Colon (anatomy)
Encyclopedia
The colon is the last part of the digestive system in most vertebrate
s; it extracts water
and salt
from solid wastes
before they are eliminated
from the body, and is the site in which flora-aided (largely bacterial) fermentation of unabsorbed material occurs. Unlike the small intestine
, the colon does not play a major role in absorption of foods and nutrients. However, the colon does absorb water, sodium and some fat soluble vitamins.
In mammal
s, the colon consists of four sections: the ascending colon
, the transverse colon
, the descending colon
, and the sigmoid colon
(the proximal colon usually refers to the ascending colon and transverse colon). The colon, cecum
, and rectum
make up the large intestine
.
. The colon in those areas is fixed in location.
The haustra
of the colon are the small pouches caused by sacculation
, which give the colon its segmented appearance. The taenia coli
runs the length of the large intestine. Because the taenia coli is shorter than the intestine, the colon becomes sacculated between the taenia, forming the haustra.
supply to the colon comes from branches of the superior mesenteric artery
(SMA) and inferior mesenteric artery
(IMA). Flow between these two systems communicates via a "marginal artery" that runs parallel to the colon for its entire length. Historically, it has been believed that the arc of Riolan, or the meandering mesenteric artery (of Moskowitz), is a variable vessel connecting the proximal SMA to the proximal IMA that can be extremely important if either vessel is occluded. However, recent studies conducted with improved imaging technology have questioned the actual existence of this vessel, with some experts calling for the abolition of the terms from future medical literature.
Venous
drainage usually mirrors colonic arterial supply, with the inferior mesenteric vein
draining into the splenic vein
, and the superior mesenteric vein
joining the splenic vein to form the hepatic portal vein
that then enters the liver
.
Lymphatic drainage
from the entire colon and proximal two-thirds of the rectum
is to the paraaortic lymph node
s that then drain into the cisterna chyli
. The lymph from the remaining rectum and anus
can either follow the same route, or drain to the internal iliac
and superficial inguinal nodes. The pectinate line
only roughly marks this transition.
to the hepatic flexure
(the turn of the colon by the liver). It is secondarily retroperitoneal in most humans. In ruminant grazing animals, the cecum empties into the spiral colon
.
Anteriorly it is related to the coils of small intestine
, the right edge of the greater omentum
, and the anterior abdominal wall.
Posteriorly, it is related to the iliacus
, the iliolumbar ligament, the quadratus lumborum
, the transverse abdominis
, the diaphragm
at the tip of the last rib; the lateral cutaneous, ilioinguinal, and iliohypogastric nerve
s; the iliac branches of the iliolumbar vessels, the fourth lumbar artery
, and the right kidney
.
The ascending colon is supplied by parasympathetic fibers of the vagus nerve (CN X)
.
Arterial supply of the ascending colon comes from the ileocolic artery
and right colic artery
, both branches of the SMA. While the ileocolic artery
is almost always present, the right colic may be absent in 5–15% of individuals.
(the turn of the colon by the spleen
). The transverse colon hangs off the stomach
, attached to it by a wide band of tissue
called the greater omentum. On the posterior side, the transverse colon is connected to the posterior abdominal wall by a mesentery
known as the transverse mesocolon
.
The transverse colon is encased in peritoneum
, and is therefore mobile (unlike the parts of the colon immediately before and after it). Cancer
s form more frequently further along the large intestine
as the contents become more solid (water is removed) in order to form feces
.
The proximal two-thirds of the transverse colon is perfused by the middle colic artery
, a branch of SMA, while the latter third is supplied by branches of the IMA. The "watershed" area between these two blood supplies, which represents the embryologic division between the midgut
and hindgut
, is an area sensitive to ischemia
.
.
after the descending colon and before the rectum. The name sigmoid means S-shaped (see sigmoid). The walls of the sigmoid colon are muscular, and contract to increase the pressure inside the colon, causing the stool
to move into the rectum.
The sigmoid colon is supplied with blood from several branches (usually between 2 and 6) of the sigmoid arteries
, a branch of the IMA. The IMA terminates as the superior rectal artery
.
Sigmoidoscopy
is a common diagnostic technique used to examine the sigmoid colon.
occurs resulting in obstruction and requiring immediate medical attention. A significant indirect health consequence is that use of a standard adult colonoscope is difficult and in some cases impossible when a redundant colon is present, though specialized variants on the instrument (including the pediatric variant) are useful in overcoming this problem.
gradient. The standing gradient osmosis is a term used to describe the reabsorption of water against the osmotic gradient in the intestines. This hypertonic
fluid creates an osmotic pressure that drives water into the lateral intercellular spaces by osmosis via tight junction
s and adjacent cells, which then in turn moves across the basement membrane
and into the capillaries
.
s. The large intestine is mainly responsible for storing waste, reclaiming water, maintaining the water balance
, absorbing some vitamin
s, such as vitamin K
, and providing a location for flora-aided fermentation.
