476    Romulus Augustus, last emperor of the Western Roman Empire, is deposed when Odoacer proclaims himself King of Italy, thus ending Western Roman Empire.

489    Theodoric, king of the Ostrogoths defeats Odoacer at the Battle of Isonzo, forcing his way into Italy.

1071    Bari falls to Robert Guiscard, ending Byzantine rule in Italy.

1310    Duccio's Maestà Altarpiece, a seminal artwork of the early Italian Renaissance, is unveiled and installed in the Siena Cathedral in Siena, Italy.

1341    Sack of Saluzzo (Italy) by Italian-Angevine troops under Manfred V of Saluzzo.

1343    A tsunami, caused by the earthquake in the Tyrrhenian Sea, devastates Naples (Italy) and the Maritime Republic of Amalfi, among other places.

1377    More than 2,000 people of the Italian city of Cesena are slaughtered by Papal Troops (Cesena Bloodbath).

1497    The bonfire of the vanities occurs in which supporters of Girolamo Savonarola burn thousands of objects like cosmetics, art, and books in Florence, Italy.

1498    Girolamo Savonarola is burned at the stake in Florence, Italy, on the orders of Pope Alexander VI.

1503    Important victory of the Great captain at the Battle of Cerignola, ruling a small Spanish armies over a French four times bigger in number, in Cerignola, next Bari, Southern Italy. It is noted as the first battle in history won by gunpowder small arms.