Clerodendrum infortunatum - AbsoluteAstronomy.com

Clerodendrum infortunatum (common name hill glory bower; synonyms Clerodendrum viscosum Vent. and Volkameria infortunata Roxb.) is a perennial shrub

Shrub

A shrub or bush is distinguished from a tree by its multiple stems and shorter height, usually under 5–6 m tall. A large number of plants may become either shrubs or trees, depending on the growing conditions they experience...

belonging to the family

Family

In human context, a family is a group of people affiliated by consanguinity, affinity, or co-residence. In most societies it is the principal institution for the socialization of children...

Lamiaceae

The mints, taxonomically known as Lamiaceae or Labiatae, are a family of flowering plants. They have traditionally been considered closely related to Verbenaceae, but in the 1990s, phylogenetic studies suggested that many genera classified in Verbenaceae belong instead in Lamiaceae...

, also sometimes classified under Verbenaceae

Verbenaceae

Verbenaceae, commonly known as the verbena family or vervain family, is a family of mainly tropical flowering plants. It contains trees, shrubs and herbs notable for heads, spikes, or clusters of small flowers, many of which have an aromatic smell.Recent phylogenetic studies have shown that...

. It is the type species

Type species

In biological nomenclature, a type species is both a concept and a practical system which is used in the classification and nomenclature of animals and plants. The value of a "type species" lies in the fact that it makes clear what is meant by a particular genus name. A type species is the species...

among ~400 species

Species

In biology, a species is one of the basic units of biological classification and a taxonomic rank. A species is often defined as a group of organisms capable of interbreeding and producing fertile offspring. While in many cases this definition is adequate, more precise or differing measures are...

of Clerodendrum. It is one of the most well-known natural health remedies in traditional practices and siddha medicine

Siddha medicine

The Siddha medicine is one of the oldest medical systems known to mankind. This system of medicine originated from south Indian Tamil traditional medicine, as part of the trio Indian medicines - ayurveda, siddha and unani. This system was very popular in ancient India...

.

The species is native to tropical regions of Asia

Asia

Asia is the world's largest and most populous continent, located primarily in the eastern and northern hemispheres. It covers 8.7% of the Earth's total surface area and with approximately 3.879 billion people, it hosts 60% of the world's current human population...

including India

India

India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

, Myanmar

Myanmar

Burma , officially the Republic of the Union of Myanmar , is a country in Southeast Asia. Burma is bordered by China on the northeast, Laos on the east, Thailand on the southeast, Bangladesh on the west, India on the northwest, the Bay of Bengal to the southwest, and the Andaman Sea on the south....

, Pakistan

Pakistan

Pakistan , officially the Islamic Republic of Pakistan is a sovereign state in South Asia. It has a coastline along the Arabian Sea and the Gulf of Oman in the south and is bordered by Afghanistan and Iran in the west, India in the east and China in the far northeast. In the north, Tajikistan...

, Thailand

Thailand

Thailand , officially the Kingdom of Thailand , formerly known as Siam , is a country located at the centre of the Indochina peninsula and Southeast Asia. It is bordered to the north by Burma and Laos, to the east by Laos and Cambodia, to the south by the Gulf of Thailand and Malaysia, and to the...

and Sri Lanka

Sri Lanka

Sri Lanka, officially the Democratic Socialist Republic of Sri Lanka is a country off the southern coast of the Indian subcontinent. Known until 1972 as Ceylon , Sri Lanka is an island surrounded by the Indian Ocean, the Gulf of Mannar and the Palk Strait, and lies in the vicinity of India and the...

Description

C. infortunatum is a flowering shrub

Shrub

or small tree

Tree

A tree is a perennial woody plant. It is most often defined as a woody plant that has many secondary branches supported clear of the ground on a single main stem or trunk with clear apical dominance. A minimum height specification at maturity is cited by some authors, varying from 3 m to...

