Benzhydryl compounds
Encyclopedia
Diphenylmethane
Diphenylmethane is an organic compound with the formula 2CH2. The compound consists of methane wherein two hydrogen atoms are replaced by two phenyl groups...
" containing, i.e. two benzene
Benzene
Benzene is an organic chemical compound. It is composed of 6 carbon atoms in a ring, with 1 hydrogen atom attached to each carbon atom, with the molecular formula C6H6....
rings adjoined by a single carbon
Carbon
Carbon is the chemical element with symbol C and atomic number 6. As a member of group 14 on the periodic table, it is nonmetallic and tetravalent—making four electrons available to form covalent chemical bonds...
. This simple definition does not include heteroaromatic ring moieties, which would grossify the situation even further. Although it may still be desired to include these for the purposes of 'completeness' they ought to be kept separate to avoid confusion.
Alcohols
- Acyclic: pridinolPridinolPridinol is a muscle relaxant.There is some evidence in one of Paul Janssens first books that pridinol cannot simply be acylated to make a reverse ester of methadone. The reason for this is steric strain making the product unstable....
- Pyrolidino: diphenylprolinol
- 2-Piperidine: pipradrolPipradrolPipradrol is a mild central nervous system stimulant that is no longer widely used in most countries due to concerns about its abuse potential, although this is less of a problem than with other stimulants that still are in current use such as methylphenidate...
- 4-Piperidine: terfenadineTerfenadineTerfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel and marketed under various brand names including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia...
, fexofenadineFexofenadineFexofenadine is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms... - Benzilic ester: QNB, JB-336N-Methyl-3-piperidyl benzilateN-Methyl-3-piperidyl benzilate is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate....
, JB-318N-Ethyl-3-piperidyl benzilateN-Ethyl-3-piperidyl benzilate is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate....
, benactyzineBenactyzineBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety...
Alkenes
- Tricycle: amitriptylineAmitriptylineAmitriptyline is a tricyclic antidepressant . It is the most widely used TCA and has at least equal efficacy against depression as the newer class of SSRIs...
, melitracenMelitracenMelitracen is a tricyclic antidepressant marketed in Europe and Japan by Lundbeck and Takeda, respectively, for the treatment of depression and anxiety...
, cyclobenzaprineCyclobenzaprineCyclobenzaprine is a muscle relaxant medication used to relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. It is the most well-studied drug for this application, and it also has been used off-label for fibromyalgia treatment.- Mechanism of action :The mechanism...
, tianeptineTianeptineTianeptine was discovered by The French Society of Medical Research in the 1960s. Under the trade-names it is a drug used for treating major depressive episodes ....
, amineptineAmineptineAmineptine was developed by the French Society of Medical research in the 1960s. Under the trade-names is used as an atypical tricyclic antidepressant that selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine, thus exerting a powerful and fast-acting...
, clopenthixolClopenthixolClopenthixol , also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961....
chlorprothixeneChlorprothixeneChlorprothixene is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized...
flupentixolFlupentixolFlupentixol , also known as flupenthixol , marketed under brand names such as Depixol and Fluanxol, is a typical antipsychotic drug of the thioxanthene class...
thiothixeneThiothixeneThiothixene is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967 by Pfizer.-Chemistry:*Bloom, B. M.; Muren, J. F.; 1967, See also:...
zuclopenthixolZuclopenthixolZuclopenthixol , also known as zuclopentixol, is a typical antipsychotic drug of the thioxanthene class... - Tricyclic and piperidine: pimethixenePimethixenePimethixene is an antihistamine and anticholinergic of the thioxanthene chemical class that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator ....
, cyproheptadineCyproheptadineCyproheptadine , sold under the brand name Periactin, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.- Indications :... - Acyclic: gilutensinGilutensinGilutensin is a stimulant drug. It was used for the treatment of hypotension ....
Alkyl(amine)s
- Acyclic: (3-phenylpropylamine), tolpropamineTolpropamineTolpropamine is an antihistamine and anticholinergic used as an antipruritic....
, tolterodineTolterodineTolterodine is an antimuscarinic drug that is used to treat urinary incontinence.It is marketed by Pfizer in Canada and the United States by its brand name Detrol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A... - Piperidine: desoxypipradrolDesoxypipradrolDesoxypipradrol, also known as 2-diphenylmethylpiperidine , acts as a norepinephrine-dopamine reuptake inhibitor developed by Ciba in the 1950s...
, budipineBudipineBudipine is an antiparkinson agent.Its mechanism of action is not well characterized. It is believed to be an NMDA receptor antagonist, however, promoting the synthesis of dopamine.... - N-alkyl-4-piperidinol: penfluridolPenfluridolPenfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects...
