia
Reggio Emilia
Reggio Emilia is an affluent city in northern Italy, in the Emilia-Romagna region. It has about 170,000 inhabitants and is the main comune of the Province of Reggio Emilia....
, ill with a fever and subsisting on a daily bowl of chicory
Chicory
Common chicory, Cichorium intybus, is a somewhat woody, perennial herbaceous plant usually with bright blue flowers, rarely white or pink. Various varieties are cultivated for salad leaves, chicons , or for roots , which are baked, ground, and used as a coffee substitute and additive. It is also...
coffee and bread crust. She took him to Rome, where he had his first bath in six years.
In 1946 his uncle, Edward Ramberg
Edward Ramberg
Edward G. Ramberg was an American physicist who contributed to the early development of electron microscopy and color television. He was the uncle of Mario Capecchi, a 2007 Nobel laureate. His mother was an American painter, Lucy Dodd Ramberg , and his father a German archaeologist, Walter Ramberg...
, an American physicist at RCA
RCA
RCA Corporation, founded as the Radio Corporation of America, was an American electronics company in existence from 1919 to 1986. The RCA trademark is currently owned by the French conglomerate Technicolor SA through RCA Trademark Management S.A., a company owned by Technicolor...
, sent his mother money to return to the United States. He and his mother moved to Pennsylvania
Pennsylvania
The Commonwealth of Pennsylvania is a U.S. state that is located in the Northeastern and Mid-Atlantic regions of the United States. The state borders Delaware and Maryland to the south, West Virginia to the southwest, Ohio to the west, New York and Ontario, Canada, to the north, and New Jersey to...
to live at an intentional cooperative community called Bryn Gweled, which had been co-founded by his uncle. (Capecchi's other maternal uncle, Walter Ramberg, was also an American physicist who served as the tenth president of the Society for Experimental Stress Analysis.) He graduated from George School
George School
George School is a private Quaker boarding and day high school located on a rural campus near Newtown, Pennsylvania, USA. It was founded at its present site in 1893, and has grown from a single building to over 20 academic, athletic, and residential buildings...
, a Quaker boarding school in Bucks County, Pennsylvania
Bucks County, Pennsylvania
- Industry and commerce :The boroughs of Bristol and Morrisville were prominent industrial centers along the Northeast Corridor during World War II. Suburban development accelerated in Lower Bucks in the 1950s with the opening of Levittown, Pennsylvania, the second such "Levittown" designed by...
, in 1956.
Mario Capecchi received his Bachelor of Science
Bachelor of Science
A Bachelor of Science is an undergraduate academic degree awarded for completed courses that generally last three to five years .-Australia:In Australia, the BSc is a 3 year degree, offered from 1st year on...
in chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
and physics
Physics
Physics is a natural science that involves the study of matter and its motion through spacetime, along with related concepts such as energy and force. More broadly, it is the general analysis of nature, conducted in order to understand how the universe behaves.Physics is one of the oldest academic...
in 1961 from Antioch College
Antioch College
Antioch College is a private, independent liberal arts college in Yellow Springs, Ohio, United States. It was the founder and the flagship institution of the six-campus Antioch University system. Founded in 1852 by the Christian Connection, the college began operating in 1853 with politician and...
in Ohio
Ohio
Ohio is a Midwestern state in the United States. The 34th largest state by area in the U.S.,it is the 7th‑most populous with over 11.5 million residents, containing several major American cities and seven metropolitan areas with populations of 500,000 or more.The state's capital is Columbus...
. Capecchi came to MIT as a graduate student intending to study physics and mathematics, but during the course of his studies, he became interested in molecular biology. He subsequently transferred to Harvard to join the lab of James D. Watson
James D. Watson
James Dewey Watson is an American molecular biologist, geneticist, and zoologist, best known as one of the co-discoverers of the structure of DNA in 1953 with Francis Crick...
, co-discoverer of the structure of DNA. Capecchi received his Ph.D.
Ph.D.
A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer...
in biophysics
Biophysics
Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...
in 1967 from Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
, with his doctoral thesis completed under the tutelage of Watson.
Capecchi was a Junior Fellow of the Society of Fellows at Harvard University from 1967 to 1969. In 1969 he became an Assistant Professor in the Department of Biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
. He was promoted to Associate Professor in 1971. In 1973 he joined the faculty at the University of Utah. Since 1988 Capecchi has also been an investigator of the Howard Hughes Medical Institute
Howard Hughes Medical Institute
Howard Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...
. He is a member of the National Academy of Sciences
United States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
. He has given a talk for Duke University
Duke University
Duke University is a private research university located in Durham, North Carolina, United States. Founded by Methodists and Quakers in the present day town of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco industrialist James B...
's Program in Genetics and Genomics as part of their Distinguished Lecturer Series.
After the Nobel committee publicly announced that Capecchi had won the Nobel prize, an Austria
Austria
Austria , officially the Republic of Austria , is a landlocked country of roughly 8.4 million people in Central Europe. It is bordered by the Czech Republic and Germany to the north, Slovakia and Hungary to the east, Slovenia and Italy to the south, and Switzerland and Liechtenstein to the...
n woman named Marlene Bonelli claimed that Capecchi was her long-lost half-brother.
In May 2008, Capecchi met with Bonelli, 69, in northern Italy, and confirmed that she was his sister.
