Centre for Magnetic Resonance Investigations
Encyclopedia
The Kingston Upon Hull Centre for Magnetic Resonance Investigations (CMRI), which opened in 1992, is a magnetic resonance imaging
centre located in the city
of Kingston upon Hull
(Hull) in the East Riding of Yorkshire
, England
, UK. It is situated in the grounds of the Hull Royal Infirmary
hospital in the centre of the city.
The centre carries out both cancer
research studies, under the auspices of the University of Hull
, and clinic
al scanning, under the auspices of the local NHS
trust, Hull and East Yorkshire Hospitals
.
The centre currently has three MRI scanners; two 1.5 tesla
scanners owned by the NHS (a Philips
Intera and a GE
Signa) and a state-of-the art 3.0 tesla MR 750 GE Signa scanner owned by the University which was installed in January 2009 (one of the first 3.0 tesla whole-body capable systems in Europe
).
The front entrance to the Kingston upon Hull Centre for Magnetic Resonance Investigations.
The three MRI scanners at the centre; (from left to right) a 1.5 tesla GE Signa, a 1.5 tesla Philips Intera and a 3.0 tesla GE Signa.
, Anlaby Road, Hull
, HU3 2JZ, UK.
T: +44 1482 674080
F: +44 1482 320137
E: a.randerson "at" hull.ac.uk
Lindsay W. Turnbull, and is devoted to the application of magnetic resonance imaging
and magnetic resonance spectroscopy
techniques to the study of cancer
.
Current research projects include investigations of cancer
of the breast
, prostate
and cervix
. Previous studies have involved investigations of cancer of the brain
.
MRI techniques employed include dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted MRI
, functional MRI
(fMRI, brain activation mapping), image textural analysis, proton
spectoscopy
and phosphorus
spectoscopy
.
Yorkshire Cancer Research.
Age, gender, and skeletal variation in bone marrow composition: A preliminary study at 3.0 Tesla.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 26 (3): 787-793 SEP 2007
2. Bernard, CP; Liney, GP; Manton, DJ; et al.
Bone marrow quantification using 3.0 tesla magnetic resonance imaging.
JOURNAL OF BONE AND MINERAL RESEARCH, 22 (7): 1140-1140 JUL 2007
3. Sreenivas, A; Lowry, M; Gibbs, P; et al.
A simple solution for reducing artefacts due to conductive and dielectric effects in clinical magnetic resonance imaging at 3 T.
EUROPEAN JOURNAL OF RADIOLOGY, 62 (1): 143-146 APR 2007
4. Pickles, MD; Gibbs, P; Lowry, M; et al.
Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer.
MAGNETIC RESONANCE IMAGING, 24 (7): 843-847 SEP 2006
5. Liney, GP; Sreenivas, M; Gibbs, P; et al.
Breast lesion analysis of shape technique: Semiautomated vs. manual morphological description.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (4): 493-498 APR 2006
6. Kneeshaw, PJ; Lowry, M; Manton, D; et al.
Differentiation of benign from malignant breast disease associated with screening detected microcalcifications using dynamic contrast enhanced magnetic resonance imaging.
BREAST, 15 (1): 29-38 FEB 2006
7. Pickles, MD; Gibbs, P; Sreenivas, M; et al.
Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0 T.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (2): 130-134 FEB 2006
8. Gibbs, P; Pickles, MD; Turnbull, LW
Diffusion imaging of the prostate at 3.0 tesla.
INVESTIGATIVE RADIOLOGY, 41 (2): 185-188 FEB 2006
9. Manton, DJ; Chaturvedi, A; Hubbard, A; et al.
Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy.
BRITISH JOURNAL OF CANCER, 94 (3): 427-435 FEB 13 2006
10. Manton, DJ; Chaturvedi, A; Hubbard, A; et al.
Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy. (vol 94, pg 1554, 2006)
BRITISH JOURNAL OF CANCER, 94 (10): 1554-1554 MAY 22 2006
11. Pickles, MD; Lowry, M; Manton, DJ; et al.
Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy.
BREAST CANCER RESEARCH AND TREATMENT, 91 (1): 1-10 MAY 2005
12. Balan, P; Turnbull, LW
Dynamic contrast enhanced magnetic resonance imaging and magnetic resonance spectroscopy in diabetic mastopathy.