- N-arylalkyl-piperidine: pimozidePimozidePimozide is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine . On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome...
- Tetrahydronaphthalene: tametralineTametralineTametraline is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline .Sertraline has been called "3,4-dichloro tametraline"...
(4-phenylaminotetralin), sertralineSertralineSertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in... - Tetrahydroisoquinoline: nomifensineNomifensineNomifensine is a norepinephrine-dopamine reuptake inhibitor developed by a team at Hoechst AG in the 1960s.. The drug was test-marketed in the United States by Hoechst AG , i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine...
, diclofensineDiclofensineDiclofensine is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and noradrenaline...
"tetrahydronaphisoquinoline", dinapsolineDinapsolineDinapsoline is a drug developed for the treatment of Parkinson's disease, that acts as a selective full agonist at the dopamine D1 receptor....
(c.f. doxanthrineDoxanthrineDoxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor....
and dinoxylineDinoxylineDinoxyline is a synthetic compound developed for scientific research, which acts as a potent full agonist at all five dopamine receptor subtypes....
) - Pyrroloisoquinoline: JNJ-7925476JNJ-7925476JNJ-7925476 is a TRI antidepressant currently under development by Johnson & Johnson.These molecules were first prepared by Bruce E. Maryanoff, et al. during the late 1970s – 1980's...
- Indanamine: Lu 19-005
- Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene9-Aminomethyl-9,10-dihydroanthraceneAMDA is an organic compound which acts as a potent and selective antagonist for the 5-HT2A receptor. It has been used to help study the shape of the 5-HT2A protein, and develop a large family of related derivatives with even higher potency and selectivity.- References :...
, phenindaminePhenindaminePhenindamine is an antihistamine and anticholinergic closely related to cyproheptadine which is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a...
(see MPTPMPTPMPTP is a neurotoxin precursor to MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain...
) - Tetracyclic: maprotilineMaprotilineMaprotiline is a tetracyclic antidepressant . It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake....
, dihydrexidineDihydrexidineDihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors. It has approximately 10-fold selectivity for D1 and D5 over the D2 receptor. Although dihydrexidine has some affinity for the D2 receptor, it has functionally selective D2 signaling, thereby explaining...
, butaclamolButaclamolButaclamol is an antipsychotic which was never marketed. Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist....
, ecopipamEcopipamEcopipam is a synthetic benzazepine derivative drug that acts as a selective dopamine D1/D5 receptor antagonist, with little affinity for either dopamine D2-like or 5-HT2 receptors... - Tetrahydrobenzazepine: SKF-83959SKF-83959SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as a selective D1 receptor antagonist and D5 receptor full agonist, as evidenced by the fact that it has high affinity for both receptors and stimulates the D5-linked PLC/PI second messenger pathway without...
, SKF-82958, SKF-81297SKF-81297SKF-81,297 is a synthetic drug of the benzazepine chemical class that acts as a selective D1/D5 receptor full agonist, and produces a characteristic stimulant-like pattern of anorexia, hyperactivity and self-administration in animals...
, SKF 38393SKF 38393SKF-38,393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects....
, fenoldopamFenoldopamFenoldopam is a drug and synthetic benzazepine derivative which acts as a peripheral selective D1 receptor weak partial agonist/antagonist and is used as an antihypertensive. It was approved by the Food and Drug Administration in September 1997...
, 6-Br-APB6-Br-APB6-Br-APB is a synthetic compound that acts as a selective D1 agonist, with the -enantiomer being a potent full agonist, while the enantiomer retains its D1 selectivity but is a weak partial agonist...
, SCH 23390SCH 23390SCH23390 is a synthetic compound that acts as a D1 receptor antagonist and has either minimal or negligible effects on the D2 receptor.... - Piperazine: amperozideAmperozideAmperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons...
- Triazaspiro: fluspirileneFluspirileneFluspirilene is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.-Chemistry:...
Alkoxy compounds
- Acyclic (3°C): diphenhydramineDiphenhydramineDiphenhydramine hydrochloride is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties which is mainly used to treat allergies. Like most other first-generation antihistamines, the drug also has a powerful hypnotic effect, and for this reason...
(c.f deramciclaneDeramciclaneDeramciclane is a drug which acts as an antagonist at the 5-HT2A receptor, as an inverse agonist at the 5-HT2C receptor, and as a GABA reuptake inhibitor....
), orphenadrineOrphenadrineOrphenadrine is an anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasms, other similar conditions, as well as the treatment...
, p-methyldiphenhydramineP-Methyldiphenhydramine4-Methyldiphenhydramine is an antihistamine and anticholinergic.It is structurally analogous to diphenhydramine.- References :... - Acyclic (4°C): moxastineMoxastineMoxastine is an antihistamine and anticholinergic....
