Indian Drugs and Pharmaceuticals Limited
Encyclopedia
Indian Drugs and Pharmaceuticals Limited (IDPL) is a large Indian government-owned pharmaceutical manufacturing company, incorporated on 5 April 1961 with the aim of achieving India
's self-sufficiency in pharmaceuticals manufacturing. IDPL performed a pioneering role in the growth of the Indian drug industry base. It contributed significantly towards this objective in the area of such essential and life-saving drugs as narrow-spectrum antibiotics. IDPL employs scientific and technical personnel and has established the necessary infrastructure and modern technology to enlarge commercial production and promote research, development, and design efforts.
With the adoption of good manufacturing practice
conforming to World Health Organization
recommendations, it has set stringent quality standards to ensure excellent products. IDPL products and services have been recognised by the World Health Organization.
, that the drug industry must be in the public sector: "I think an industry of the nature of the drug industry should not be in the private sector anyhow. There are for too much exploitation of the public in this industry". Thus IDPL was incorporated in April 1961. The main objectives were to make India self-sufficient in respect of essential life-saving medicines, to free the country from dependence on imports, and to provide medicines to the general public at affordable prices. IDPL was conceived and established as a part of the health care infrastructure, and has played a pioneering role in the growth of the Indian drug industry base.
(providing Chloroquine
) and in the prevention of dehydration
(providing oral rehydration solution). During the country’s calamitous outbreak of plague in 1994
, IDPL supplied Tetracycline for the entire nation. The company has provided an uninterrupted supply of Chloroquine
to combat malaria epidemics in different parts of the country. To combat the national emergency of a leptospirosis
epidemic arising due to floods in Maharashtra
in 2005, IDPL supplied the required Doxycycline
capsules.
. The company has two subsidiaries, IDPL (Tamil Nadu) Ltd in Chennai
and Bihar Drugs and Organic Chemicals Ltd in Muzaffarpur
, Bihar
. Two joint sector companies that work in collaboration with the state governments are Rajasthan Drugs and Pharmaceuticals Ltd (RDPL) of Rajasthan
and Orissa Drugs and Chemicals Ltd (ODCL) in Orissa
.
The plant is home to a Research and Development Centre with three main divisions: Chemistry
, Biology
(including pharmacology
and toxicology
), and Pilot. Other facilities include an instrumentation section, a glass fabrication workshop, an animal house, a large library, and an auditorium. A number of technologies for production of bulk drugs were developed and successfully implemented at this plant. About 4,500 compounds belonging to various structural types were synthesised and subjected to in-house primary and secondary screenings.
It has the capacity to manufacture oral contraceptive
and emergency pills, and is one of five regular suppliers of these pills to the Ministry of Health
and Family Welfare, Government of India
.
A separate block for production of anti-retroviral drugs to combat HIV/AIDS disease will soon be entering production. The Rishikesh plant received the National Award for Prevention of Pollution–1992 from the President of India
on 6 August 1994.
(1979) is located in Haryana
(a neighborhood of the Indian capital, New Delhi
). It is spread over 90 acre (0.3642174 km²). It has production capacities for a wide range of formulations, such as tablets (1,296 million per year), liquid orals (396,000 litres per year) and dry syrup (36 lakh
bottles per year). It has so far produced 60 formulations in various dosage forms. This plant also has a large capacity to manufacture oral contraceptive pills, and is supported by a Quality Control
Department. It has an effluent treatment plant and a Formulations Development Research Laboratory. There is also a township with 128 flats and necessary facilities.
(1965) is spread over 123 acre (0.49776378 km²). It was commissioned as an engineering-based company to manufacture surgical instruments. To improve its viability, it diversified to supply detachable scalpel blades in 1975–76, set up a fabrication shop in 1977–78, a formulations division in 1978–79, a hospital equipment division in 1992–93, and AIDS and appliances in 1994–95. In March 1994 the plant was incorporated and converted into a subsidiary unit of IDPL. It is an Implementing Agency under Assistance to Disabled Impaired Persons (ADIP) for southern States by Ministry of Welfare, Government of India, for AIDS and appliances. It has a large production capacity of formulations like tablets (900 million per year) and capsules (200 million per year).