BREAST, 14 (1): 68-70 FEB 2005
Magnetic resonance imaging
Magnetic resonance imaging , nuclear magnetic resonance imaging , or magnetic resonance tomography is a medical imaging technique used in radiology to visualize detailed internal structures...
centre located in the city
City
A city is a relatively large and permanent settlement. Although there is no agreement on how a city is distinguished from a town within general English language meanings, many cities have a particular administrative, legal, or historical status based on local law.For example, in the U.S...
of Kingston upon Hull
Kingston upon Hull
Kingston upon Hull , usually referred to as Hull, is a city and unitary authority area in the ceremonial county of the East Riding of Yorkshire, England. It stands on the River Hull at its junction with the Humber estuary, 25 miles inland from the North Sea. Hull has a resident population of...
(Hull) in the East Riding of Yorkshire
East Riding of Yorkshire
The East Riding of Yorkshire, or simply East Yorkshire, is a local government district with unitary authority status, and a ceremonial county of England. For ceremonial purposes the county also includes the city of Kingston upon Hull, which is a separate unitary authority...
, England
England
England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west; the Irish Sea is to the north west, the Celtic Sea to the south west, with the North Sea to the east and the English Channel to the south separating it from continental...
, UK. It is situated in the grounds of the Hull Royal Infirmary
Hull Royal Infirmary
Hull Royal Infirmary is one of the two main hospitals for Kingston upon Hull . It is situated on Anlaby Road, just outside of the city centre, and is run by Hull and East Yorkshire Hospitals NHS Trust....
hospital in the centre of the city.
The centre carries out both cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
research studies, under the auspices of the University of Hull
University of Hull
The University of Hull, known informally as Hull University, is an English university, founded in 1927, located in Hull, a city in the East Riding of Yorkshire...
, and clinic
Clinic
A clinic is a health care facility that is primarily devoted to the care of outpatients...
al scanning, under the auspices of the local NHS
National Health Service (England)
The National Health Service or NHS is the publicly funded healthcare system in England. It is both the largest and oldest single-payer healthcare system in the world. It is able to function in the way that it does because it is primarily funded through the general taxation system, similar to how...
trust, Hull and East Yorkshire Hospitals
Hull and East Yorkshire Hospitals NHS Trust
The Hull and East Yorkshire Hospitals NHS Trust operates in the city of Hull and the East Riding of Yorkshire, England.It is based on three sites the Trust is one of the largest in England and provides acute care for a local population of 600,000 and over 1.2 million people for our tertiary...
.
The centre currently has three MRI scanners; two 1.5 tesla
Tesla (unit)
The tesla is the SI derived unit of magnetic field B . One tesla is equal to one weber per square meter, and it was defined in 1960 in honour of the inventor, physicist, and electrical engineer Nikola Tesla...
scanners owned by the NHS (a Philips
Philips
Koninklijke Philips Electronics N.V. , more commonly known as Philips, is a multinational Dutch electronics company....
Intera and a GE
General Electric
General Electric Company , or GE, is an American multinational conglomerate corporation incorporated in Schenectady, New York and headquartered in Fairfield, Connecticut, United States...
Signa) and a state-of-the art 3.0 tesla MR 750 GE Signa scanner owned by the University which was installed in January 2009 (one of the first 3.0 tesla whole-body capable systems in Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...
).
The front entrance to the Kingston upon Hull Centre for Magnetic Resonance Investigations.
The three MRI scanners at the centre; (from left to right) a 1.5 tesla GE Signa, a 1.5 tesla Philips Intera and a 3.0 tesla GE Signa.
Contact details
MRI Centre, Hull Royal InfirmaryHull Royal Infirmary
Hull Royal Infirmary is one of the two main hospitals for Kingston upon Hull . It is situated on Anlaby Road, just outside of the city centre, and is run by Hull and East Yorkshire Hospitals NHS Trust....
, Anlaby Road, Hull
Kingston upon Hull
Kingston upon Hull , usually referred to as Hull, is a city and unitary authority area in the ceremonial county of the East Riding of Yorkshire, England. It stands on the River Hull at its junction with the Humber estuary, 25 miles inland from the North Sea. Hull has a resident population of...