, ClemastineClemastineClemastine, also known as meclastin, is an antihistamine and anticholinergic. Unlike loratadine or fexofenadine, clemastine is a sedating antihistamine, however it exhibits fewer other side effects than most of the widely used antihistamines. Clemastine is also classified as an antipruritic...
, embramineEmbramineEmbramine is an antihistamine and anticholinergic....
, - Piperazine: GBR-12935GBR-12935GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins...
, GBR 12909, DBL-583DBL-583DBL-583 is a selective dopamine reuptake inhibitor of the piperazine chemical class. It is the decanoate ester of vanoxerine. DBL-583 breaks down very slowly in the body, lasting for up to a month after a single injection.... - Tropine: benztropineBenztropineBenzatropine , also known as benztropine , is an anticholinergic marketed under the trade name Cogentin which is used in the treatment of Parkinson's disease, parkinsonism, akathisia, and dystonia.- Indications :...
, deptropineDeptropineDeptropine also known as dibenzheptropine, is an antihistamine with anticholinergic properties. It is usually marketed as the citrate salt....
, etybenzatropineEtybenzatropineEtybenzatropine , also known as ethybenztropine and tropethydrylin, is an anticholinergic/antihistamine marketed under the trade names Panolid, Ponalid, and Ponalide, which is used as an antiparkinsonian agent. Like its analogue benzatropine, it may act as a dopamine reuptake inhibitor.-...
, difluoropineDifluoropine--2β-Carbomethoxy-3α-tropane is a stimulant drug synthesised from tropinone, which acts as a potent and selective dopamine reuptake inhibitor... - Piperidine: diphenylpyralineDiphenylpyralineDiphenylpyraline is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies...
- Phthalane: talopramTalopramTalopram , also known as phthalapromine, is a selective norepinephrine reuptake inhibitor which was researched for the management of depression in the 1960s and 1970s but was never commercialized. Along with talsupram, talopram is structurally related to the selective serotonin reuptake inhibitor ...
, citalopramCitalopramCitalopram brand names: Celexa, Cipramil) is an antidepressant drug of the selective serotonin reuptake inhibitor class. It has U.S... - Octahedral: nefopamNefopamNefopam is a centrally-acting but non-opioid analgesic drug of the benzoxazocine chemical class which was developed by Riker Laboratories in the 1960s. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs...
- Benzdihydropyran: A-68930A-68930A-68930 is a synthetic compound that acts as a selective dopamine receptor D1 partial agonist. It is orally active and has antidepressant and anorectic effects in animals, producing wakefulness and tachycardia, but without stimulant effects, instead producing sedation...
(isochromene)
Amines
- Piperazine: CyclizineCyclizineCyclizine is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operatively following administration of general anaesthesia and opioids.-Indications:...
, ClocinizineClocinizineClocinizine is an first-generation antihistamine of the phenylpiperazine class....
, HydroxyzineHydroxyzineHydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine classes. It was first synthesized by Union Chimique Belge in 1956 and was marketed by Pfizer in the United States later the same year, and is still in widespread use today....
, MeclozineMeclozineMeclozine is an antihistamine considered to be an antiemetic. It is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine . Emesafene is a combination of meclozine and pyridoxine...
, CetirizineCetirizineCetirizine , a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.-Availability:...
dotarizineDotarizineDotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has...
, CinnarizineCinnarizineCinnarizine is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955...
. - BenzazepineBenzazepineBenzazepines are chemical compounds containing both a benzene and an azepine group.Examples include fenoldopam....
: mianserinMianserinMianserin is a psychoactive drug of the tetracyclic antidepressant chemical class which is classified as a noradrenergic and specific serotonergic antidepressant and has antidepressant, anxiolytic, hypnotic, antiemetic, orexigenic, and antihistamine effects...
(c.f. piperazine; azapine?) - Tetracyclic: dizocilpineDizocilpineDizocilpine , also known as MK-801, is a non-competitive antagonist of the N-methyl-d-aspartate receptor, a glutamate receptor. Glutamate is the brain's primary excitatory neurotransmitter...
Other
- Aromatic alkoxy: bifemelaneBifemelaneBifemelane is a pharmaceutical drug used in the treatment of senile dementia in Japan. It has nootropic, neuroprotective, and antidepressant effects, and acts through the cholinergic system in the brain. Bifemelane is also useful for the treatment of glaucoma....
, phenyltoloxaminePhenyltoloxaminePhenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and an anticholinergic.-Common use:... - Keto: phenadoxonePhenadoxonePhenadoxone is an opioid analgesic of the open chain class invented in by Hoechst in 1947...
, methadoneMethadoneMethadone is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive for use in patients with opioid dependency. It was developed in Germany in 1937...
