Tribbles homolog 3 is a protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the TRIB3 gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...



TRIB3 has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with CSNK2B
Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Serine or Threonine in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits...

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.-Interactions:TIAF1 has been shown to interact with Janus kinase 3 and TRIB3.-Further reading:...

Transcription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.-Interactions:MCM3AP has been shown to interact with MCM3 and TRIB3.-Further reading:...

, ATF5
Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.- Function :First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor /cAMP response-element binding protein family.ATF5...

, Granulin
Granulin is a protein that in humans is encoded by the GRN gene.- Structure :Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein,...

, ATF4
Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.- Function :...

, AKT1
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. Multiple alternatively spliced transcript variants have been found for this gene.- Function :...

, Fibronectin
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans...

 and SIAH1
E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene.-Interactions:SIAH1 has been shown to interact with PEG10, CACYBP, POU2AF1, RBBP8, BAG1, TRIB3, NUMB, KIF22, KHDRBS3, PEG3 and APC.-References:...


Further reading

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