Knockout mice
Capecchi is particularly well known for his pioneering work in gene targeting of the mouse embryo-derived stem cells, working on the knockout miceKnockout mouse
A knockout mouse is a genetically engineered mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA...
(a genetically engineered mouse in which one or more genes have been turned off through a targeted mutation). This work was accomplished together with the efforts of Martin Evans
Martin Evans
Sir Martin John Evans FRS is a British scientist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981...
and Oliver Smithies
Oliver Smithies
Oliver Smithies is a British-born American geneticist and Nobel laureate, credited with the invention of gel electrophoresis in 1955, and the simultaneous discovery, with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more...
, and recognized in the 2007 Nobel prize for medicine or physiology.
Capecchi has also pursued a systematic analysis of the mouse Hox gene family. This gene family plays a key role in the control of embryonic development in all multicellular animals.
Honours
- 1992 - Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research
- 1993 - Gairdner FoundationGairdner FoundationThe Gairdner Foundation was created in 1957 by James Arthur Gairdner to recognize and reward the achievements of medical researchers whose work contributes significantly to improving the quality of human life. Since the first awards were made in 1959, the Gairdner Awards have become Canada's...
International Award for Achievements in Medical Sciences - 1993 - Gairdner Foundation International AwardGairdner Foundation International AwardThe Gairdner Foundation International Award is given annually at a special dinner to three to six people for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2007, 69 Nobel...
- 1994 - General MotorsGeneral MotorsGeneral Motors Company , commonly known as GM, formerly incorporated as General Motors Corporation, is an American multinational automotive corporation headquartered in Detroit, Michigan and the world's second-largest automaker in 2010...
Cancer Reseearch Foundation Alfred P. Sloan Jr. Prize - 1996 - Kyoto PrizeKyoto PrizeThe has been awarded annually since 1985 by the Inamori Foundation, founded by Kazuo Inamori. The prize is a Japanese award similar in intent to the Nobel Prize, as it recognizes outstanding works in the fields of philosophy, arts, science and technology...
in Basic Sciences - 1996 - German Molecular Bioanalytics Prize
- 1997 - Franklin MedalFranklin MedalThe Franklin Medal was a science and engineering award presented by the Franklin Institute, of Philadelphia, PA, USA.-Laureates:*1915 - Thomas Alva Edison *1915 - Heike Kamerlingh Onnes *1916 - John J...
for Advancing Our Knowledge of the Physical Sciences - 1998 - Feodor Lynen Lectureship
- 1998 - Rosenblatt Prize for Excellence
- 1998 - Baxter Award for Distinguished Research in the Biomedical Sciences
- 1999 - Helen Lowe Bamberger Colby and John E. Bamberger Presidential Endowed Chair in the University of Utah Health Sciences Center
- 2000 - Lectureship in the Life Sciences for the Collège de France
- 2000 - Horace MannHorace MannHorace Mann was an American education reformer, and a member of the Massachusetts House of Representatives from 1827 to 1833. He served in the Massachusetts Senate from 1834 to 1837. In 1848, after serving as Secretary of the Massachusetts State Board of Education since its creation, he was...
Distinguished Alumni Award, Antioch College - 2000 - Italian Premio Phoenix-Anni Verdi for Genetics Research Award
- 2001 - Albert Lasker Award for Basic Medical ResearchAlbert Lasker Award for Basic Medical ResearchThe Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease...
, co-winner with Martin EvansMartin EvansSir Martin John Evans FRS is a British scientist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981...
and Oliver SmithiesOliver SmithiesOliver Smithies is a British-born American geneticist and Nobel laureate, credited with the invention of gel electrophoresis in 1955, and the simultaneous discovery, with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more... - 2001 - Spanish Jiménez-Diáz Prize
- 2001 - Pioneers of Progress Award
- 2001 - National Medal of ScienceNational Medal of ScienceThe National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social sciences, biology, chemistry, engineering, mathematics and...
- 2002 - John Scott Medal Award
- 2002 - Massry Prize
- 2003 - Pezcoller Foundation-AACR International Award for Cancer Research
- 2002/3 - Wolf Prize in MedicineWolf Prize in MedicineThe Wolf Prize in Medicine is awarded once a year by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The Prize is probably the third most prestigious award...
- 2005 - March of Dimes Prize in Developmental BiologyMarch of Dimes Prize in Developmental BiologyThe March of Dimes Prize in Developmental Biology is awarded once a year by the March of Dimes. It carries a $250,000 award "to an investigator whose research brings us closer to the day when all babies will be born healthy." It also includes a medal in the shape of a Roosevelt dime.- Laureates...
- 2007 - Nobel Prize in Physiology or MedicineNobel Prize in Physiology or MedicineThe Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
, co-winner with Martin EvansMartin EvansSir Martin John Evans FRS is a British scientist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981...
and Oliver SmithiesOliver SmithiesOliver Smithies is a British-born American geneticist and Nobel laureate, credited with the invention of gel electrophoresis in 1955, and the simultaneous discovery, with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more...
External links
- Howard Hughes Medical Institute biography
- Mario Capecchi iBioMagazine talk: The Birth of Gene Targeting
- Mario Capecchi Nobel Prize lecture
- Eccles Institute of Human Genetics biography
- University of Utah biography
- Interviews with Mario Capecchi from Dolan DNA Learning Center's DNA Interactive
- Capecchi animation from Dolan DNA Learning Center's DNA from the Beginning
- Interview with Dr Capecchi Futures in Biotech 63: How To Use A Mouse