Paul D. Boyer
Encyclopedia
Paul Delos Boyer is an American
biochemist
and analytical chemist. He shared the 1997 Nobel Prize in Chemistry
for research
on the "enzymatic mechanism underlying the biosynthesis
of adenosine triphosphate
(ATP)" (ATP synthase
) with John E. Walker
; the remainder of the Prize in that year was awarded to Danish chemist Jens Christian Skou
for his discovery of the Na+/K+-ATPase
.
. He grew up in a nonpracticing Mormon family. He attended Provo High School
, where he was active in student government and the debating team. He received a B.S.
in chemistry
from Brigham Young University
in 1939 and obtained a Wisconsin Alumni Research Foundation Scholarship
for graduate studies. Five days before leaving for Wisconsin
, Paul married Lyda Whicker. They remain married and have three children: Gail B. Hayes, Alexandra Boyer and Dr. Douglas Boyer; and eight grandchildren: Imran Clark, Mashuri Clark, Rashid Clark, Djahari Clark, Faisal Clark, Lisa A. Hayes, Leah Boyer and Josh Boyer.
Though the Boyers connected with the Mormon community in Wisconsin, they considered themselves "on the wayward fringe" and doubted the doctrinal claims of The Church of Jesus Christ of Latter-day Saints (LDS Church). After experimenting with Unitarianism
, Boyer's scientific background led him to eventually accept atheism
.
from the University of Wisconsin–Madison
in 1943, he spent years at Stanford University
on a war-related research project dedicated to stabilization of serum albumin for transfusions. He began his independent research career at the University of Minnesota
and introduced kinetic, isotopic, and chemical methods for investigating enzyme
mechanisms. In 1955, he received a Guggenheim Fellowship
and worked with Professor
Hugo Theorell
on the mechanism of alcohol dehydrogenase
. In 1956, he accepted a Hill Foundation Professorship and moved to the medical campus of the University of Minnesota. In 1959-1960, he served as Chairman of the Biochemistry Section of the American Chemical Society
(ACS) and in 1969-1970 as President
of the American Society of Biological Chemists.
Since 1963, he has been a Professor in the Department of Chemistry and Biochemistry at University of California, Los Angeles
. In 1965, he became the Founding Director of the Molecular Biology
Institute and spearheaded the construction of the building and the organization of an interdepartmental Ph.D. program. This institutional service did not diminish the creativity and originality of his research program, which led to three postulates for the binding mechanism for ATP synthesis—that energy input was not used primarily to form ATP but to promote the binding of phosphate
and mostly the release of tightly bound ATP; that three identical catalytic sites went through compulsory, sequential binding changes; and that the binding changes of the catalytic subunites, circularly arranged on the periphery of the enzyme, were driven by the rotation of a smaller internal subunit
.
Paul Boyer was Editor
or Associate Editor of the Annual Review of Biochemistry from 1963-1989. He was Editor of the classic series, "The Enzymes". In 1981, he was Faculty Research Lecturer at UCLA. In that same year, he was awarded the prestigious Tolman Medal by the Southern California Section of the American Chemical Society
.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
biochemist
Biochemist
Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...
and analytical chemist. He shared the 1997 Nobel Prize in Chemistry
Nobel Prize in Chemistry
The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature,...
for research
Research
Research can be defined as the scientific search for knowledge, or as any systematic investigation, to establish novel facts, solve new or existing problems, prove new ideas, or develop new theories, usually using a scientific method...
on the "enzymatic mechanism underlying the biosynthesis
Biosynthesis
Biosynthesis is an enzyme-catalyzed process in cells of living organisms by which substrates are converted to more complex products. The biosynthesis process often consists of several enzymatic steps in which the product of one step is used as substrate in the following step...
of adenosine triphosphate
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
(ATP)" (ATP synthase
ATP synthase
right|thumb|300px|Molecular model of ATP synthase by X-ray diffraction methodATP synthase is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate . ATP is the most commonly used "energy currency" of cells from most organisms...
) with John E. Walker
John E. Walker
Professor Sir John Ernest Walker is an English chemist who won the Nobel Prize in Chemistry in 1997. He is currently the director of the MRC Mitochondrial Biology Unit in Cambridge, and a Fellow of Sidney Sussex College.He was born in Halifax, Yorkshire, the son of Thomas Ernest Walker, a...
