Treehouse of Horror XV
Encyclopedia
"Treehouse of Horror XV" is the first episode of Season 16 and also the fifteenth Halloween
Halloween
Hallowe'en , also known as Halloween or All Hallows' Eve, is a yearly holiday observed around the world on October 31, the night before All Saints' Day...

 episode of The Simpsons
The Simpsons
The Simpsons is an American animated sitcom created by Matt Groening for the Fox Broadcasting Company. The series is a satirical parody of a middle class American lifestyle epitomized by its family of the same name, which consists of Homer, Marge, Bart, Lisa and Maggie...

, airing November 7, 2004, one week after Halloween in the US, the latest any Halloween episode has ever aired. In this year's installment, Ned Flanders' head injury gives him the power to predict doom in "The Ned Zone," Bart and Lisa play detective when a string of Victorian-era prostitutes are murdered by a ripper in "Four Beheadings and a Funeral," and The Simpsons go on a fantastic voyage
Fantastic Voyage
Fantastic Voyage is a 1966 science fiction film written by Harry Kleiner, based on a story by Otto Klement and Jerome Bixby.Bantam Books obtained the rights for a paperback novelization based on the screenplay and approached Isaac Asimov to write it....

 inside Mr. Burns' body to save Maggie in "In the Belly of the Boss." 11.29 million people watched this episode on its first airing on Fox
Fox Broadcasting Company
Fox Broadcasting Company, commonly referred to as Fox Network or simply Fox , is an American commercial broadcasting television network owned by Fox Entertainment Group, part of Rupert Murdoch's News Corporation. Launched on October 9, 1986, Fox was the highest-rated broadcast network in the...

.

Because of the brutal violence against women and scenes depicting opium smoking (including a scene where a child character Ralph Wiggum
Ralph Wiggum
Ralph Wiggum is a recurring fictional character on the animated series The Simpsons, voiced by Nancy Cartwright. The son of Police Chief Wiggum and a classmate of Lisa Simpson, Ralph is best known as the show's resident oddball, and is noted for his non sequiturs and erratic behavior...

 is shown smoking opium), this episode has been given an "M" rating in Australia for violence and drug abuse. In the U.S., this episode was given a TV-14 rating for the first time since season ten's "Treehouse of Horror IX
Treehouse of Horror IX
"Treehouse of Horror IX" is the fourth episode of the tenth season of The Simpsons. It first aired on the Fox network in the United States on October 25, 1998...

" (which was given a TV-14 rating for the bleeped out offensive language in "Starship Poopers" and the brutal violence in "Hell Toupee" and "Terror in Tiny Toon").

Opening sequence

Kang and Kodos star in a fictional sitcom, entitled Keepin' it Kodos. In it, Kodos is preparing their boss' visit by cooking dinner: Homer
Homer Simpson
Homer Jay Simpson is a fictional character in the animated television series The Simpsons and the patriarch of the eponymous family. He is voiced by Dan Castellaneta and first appeared on television, along with the rest of his family, in The Tracey Ullman Show short "Good Night" on April 19, 1987...

, on a baking tray (continually eating himself), Bart, on a fryer, Marge
Marge Simpson
Marjorie "Marge" Simpson is a fictional main character in the animated television series The Simpsons and part of the eponymous family. She is voiced by actress Julie Kavner and first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987...

 and Maggie
Maggie Simpson
Margaret "Maggie" Simpson is a fictional character in the animated television series The Simpsons. She first appeared on television in the Tracey Ullman Show short "Good Night" on April 19, 1987. Maggie was created and designed by cartoonist Matt Groening while he was waiting in the lobby of James...

 in a pie
Pie
A pie is a baked dish which is usually made of a pastry dough casing that covers or completely contains a filling of various sweet or savoury ingredients....

, and Lisa in a soup
Soup
Soup is a generally warm food that is made by combining ingredients such as meat and vegetables with stock, juice, water, or another liquid. Hot soups are additionally characterized by boiling solid ingredients in liquids in a pot until the flavors are extracted, forming a broth.Traditionally,...

