Organon International
Encyclopedia
Organon is a human pharmaceutical company headquartered in Oss
, Netherlands
. In November 2007 the company became a part of Schering-Plough
Corporation, acquired Organon, active pharmaceutical ingredient producer Diosynth
(separate from Organon until 2004), and its veterinary pharmaceutical sister company Intervet from Akzo Nobel
. In November 2009 Schering-Plough
merged with Merck & Co.
under the name Merck & Co., known as Merck Sharp & Dohme or MSD outside the United States and Canada.
Organon deals in the following core therapeutic fields: reproductive medicine
, contraception
, psychiatry
, HRT
and anesthesia
. Organon sells to international markets.
, the Netherlands, in 1923 as Zwanenberg-Organon. Its first product was insulin
in 1923. In the thirties it manufactured estrogen
s. In 1948, Organon acquired the Newhouse research site
in Scotland
, United Kingdom
. The production of cortison was initiated in 1953. The now named Koninklijke Zwanenberg-Organon (KZO) fused with the fiber producer AKU in 1969 to become AKZO, later Akzo Nobel. Organon is the human health care business unit of Akzo Nobel
and transferred its headquarters to the USA while the main headquarter of Akzo Nobel remained in Arnhem
, and has since moved to Amsterdam
. Manufacturing facilities are in the Netherlands, Germany, the United Kingdom, Ireland, China, Japan, and the USA.
, Remeron, Remeron SolTab, Sugammadex
, Sustanon
, Deca-Durabolin, Pregnyl, Implanon
, NuvaRing
, Marvelon, Desolett and a variety of other contraceptive products.
Oss
Oss is a municipality and a city in the southern Netherlands, in the province of Noord Brabant.- Population centres :-Transportation:* Railway stations: Oss, Oss West, Ravenstein- The city of Oss :...
, Netherlands
Netherlands
The Netherlands is a constituent country of the Kingdom of the Netherlands, located mainly in North-West Europe and with several islands in the Caribbean. Mainland Netherlands borders the North Sea to the north and west, Belgium to the south, and Germany to the east, and shares maritime borders...
. In November 2007 the company became a part of Schering-Plough
Schering-Plough
Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...
Corporation, acquired Organon, active pharmaceutical ingredient producer Diosynth
Diosynth
Diosynth is a company that develops manufacturing processes for active ingredients for pharmaceutical companies all over the world.The company started in Oss, Netherlands in 1923 with the extraction of insulin from bovine pancreas, and porcine insulin extraction in 1930, both of which are still...
(separate from Organon until 2004), and its veterinary pharmaceutical sister company Intervet from Akzo Nobel
Akzo Nobel
Akzo Nobel N.V., trading as AkzoNobel, is a Dutch multinational, active in the fields of decorative paints, performance coatings and specialty chemicals. Headquartered in Amsterdam, the company has activities in more than 80 countries, and employs approximately 55,000 people. Sales in 2010 were EUR...
. In November 2009 Schering-Plough
Schering-Plough
Schering-Plough Corporation was a United States-based pharmaceutical company. It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. In 1971, the Schering Corporation merged with Plough to form Schering-Plough. On November 4, 2009 Merck & Co...
merged with Merck & Co.
Merck & Co.
Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...
under the name Merck & Co., known as Merck Sharp & Dohme or MSD outside the United States and Canada.
Organon deals in the following core therapeutic fields: reproductive medicine
Reproductive medicine
Reproductive medicine is a branch of medicine that deals with prevention, diagnosis and management of reproductive problems; goals include improving or maintaining reproductive health and allowing people to have children at a time of their choosing...
, contraception
Contraception
Contraception is the prevention of the fusion of gametes during or after sexual activity. The term contraception is a contraction of contra, which means against, and the word conception, meaning fertilization...
, psychiatry
Psychiatry
Psychiatry is the medical specialty devoted to the study and treatment of mental disorders. These mental disorders include various affective, behavioural, cognitive and perceptual abnormalities...
, HRT
HRT
-Medical:* Habit reversal training* Heart rate turbulence* Hormone replacement therapy , for women* Hormone replacement therapy , for men* Hormone replacement therapy , for trans women...
and anesthesia
Anesthesia
Anesthesia, or anaesthesia , traditionally meant the condition of having sensation blocked or temporarily taken away...
. Organon sells to international markets.
History
Organon was founded by Dr. Saal van Zwanenberg in OssOss
Oss is a municipality and a city in the southern Netherlands, in the province of Noord Brabant.- Population centres :-Transportation:* Railway stations: Oss, Oss West, Ravenstein- The city of Oss :...