Bihar Drugs & Organic Chemicals Ltd Muzaffarpur
, Bihar (1979) is an organic chemical plant. In March 1994 the plant became a subsidiary unit of IDPL. This is the only plant in the country manufacturing Niacinamide starting from alcohol as principal raw material. It has a locational advantage, as several alcohol-producing distilleries and more than 15 sugar mills, which feed molasses to these distilleries, are situated within a radius of 150 kilometres (93.2 mi). It has a large production capacity to manufacture Acetaldehyde
(7,500 metric tons), Acetic acid
(4,500 metric tonnes), Methyl-Ethyl Pyridine (1,200 metric tons), Niacin
(500 metric tons) and Niacinamide (300 metric tons). The plant is being upgraded to manufacture antibiotic macrolides—Roxithromycin
, Azithromycin
, and Clarithromycin
. The production of these bulk drugs is likely to be started shortly.
(R&D) is fully equipped with modern technologies to enable it to help India build self-reliance and meet its health needs. IDPL has two R&D Centres, one at Hyderabad Unit and another at Rishikesh Unit, with large animal houses. These centres endeavour to create substitutes for imports, improve and update technologies, develop new drugs and formulations, and create high-yielding strains for antibiotics. Vitamin B6 was produced in India for the first time because of IDPL’s technology. It has also succeeded in developing and implementing technologies for production of Methyl-DOPA
and Chloroquine Phosphate
. Three compounds having promising therapeutic value are in advanced stage of biological evaluation. A non-steroidal anti-inflammatory and anti-arthritic
compound has completed Phase-III clinical trials.
IDPL has a Formulations Development Research Laboratory at the Rishikesh plant. A number of the company’s formulations have been developed through in-house research.
External Links=
India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
's self-sufficiency in pharmaceuticals manufacturing. IDPL performed a pioneering role in the growth of the Indian drug industry base. It contributed significantly towards this objective in the area of such essential and life-saving drugs as narrow-spectrum antibiotics. IDPL employs scientific and technical personnel and has established the necessary infrastructure and modern technology to enlarge commercial production and promote research, development, and design efforts.
With the adoption of good manufacturing practice
Good Manufacturing Practice
"Good manufacturing practice" or "GMP" are practices and the systems required to be adapted in pharmaceutical manufacturing, quality control, quality system covering the manufacture and testing of pharmaceuticals or drugs including active pharmaceutical ingredients, diagnostics, foods,...
conforming to World Health Organization
World Health Organization
The World Health Organization is a specialized agency of the United Nations that acts as a coordinating authority on international public health. Established on 7 April 1948, with headquarters in Geneva, Switzerland, the agency inherited the mandate and resources of its predecessor, the Health...
recommendations, it has set stringent quality standards to ensure excellent products. IDPL products and services have been recognised by the World Health Organization.
Foundation
It was the vision of Jawahar Lal Nehru, the first Prime Minister of IndiaPrime Minister of India
The Prime Minister of India , as addressed to in the Constitution of India — Prime Minister for the Union, is the chief of government, head of the Council of Ministers and the leader of the majority party in parliament...
, that the drug industry must be in the public sector: "I think an industry of the nature of the drug industry should not be in the private sector anyhow. There are for too much exploitation of the public in this industry". Thus IDPL was incorporated in April 1961. The main objectives were to make India self-sufficient in respect of essential life-saving medicines, to free the country from dependence on imports, and to provide medicines to the general public at affordable prices. IDPL was conceived and established as a part of the health care infrastructure, and has played a pioneering role in the growth of the Indian drug industry base.
Role during birth control and national disaster
IDPL played a major role in the strategy of several national health programmes, such as the family welfare program and the population control initiative. They provide quality medicines in the fight against malariaMalaria
Malaria is a mosquito-borne infectious disease of humans and other animals caused by eukaryotic protists of the genus Plasmodium. The disease results from the multiplication of Plasmodium parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases...