, HU3 2JZ, UK.
T: +44 1482 674080
F: +44 1482 320137
E: a.randerson "at" hull.ac.uk
Research activities
The medical research is carried out under the Directorship of ProfessorProfessor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
Lindsay W. Turnbull, and is devoted to the application of magnetic resonance imaging
Magnetic resonance imaging
Magnetic resonance imaging , nuclear magnetic resonance imaging , or magnetic resonance tomography is a medical imaging technique used in radiology to visualize detailed internal structures...
and magnetic resonance spectroscopy
In vivo magnetic resonance spectroscopy
In vivo magnetic resonance spectroscopy is a specialised technique associated to magnetic resonance imaging ....
techniques to the study of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
.
Current research projects include investigations of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
of the breast
Breast
The breast is the upper ventral region of the torso of a primate, in left and right sides, which in a female contains the mammary gland that secretes milk used to feed infants.Both men and women develop breasts from the same embryological tissues...
, prostate
Prostate
The prostate is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals....
and cervix
Cervix
The cervix is the lower, narrow portion of the uterus where it joins with the top end of the vagina. It is cylindrical or conical in shape and protrudes through the upper anterior vaginal wall...
. Previous studies have involved investigations of cancer of the brain
Brain
The brain is the center of the nervous system in all vertebrate and most invertebrate animals—only a few primitive invertebrates such as sponges, jellyfish, sea squirts and starfishes do not have one. It is located in the head, usually close to primary sensory apparatus such as vision, hearing,...
.
MRI techniques employed include dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted MRI
Diffusion MRI
Diffusion MRI is a magnetic resonance imaging method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion, which is capable of showing connections between brain regions...
, functional MRI
Functional magnetic resonance imaging
Functional magnetic resonance imaging or functional MRI is a type of specialized MRI scan used to measure the hemodynamic response related to neural activity in the brain or spinal cord of humans or other animals. It is one of the most recently developed forms of neuroimaging...
(fMRI, brain activation mapping), image textural analysis, proton
Proton
The proton is a subatomic particle with the symbol or and a positive electric charge of 1 elementary charge. One or more protons are present in the nucleus of each atom, along with neutrons. The number of protons in each atom is its atomic number....
spectoscopy
In vivo magnetic resonance spectroscopy
In vivo magnetic resonance spectroscopy is a specialised technique associated to magnetic resonance imaging ....
and phosphorus
Phosphorus
Phosphorus is the chemical element that has the symbol P and atomic number 15. A multivalent nonmetal of the nitrogen group, phosphorus as a mineral is almost always present in its maximally oxidized state, as inorganic phosphate rocks...
spectoscopy
In vivo magnetic resonance spectroscopy
In vivo magnetic resonance spectroscopy is a specialised technique associated to magnetic resonance imaging ....
.
Funding
The research is wholly funded by the charityCharitable organization
A charitable organization is a type of non-profit organization . It differs from other types of NPOs in that it centers on philanthropic goals A charitable organization is a type of non-profit organization (NPO). It differs from other types of NPOs in that it centers on philanthropic goals A...
Yorkshire Cancer Research.
Research staff
- Scientific Director: ProfessorProfessorA professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
Lindsay W. Turnbull, M.D., F.R.C.R.Royal College of RadiologistsThe Royal College of Radiologists is the professional body responsible for the specialty of clinical oncology and clinical radiology throughout the United Kingdom. Its role is to advance the science and practice of radiology and oncology, further public education and set appropriate professional...
(Radiologist) - Medical physicistsMedical physicsMedical physics is the application of physics to medicine. It generally concerns physics as applied to medical imaging and radiotherapy, although a medical physicist may also work in many other areas of healthcare...
: Peter Gibbs, Ph.D; David J. Manton, Ph.D. - BiochemistBiochemistryBiochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
: Martin Lowry, D.Phil. - Research scientistScientistA scientist in a broad sense is one engaging in a systematic activity to acquire knowledge. In a more restricted sense, a scientist is an individual who uses the scientific method. The person may be an expert in one or more areas of science. This article focuses on the more restricted use of the word...