. The boss gives the meal a delicious rating, but ends up liberating Bart, and gives Kang and Kodos a hyper-galactic promotion, much to the aliens' delight. Bart is sad about the loss of his parents
Orphan
An orphan is a child permanently bereaved of or abandoned by his or her parents. In common usage, only a child who has lost both parents is called an orphan...

 and younger siblings, but Kang and Kodos adopt
Adoption
Adoption is a process whereby a person assumes the parenting for another and, in so doing, permanently transfers all rights and responsibilities from the original parent or parents...

 him. The Treehouse of Horror logo appears on the screen, as an alien hand stamps the "XV" underneath which makes it say, "Treehouse of Horror XV" in the fashion of the Mark VII Productions company logo.

The Ned Zone

While trying to get his frisbee
Frisbee
A flying disc is a disc-shaped glider that is generally plastic and roughly in diameter, with a lip. The shape of the disc, an airfoil in cross-section, allows it to fly by generating lift as it moves through the air while rotating....

 from the roof, Homer
Homer Simpson
Homer Jay Simpson is a fictional character in the animated television series The Simpsons and the patriarch of the eponymous family. He is voiced by Dan Castellaneta and first appeared on television, along with the rest of his family, in The Tracey Ullman Show short "Good Night" on April 19, 1987...

 throws a bowling ball
Bowling ball
A bowling ball is a spherical ball made from plastic, reactive resin, urethane or a combination of these materials which is used in the sport of bowling. Ten-pin bowling balls generally have a set of three holes drilled in them, one each for the ring and middle finger, and one for the thumb;...

 onto the roof, which rolls off to the side, and strikes a passing Ned
Ned Flanders
Nedward "Ned" Flanders, Jr. is a recurring fictional character in the animated television series The Simpsons. He is voiced by Harry Shearer, and first appeared in the series premiere episode "Simpsons Roasting on an Open Fire". He is the next door neighbor to the Simpson family and is generally...

 on the head. When Ned recovers in Dr. Hibbert's hospital, he has a vision of Dr. Hibbert falling out of a window to his death, which causes him distress. Homer then asks Hibbert to retrieve his frisbee from a ledge on the hospital, to which he reluctantly agrees to do, ironically saying it would be the last time he did so. As he reaches for the ledge, he slips out of the window as to Ned's horror, his vision comes true
Prophecy
Prophecy is a process in which one or more messages that have been communicated to a prophet are then communicated to others. Such messages typically involve divine inspiration, interpretation, or revelation of conditioned events to come as well as testimonies or repeated revelations that the...

. In a parody of The Dead Zone
The Dead Zone (novel)
The Dead Zone is a horror novel by Stephen King published in 1979. It concerns Johnny Smith, who is injured in an accident and enters a coma for nearly five years. When he emerges, he can see horrifying secrets but cannot identify all the details in his "dead zone", an area of his brain that...

, Ned realizes that he can see the deaths of people whom he touches. After he gets out of the hospital, he attempts to save Hans Moleman
Hans Moleman
Hans Moleman is a recurring character in the animated television series The Simpsons. He is voiced by Dan Castellaneta, and first appeared in the episode "Principal Charming". He normally appears in a running gag, where he usually suffers unfortunate, nearly fatal, events...

 from falling down but when he touches Hans, has a vision of him getting chewed up by American alligator
American Alligator
The American alligator , sometimes referred to colloquially as a gator, is a reptile endemic only to the Southeastern United States. It is one of the two living species of alligator, in the genus Alligator, within the family Alligatoridae...

s. In shock, he drops Moleman – right into an open manhole
Manhole
A manhole is an opening used to gain access to sewers or other underground structures, usually for maintenance.Manhole may also refer to:* Manhole , a metal band from Los Angeles* The Manhole, a computer game...

 full of alligators. Soon after, he also predicts the closing of the Rosie O' Donnell Musical, but he "didn't need special powers to know that was coming!"