; the remainder of the Prize in that year was awarded to Danish chemist Jens Christian Skou
Jens Christian Skou
Jens Christian Skou is a Danish chemist and Nobel laureate.Skou was born in Lemvig, Denmark to a wealthy family. His father Magnus Martinus Skou was a timber and coal merchant. His mother Ane-Margrethe Skou took over the company after the death of his father. At the age of 15 Skou entered a...
for his discovery of the Na+/K+-ATPase
Na+/K+-ATPase
Na+/K+-ATPase is an enzyme located in the plasma membrane in all animals.- Sodium-potassium pumps :Active transport is responsible for cells containing relatively high...
.
Birth and education
Boyer was born in Provo, UtahProvo, Utah
Provo is the third largest city in the U.S. state of Utah, located about south of Salt Lake City along the Wasatch Front. Provo is the county seat of Utah County and lies between the cities of Orem to the north and Springville to the south...
. He grew up in a nonpracticing Mormon family. He attended Provo High School
Provo High School
Provo High School is a public secondary school located in Provo, Utah. It is one of the schools in the Provo District. It is part of the Provo City School District, and is the oldest existent secondary school in the city...
, where he was active in student government and the debating team. He received a B.S.
Bachelors Of Science
Bachelors of Science is the stage name of Phil "Rene", Chris and Lukeino. They met in California and formed a successful act, quickly becoming one of the top drum and bass producers in the electronic music scene...
in chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
from Brigham Young University
Brigham Young University
Brigham Young University is a private university located in Provo, Utah. It is owned and operated by The Church of Jesus Christ of Latter-day Saints , and is the United States' largest religious university and third-largest private university.Approximately 98% of the university's 34,000 students...
in 1939 and obtained a Wisconsin Alumni Research Foundation Scholarship
Scholarship
A scholarship is an award of financial aid for a student to further education. Scholarships are awarded on various criteria usually reflecting the values and purposes of the donor or founder of the award.-Types:...
for graduate studies. Five days before leaving for Wisconsin
Wisconsin
Wisconsin is a U.S. state located in the north-central United States and is part of the Midwest. It is bordered by Minnesota to the west, Iowa to the southwest, Illinois to the south, Lake Michigan to the east, Michigan to the northeast, and Lake Superior to the north. Wisconsin's capital is...
, Paul married Lyda Whicker. They remain married and have three children: Gail B. Hayes, Alexandra Boyer and Dr. Douglas Boyer; and eight grandchildren: Imran Clark, Mashuri Clark, Rashid Clark, Djahari Clark, Faisal Clark, Lisa A. Hayes, Leah Boyer and Josh Boyer.
Though the Boyers connected with the Mormon community in Wisconsin, they considered themselves "on the wayward fringe" and doubted the doctrinal claims of The Church of Jesus Christ of Latter-day Saints (LDS Church). After experimenting with Unitarianism
Unitarianism
Unitarianism is a Christian theological movement, named for its understanding of God as one person, in direct contrast to Trinitarianism which defines God as three persons coexisting consubstantially as one in being....
, Boyer's scientific background led him to eventually accept atheism
Atheism
Atheism is, in a broad sense, the rejection of belief in the existence of deities. In a narrower sense, atheism is specifically the position that there are no deities...
.
Academic career
After Boyer received his Ph.D. degree in biochemistryBiochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
from the University of Wisconsin–Madison
University of Wisconsin–Madison
The University of Wisconsin–Madison is a public research university located in Madison, Wisconsin, United States. Founded in 1848, UW–Madison is the flagship campus of the University of Wisconsin System. It became a land-grant institution in 1866...
in 1943, he spent years at Stanford University
Stanford University
The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private research university on an campus located near Palo Alto, California. It is situated in the northwestern Santa Clara Valley on the San Francisco Peninsula, approximately northwest of San...
on a war-related research project dedicated to stabilization of serum albumin for transfusions. He began his independent research career at the University of Minnesota
University of Minnesota
The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. It is the oldest and largest part of the University of Minnesota system and has the fourth-largest main campus student body in the United States, with 52,557...
and introduced kinetic, isotopic, and chemical methods for investigating enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
mechanisms. In 1955, he received a Guggenheim Fellowship
Guggenheim Fellowship
Guggenheim Fellowships are American grants that have been awarded annually since 1925 by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the arts." Each year, the foundation makes...
and worked with Professor
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
Hugo Theorell
Hugo Theorell
Axel Hugo Theodor Theorell was a Swedish scientist and Nobel Prize laureate in medicine.He was born in Linköping as the son of Thure Theorell and his wife Armida Bill. Theorell went to Secondary School at Katedralskolan in Linköping and passed his examination there on 23 May 1921...
on the mechanism of alcohol dehydrogenase
Alcohol dehydrogenase
Alcohol dehydrogenases are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide...