By the time the chyme
has reached this tube, most nutrient
s and 90% of the water have been absorbed by the body. At this point some electrolyte
s like sodium
, magnesium
, and chloride
are left as well as indigestible parts of ingested food (e.g., a large part of ingested amylose
, protein which has been shielded from digestion heretofore, and dietary fiber
, which is largely indigestible carbohydrate
in either soluble or insoluble form). As the chyme moves through the large intestine
, most of the remaining water
is removed, while the chyme is mixed with mucus
and bacteria
(known as gut flora
), and becomes feces. The ascending colon
receives fecal material as a liquid. The muscles of the colon then move the watery waste material forward and slowly absorb all the excess water. The stools get to become semi solid as they move along into the descending colon
The bacteria break down some of the fiber
for their own nourishment and create acetate
, propionate
, and butyrate
as waste products, which in turn are used by the cell lining of the colon for nourishment. No protein is made available. In humans, perhaps 10% of the undigested carbohydrate thus becomes available; in other animals, including other apes and primates, who have proportionally larger colons, more is made available, thus permitting a higher portion of plant material in the diet. This is an example of a symbiotic relationship and provides about one hundred calorie
s a day to the body. The large intestine produces no digestive enzyme
s -— chemical digestion is completed in the small intestine
before the chyme reaches the large intestine. The pH
in the colon varies between 5.5 and 7 (slightly acid
ic to neutral).
Good line)
Vertebrate
Vertebrates are animals that are members of the subphylum Vertebrata . Vertebrates are the largest group of chordates, with currently about 58,000 species described. Vertebrates include the jawless fishes, bony fishes, sharks and rays, amphibians, reptiles, mammals, and birds...
s; it extracts water
Water
Water is a chemical substance with the chemical formula H2O. A water molecule contains one oxygen and two hydrogen atoms connected by covalent bonds. Water is a liquid at ambient conditions, but it often co-exists on Earth with its solid state, ice, and gaseous state . Water also exists in a...
and salt
Salt
In chemistry, salts are ionic compounds that result from the neutralization reaction of an acid and a base. They are composed of cations and anions so that the product is electrically neutral...
from solid wastes
Feces
Feces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
before they are eliminated
Defecation
Defecation is the final act of digestion by which organisms eliminate solid, semisolid or liquid waste material from the digestive tract via the anus. Waves of muscular contraction known as peristalsis in the walls of the colon move fecal matter through the digestive tract towards the rectum...
from the body, and is the site in which flora-aided (largely bacterial) fermentation of unabsorbed material occurs. Unlike the small intestine
Small intestine
The small intestine is the part of the gastrointestinal tract following the stomach and followed by the large intestine, and is where much of the digestion and absorption of food takes place. In invertebrates such as worms, the terms "gastrointestinal tract" and "large intestine" are often used to...
, the colon does not play a major role in absorption of foods and nutrients. However, the colon does absorb water, sodium and some fat soluble vitamins.
In mammal
Mammal
Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...
s, the colon consists of four sections: the ascending colon
Ascending colon
The ascending colon is smaller in caliber than the cecum.It passes upward, from its commencement at the cecum, opposite the colic valve, to the under surface of the right lobe of the liver, on the right of the gall-bladder, where it is lodged in a shallow depression, the colic impression; here it...
, the transverse colon
Transverse colon
The transverse colon, the longest and most movable part of the colon, passes with a downward convexity from the right hypochondrium region across the abdomen, opposite the confines of the epigastric and umbilical zones, into the left hypochondrium region, where it curves sharply on itself beneath...
, the descending colon
Descending colon
The descending colon of humans passes downward through the left hypochondrium and lumbar regions, along the lateral border of the left kidney....
, and the sigmoid colon
Sigmoid colon
The sigmoid colon is the part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm...
(the proximal colon usually refers to the ascending colon and transverse colon). The colon, cecum
Cecum
The cecum or caecum is a pouch, connecting the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve or Bauhin's valve, and is considered to be the beginning of the large intestine. It is also separated from the colon by the cecocolic...
, and rectum
Rectum
The rectum is the final straight portion of the large intestine in some mammals, and the gut in others, terminating in the anus. The human rectum is about 12 cm long...
make up the large intestine
Large intestine
The large intestine is the third-to-last part of the digestive system — — in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass useless waste material from the body...