A later vision depicts him shooting Homer; when Homer finds out, he taunts Ned and even gives him Chief Wiggum's gun to shoot him with, and says he could not even shoot him by accident. No matter what Homer does, Ned refrains from shooting Homer, and realizes he has changed the future, but then has another vision, this time of Homer blowing up Springfield
Springfield (The Simpsons)
Springfield is the fictional town in which the American animated sitcom The Simpsons is set. A mid-sized town in an undetermined state of the United States, Springfield acts as a complete universe in which characters can explore the issues faced by modern society. The geography of the town and its...

 by pressing the 'Core Destruct' button at the nuclear power plant. Ned tries to dissuade Homer from going to work, but Homer goes anyway because of ice cream cake
Ice cream cake
Ice cream cake is either ice cream in the shape of a cake or ice cream and cake layered together to make a single form. The idea of ice cream cake came from desserts composed of cream and cookies or cake called trifles, which first turned up in the Renaissance...

 for Lenny's birthday. Ned rushes to the power plant to stop Homer, but his warning is scrambled by static over the intercom, sounding as if he is encouraging Homer to press the button. In desperation, Ned grabs a nearby security guard's gun and forces himself to shoot Homer (thereby fulfilling the original prediction); but in his death throes, Homer presses the destruct button with his tongue
Tongue
The tongue is a muscular hydrostat on the floors of the mouths of most vertebrates which manipulates food for mastication. It is the primary organ of taste , as much of the upper surface of the tongue is covered in papillae and taste buds. It is sensitive and kept moist by saliva, and is richly...

. Ned has enough time to say "You stupid son of a..." before the power plant explodes and Springfield is destroyed. Ned, The Simpsons, and their garage (which Homer was assigned to clean, leading Marge to believe he blew up the town specifically to get out of doing so) go to Heaven
Heaven
Heaven, the Heavens or Seven Heavens, is a common religious cosmological or metaphysical term for the physical or transcendent place from which heavenly beings originate, are enthroned or inhabit...

 as angel
Angel
Angels are mythical beings often depicted as messengers of God in the Hebrew and Christian Bibles along with the Quran. The English word angel is derived from the Greek ἄγγελος, a translation of in the Hebrew Bible ; a similar term, ملائكة , is used in the Qur'an...

s and meet God
God
God is the English name given to a singular being in theistic and deistic religions who is either the sole deity in monotheism, or a single deity in polytheism....

, who proceeds to give Homer "what he deserves" – returning his frisbee.

Four Beheadings and a Funeral

In 1890 London
London
London is the capital city of :England and the :United Kingdom, the largest metropolitan area in the United Kingdom, and the largest urban zone in the European Union by most measures. Located on the River Thames, London has been a major settlement for two millennia, its history going back to its...

, the city's prostitutes are being killed with swords in a series of unsolved murders by "The Muttonchop Murderer
Jack the Ripper
"Jack the Ripper" is the best-known name given to an unidentified serial killer who was active in the largely impoverished areas in and around the Whitechapel district of London in 1888. The name originated in a letter, written by someone claiming to be the murderer, that was disseminated in the...

". Scotland Yard
Scotland Yard
Scotland Yard is a metonym for the headquarters of the Metropolitan Police Service of London, UK. It derives from the location of the original Metropolitan Police headquarters at 4 Whitehall Place, which had a rear entrance on a street called Great Scotland Yard. The Scotland Yard entrance became...

 Detective Eliza Simpson
Lisa Simpson
Lisa Marie Simpson is a fictional main character in the animated television series The Simpsons. She is the middle child of the Simpson family. Voiced by Yeardley Smith, Lisa first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987. Cartoonist Matt Groening...

 and her easily-amazed assistant Dr. Bartley
Bart Simpson
Bartholomew JoJo "Bart" Simpson is a fictional main character in the animated television series The Simpsons and part of the Simpson family. He is voiced by actress Nancy Cartwright and first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987...