(providing Chloroquine
Chloroquine
Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of malaria.-History:Chloroquine , N'--N,N-diethyl-pentane-1,4-diamine, was discovered in 1934 by Hans Andersag and co-workers at the Bayer laboratories who named it "Resochin". It was ignored for a decade because it was...
) and in the prevention of dehydration
Dehydration
In physiology and medicine, dehydration is defined as the excessive loss of body fluid. It is literally the removal of water from an object; however, in physiological terms, it entails a deficiency of fluid within an organism...
(providing oral rehydration solution). During the country’s calamitous outbreak of plague in 1994
1994 plague in India
In 1994, a total of 693 suspected bubonic or pneumonic plague cases were reported to WHO by Government of India. These cases were from Maharashtra, Gujarat, Karnataka, Madhya Pradesh, Uttar Pradesh and New Delhi. Positive laboratory test results for Yersinia pestis were reported by India. The...
, IDPL supplied Tetracycline for the entire nation. The company has provided an uninterrupted supply of Chloroquine
Chloroquine
Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of malaria.-History:Chloroquine , N'--N,N-diethyl-pentane-1,4-diamine, was discovered in 1934 by Hans Andersag and co-workers at the Bayer laboratories who named it "Resochin". It was ignored for a decade because it was...
to combat malaria epidemics in different parts of the country. To combat the national emergency of a leptospirosis
Leptospirosis
Leptospirosis is caused by infection with bacteria of the genus Leptospira, and affects humans as well as other mammals, birds, amphibians, and reptiles.The...
epidemic arising due to floods in Maharashtra
Maharashtra
Maharashtra is a state located in India. It is the second most populous after Uttar Pradesh and third largest state by area in India...
in 2005, IDPL supplied the required Doxycycline
Doxycycline
Doxycycline INN is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. Doxycycline is a semisynthetic tetracycline invented and clinically developed in the early 1960s by Pfizer Inc. and marketed under the brand name Vibramycin. Vibramycin...
capsules.
Products
- Essential medicines
- Surgical medicines
- Veterinary medicineVeterinary medicineVeterinary Medicine is the branch of science that deals with the prevention, diagnosis and treatment of disease, disorder and injury in non-human animals...
s - Homeopathic medicines
- Ayurvedic medicines
Manufacturing plants
IDPL has three manufacturing plants, at Hyderabad, Rishikesh, and GurgaonGurgaon
Gurgaon is the second largest city in the Indian state of Haryana. Gurgaon is the industrial and financial center of Haryana. It is located 30 km south of national capital New Delhi, about 10 kilometers from Dwarka Sub City and 268 km south of Chandigarh, the state capital...
. The company has two subsidiaries, IDPL (Tamil Nadu) Ltd in Chennai
Chennai
Chennai , formerly known as Madras or Madarasapatinam , is the capital city of the Indian state of Tamil Nadu, located on the Coromandel Coast off the Bay of Bengal. Chennai is the fourth most populous metropolitan area and the sixth most populous city in India...
and Bihar Drugs and Organic Chemicals Ltd in Muzaffarpur
Muzaffarpur
Muzaffarpur Town is a town in Muzaffarpur district in the Indian state of Bihar. It serves as the headquarters of Muzaffarpur district and Tirhut division....
, Bihar
Bihar
Bihar is a state in eastern India. It is the 12th largest state in terms of geographical size at and 3rd largest by population. Almost 58% of Biharis are below the age of 25, which is the highest proportion in India....
. Two joint sector companies that work in collaboration with the state governments are Rajasthan Drugs and Pharmaceuticals Ltd (RDPL) of Rajasthan
Rajasthan
Rājasthān the land of Rajasthanis, , is the largest state of the Republic of India by area. It is located in the northwest of India. It encompasses most of the area of the large, inhospitable Great Indian Desert , which has an edge paralleling the Sutlej-Indus river valley along its border with...
and Orissa Drugs and Chemicals Ltd (ODCL) in Orissa
Orissa
Orissa , officially Odisha since Nov 2011, is a state of India, located on the east coast of India, by the Bay of Bengal. It is the modern name of the ancient nation of Kalinga, which was invaded by the Maurya Emperor Ashoka in 261 BC. The modern state of Orissa was established on 1 April...