. In 1956, he accepted a Hill Foundation Professorship and moved to the medical campus of the University of Minnesota. In 1959-1960, he served as Chairman of the Biochemistry Section of the American Chemical Society
American Chemical Society
The American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 161,000 members at all degree-levels and in all fields of chemistry, chemical...
(ACS) and in 1969-1970 as President
President
A president is a leader of an organization, company, trade union, university, or country.Etymologically, a president is one who presides, who sits in leadership...
of the American Society of Biological Chemists.
Since 1963, he has been a Professor in the Department of Chemistry and Biochemistry at University of California, Los Angeles
University of California, Los Angeles
The University of California, Los Angeles is a public research university located in the Westwood neighborhood of Los Angeles, California, USA. It was founded in 1919 as the "Southern Branch" of the University of California and is the second oldest of the ten campuses...
. In 1965, he became the Founding Director of the Molecular Biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
Institute and spearheaded the construction of the building and the organization of an interdepartmental Ph.D. program. This institutional service did not diminish the creativity and originality of his research program, which led to three postulates for the binding mechanism for ATP synthesis—that energy input was not used primarily to form ATP but to promote the binding of phosphate
Phosphate
A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in...
and mostly the release of tightly bound ATP; that three identical catalytic sites went through compulsory, sequential binding changes; and that the binding changes of the catalytic subunites, circularly arranged on the periphery of the enzyme, were driven by the rotation of a smaller internal subunit
Protein subunit
In structural biology, a protein subunit or subunit protein is a single protein molecule that assembles with other protein molecules to form a protein complex: a multimeric or oligomeric protein. Many naturally occurring proteins and enzymes are multimeric...
.
Paul Boyer was Editor
Editing
Editing is the process of selecting and preparing written, visual, audible, and film media used to convey information through the processes of correction, condensation, organization, and other modifications performed with an intention of producing a correct, consistent, accurate, and complete...
or Associate Editor of the Annual Review of Biochemistry from 1963-1989. He was Editor of the classic series, "The Enzymes". In 1981, he was Faculty Research Lecturer at UCLA. In that same year, he was awarded the prestigious Tolman Medal by the Southern California Section of the American Chemical Society
American Chemical Society
The American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 161,000 members at all degree-levels and in all fields of chemistry, chemical...
.
Publications
- Dahms, A. S. & P. D. Boyer. "Occurrence and Characteristics of {sup 18}O-exchange Reactions Catalyzed By Sodium- and Potassium-dependent Adenosine Triphosphatases", University of California Los Angeles (UCLA), United States Department of EnergyUnited States Department of EnergyThe United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material...
(through predecessor agency the Atomic Energy CommissionUnited States Atomic Energy CommissionThe United States Atomic Energy Commission was an agency of the United States government established after World War II by Congress to foster and control the peace time development of atomic science and technology. President Harry S...
), (1972). - Kanazawa, T. & P. D. Boyer. "Occurrence and Characteristics of a Rapid Exchange of Phosphate Oxygens Catalyzed by Sarcoplasmic Reticulum Vesicles", University of California Los Angeles (UCLA), United States Department of EnergyUnited States Department of EnergyThe United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material...
(through predecessor agency the Atomic Energy CommissionUnited States Atomic Energy CommissionThe United States Atomic Energy Commission was an agency of the United States government established after World War II by Congress to foster and control the peace time development of atomic science and technology. President Harry S...
), (1972). - Boyer, P. D. "Isotopic Studies on Structure-function Relationships of Nucleic Acids and Enzymes. Three Year Progress Report, May 1972 — October 1975", University of California Los Angeles (UCLA), United States Department of EnergyUnited States Department of EnergyThe United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material...
(through predecessor agency the Energy Research and Development Administration), (1975). - Boyer, P. D. "Energy Capture and Use in Plants and Bacteria. Final Technical Report", University of California Los Angeles (UCLA), United States Department of EnergyUnited States Department of EnergyThe United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material...
, (December 31, 1993).
External links
- Photograph, Biography and Bibliographic Resources, from the Office of Scientific and Technical InformationOffice of Scientific and Technical InformationThe Office of Scientific and Technical Information is a component of the Office of Science within the U.S. Department of Energy...
, United States Department of EnergyUnited States Department of EnergyThe United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material... - Nobel autobio. — Paul D. Boyer
- Nobel Prize press release — The 1997 Nobel Prize in Chemistry
- UCLA webpage — Paul D. Boyer