 (parodying Sherlock Holmes
Sherlock Holmes
Sherlock Holmes is a fictional detective created by Scottish author and physician Sir Arthur Conan Doyle. The fantastic London-based "consulting detective", Holmes is famous for his astute logical reasoning, his ability to take almost any disguise, and his use of forensic science skills to solve...

 and Doctor Watson) trace the swords used back to the "wicked industrialist" C. Ebenezer Burns
Montgomery Burns
Charles Montgomery "Monty" Burns, usually referred to as Mr. Burns, is a recurring fictional character in the animated television series The Simpsons, who is voiced by Harry Shearer and previously Christopher Collins. Burns is the evil owner of the Springfield Nuclear Power Plant and is Homer...

 (so wicked, Bartley claims, that he makes coal out of babies). They find him in Mao's Den of Inequity, a London opium den
Opium den
An opium den was an establishment where opium was sold and smoked. Opium dens were prevalent in many parts of the world in the 19th century, most notably China, Southeast Asia, North America and France...

, where he claims he lost all his wealth in sword
Sword
A sword is a bladed weapon used primarily for cutting or thrusting. The precise definition of the term varies with the historical epoch or the geographical region under consideration...

s to opium
Opium
Opium is the dried latex obtained from the opium poppy . Opium contains up to 12% morphine, an alkaloid, which is frequently processed chemically to produce heroin for the illegal drug trade. The latex also includes codeine and non-narcotic alkaloids such as papaverine, thebaine and noscapine...

. The next suspect in mind is Homer
Homer Simpson
Homer Jay Simpson is a fictional character in the animated television series The Simpsons and the patriarch of the eponymous family. He is voiced by Dan Castellaneta and first appeared on television, along with the rest of his family, in The Tracey Ullman Show short "Good Night" on April 19, 1987...

, another man in the den possessing a set of 'muttonchops'. The police arrest Homer and are about to hang him when Eliza finds the real murderer: Inspector Wiggum, whose eel-pie covered handprints were all over a sword used to kill Selma, attempting to create a case that even Eliza could not solve. Wiggum attempts to escape in a hot-air balloon, which is destroyed by a large steampunk
Steampunk
Steampunk is a sub-genre of science fiction, fantasy, alternate history, and speculative fiction that came into prominence during the 1980s and early 1990s. Steampunk involves a setting where steam power is still widely used—usually Victorian era Britain or "Wild West"-era United...

-style flying saucer flown by Kang and Kodos (both with muttonchops), who comment on destroying the Earth's air force. However, it all turns out to be a dream that Ralph Wiggum
Ralph Wiggum
Ralph Wiggum is a recurring fictional character on the animated series The Simpsons, voiced by Nancy Cartwright. The son of Police Chief Wiggum and a classmate of Lisa Simpson, Ralph is best known as the show's resident oddball, and is noted for his non sequiturs and erratic behavior...

 is having while smoking opium
Opium
Opium is the dried latex obtained from the opium poppy . Opium contains up to 12% morphine, an alkaloid, which is frequently processed chemically to produce heroin for the illegal drug trade. The latex also includes codeine and non-narcotic alkaloids such as papaverine, thebaine and noscapine...

 in an opium den, which is part of an even crazier dream.

In the Belly of the Boss

At the "Invention Expo", Professor Frink
Professor Frink
Professor John Nerdelbaum Frink, Jr., or simply Professor Frink, is a recurring character in the animated television series The Simpsons. He is voiced by Hank Azaria, and first appeared in the 1991 episode "Old Money". Frink is Springfield's nerdy scientist and professor and is extremely...

 creates a machine that shrinks objects. Maggie
Maggie Simpson
Margaret "Maggie" Simpson is a fictional character in the animated television series The Simpsons. She first appeared on television in the Tracey Ullman Show short "Good Night" on April 19, 1987. Maggie was created and designed by cartoonist Matt Groening while he was waiting in the lobby of James...

 (thinking that it is a ball pit
Ball pit
A ball pit is a pit, usually rectangular and padded, filled with small colorful hollow plastic balls...

) crawls inside a giant pill
Pill (pharmacy)
A pill is a small, round, solid pharmaceutical oral dosage form that was in use before the advent of tablets and capsules. Pills were made by mixing the active ingredients with an excipient such as glucose syrup in a mortar and pestle to form a paste, then rolling the mass into a long cylindrical...

