SKF-81297
Encyclopedia
SKF-81,297 is a synthetic drug
of the benzazepine
chemical class that acts as a selective
D1/D5 receptor full agonist, and produces a characteristic stimulant
-like pattern of anorexia
, hyperactivity and self-administration
in animals. This profile is shared with several related drugs such as 6-Br-APB
and SKF-82,958, but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity
of D1 activation.
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
of the benzazepine
Benzazepine
Benzazepines are chemical compounds containing both a benzene and an azepine group.Examples include fenoldopam....
chemical class that acts as a selective
Binding selectivity
Binding selectivity refers to the differing affinities with which different ligands bind to a substrate forming a complex. A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate...
D1/D5 receptor full agonist, and produces a characteristic stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
-like pattern of anorexia
Anorexia (symptom)
Anorexia is the decreased sensation of appetite...
, hyperactivity and self-administration
Self-administration
Self-administration is, in its medical sense, the process of a subject administering a pharmacological substance to him-, her-, or itself. A clinical example of this is the subcutaneous "self-injection" of insulin by a diabetic patient....
in animals. This profile is shared with several related drugs such as 6-Br-APB
6-Br-APB
6-Br-APB is a synthetic compound that acts as a selective D1 agonist, with the -enantiomer being a potent full agonist, while the enantiomer retains its D1 selectivity but is a weak partial agonist...
and SKF-82,958, but not with certain other D1 full agonists such as A-77,636, reflecting functional selectivity
Functional Selectivity
Functional selectivity is the ligand-dependent selectivity for certain signal transduction pathways in one and the same receptor. This can be present when a receptor has several possible signal transduction pathways...
of D1 activation.