.
Anatomy
The location of the parts of the colon is either in the abdominal cavity or behind it in the retroperitoneumRetroperitoneum
The retroperitoneal space is the anatomical space in the abdominal cavity behind the peritoneum. It has no specific delineating anatomical structures...
. The colon in those areas is fixed in location.
The haustra
Haustra
The haustra of the colon are the small pouches caused by sacculation, which give the colon its segmented appearance. The taenia coli runs the length of the large intestine...
of the colon are the small pouches caused by sacculation
Sacculation
Sacculation in terms of anatomy is the formation of a pouch in various organs ....
, which give the colon its segmented appearance. The taenia coli
Taenia coli
The taenia coli are three separate longitudinal ribbons of smooth muscle on the outside of the ascending, transverse, descending and sigmoid colons. They are visible, and can be seen just below the serosa or fibrosa....
runs the length of the large intestine. Because the taenia coli is shorter than the intestine, the colon becomes sacculated between the taenia, forming the haustra.
Blood supply and lymphatics
ArterialArtery
Arteries are blood vessels that carry blood away from the heart. This blood is normally oxygenated, exceptions made for the pulmonary and umbilical arteries....
supply to the colon comes from branches of the superior mesenteric artery
Superior mesenteric artery
In human anatomy, the superior mesenteric artery arises from the anterior surface of the abdominal aorta, just inferior to the origin of the celiac trunk, and supplies the intestine from the lower part of the duodenum through two-thirds of the transverse colon, as well as the pancreas.-Location...
(SMA) and inferior mesenteric artery
Inferior mesenteric artery
In human anatomy, the inferior mesenteric artery, often abbreviated as IMA, supplies the large intestine from the left colic flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum...
(IMA). Flow between these two systems communicates via a "marginal artery" that runs parallel to the colon for its entire length. Historically, it has been believed that the arc of Riolan, or the meandering mesenteric artery (of Moskowitz), is a variable vessel connecting the proximal SMA to the proximal IMA that can be extremely important if either vessel is occluded. However, recent studies conducted with improved imaging technology have questioned the actual existence of this vessel, with some experts calling for the abolition of the terms from future medical literature.
Venous
Vein
In the circulatory system, veins are blood vessels that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart...
drainage usually mirrors colonic arterial supply, with the inferior mesenteric vein
Inferior mesenteric vein
In human anatomy, the inferior mesenteric vein is a blood vessel that drains blood from the large intestine. It usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein...
draining into the splenic vein
Splenic vein
In anatomy, the splenic vein is the blood vessel that drains blood from the spleen.It joins with the superior mesenteric vein, to form the hepatic portal vein and follows a course superior to the pancreas, alongside of the similarly named artery, the splenic artery.It collects branches from the...
, and the superior mesenteric vein
Superior mesenteric vein
In anatomy, the superior mesenteric vein is a blood vessel that drains blood from the small intestine . At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein...
joining the splenic vein to form the hepatic portal vein
Hepatic portal vein
The hepatic portal vein is not a true vein, because it does not conduct blood directly to the heart. It is a vessel in the abdominal cavity that drains blood from the gastrointestinal tract and spleen to capillary beds in the liver...
that then enters the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...
.
Lymphatic drainage
Lymphatic system
The lymphoid system is the part of the immune system comprising a network of conduits called lymphatic vessels that carry a clear fluid called lymph unidirectionally toward the heart. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated...
from the entire colon and proximal two-thirds of the rectum
Rectum
The rectum is the final straight portion of the large intestine in some mammals, and the gut in others, terminating in the anus. The human rectum is about 12 cm long...
is to the paraaortic lymph node
Paraaortic lymph node
The paraaortic lymph nodes are a group of lymph nodes that lie in front of the lumbar vertebral bodies near the aorta...
s that then drain into the cisterna chyli
Cisterna chyli
The cisterna chyli is a dilated sac at the lower end of the thoracic duct into which lymph from the intestinal trunk and two lumbar lymphatic trunks flow.-Flow of lymph:...
. The lymph from the remaining rectum and anus
Anus
The anus is an opening at the opposite end of an animal's digestive tract from the mouth. Its function is to control the expulsion of feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest,...
can either follow the same route, or drain to the internal iliac
Ilium (bone)
The ilium is the uppermost and largest bone of the pelvis, and appears in most vertebrates including mammals and birds, but not bony fish. All reptiles have an ilium except snakes, although some snake species have a tiny bone which is considered to be an ilium.The name comes from the Latin ,...
and superficial inguinal nodes. The pectinate line
Pectinate line
The pectinate line is a line which divides the upper 2/3s and lower 1/3 of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction....
only roughly marks this transition.
