Diphenylpyraline is a first-generation antihistamine with anticholinergic

Anticholinergic

An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicycloverine, and the classic example is atropine....

 effects of the diphenylpiperidine

Piperidine

Piperidine is an organic compound with the molecular formula 5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom...

 class. It is marketed in Europe

Europe

Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...

 for the treatment of allergies

Allergy

An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...

. DPP has also been found to act as a dopamine reuptake inhibitor

Dopamine reuptake inhibitor

A dopamine reuptake inhibitor is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter...

 and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism

Parkinsonism

Parkinsonism is a neurological syndrome characterized by tremor, hypokinesia, rigidity, and postural instability. The underlying causes of parkinsonism are numerous, and diagnosis can be complex...

.

Chemistry

Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine, is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.

• H.K. Lawrence, R. Kapp, (1949).
• W.A. Schuler, (1951).

See also

• 2-Diphenylmethylpyrrolidine
  2-Diphenylmethylpyrrolidine
  2-Diphenylmethylpyrrolidine is a stimulant drug closely related to desoxypipradrol and diphenylprolinol. It has two enantiomers which are used industrially in their purified form for resolution of chiral reagents during chemical synthesis....
  
  
• Difemetorex
  Difemetorex
  Difemetorex , also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use. It was introduced in France by Ciba-Geigy in 1966 but is now no longer marketed....
  
  
• Diphenylprolinol
• Desoxypipradrol
  Desoxypipradrol
  Desoxypipradrol, also known as 2-diphenylmethylpiperidine , acts as a norepinephrine-dopamine reuptake inhibitor developed by Ciba in the 1950s...
  
  
• Pipradrol
  Pipradrol
  Pipradrol is a mild central nervous system stimulant that is no longer widely used in most countries due to concerns about its abuse potential, although this is less of a problem than with other stimulants that still are in current use such as methylphenidate...