, which is miniaturized and swallowed by Mr. Burns. The rest of the family agrees to be shrunk within a craft and injected into Mr. Burns' body (parodying Fantastic Voyage
Fantastic Voyage
Fantastic Voyage is a 1966 science fiction film written by Harry Kleiner, based on a story by Otto Klement and Jerome Bixby.Bantam Books obtained the rights for a paperback novelization based on the screenplay and approached Isaac Asimov to write it....

). Homer is the captain, Lisa is in charge of science and research, Bart is in charge of security, and Marge is just herself. When Homer refuses to follow Frink's instructions, the ship gets stuck in Burns' heart
Heart
The heart is a myogenic muscular organ found in all animals with a circulatory system , that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions...

. The crew manage to get the ship free and are able to reach the stomach by catching a ride on a nerve impulse. They manage to save Maggie, but are forced to leave Homer behind when their craft does not have enough power to save them all due to the addition of Maggie's weight. The submarine successfully escapes, and Prof. Frink tells them there is time to save Homer, but he is wrong, as Homer instantly returns to his original size inside Mr. Burns' skin after eating a huge marshmallow. Even though Homer complains that Mr. Burns needs several extra holes, Burns is confident that things will work out. The episode ends with Burns and Homer leading a dance to the tune of "I've Got You Under My Skin
I've Got You Under My Skin
"I've Got You Under My Skin" is a song by Cole Porter.I've Got You Under My Skin may also refer to:* "I've Got You Under My Skin" , a 1998 episode of the television series Charmed...

" (along with characters from all three segments and the opening sequence).

Cultural references

  • The hammering in of the Roman numeral in the opening is a reference to the logo of the production company Mark VII Limited
    Mark VII Limited
    Mark VII Limited was the production company of actor, producer, and director Jack Webb, and was active from 1951 to 1982. Many of its series were produced in association with Universal Television; most of them aired on the NBC television network in the U.S....

    .
  • "The Ned Zone" is a parody of The Dead Zone
    The Dead Zone (novel)
    The Dead Zone is a horror novel by Stephen King published in 1979. It concerns Johnny Smith, who is injured in an accident and enters a coma for nearly five years. When he emerges, he can see horrifying secrets but cannot identify all the details in his "dead zone", an area of his brain that...

    .
  • "The Ned Zone" is also a parody of The Twilight Zone
    The Twilight Zone (1959 TV series)
    The Twilight Zone is an American anthology television series created by Rod Serling, which ran for five seasons on CBS from 1959 to 1964. The series consisted of unrelated episodes depicting paranormal, futuristic, dystopian, or simply disturbing events; each show typically featured a surprising...

     episode "A Most Unusual Camera
    A Most Unusual Camera
    "A Most Unusual Camera" is an episode of the American television anthology series The Twilight Zone.-Synopsis:Two thieves, Chester and Paula, rob a curio shop, and among the things they steal is a strange camera. The pair come to realize that its pictures reveal the future, specifically five...

    ".
  • The sign outside the opium den in "Four Beheadings and a Funeral" reads 'Happiness is a warm poppy', a reference to the Peanuts' cartoon collection Happiness is a Warm Puppy.
  • Ned's messages to Homer being misunderstood due to static over the intercom, causing Homer to (attempt to) set off the explosion, is a reference to the Tenerife airport disaster.
  • The "Four Beheadings and a Funeral" section is a reference to the movie Four Weddings and a Funeral
    Four Weddings and a Funeral
    Four Weddings and a Funeral is a 1994 British comedy film directed by Mike Newell. It was the first of several films by screenwriter Richard Curtis to feature Hugh Grant...

    and the Jack the Ripper
    Jack the Ripper
    "Jack the Ripper" is the best-known name given to an unidentified serial killer who was active in the largely impoverished areas in and around the Whitechapel district of London in 1888. The name originated in a letter, written by someone claiming to be the murderer, that was disseminated in the...

     murders in 19th century London
    London
    London is the capital city of :England and the :United Kingdom, the largest metropolitan area in the United Kingdom, and the largest urban zone in the European Union by most measures. Located on the River Thames, London has been a major settlement for two millennia, its history going back to its...