Ascending colon
The ascending colon, on the right side of the abdomen, is about 25 cm long in humans. It is the part of the colon from the cecumCecum
The cecum or caecum is a pouch, connecting the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve or Bauhin's valve, and is considered to be the beginning of the large intestine. It is also separated from the colon by the cecocolic...
to the hepatic flexure
Hepatic flexure
Hepatic flexure is the sharp bend between the ascending and the transverse colon. The right colic flexure is adjacent to the liver, and is therefore also known as the hepatic flexure. Thus, the left colic flexure is also known as the splenic flexure...
(the turn of the colon by the liver). It is secondarily retroperitoneal in most humans. In ruminant grazing animals, the cecum empties into the spiral colon
Spiral colon
The spiral colon is the ascending colon of ruminants..Caecum receives the solid wastes of digestion from the ileum via the Ileocaecal valve.The spiral colon is responsible for the reabsorption of water and minerals from faecal material...
.
Anteriorly it is related to the coils of small intestine
Small intestine
The small intestine is the part of the gastrointestinal tract following the stomach and followed by the large intestine, and is where much of the digestion and absorption of food takes place. In invertebrates such as worms, the terms "gastrointestinal tract" and "large intestine" are often used to...
, the right edge of the greater omentum
Greater omentum
The greater omentum is a large fold of parietal peritoneum that hangs down from the stomach...
, and the anterior abdominal wall.
Posteriorly, it is related to the iliacus
Iliacus muscle
The iliacus is a flat, triangular muscle which fills the iliac fossa.- Course :The iliacus arises from the iliac fossa on the interior side of the hip bone, and also from the region of the anterior inferior iliac spine...
, the iliolumbar ligament, the quadratus lumborum
Quadratus lumborum muscle
The Quadratus lumborum is irregular and quadrilateral in shape, and broader below than above.-Origin and insertion:It arises by aponeurotic fibers from the iliolumbar ligament and the adjacent portion of the iliac crest for about 5 cm., and is inserted into the lower border of the last rib for...
, the transverse abdominis
Transversus abdominis muscle
The transversus abdominis muscle, also known as the transverse abdominus, transversalis muscle and transverse abdominal muscle, is a muscle layer of the anterior and lateral abdominal wall which is deep to the internal oblique muscle...
, the diaphragm
Thoracic diaphragm
In the anatomy of mammals, the thoracic diaphragm, or simply the diaphragm , is a sheet of internal skeletal muscle that extends across the bottom of the rib cage. The diaphragm separates the thoracic cavity from the abdominal cavity and performs an important function in respiration...
at the tip of the last rib; the lateral cutaneous, ilioinguinal, and iliohypogastric nerve
Iliohypogastric nerve
The iliohypogastric nerve is the superior branch of the anterior ramus of spinal nerve L1 after this nerve receives fibers from T12 . The inferior branch is the ilioinguinal nerve....
s; the iliac branches of the iliolumbar vessels, the fourth lumbar artery
Lumbar arteries
The lumbar arteries are in parallel with the intercostals.They are usually four in number on either side, and arise from the back of the aorta, opposite the bodies of the upper four lumbar vertebræ....
, and the right kidney
Kidney
The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...
.
The ascending colon is supplied by parasympathetic fibers of the vagus nerve (CN X)
Vagus nerve
The vagus nerve , also called pneumogastric nerve or cranial nerve X, is the tenth of twelve paired cranial nerves...
.
Arterial supply of the ascending colon comes from the ileocolic artery
Ileocolic artery
The ileocolic artery is the lowest branch arising from the concavity of the superior mesenteric artery.It passes downward and to the right behind the peritoneum toward the right iliac fossa, where it divides into a superior and an inferior branch; the inferior anastomoses with the end of the...
and right colic artery
Right colic artery
The Right Colic Artery arises from about the middle of the concavity of the superior mesenteric artery, or from a stem common to it and the ileocolic....
, both branches of the SMA. While the ileocolic artery
Ileocolic artery
The ileocolic artery is the lowest branch arising from the concavity of the superior mesenteric artery.It passes downward and to the right behind the peritoneum toward the right iliac fossa, where it divides into a superior and an inferior branch; the inferior anastomoses with the end of the...
is almost always present, the right colic may be absent in 5–15% of individuals.