, and is so named because of its rather ugly leaf. The stem is eresct, 0.5–4 m high, with no branches and produce circular leaves with 6 inch diameter. Leaves are simple, opposite; both surfaces sparsely villous-pubes-cent, elliptic, broadly elliptic, ovate or elongate ovate, 3.5–20 cm wide, 6–25 cm long, dentate, inflorescence

Inflorescence

An inflorescence is a group or cluster of flowers arranged on a stem that is composed of a main branch or a complicated arrangement of branches. Strictly, it is the part of the shoot of seed plants where flowers are formed and which is accordingly modified...

in terminal, peduncled, few-flowered cyme; flowers white with purplish pink or dull-purple throat, pubescent. Fruit berry

Berry

The botanical definition of a berry is a fleshy fruit produced from a single ovary. Grapes are an example. The berry is the most common type of fleshy fruit in which the entire ovary wall ripens into an edible pericarp. They may have one or more carpels with a thin covering and fleshy interiors....

, globose, turned bluish-black or black when ripe, enclosed in the red accrescent fruiting-calyx. The stem is hollow and the leaves are 6-8 inch (15–20 cm) long, borne in whorls of four on very short petioles

Petiole (botany)

In botany, the petiole is the stalk attaching the leaf blade to the stem. The petiole usually has the same internal structure as the stem. Outgrowths appearing on each side of the petiole are called stipules. Leaves lacking a petiole are called sessile, or clasping when they partly surround the...

. The inflorescence is huge, consisting of many tubular snow white flowers in a terminal cluster up to 2 ft (0.6 m) long. The tubes of the flowers are about 4 inch (10 cm) long and droop downward, and the expanded corollas are about 2 inch (5 cm) across. The fruits are attractive dark metallic blue drupe

Drupe

In botany, a drupe is a fruit in which an outer fleshy part surrounds a shell of hardened endocarp with a seed inside. These fruits develop from a single carpel, and mostly from flowers with superior ovaries...

s, about a half inch in diameter. Fruit usually with 4 dry nutlets and the seeds may be with or without endosperm

Endosperm

Endosperm is the tissue produced inside the seeds of most flowering plants around the time of fertilization. It surrounds the embryo and provides nutrition in the form of starch, though it can also contain oils and protein. This makes endosperm an important source of nutrition in human diet...

. It flowers from April to August.

Chemical constituents

The major compounds are sterols, sugars, flavonoids and saponins. Novel crystalline compounds such as clerodolone, clerodone, clerodol and a sterol designated clerosterol have been isolated from the root. Seven sugars namely raffinose

Raffinose

Raffinose is a trisaccharide composed of galactose, fructose, and glucose. It can be found in beans, cabbage, brussels sprouts, broccoli, asparagus, other vegetables, and whole grains. Raffinose can be hydrolyzed to D-galactose and sucrose by the enzyme α-galactosidase , an enzyme not found in the...

, lactose

Lactose

Lactose is a disaccharide sugar that is found most notably in milk and is formed from galactose and glucose. Lactose makes up around 2~8% of milk , although the amount varies among species and individuals. It is extracted from sweet or sour whey. The name comes from or , the Latin word for milk,...

, maltose

Maltose

Maltose , or malt sugar, is a disaccharide formed from two units of glucose joined with an αbond, formed from a condensation reaction. The isomer "isomaltose" has two glucose molecules linked through an α bond. Maltose is the second member of an important biochemical series of glucose chains....

, sucrose

Sucrose

Sucrose is the organic compound commonly known as table sugar and sometimes called saccharose. A white, odorless, crystalline powder with a sweet taste, it is best known for its role in human nutrition. The molecule is a disaccharide composed of glucose and fructose with the molecular formula...

, galactose

Galactose

Galactose , sometimes abbreviated Gal, is a type of sugar that is less sweet than glucose. It is a C-4 epimer of glucose....

, glucose

Glucose

Glucose is a simple sugar and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate...

and fructose

Fructose

Fructose, or fruit sugar, is a simple monosaccharide found in many plants. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion. Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847...

were identified. Fumaric acid

Fumaric acid

Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO2CCH=CHCO2H. This white crystalline compound is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid. In fumaric acid the carboxylic acid groups are trans and in maleic acid they are cis...

, caffeic acid

Caffeic acid

Caffeic acid is a hydroxycinnamic acid, a naturally occurring organic compound. This yellow solid consists of both phenolic and acrylic functional groups...

esters, β-sitosterol

Beta-sitosterol

β-Sitosterol is one of several phytosterols with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a characteristic odor...

and β-sitosterol glucoside were isolated from the flowers. Apigenin

Apigenin

Apigenin is a flavone that is the aglycone of several glycosides. It is a yellow crystalline solid that has been used to dye wool. Apigenin may contribute to the chemopreventive action of vegetables and fruits...

