RELA
Encyclopedia
Transcription factor p65 is a protein
that in humans is encoded by the RELA gene
.
with NFKBIB
, ETHE1
, NFKBIE
, RFC1
, TRIB3
, CREB binding protein
, Neutrophil cytosolic factor 1, Glucocorticoid receptor
, MTPN
, BRCA1
, C-Fos
, POU2F1
, BTRC
, TATA-binding protein, IκBα, NFKB2
, NFKB1
, Nuclear receptor co-repressor 2
, Aryl hydrocarbon receptor
, CEBPB
, HDAC3
, DHX9
, PARP1
, ASCC3
, HDAC1
, CSNK2A2
, Histone deacetylase 2
, Casein kinase 2, alpha 1, Protein kinase Mζ, STAT3
, RNF25
, Sp1 transcription factor, CDK9
, TAF4B
, MEN1
, PPP1R13L
, APBA2
, REL
, ING4
, EP300
, FUS
, PIAS3
and C-jun
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the RELA gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
RELA has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NFKBIB
NFKBIB
NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.-Interactions:NFKBIB has been shown to interact with RELA, Retinoid X receptor alpha and IKK2.-Further reading:...
, ETHE1
ETHE1
Protein ETHE1, mitochondrial is a protein that in humans is encoded by the ETHE1 gene.-Further reading:...
, NFKBIE
NFKBIE
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.- Function :...
, RFC1
RFC1
Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.-Interactions:RFC1 has been shown to interact with BRD4, HDAC1, RFC3, RELA and PCNA.-Further reading:...
, TRIB3
TRIB3
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.-Interactions:TRIB3 has been shown to interact with CSNK2B, TIAF1, RELA, MCM3AP, ATF5, Granulin, ATF4, AKT1, Fibronectin and SIAH1.-Further reading:...
, CREB binding protein
CREB binding protein
CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor...
, Neutrophil cytosolic factor 1, Glucocorticoid receptor
Glucocorticoid receptor
The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....
, MTPN
MTPN
Myotrophin is a protein that in humans is encoded by the MTPN gene.-Interactions:MTPN has been shown to interact with RELA and REL.-Further reading:...
, BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
, C-Fos
C-Fos
In the field of molecular biology and Genetics, c-Fos is a protein encoded by the FOS gene.-Structure and function:c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at...
, POU2F1
POU2F1
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.-Interactions:POU2F1 has been shown to interact with SNAPC4, Ku80, Glucocorticoid receptor, Sp1 transcription factor, NPAT, POU2AF1, Host cell factor C1, TATA binding protein, RELA, Nuclear...
, BTRC
BTRC (gene)
F-box/WD repeat-containing protein 1A also known as βTrCP1 or Fbxw1 or hsSlimb or pIkappaBalpha-E3 receptor subunit is a protein that in humans is encoded by the BTRC gene....
, TATA-binding protein, IκBα, NFKB2
NFKB2
Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.-Interactions:NFKB2 has been shown to interact with NFKBIE, BCL3, MAP3K8, BTRC, RELA, RELB, NFKB1, REL and TSC22D3.-Further reading:...
, NFKB1
NFKB1
Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...
, Nuclear receptor co-repressor 2
Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target...
, Aryl hydrocarbon receptor
Aryl hydrocarbon receptor
The Aryl hydrocarbon receptor is a member of the family of basic-helix-loop-helix transcription factors. AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones...
, CEBPB
CEBPB
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.- Function :The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins...
, HDAC3
HDAC3
Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.-Interactions:HDAC3 has been shown to interact with HDAC9, HDAC7A, Retinoblastoma protein, RBBP4, Testicular receptor 2, MAP3K7IP2, Peroxisome proliferator-activated receptor delta, GTF2I, Histone deacetylase 5, RELA,...
, DHX9
DHX9
ATP-dependent RNA helicase A is an enzyme that in humans is encoded by the DHX9 gene.-Interactions:...
, PARP1
PARP1
Poly [ADP-ribose] polymerase 1 also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.- Function :PARP1 works:...
, ASCC3
ASCC3
Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.-Interactions:ASCC3 has been shown to interact with RELA, C-jun and Serum response factor.-Further reading:...
, HDAC1
HDAC1
Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...
, CSNK2A2
CSNK2A2
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A2 gene.-Interactions:CSNK2A2 has been shown to interact with CSNK2B, FGF1, PTEN, RELA, ATF1, Nucleolin, CREB binding protein, Activating transcription factor 2, PIN1, C-jun and C-Fos.-Further reading:...
, Histone deacetylase 2
Histone deacetylase 2
Histone deacetylase 2 is an enzyme that in humans is encoded by the HDAC2 gene.-Interactions:Histone deacetylase 2 has been shown to interact with CHD3, MTA1, FKBP3, CHD4, RCOR1, Retinoblastoma protein, CDC20, RBBP4, CDH1, EED, GTF2I, Host cell factor C1, PHF21A, BUB3, MXD1, HDAC10, RELA, Sp3...
, Casein kinase 2, alpha 1, Protein kinase Mζ, STAT3
STAT3
Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene.- Function :The protein encoded by this gene is a member of the STAT protein family...
, RNF25
RNF25
E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.-Further reading:...
, Sp1 transcription factor, CDK9
CDK9
CDK9 or cyclin-dependent kinase 9 is a cyclin-dependent kinase associated with P-TEFb.CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle...
, TAF4B
TAF4B
Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.-Further reading:...
, MEN1
MEN1
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1....
, PPP1R13L
PPP1R13L
RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene.-Interactions:PPP1R13L has been shown to interact with Sp1 transcription factor and RELA.-Further reading:...
, APBA2
APBA2
Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.-Interactions:APBA2 has been shown to interact with CLSTN1, RELA and Amyloid precursor protein.-Further reading:...
, REL
REL
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell...
, ING4
ING4
Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.-Interactions:ING4 has been shown to interact with EP300, RELA and P53.-Further reading:...
, EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
, FUS
FUS
RNA-binding protein FUS is a protein that in humans is encoded by the FUS gene.- Function :The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding...
, PIAS3
PIAS3
E3 SUMO-protein ligase PIAS3 is an enzyme that in humans is encoded by the PIAS3 gene.-Interactions:PIAS3 has been shown to interact with GFI1, RELA, Mothers against decapentaplegic homolog 3, Microphthalmia-associated transcription factor, HMGA2 and Mothers against decapentaplegic homolog...
and C-jun
C-jun
c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...
.