Transverse colon
The transverse colon is the part of the colon from the hepatic flexure to the splenic flexureSplenic flexure
The splenic flexure is a sharp bend between the transverse and the descending colon in the left upper quadrant of humans. The left colic flexure is near the spleen, and hence called the splenic flexure. There are two colic flexures in the transverse colon — the other being the hepatic...
(the turn of the colon by the spleen
Spleen
The spleen is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock...
). The transverse colon hangs off the stomach
Stomach
The stomach is a muscular, hollow, dilated part of the alimentary canal which functions as an important organ of the digestive tract in some animals, including vertebrates, echinoderms, insects , and molluscs. It is involved in the second phase of digestion, following mastication .The stomach is...
, attached to it by a wide band of tissue
Tissue (biology)
Tissue is a cellular organizational level intermediate between cells and a complete organism. A tissue is an ensemble of cells, not necessarily identical, but from the same origin, that together carry out a specific function. These are called tissues because of their identical functioning...
called the greater omentum. On the posterior side, the transverse colon is connected to the posterior abdominal wall by a mesentery
Mesentery
In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.-Mesentery :The...
known as the transverse mesocolon
Transverse mesocolon
The transverse mesocolon is a broad, meso-fold of peritoneum, which connects the transverse colon to the posterior wall of the abdomen.It is continuous with the two posterior layers of the greater omentum, which, after separating to surround the transverse colon, join behind it, and are continued...
.
The transverse colon is encased in peritoneum
Peritoneum
The peritoneum is the serous membrane that forms the lining of the abdominal cavity or the coelom — it covers most of the intra-abdominal organs — in amniotes and some invertebrates...
, and is therefore mobile (unlike the parts of the colon immediately before and after it). Cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
s form more frequently further along the large intestine
Large intestine
The large intestine is the third-to-last part of the digestive system — — in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass useless waste material from the body...
as the contents become more solid (water is removed) in order to form feces
Feces
Feces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
.
The proximal two-thirds of the transverse colon is perfused by the middle colic artery
Middle colic artery
The middle colic artery is a branch of the superior mesenteric artery that mostly supplies the transverse colon. It arises just below the pancreas, and, passing downward and forward between the layers of the transverse mesocolon, divides into two branches: right and left.* The right branch...
, a branch of SMA, while the latter third is supplied by branches of the IMA. The "watershed" area between these two blood supplies, which represents the embryologic division between the midgut
Midgut
The midgut is the portion of the embryo from which most of the intestines develop. After it bends around the superior mesenteric artery, it is called the "midgut loop"...
and hindgut
Hindgut
The hindgut is the posterior part of the alimentary canal. In mammals, it includes the distal third of the transverse colon and the splenic flexure, the descending colon, sigmoid colon and rectum.-Blood flow:...
, is an area sensitive to ischemia
Ischemia
In medicine, ischemia is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. It may also be spelled ischaemia or ischæmia...
.
Descending colon
The descending colon is the part of the colon from the splenic flexure to the beginning of the sigmoid colon. The function of the descending colon in the digestive system is to store food that will be emptied into the rectum. It is retroperitoneal in two-thirds of humans. In the other third, it has a (usually short) mesentery. The arterial supply comes via the left colic arteryLeft colic artery
The left colic artery is a branch of the inferior mesenteric artery that runs to the left behind the peritoneum and in front of the psoas major muscle, and after a short, but variable, course divides into an ascending and a descending branch; the stem of the artery or its branches cross the left...
.
Sigmoid colon
The sigmoid colon is the part of the large intestineLarge intestine
The large intestine is the third-to-last part of the digestive system — — in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass useless waste material from the body...
after the descending colon and before the rectum. The name sigmoid means S-shaped (see sigmoid). The walls of the sigmoid colon are muscular, and contract to increase the pressure inside the colon, causing the stool
Feces
Feces, faeces, or fæces is a waste product from an animal's digestive tract expelled through the anus or cloaca during defecation.-Etymology:...
to move into the rectum.
The sigmoid colon is supplied with blood from several branches (usually between 2 and 6) of the sigmoid arteries
Sigmoid arteries
The sigmoid arteries, two or three in number, run obliquely downward and to the left behind the peritoneum and in front of the Psoas major, ureter, and internal spermatic vessels....
, a branch of the IMA. The IMA terminates as the superior rectal artery
Superior rectal artery
The superior rectal artery is an artery that descends into the pelvis to supply blood to the rectum.-Structure:The superior rectal artery is the continuation of the inferior mesenteric artery...
.