    .
  • "Eliza Simpson" is a parody of Sherlock Holmes
    Sherlock Holmes
    Sherlock Holmes is a fictional detective created by Scottish author and physician Sir Arthur Conan Doyle. The fantastic London-based "consulting detective", Holmes is famous for his astute logical reasoning, his ability to take almost any disguise, and his use of forensic science skills to solve...

     and "Dr. Bartley" is a parody of Dr. Watson.
  • When Inspector Wiggum eats the eel pie, a live eel tries to come out of his mouth. This is a reference to the urban myth about having snakes living in your stomach.
  • The kidnapping suspect is Peter Pan
    Peter Pan
    Peter Pan is a character created by Scottish novelist and playwright J. M. Barrie . A mischievous boy who can fly and magically refuses to grow up, Peter Pan spends his never-ending childhood adventuring on the small island of Neverland as the leader of his gang the Lost Boys, interacting with...

     (Squeaky-Voiced Teen).
  • Marge is parody of G.B. Shaw's Eliza Doolittle from the play Pygmalion
    Pygmalion (play)
    Pygmalion: A Romance in Five Acts is a play by Irish playwright George Bernard Shaw. Professor of phonetics Henry Higgins makes a bet that he can train a bedraggled Cockney flower girl, Eliza Doolittle, to pass for a duchess at an ambassador's garden party by teaching her to assume a veneer of...

    , which had been adapted in a musical and then inspired My Fair Lady
    My Fair Lady (film)
    My Fair Lady is a 1964 musical film adaptation of the Lerner and Loewe stage musical, of the same name, based on the 1938 film adaptation of the original stage play Pygmalion by George Bernard Shaw. The ballroom scene and the ending were taken from the previous film adaptation , rather than from...

    starring Audrey Hepburn
    Audrey Hepburn
    Audrey Hepburn was a British actress and humanitarian. Although modest about her acting ability, Hepburn remains one of the world's most famous actresses of all time, remembered as a film and fashion icon of the twentieth century...

    .
  • Many characters in “Four Beheadings and a Funeral” speak with a pronounced Cockney accent
    Cockney
    The term Cockney has both geographical and linguistic associations. Geographically and culturally, it often refers to working class Londoners, particularly those in the East End...

    .
  • Ebenezer Burns is a reference to Ebenezer Scrooge
    Ebenezer Scrooge
    Ebenezer Scrooge is the principal character in Charles Dickens's 1843 novel, A Christmas Carol. At the beginning of the novel, Scrooge is a cold-hearted, tight-fisted and greedy man, who despises Christmas and all things which give people happiness...

    .
  • The Quimby character in “Four Beheadings and a Funeral” wears a sash saying “Lord Mayor”, thus being Lord Mayor of the City of London.
  • In “Four Beheadings and a Funeral” Homer says he has "never known the pleasures of a woman or a proper eating apple" in reference to Captain Barbossa
    Hector Barbossa
    Hector Barbossa is a fictional character and pirate in the Disney film series Pirates of the Caribbean. Barbossa was first introduced in the series as the main antagonist of the first film, and pirate captain of the Black Pearl after committing mutiny against the ship's former captain, Jack...

     from Pirates of the Caribbean: The Curse of the Black Pearl
    Pirates of the Caribbean: The Curse of the Black Pearl
    Pirates of the Caribbean: The Curse of the Black Pearl is a 2003 adventure fantasy film based on the Pirates of the Caribbean ride at Disney theme parks. It was directed by Gore Verbinski and produced by Jerry Bruckheimer...

    .
  • Inspector Wiggum and his son flying out of an ice-castle on a bed is a reference to the comic Little Nemo in Slumberland
    Little Nemo
    Little Nemo is the main fictional character in a series of weekly comic strips by Winsor McCay that appeared in the New York Herald and William Randolph Hearst's New York American newspapers from October 15, 1905 – April 23, 1911 and April 30, 1911 – July 26, 1914; respectively.The...