, acacetin

Acacetin

Acacetin is an O-methylated flavone found in Robinia pseudoacacia and Turnera diffusa .The enzyme apigenin 4'-O-methyltransferase uses S-adenosyl methionine and 5,7,4'-trihydroxyflavone to produce S-adenosylhomocysteine and 4'-methoxy-5,7-dihydroxyflavone ....

and a new flavone glycoside, characterised as the methyl ester of acacetin-7-0-glucuronide are isolated from the flowers. Saponin is one of the major compounds of the leaf. 24 beta-ethylsterols, clerosterol and 22-dehydroclerosterol, 24-methyl-sterols (24-methylcholestanol, 24-methylcholesterol, 24-methyl-22-dehydrocholesterol, and 24-methyllathostero) and 24 beta-ethyl-22-dehydrocholestanol are found in the seeds. Scutellarin

Scutellarin

Scutellarin is a chemical compound that can be found in Scutellaria barbata and S. lateriflora. The determination of the structure of scutellarin took Guido Goldschmiedt many years: after the first publication on that topic in 1901, only in 1910 he managed to obtain enough starting material for...

and hispidulin-7-O-glucuronide are present in the leaf. Poriferasterol and stigmasterol

Stigmasterol

Stigmasterol is one of a group of plant sterols, or phytosterols, that include beta-sitosterol, campesterol, ergosterol , brassicasterol, delta-7-stigmasterol and delta-7-avenasterol, that are chemically similar to animal cholesterol...

are the components of the aerial parts.

Ayurvedic and Siddha Medicines

The leaves and roots of C. infortunatum are used as herbal remedy for alopecia

Alopecia

Alopecia means loss of hair from the head or body. Alopecia can mean baldness, a term generally reserved for pattern alopecia or androgenic alopecia. Compulsive pulling of hair can also produce hair loss. Hairstyling routines such as tight ponytails or braids may induce Traction alopecia. Both...

, asthma

Asthma

Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath...

, cough

Cough

A cough is a sudden and often repetitively occurring reflex which helps to clear the large breathing passages from secretions, irritants, foreign particles and microbes...

, diarrhoea, rheumatism

Rheumatism

Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and connective tissue. The study of, and therapeutic interventions in, such disorders is called rheumatology.-Terminology:...

, fever

Fever

Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...

and skin diseases. It is also known to have hepato-protective

Hepatoprotection

Hepatoprotection or antihepatotoxicity is the ability to prevent damage to the liver.An example of a hepatoprotective medicine is silibinin, derived from Milk Thistle, which selectively inhibits leukotriene formation by Kupffer cells....

and antimicrobial

Antimicrobial

An anti-microbial is a substance that kills or inhibits the growth of microorganisms such as bacteria, fungi, or protozoans. Antimicrobial drugs either kill microbes or prevent the growth of microbes...

activities. The roots and bark of stem of this plant prepared as decoction and given in the dose of 60-80 ml twice daily for respiratory diseases, fever, periodic fever, cough, bronchial asthma, etc. The leaves are ground well and applied externally to induce ripenning of ulcers and swellings. A paste of leaves and roots are applied externally over skin diseases especially fungal infections and alopecia. Fresh leaves are given for diarrhoea, liver

Liver

The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...

disorders and headache

Headache

A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions of the head and neck. The brain tissue itself is not sensitive to pain because it lacks pain receptors. Rather, the pain is caused by disturbance of the...

Traditional Practices

The leaf and root are widely used as antidandruff

Dandruff

Dandruff is the shedding of dead skin cells from the scalp . Dandruff is sometimes caused by frequent exposure to extreme heat and cold. As it is normal for skin cells to die and flake off, a small amount of flaking is normal and common; about 487,000 cells/cm2 get released normally after...

, antipyretic

Antipyretic

Antipyretics ; an-tee-pahy-ret-iks; from the Greek anti, against, and pyreticus, are drugs or herbs that reduce fever. Normally, they will not lower body temperature if one does not have a fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature...