Sigmoidoscopy
Sigmoidoscopy
Sigmoidoscopy From Greek Sigma - eidos - scopy, to look inside an s-like object, is the minimally invasive medical examination of the large intestine from the rectum through the last part of the colon. There are two types of sigmoidoscopy, flexible sigmoidoscopy, which uses a flexible endoscope,...
is a common diagnostic technique used to examine the sigmoid colon.
Redundant colon
One variation on the normal anatomy of the colon occurs when extra loops form, resulting in a longer than normal organ. This condition, referred to as redundant colon, typically has no direct major health consequences, though rarely volvulusVolvulus
A volvulus is a bowel obstruction with a loop of bowel whose nose has abnormally twisted on itself.-Types:* Volvulus Neonatorum.* Volvulus Small Intestine.* Volvulus Caecum.* Volvulus Sigmoid Colon .* Gastric volvulus....
occurs resulting in obstruction and requiring immediate medical attention. A significant indirect health consequence is that use of a standard adult colonoscope is difficult and in some cases impossible when a redundant colon is present, though specialized variants on the instrument (including the pediatric variant) are useful in overcoming this problem.
Standing gradient osmosis
Water absorption at the colon typically proceeds against a transmucosal osmotic pressureOsmotic pressure
Osmotic pressure is the pressure which needs to be applied to a solution to prevent the inward flow of water across a semipermeable membrane....
gradient. The standing gradient osmosis is a term used to describe the reabsorption of water against the osmotic gradient in the intestines. This hypertonic
Tonicity
Tonicity is a measure of the osmotic pressure gradient of two solutions separated by a semipermeable membrane. It is commonly used when describing the response of cells immersed in an external solution...
fluid creates an osmotic pressure that drives water into the lateral intercellular spaces by osmosis via tight junction
Tight junction
Tight junctions, or zonula occludens, are the closely associated areas of two cells whose membranes join together forming a virtually impermeable barrier to fluid. It is a type of junctional complex present only in vertebrates...
s and adjacent cells, which then in turn moves across the basement membrane
Basal lamina
The basal lamina is a layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits. It is often confused with the basement membrane, and sometimes used inconsistently in the literature, see below....
and into the capillaries
Capillary
Capillaries are the smallest of a body's blood vessels and are parts of the microcirculation. They are only 1 cell thick. These microvessels, measuring 5-10 μm in diameter, connect arterioles and venules, and enable the exchange of water, oxygen, carbon dioxide, and many other nutrient and waste...
.
Function
There are differences in the large intestine between different organismOrganism
In biology, an organism is any contiguous living system . In at least some form, all organisms are capable of response to stimuli, reproduction, growth and development, and maintenance of homoeostasis as a stable whole.An organism may either be unicellular or, as in the case of humans, comprise...
s. The large intestine is mainly responsible for storing waste, reclaiming water, maintaining the water balance
Water balance
In hydrology, a water balance equation can be used to describe the flow of water in and out of a system. A system can be one of several hydrological domains, such as a column of soil or a drainage basin....
, absorbing some vitamin
Vitamin
A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. In other words, an organic chemical compound is called a vitamin when it cannot be synthesized in sufficient quantities by an organism, and must be obtained from the diet. Thus, the term is conditional both on...
s, such as vitamin K
Vitamin K
Vitamin K is a group of structurally similar, fat soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone derivatives...
, and providing a location for flora-aided fermentation.
By the time the chyme
Chyme
Chyme is the semifluid mass of partly digested food expelled by the stomach into the duodenum.Also known as chymus, it is the liquid substance found in the stomach before passing through the pyloric valve and entering the duodenum...
has reached this tube, most nutrient
Nutrient
A nutrient is a chemical that an organism needs to live and grow or a substance used in an organism's metabolism which must be taken in from its environment. They are used to build and repair tissues, regulate body processes and are converted to and used as energy...
s and 90% of the water have been absorbed by the body. At this point some electrolyte
Electrolyte
In chemistry, an electrolyte is any substance containing free ions that make the substance electrically conductive. The most typical electrolyte is an ionic solution, but molten electrolytes and solid electrolytes are also possible....
s like sodium
Sodium
Sodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...
, magnesium
Magnesium
Magnesium is a chemical element with the symbol Mg, atomic number 12, and common oxidation number +2. It is an alkaline earth metal and the eighth most abundant element in the Earth's crust and ninth in the known universe as a whole...
, and chloride
Chloride
The chloride ion is formed when the element chlorine, a halogen, picks up one electron to form an anion Cl−. The salts of hydrochloric acid HCl contain chloride ions and can also be called chlorides. The chloride ion, and its salts such as sodium chloride, are very soluble in water...
are left as well as indigestible parts of ingested food (e.g., a large part of ingested amylose
Amylose
Amylose is a linear polymer made up of D-glucose units.This polysaccharide is one of the two components of starch, making up approximately 2-30% of the structure...