.
Hyderabad plant
The IDPL plant at Hyderabad (1967) is spread over 891 acres (3.6 km²) of land. It has the capacity to produce tablets (4000 million per year), capsules (100 million per year), syrups (600,000 litres per year), injections (2 million per year), and powders (600 metric tons per year). The production facilities are fully supported by a quality control department with good laboratory practices. It is equipped with an Effluent Treatment Plant that also treats the effluent of nearby industries.The plant is home to a Research and Development Centre with three main divisions: Chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
, Biology
Biology
Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...
(including pharmacology
Pharmacology
Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function...
and toxicology
Toxicology
Toxicology is a branch of biology, chemistry, and medicine concerned with the study of the adverse effects of chemicals on living organisms...
), and Pilot. Other facilities include an instrumentation section, a glass fabrication workshop, an animal house, a large library, and an auditorium. A number of technologies for production of bulk drugs were developed and successfully implemented at this plant. About 4,500 compounds belonging to various structural types were synthesised and subjected to in-house primary and secondary screenings.
Rishikesh plant
IDPL Rishikesh (1967) is located in Uttaranchal. It is spread on 834 acres (3.4 km²). It has a large antibiotics fermentation facility with required downstream recovery and purification equipment. It has so far produced 18 bulk antibiotics and intermediates. It has a large production capacity for manufacturing of tablets (765 million per year) and capsules (390 million per year).It has the capacity to manufacture oral contraceptive
Oral contraceptive
The combined oral contraceptive pill , often referred to as the birth-control pill or colloquially as "the Pill", is a birth control method that includes a combination of an estrogen and a progestin . When taken by mouth every day, these pills inhibit female fertility...
and emergency pills, and is one of five regular suppliers of these pills to the Ministry of Health
Ministry of Health
Ministry of Health may refer to:*Ministry of Health *Ministry of Health *Ministry of Health *Ministry of Health...
and Family Welfare, Government of India
Government of India
The Government of India, officially known as the Union Government, and also known as the Central Government, was established by the Constitution of India, and is the governing authority of the union of 28 states and seven union territories, collectively called the Republic of India...
.
A separate block for production of anti-retroviral drugs to combat HIV/AIDS disease will soon be entering production. The Rishikesh plant received the National Award for Prevention of Pollution–1992 from the President of India
President of India
The President of India is the head of state and first citizen of India, as well as the Supreme Commander of the Indian Armed Forces. President of India is also the formal head of all the three branches of Indian Democracy - Legislature, Executive and Judiciary...
on 6 August 1994.
Gurgaon plant
IDPL GurgaonGurgaon
Gurgaon is the second largest city in the Indian state of Haryana. Gurgaon is the industrial and financial center of Haryana. It is located 30 km south of national capital New Delhi, about 10 kilometers from Dwarka Sub City and 268 km south of Chandigarh, the state capital...
(1979) is located in Haryana
Haryana
Haryana is a state in India. Historically, it has been a part of the Kuru region in North India. The name Haryana is found mentioned in the 12th century AD by the apabhramsha writer Vibudh Shridhar . It is bordered by Punjab and Himachal Pradesh to the north, and by Rajasthan to the west and south...
(a neighborhood of the Indian capital, New Delhi
New Delhi
New Delhi is the capital city of India. It serves as the centre of the Government of India and the Government of the National Capital Territory of Delhi. New Delhi is situated within the metropolis of Delhi. It is one of the nine districts of Delhi Union Territory. The total area of the city is...
