Haplotypes groups	DQA*01:DRB1*0701
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*0701
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR7 (DR7) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*0701 to *0705 gene products.

Serology

DR7 serological recognition of the gene products of some DRB1*07 alleles

DRB1*	DR7	Sample
allele	%	size (N)
0701	99	7390
0704	>30%	1

The serological reaction of DR7 is excellent for *0701. The serology of *0703 to *0705 to *0709, and *0711 to *0714 serotypes is unknown. DRB1*0710N is a null

Null

-In computing:* Null , a special marker and keyword in SQL* Null character, the zero-valued ASCII character, also designated by NUL, often used as a terminator, separator or filler* Null device, a special computer file that discards all data written to it...

 allele. DRB1*0702 nomenclature has been deleted.

By Allele group

DRB1*07 is linked to T. cruzi infection with cardiomyopathy

Cardiomyopathy

Cardiomyopathy, which literally means "heart muscle disease," is the deterioration of the function of the myocardium for any reason. People with cardiomyopathy are often at risk of arrhythmia or sudden cardiac death or both. Cardiomyopathy can often go undetected, making it especially dangerous to...

 (Also called Chaga's cardiomyopathy

By extended haplotype

DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease

Graves' disease

Graves' disease is an autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones...

 

DR7-DQ2/DR5

HLA-DR5

HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.-Serology:With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.-Disease associations:...

-DQ7 phenotype (transhaplotype encoded isoform DQα⁵β²) is the primary risk DQ isoform in celiac disease. DR7-DQ2/DR5-DQ7 (/DR11

HLA-DR11

HLA-DR11 is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.-Serology:...

-DQ7 or /DR12

HLA-DR12

HLA-DR12 is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.-Serology:...

-DQ7) is a clarifying identifyer for the at risk transhaplotype.

DR53-DR7 maybe associated with sclerosis/lupus associated anti-apolipoprotein antibodies

Anti-apolipoprotein antibodies

In autoimmune disease, anti-apolipoprotein H antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus....

Genetic Linkage

Serotypes	DRA	DRB1		DR7-DR53 HLA-DR53 HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to HLA-DR7...	*0101	*0701	*01
Serotypes	DQA1	DQB1	| DRB1
DR7-DQ2 HLA-DQ2 HLA-DQ2 is a serotype group within HLA-DQ serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles,...  (2.2)	*0201	*0202	*0701
DR7-DQ9 HLA-DQ9 HLA-DQ9 is a human leukocyte antigen serotype within the HLA-DQ serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.-Serology:...  (9.2, 3)	*0201	*0303	*0701
Serotypes	HLA-A HLA-A HLA-A are a group of human leukocyte antigens that are encoded by the HLA-A locus on human chromosome 6p. The HLA genes constitute a large subset of the Major histocompatibility complex of humans. HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the...	HLA-C HLA-C HLA-C belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane...	HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...	| DRB1
A29(19)-Cw16-B44(16)-DR7	*2902	*1601	*4403	*0701
A30(19)-Cw6-B13-DR7	*3001	*0602	*1302	*0701
A33(19)-Cw7-B44(16)-DR7	*3301	*0701	*4403	*0701

HLA-DR7 is genetically linked HLA-DR53

HLA-DR53

HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution. and the DRB4 locus presence is linked to HLA-DR7...

, and is linked to DQ2

HLA-DQ2

HLA-DQ2 is a serotype group within HLA-DQ serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles,...

 serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

s. There are a few interesting genetics with DR7. The A29-Cw16-B44-DR7-DQ2 haplotype

Haplotype

A haplotype in genetics is a combination of alleles at adjacent locations on the chromosome that are transmitted together...

 is in strong linkage disequilibrium particularly in Northwestern Europe. The highest frequencies tend to be coastal countries along the Atlantic. The Cw16 allele is undoubtedly derived from Western Africa the diversity and frequency of Cw16 declines away from the along the Greenwich

Greenwich

Greenwich is a district of south London, England, located in the London Borough of Greenwich.Greenwich is best known for its maritime history and for giving its name to the Greenwich Meridian and Greenwich Mean Time...

 longitudinal line. The level of linkage disequilibration about Cw16 postulates a recent arrival from Africa, and indicates a substantial contribution as far north as Ireland

Ireland

Ireland is an island to the northwest of continental Europe. It is the third-largest island in Europe and the twentieth-largest island on Earth...

. The A33-Cw7-B44-DR7 offers the same scenario. This haplotype is found in Korea but not Japan, in fact Japan is an antinode of DR7. The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into Korea

Korea

Korea ) is an East Asian geographic region that is currently divided into two separate sovereign states — North Korea and South Korea. Located on the Korean Peninsula, Korea is bordered by the People's Republic of China to the northwest, Russia to the northeast, and is separated from Japan to the...

 after the Japan

Japan

Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south...

's Yayoi migration when most of the Korean contribution occurred. Similarities with Mongol genes suggest that Central and East- Central Asian are the likely source, confirmed by the fact the haplotype is found in Pakistan

Pakistan

Pakistan , officially the Islamic Republic of Pakistan is a sovereign state in South Asia. It has a coastline along the Arabian Sea and the Gulf of Oman in the south and is bordered by Afghanistan and Iran in the west, India in the east and China in the far northeast. In the north, Tajikistan...

, China

China

Chinese civilization may refer to:* China for more general discussion of the country.* Chinese culture* Greater China, the transnational community of ethnic Chinese.* History of China* Sinosphere, the area historically affected by Chinese culture...

 and India

India

India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

. There is the possibility that this haplotype is a recent (Holocene

Holocene

The Holocene is a geological epoch which began at the end of the Pleistocene and continues to the present. The Holocene is part of the Quaternary period. Its name comes from the Greek words and , meaning "entirely recent"...

) arrival from Africa or the Middle East to Central Asia as this best explains the alleles within the haplotype. The A19 (A29, A30, A31, A32, A33, A74) serotypes are very much enriched in sub-sarahan and Western Africa, including Iberia, and disequilibrated components of DR7 show a tendency to be linked to A19 serotypes.