, protein which has been shielded from digestion heretofore, and dietary fiber
Dietary fiber
Dietary fiber, dietary fibre, or sometimes roughage is the indigestible portion of plant foods having two main components:* soluble fiber that is readily fermented in the colon into gases and physiologically active byproducts, and* insoluble fiber that is metabolically inert, absorbing water as it...
, which is largely indigestible carbohydrate
Carbohydrate
A carbohydrate is an organic compound with the empirical formula ; that is, consists only of carbon, hydrogen, and oxygen, with a hydrogen:oxygen atom ratio of 2:1 . However, there are exceptions to this. One common example would be deoxyribose, a component of DNA, which has the empirical...
in either soluble or insoluble form). As the chyme moves through the large intestine
Large intestine
The large intestine is the third-to-last part of the digestive system — — in vertebrate animals. Its function is to absorb water from the remaining indigestible food matter, and then to pass useless waste material from the body...
, most of the remaining water
Water
Water is a chemical substance with the chemical formula H2O. A water molecule contains one oxygen and two hydrogen atoms connected by covalent bonds. Water is a liquid at ambient conditions, but it often co-exists on Earth with its solid state, ice, and gaseous state . Water also exists in a...
is removed, while the chyme is mixed with mucus
Mucus
In vertebrates, mucus is a slippery secretion produced by, and covering, mucous membranes. Mucous fluid is typically produced from mucous cells found in mucous glands. Mucous cells secrete products that are rich in glycoproteins and water. Mucous fluid may also originate from mixed glands, which...
and bacteria
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...
(known as gut flora
Gut flora
Gut flora consists of microorganisms that live in the digestive tracts of animals and is the largest reservoir of human flora. In this context, gut is synonymous with intestinal, and flora with microbiota and microflora....
), and becomes feces. The ascending colon
Ascending colon
The ascending colon is smaller in caliber than the cecum.It passes upward, from its commencement at the cecum, opposite the colic valve, to the under surface of the right lobe of the liver, on the right of the gall-bladder, where it is lodged in a shallow depression, the colic impression; here it...
receives fecal material as a liquid. The muscles of the colon then move the watery waste material forward and slowly absorb all the excess water. The stools get to become semi solid as they move along into the descending colon
Descending colon
The descending colon of humans passes downward through the left hypochondrium and lumbar regions, along the lateral border of the left kidney....
The bacteria break down some of the fiber
Fiber
Fiber is a class of materials that are continuous filaments or are in discrete elongated pieces, similar to lengths of thread.They are very important in the biology of both plants and animals, for holding tissues together....
for their own nourishment and create acetate
Acetate
An acetate is a derivative of acetic acid. This term includes salts and esters, as well as the anion found in solution. Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In...
, propionate
Propionate
The propanoate or propionate ion is C2H5COO− .A propanoic or propionic compound is a salt or ester of propanoic acid....
, and butyrate
Butyrate
Butyrate is the traditional name for the conjugate base of butanoic acid . The formula of the butanoate ion is C4H7O2-. The archaic name is used as part of the name of butyrates or butanoates, or esters and salts of butyric acid, a short chain fatty acid...
as waste products, which in turn are used by the cell lining of the colon for nourishment. No protein is made available. In humans, perhaps 10% of the undigested carbohydrate thus becomes available; in other animals, including other apes and primates, who have proportionally larger colons, more is made available, thus permitting a higher portion of plant material in the diet. This is an example of a symbiotic relationship and provides about one hundred calorie
Calorie
The calorie is a pre-SI metric unit of energy. It was first defined by Nicolas Clément in 1824 as a unit of heat, entering French and English dictionaries between 1841 and 1867. In most fields its use is archaic, having been replaced by the SI unit of energy, the joule...
s a day to the body. The large intestine produces no digestive enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
s -— chemical digestion is completed in the small intestine
Small intestine
The small intestine is the part of the gastrointestinal tract following the stomach and followed by the large intestine, and is where much of the digestion and absorption of food takes place. In invertebrates such as worms, the terms "gastrointestinal tract" and "large intestine" are often used to...
before the chyme reaches the large intestine. The pH
PH
In chemistry, pH is a measure of the acidity or basicity of an aqueous solution. Pure water is said to be neutral, with a pH close to 7.0 at . Solutions with a pH less than 7 are said to be acidic and solutions with a pH greater than 7 are basic or alkaline...
in the colon varies between 5.5 and 7 (slightly acid
Acid
An acid is a substance which reacts with a base. Commonly, acids can be identified as tasting sour, reacting with metals such as calcium, and bases like sodium carbonate. Aqueous acids have a pH of less than 7, where an acid of lower pH is typically stronger, and turn blue litmus paper red...
ic to neutral).
