Org 21465
Encyclopedia
Org 21465 is a synthetic neuroactive steroid
, with sedative
effects resulting from its action as a GABAA receptor positive modulator. It is similar to related drugs such as Org 20599
, and was similarly developed as an improved alternative to other sedative steroids such as althesin
and allopregnanolone
, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.
Neuroactive steroid
Neuroactive steroids rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels. In addition, these steroids may also exert effects on gene expression via intracellular steroid hormone receptors...
, with sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
effects resulting from its action as a GABAA receptor positive modulator. It is similar to related drugs such as Org 20599
Org 20599
Org 20599 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive modulator. It was developed for use as an anaesthetic agent but was never marketed for this purpose, although it is still used in scientific research....
, and was similarly developed as an improved alternative to other sedative steroids such as althesin
Althesin
Alfaxolone/alfadolone is a short acting intravenous anaesthetic agent, now withdrawn from the market due to severe drug reactions. It is composed of a mixture of alfaxalone and alfadolone, two neurosteroids.Cremophor EL Alfaxolone/alfadolone (Althesin) is a short acting intravenous anaesthetic...
and allopregnanolone
Allopregnanolone
Allopregnanolone is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors...
, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.