    .
  • The third title, "In the Belly of the Boss" is a reference to In the Belly of the Beast
    In the Belly of the Beast
    In the Belly of the Beast is a book written by Jack Abbott and published in 1981.Jack Abbott was an American career criminal and the book consists of his letters to Norman Mailer about his experiences in what Abbott saw as a brutal and unjust prison system...

    , but the plot is a parody of Fantastic Voyage
    Fantastic Voyage
    Fantastic Voyage is a 1966 science fiction film written by Harry Kleiner, based on a story by Otto Klement and Jerome Bixby.Bantam Books obtained the rights for a paperback novelization based on the screenplay and approached Isaac Asimov to write it....

    .
  • Professor Frink
    Professor Frink
    Professor John Nerdelbaum Frink, Jr., or simply Professor Frink, is a recurring character in the animated television series The Simpsons. He is voiced by Hank Azaria, and first appeared in the 1991 episode "Old Money". Frink is Springfield's nerdy scientist and professor and is extremely...

     shows a drawing of a "retro-virus"
    Retrovirus
    A retrovirus is an RNA virus that is duplicated in a host cell using the reverse transcriptase enzyme to produce DNA from its RNA genome. The DNA is then incorporated into the host's genome by an integrase enzyme. The virus thereafter replicates as part of the host cell's DNA...

    . Its style greatly resembles the works of Robert Crumb
    Robert Crumb
    Robert Dennis Crumb —known as Robert Crumb and R. Crumb—is an American artist, illustrator, and musician recognized for the distinctive style of his drawings and his critical, satirical, subversive view of the American mainstream.Crumb was a founder of the underground comix movement and is regarded...

    , who is said to have drawn it.
  • When Lisa and Bart pass a movie theater the movie showing is called Abbott and Costello Meet Polio. This is a reference to some of Bud Abbott
    Bud Abbott
    William Alexander "Bud" Abbott was an American actor, producer and comedian. He is best remembered as the straight man of the comedy team of Abbott and Costello, with Lou Costello.-Early life:...

    s and Lou Costello
    Lou Costello
    Louis Francis "Lou" Costello was an American actor and comedian best known as half of the comedy team of Abbott and Costello, with Bud Abbott...

    's films that started with Abbott and Costello Meet...
  • While the Simpsons are being injected into Mr. Burns’s body, he is reading Premiere magazine
    Premiere (magazine)
    Premiere was an American and New York City-based film magazine published by Hachette Filipacchi Media U.S., published between the years 1987 and 2007. The original version of the magazine, Première , was started in France in 1976 and is still being published there.-History:The magazine originally...

    .
  • The song playing at the end of the last sketch is Frank Sinatra’s
    Frank Sinatra
    Francis Albert "Frank" Sinatra was an American singer and actor.Beginning his musical career in the swing era with Harry James and Tommy Dorsey, Sinatra became an unprecedentedly successful solo artist in the early to mid-1940s, after being signed to Columbia Records in 1943. Being the idol of the...

     “I've Got You Under My Skin
    I've Got You Under My Skin
    "I've Got You Under My Skin" is a song by Cole Porter.I've Got You Under My Skin may also refer to:* "I've Got You Under My Skin" , a 1998 episode of the television series Charmed...

    ”.
  • The end credits play the opening theme of Perfect Strangers
    Perfect Strangers (TV series)
    Perfect Strangers is an American sitcom that ran for eight seasons from March 25, 1986, to August 6, 1993, on the ABC television network. Created by Dale McRaven, the series chronicles the rocky coexistence of midwestern American Larry Appleton and his distant cousin from eastern Mediterranean...

    . This song also plays at the beginning of this episode.
  • The Sherlock Holmes story "The Man with the Twisted Lip
    The Man with the Twisted Lip
    "The Man with the Twisted Lip", one of the 56 short Sherlock Holmes stories written by British author Sir Arthur Conan Doyle, is the sixth of the twelve stories in The Adventures of Sherlock Holmes. The story was first published in the Strand Magazine in December 1891...

    " is set in an opium den.
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