Pathology
Following are the most common diseases or disorders of the colon:- AngiodysplasiaAngiodysplasiaIn medicine , angiodysplasia is a small vascular malformation of the gut. It is a common cause of otherwise unexplained gastrointestinal bleeding and anemia. Lesions are often multiple, and frequently involve the cecum or ascending colon, although they can occur at other places...
of the colon - AppendicitisAppendicitisAppendicitis is a condition characterized by inflammation of the appendix. It is classified as a medical emergency and many cases require removal of the inflamed appendix, either by laparotomy or laparoscopy. Untreated, mortality is high, mainly because of the risk of rupture leading to...
- Chronic functional abdominal painChronic functional abdominal painChronic functional abdominal pain is the ongoing presence of abdominal pain for which there is no known medical explanation. It is quite similar to, but less common than, irritable bowel syndrome , and many of the same treatments for IBS can also be of benefit to those with CFAP...
NF - ColitisColitisIn medicine, colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine .Colitides may be acute and self-limited or chronic, i.e...
- Colorectal cancerColorectal cancerColorectal cancer, commonly known as bowel cancer, is a cancer caused by uncontrolled cell growth , in the colon, rectum, or vermiform appendix. Colorectal cancer is clinically distinct from anal cancer, which affects the anus....
- ConstipationConstipationConstipation refers to bowel movements that are infrequent or hard to pass. Constipation is a common cause of painful defecation...
- Crohn's diseaseCrohn's diseaseCrohn's disease, also known as regional enteritis, is a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms...
- DiarrheaDiarrheaDiarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...
- DiverticulitisDiverticulitisDiverticulitis is a common digestive disease particularly found in the large intestine. Diverticulitis develops from diverticulosis, which involves the formation of pouches on the outside of the colon...
NF - DiverticulosisDiverticulosisDiverticulosis also known as "diverticular disease" is the condition of having diverticula in the colon, which are outpocketings of the colonic mucosa and submucosa through weaknesses of muscle layers in the colon wall. These are more common in the sigmoid colon, which is a common place for...
- Hirschsprung's diseaseHirschsprung's diseaseHirschsprung's disease , or congenital aganglionic megacolon is a serious medical problem where the enteric nervous system is missing from the end of the bowel. The enteric nervous system is a complex network of neurons and glia that controls most aspects of intestinal function...
(aganglionosis) - IleusIleusIleus is a disruption of the normal propulsive ability of the gastrointestinal tract.Ileus is commonly defined simply as bowel obstruction. However, authoritative sources define it as decreased motor activity of the GI tract due to non-mechanical causes...
- IntussusceptionIntussusception (medical disorder)An intussusception is a medical condition in which a part of the intestine has invaginated into another section of intestine, similar to the way in which the parts of a collapsible telescope slide into one another. This can often result in an obstruction...
- Irritable bowel syndromeIrritable bowel syndromeIrritable bowel syndrome is a diagnosis of exclusion. It is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. In some cases, the symptoms are relieved by bowel movements...
- Polyp (medicine)Polyp (medicine)A polyp is an abnormal growth of tissue projecting from a mucous membrane. If it is attached to the surface by a narrow elongated stalk, it is said to be pedunculated. If no stalk is present, it is said to be sessile. Polyps are commonly found in the colon, stomach, nose, sinus, urinary bladder...
(see also Colorectal polypColorectal polypA colorectal polyp is a polyp occurring on the lining of the colon or rectum. Untreated colorectal polyps can develop into colorectal cancer....
) - Pseudomembranous colitisPseudomembranous colitisPseudomembranous colitis, a cause of antibiotic-associated diarrhea , is an infection of the colon. It is often, but not always, caused by the bacterium Clostridium difficile. Because of this, the informal name C. difficile colitis is also commonly used. The illness is characterized by...
- Ulcerative colitisUlcerative colitisUlcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the colon , that includes characteristic ulcers, or open sores. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset...
and toxic megacolonToxic megacolonToxic megacolon is an acute form of colonic distension. It is characterized by a very dilated colon , accompanied by abdominal distension , and sometimes fever, abdominal pain, or shock....
External links
- Overview and diagrams at seer.cancer.gov - "Abdominal Cavity: The Colon and its Divisions"
- Video: What is Colorectal Cancer? NONE
Good line)