, dipipanoneDipipanoneDipipanone is a strong opioid analgesic drug, used for very severe pain in cases where other analgesics are unsuitable, for instance where morphine is indicated but cannot be used due to the patient being allergic to morphine.-Dosage forms:...
, etc. - Amido: dextromoramideDextromoramideDextromoramide is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties, and by the criminal law of individual states...
- Imino: benzodiazepineBenzodiazepineA benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
, GYKI-52895GYKI-52895GYKI-52895 is a drug which is a 2,3-benzodiazepine derivative. Unlike other similar drugs, GYKI-52895 is a selective dopamine reuptake inhibitor, which presumably would produce stimulant effects in vivo.... - Sulfinyl: modafinilModafinilModafinil is an analeptic drug manufactured by Cephalon, and is approved by the U.S. Food and Drug Administration for the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea...
, adrafinilAdrafinilAdrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients...
Heteroaromatic rings
- Alkene: thiambuteneThiambuteneThe Thiambutenes are a family of opioid analgesic drugs developed at the British research laboratory of Burroughs-Wellcome in the late 1940s.The parent compound thiambutene has no analgesic effects, but several compounds from this group are analgesics with around the same potency as...
, loratidine - Alkylamine: A-86929A-86929A-86929 is a synthetic compound that acts as a selective dopamine receptor D1 agonist. It was developed as a possible treatment for Parkinson's disease, as well as for other applications such as treatment of cocaine addiction, but while it had reasonable efficacy in humans it also caused...
, amfonelic acidAmfonelic acidAmfonelic acid is a psychoactive drug and research chemical used in scientific studies. It was discovered while researchers were investigating novel antibiotics. It acts as a potent and highly selective dopamine reuptake inhibitor . It has a moderately long half-life of approximately 12 hours...
Benzenes linked by a non-carbon atom
- Nitrogen: promethazinePromethazinePromethazine is a first-generation antihistamine of the phenothiazine family. The drug has anti-motion sickness, antiemetic, and anticholinergic effects, as well as a strong sedative effect and in some countries is prescribed for insomnia when benzodiazepines are contraindicated...
, imipramineImipramineImipramine , also known as melipramine, is an antidepressant medication, a tricyclic antidepressant of the dibenzazepine group...
, acepromazineAcepromazineAcepromazine or acetylpromazine is a phenothiazine derivative antipsychotic drug. It was first used in humans in the 1950s, but is now little used in humans...
, chlorpromazineChlorpromazineChlorpromazine is a typical antipsychotic...
, fluphenazineFluphenazineFluphenazine is a typical antipsychotic drug used for the treatment of psychoses such as schizophrenia and acute manic phases of bipolar disorder. It belongs to the piperazine class of phenothiazines....
, mesoridazineMesoridazineMesoridazine is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine...
, levomepromazineLevomepromazineLevomepromazine in Germany and Methotrimeprazine in America is an aliphatic phenothiazine neuroleptic drug...
, perazinePerazinePerazine is a moderate-potency typical antipsychotic of the phenothiazine class. It is quite similar to chlorpromazine, and acts as a dopamine antagonist.- External links :...
, periciazinePericiazinePericyazine is a medication that belongs to the phenothiazine class of antipsychotics. It has also been studied in the treatment of opiate dependence....
, perphenazinePerphenazinePerphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. It has been in clinical use for decades....
, prochlorperazineProchlorperazineProchlorperazine is a dopamine receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly-potent typical antipsychotic, 10-20x more potent than chlorpromazine...
, sulforidazineSulforidazineSulforidazine a typical antipsychotic and a metabolite of thioridazine; it and mesoridazine are more potent than the parent compound, whose pharmacological effects are believed by some to be largely due to its metabolism into sulforidazine and mesoridazine.- References :...
, thioridazineThioridazineThioridazine is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis...
, trifluoperazineTrifluoperazineTrifluoperazine is a typical antipsychotic of the phenothiazine chemical class.- Uses :...
, triflupromazineTriflupromazineTriflupromazine is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis...
, clozapineClozapineClozapine is an antipsychotic medication used in the treatment of schizophrenia, and is also used off-label in the treatment of bipolar disorder. Wyatt. R and Chew...
, thiethylperazineThiethylperazineThiethylperazine is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.... - Indolic nitrogen: sertindoleSertindoleSertindole is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company H. Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of...
- Oxygen: loxapineLoxapineLoxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and as a dibenzazepine derivative, it is structurally related to clozapine...
, asenapineAsenapineAsenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough after its November 19, 2007 merger with Organon International. Development of the drug, through Phase III trials, began while Organon was still...
, tyrimaTyrimaTyrima is a selective and reversible inhibitor of MAO-A . It is currently in phase II clinical trials for the treatment of depression.- References :...