, the Netherlands, in 1923 as Zwanenberg-Organon. Its first product was insulin
Insulin
Insulin is a hormone central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle....
in 1923. In the thirties it manufactured estrogen
Estrogen
Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...
s. In 1948, Organon acquired the Newhouse research site
Newhouse Research Site
The Newhouse Research Site is a drug research facility situated east of Glasgow in central Scotland. It is located beside the M8 motorway in Newhouse, North Lanarkshire. The site is an early drug discovery research centre with a track record of generating a succession of products in the areas of...
in Scotland
Scotland
Scotland is a country that is part of the United Kingdom. Occupying the northern third of the island of Great Britain, it shares a border with England to the south and is bounded by the North Sea to the east, the Atlantic Ocean to the north and west, and the North Channel and Irish Sea to the...
, United Kingdom
United Kingdom
The United Kingdom of Great Britain and Northern IrelandIn the United Kingdom and Dependencies, other languages have been officially recognised as legitimate autochthonous languages under the European Charter for Regional or Minority Languages...
. The production of cortison was initiated in 1953. The now named Koninklijke Zwanenberg-Organon (KZO) fused with the fiber producer AKU in 1969 to become AKZO, later Akzo Nobel. Organon is the human health care business unit of Akzo Nobel
Akzo Nobel
Akzo Nobel N.V., trading as AkzoNobel, is a Dutch multinational, active in the fields of decorative paints, performance coatings and specialty chemicals. Headquartered in Amsterdam, the company has activities in more than 80 countries, and employs approximately 55,000 people. Sales in 2010 were EUR...
and transferred its headquarters to the USA while the main headquarter of Akzo Nobel remained in Arnhem
Arnhem
Arnhem is a city and municipality, situated in the eastern part of the Netherlands. It is the capital of the province of Gelderland and located near the river Nederrijn as well as near the St. Jansbeek, which was the source of the city's development. Arnhem has 146,095 residents as one of the...
, and has since moved to Amsterdam
Amsterdam
Amsterdam is the largest city and the capital of the Netherlands. The current position of Amsterdam as capital city of the Kingdom of the Netherlands is governed by the constitution of August 24, 1815 and its successors. Amsterdam has a population of 783,364 within city limits, an urban population...
. Manufacturing facilities are in the Netherlands, Germany, the United Kingdom, Ireland, China, Japan, and the USA.
Products
Products include: Bridion, EsmirtazapineEsmirtazapine
Esmirtazapine is a drug which is under development by Organon for the treatment of insomnia and vasomotor symptoms associated with menopause. As of 2009 it is in phase III clinical trials...
, Remeron, Remeron SolTab, Sugammadex
Sugammadex
Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent and was discovered at the Newhouse research site in Scotland. . These scientists who discovered Sugammadex worked for the pharmaceutical...
, Sustanon
Sustanon
Sustanon 250 is a trade name for an oil-based injectable blend of four esterized testosterone compounds:* 30 mg testosterone propionate* 60 mg testosterone phenylpropionate* 60 mg testosterone isocaproate* 100 mg testosterone decanoate...
, Deca-Durabolin, Pregnyl, Implanon
Implanon
Implanon, made by Organon International, is a single-rod long acting reversible hormonal contraceptive subdermal implant that is inserted just under the skin of a woman's upper arm. The 4 cm by 2 mm Implanon rod contains 68 milligrams of etonogestrel which is released over a three year...
, NuvaRing
NuvaRing
NuvaRing is the trade name for a combined hormonal contraceptive vaginal ring manufactured by Merck that is available by prescription...
, Marvelon, Desolett and a variety of other contraceptive products.
Research compounds
During its period of independent operation, Organon developed a large number of compounds which were never adopted for medical use, but continue to be used for a variety of scientific research. Notable compounds include:- Org 12,962Org 12,962Org 12,962 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes...
- Org 20599Org 20599Org 20599 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive modulator. It was developed for use as an anaesthetic agent but was never marketed for this purpose, although it is still used in scientific research....
- Org 21465Org 21465Org 21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive modulator. It is similar to related drugs such as Org 20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and...
- Org 25435Org 25435Org 25435 is a synthetic drug which acts as a GABAA receptor positive modulator, and produces sedative effects. It has been researched for use as an intravenous anesthetic agent, with positive results in initial trials, although negative side effects like hypotension and tachycardia, as well as...
- Org 25935Org 25935Org 25935 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1. In animal tests it reduces alcohol consumption and has analgesic and anticonvulsant effects, but it has mainly been studied for its antipsychotic properties, and...
- Org 26576 ([9aS]-8,9,9a,10-tetrahydro-5H,7H-pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one)
- Org 27569Org 27569Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP...
- Org 28312Org 28312Org 28312 is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors...
- Org 28611Org 28611Org 28611 is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors...
- Org 37,684