: Martin D. Pickles, Ph.D.Ph.D.A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer... - Ph.D.Ph.D.A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer...
students: Victor Lazar (from ChennaiChennaiChennai , formerly known as Madras or Madarasapatinam , is the capital city of the Indian state of Tamil Nadu, located on the Coromandel Coast off the Bay of Bengal. Chennai is the fourth most populous metropolitan area and the sixth most populous city in India...
, IndiaIndiaIndia , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
); Arfan Ahmed; Lawrence Kenning - Research technologists (Radiographers): Julie Pounder(Superintendent Radiographer); Daniel Siddons, Ph.D.
- Grants consultant: Ian Harvey, Ph.D.Ph.D.A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer...
Recent publications
1. Liney, GP; Bernard, CP; Manton, DJ; et al.Age, gender, and skeletal variation in bone marrow composition: A preliminary study at 3.0 Tesla.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 26 (3): 787-793 SEP 2007
2. Bernard, CP; Liney, GP; Manton, DJ; et al.
Bone marrow quantification using 3.0 tesla magnetic resonance imaging.
JOURNAL OF BONE AND MINERAL RESEARCH, 22 (7): 1140-1140 JUL 2007
3. Sreenivas, A; Lowry, M; Gibbs, P; et al.
A simple solution for reducing artefacts due to conductive and dielectric effects in clinical magnetic resonance imaging at 3 T.
EUROPEAN JOURNAL OF RADIOLOGY, 62 (1): 143-146 APR 2007
4. Pickles, MD; Gibbs, P; Lowry, M; et al.
Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer.
MAGNETIC RESONANCE IMAGING, 24 (7): 843-847 SEP 2006
5. Liney, GP; Sreenivas, M; Gibbs, P; et al.
Breast lesion analysis of shape technique: Semiautomated vs. manual morphological description.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (4): 493-498 APR 2006
6. Kneeshaw, PJ; Lowry, M; Manton, D; et al.
Differentiation of benign from malignant breast disease associated with screening detected microcalcifications using dynamic contrast enhanced magnetic resonance imaging.
BREAST, 15 (1): 29-38 FEB 2006
7. Pickles, MD; Gibbs, P; Sreenivas, M; et al.
Diffusion-weighted imaging of normal and malignant prostate tissue at 3.0 T.
JOURNAL OF MAGNETIC RESONANCE IMAGING, 23 (2): 130-134 FEB 2006
8. Gibbs, P; Pickles, MD; Turnbull, LW
Diffusion imaging of the prostate at 3.0 tesla.
INVESTIGATIVE RADIOLOGY, 41 (2): 185-188 FEB 2006
9. Manton, DJ; Chaturvedi, A; Hubbard, A; et al.
Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy.
BRITISH JOURNAL OF CANCER, 94 (3): 427-435 FEB 13 2006
10. Manton, DJ; Chaturvedi, A; Hubbard, A; et al.
Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy. (vol 94, pg 1554, 2006)
BRITISH JOURNAL OF CANCER, 94 (10): 1554-1554 MAY 22 2006
11. Pickles, MD; Lowry, M; Manton, DJ; et al.
Role of dynamic contrast enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy.
BREAST CANCER RESEARCH AND TREATMENT, 91 (1): 1-10 MAY 2005
12. Balan, P; Turnbull, LW
Dynamic contrast enhanced magnetic resonance imaging and magnetic resonance spectroscopy in diabetic mastopathy.
BREAST, 14 (1): 68-70 FEB 2005
External links
- The University of HullUniversity of HullThe University of Hull, known informally as Hull University, is an English university, founded in 1927, located in Hull, a city in the East Riding of Yorkshire...
research department: http://www.hull.ac.uk/mri - The NHS MRI Department: http://www.hey.nhs.uk/mri/Default.asp
- Hull and East Yorkshire Hospitals NHS TrustHull and East Yorkshire Hospitals NHS TrustThe Hull and East Yorkshire Hospitals NHS Trust operates in the city of Hull and the East Riding of Yorkshire, England.It is based on three sites the Trust is one of the largest in England and provides acute care for a local population of 600,000 and over 1.2 million people for our tertiary...
: http://www.hull.nhs.uk/