, ascaricide

Ascaricide

Ascaricides are drugs to treat ascariasis that is caused by infections with parasitic nematodes of the genus Ascaris...

, laxative

Laxative

Laxatives are foods, compounds, or drugs taken to induce bowel movements or to loosen the stool, most often taken to treat constipation. Certain stimulant, lubricant, and saline laxatives are used to evacuate the colon for rectal and/or bowel examinations, and may be supplemented by enemas under...

, vermifuge, and in treatments of convulsion

Convulsion

A convulsion is a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body. Because a convulsion is often a symptom of an epileptic seizure, the term convulsion is sometimes used as a synonym for seizure...

, diabetes, gravel, malaria

Malaria

Malaria is a mosquito-borne infectious disease of humans and other animals caused by eukaryotic protists of the genus Plasmodium. The disease results from the multiplication of Plasmodium parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases...

, scabies

Scabies

Scabies , known colloquially as the seven-year itch, is a contagious skin infection that occurs among humans and other animals. It is caused by a tiny and usually not directly visible parasite, the mite Sarcoptes scabiei, which burrows under the host's skin, causing intense allergic itching...

, skin diseases, sore

Sore

Sore may refer to:* A mild pain or ache* A small skin ulcer, usually open from skin infection* A slang term for angry* Sore , an Indonesian rock band* Sore, Landes, a village in the Landes département of France* Sore , by Buzzov*en...

, spasm

Spasm

In medicine a spasm is a sudden, involuntary contraction of a muscle, a group of muscles, or a hollow organ, or a similarly sudden contraction of an orifice. It is sometimes accompanied by a sudden burst of pain, but is usually harmless and ceases after a few minutes...

, scorpion sting

Scorpion sting

Scorpion stings are a cutaneous condition caused by the stinging of scorpions, usually resulting in pain, paresthesia, and variable swelling. The anatomical part of the scorpion that delivers the sting is called a "telson".- See also :* Scorpion venom...

, snake bite and tumor

Tumor

A tumor or tumour is commonly used as a synonym for a neoplasm that appears enlarged in size. Tumor is not synonymous with cancer...

. In Thai

Thai people

The Thai people, or Siamese, are the main ethnic group of Thailand and are part of the larger Tai ethnolinguistic peoples found in Thailand and adjacent countries in Southeast Asia as well as southern China. Their language is the Thai language, which is classified as part of the Kradai family of...

medicine the leaves and root are known to be diuretic

Diuretic

A diuretic provides a means of forced diuresis which elevates the rate of urination. There are several categories of diuretics. All diuretics increase the excretion of water from bodies, although each class does so in a distinct way.- Medical uses :...

; and used for treatment of intestinal infections and kidney

Kidney

The kidneys, organs with several functions, serve essential regulatory roles in most animals, including vertebrates and some invertebrates. They are essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acid–base balance, and...

disfunction; when boiled or ground with water, it is take to increase milk secretion

Lactation

Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process occurs in all female mammals, however it predates mammals. In humans the process of feeding milk is called breastfeeding or nursing...

for post-labor. In many traditional practices the leaves and root are widely used as antihyperglycemic.

Scientific Evidences

The ethanolic extracts is shown to have significant anti-microbial activity comparable to the standard drug tetracycline. The antioxidant

Antioxidant

An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When...

and its protective effects against CCl4 induced oxidative stress

Oxidative stress

Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage...

in rats

RATS

RATS may refer to:* RATS , Regression Analysis of Time Series, a statistical package* Rough Auditing Tool for Security, a computer program...

were significantly high. It reportedly decreased the duration of seizures and gave protection in a dose-dependent manner against leptazol-induced convulsions. Methanolic extract caused significant reduction of fatty degeneration and liver necrosis, thus, indicating moderate hepatoprotective activity. The methanol extract of the leaves was demonstrated to reduce blood sugar

Blood sugar

The blood sugar concentration or blood glucose level is the amount of glucose present in the blood of a human or animal. Normally in mammals, the body maintains the blood glucose level at a reference range between about 3.6 and 5.8 mM , or 64.8 and 104.4 mg/dL...

level in streptozotocin

Streptozotocin

Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals...

-induced diabetes in Wistar rats.

External links

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