). It is spread over 90 acre (0.3642174 km²). It has production capacities for a wide range of formulations, such as tablets (1,296 million per year), liquid orals (396,000 litres per year) and dry syrup (36 lakh
Lakh
A lakh is a unit in the Indian numbering system equal to one hundred thousand . It is widely used both in official and other contexts in Pakistan, Bangladesh, India, Maldives, Nepal, Sri Lanka, Myanmar and is often used in Indian English.-Usage:...
bottles per year). It has so far produced 60 formulations in various dosage forms. This plant also has a large capacity to manufacture oral contraceptive pills, and is supported by a Quality Control
Quality control
Quality control, or QC for short, is a process by which entities review the quality of all factors involved in production. This approach places an emphasis on three aspects:...
Department. It has an effluent treatment plant and a Formulations Development Research Laboratory. There is also a township with 128 flats and necessary facilities.
Subsidiary units
IDPL (Tamil Nadu) Ltd, ChennaiChennai
Chennai , formerly known as Madras or Madarasapatinam , is the capital city of the Indian state of Tamil Nadu, located on the Coromandel Coast off the Bay of Bengal. Chennai is the fourth most populous metropolitan area and the sixth most populous city in India...
(1965) is spread over 123 acre (0.49776378 km²). It was commissioned as an engineering-based company to manufacture surgical instruments. To improve its viability, it diversified to supply detachable scalpel blades in 1975–76, set up a fabrication shop in 1977–78, a formulations division in 1978–79, a hospital equipment division in 1992–93, and AIDS and appliances in 1994–95. In March 1994 the plant was incorporated and converted into a subsidiary unit of IDPL. It is an Implementing Agency under Assistance to Disabled Impaired Persons (ADIP) for southern States by Ministry of Welfare, Government of India, for AIDS and appliances. It has a large production capacity of formulations like tablets (900 million per year) and capsules (200 million per year).
Bihar Drugs & Organic Chemicals Ltd Muzaffarpur
Muzaffarpur
Muzaffarpur Town is a town in Muzaffarpur district in the Indian state of Bihar. It serves as the headquarters of Muzaffarpur district and Tirhut division....
, Bihar (1979) is an organic chemical plant. In March 1994 the plant became a subsidiary unit of IDPL. This is the only plant in the country manufacturing Niacinamide starting from alcohol as principal raw material. It has a locational advantage, as several alcohol-producing distilleries and more than 15 sugar mills, which feed molasses to these distilleries, are situated within a radius of 150 kilometres (93.2 mi). It has a large production capacity to manufacture Acetaldehyde
Acetaldehyde
Acetaldehyde is an organic chemical compound with the formula CH3CHO or MeCHO. It is one of the most important aldehydes, occurring widely in nature and being produced on a large scale industrially. Acetaldehyde occurs naturally in coffee, bread, and ripe fruit, and is produced by plants as part...
(7,500 metric tons), Acetic acid
Acetic acid
Acetic acid is an organic compound with the chemical formula CH3CO2H . It is a colourless liquid that when undiluted is also called glacial acetic acid. Acetic acid is the main component of vinegar , and has a distinctive sour taste and pungent smell...
(4,500 metric tonnes), Methyl-Ethyl Pyridine (1,200 metric tons), Niacin
Niacin
"Niacin" redirects here. For the neo-fusion band, see Niacin .Niacin is an organic compound with the formula and, depending on the definition used, one of the forty to eighty essential human nutrients.Niacin is one of five vitamins associated with a pandemic deficiency disease: niacin deficiency...
(500 metric tons) and Niacinamide (300 metric tons). The plant is being upgraded to manufacture antibiotic macrolides—Roxithromycin
Roxithromycin
Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring...
, Azithromycin
Azithromycin
Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics...
, and Clarithromycin
Clarithromycin
Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia , skin and skin structure infections...
. The production of these bulk drugs is likely to be started shortly.
Research and development
IDPL Research and DevelopmentResearch and development
The phrase research and development , according to the Organization for Economic Co-operation and Development, refers to "creative work undertaken on a systematic basis in order to increase the stock of knowledge, including knowledge of man, culture and society, and the use of this stock of...
(R&D) is fully equipped with modern technologies to enable it to help India build self-reliance and meet its health needs. IDPL has two R&D Centres, one at Hyderabad Unit and another at Rishikesh Unit, with large animal houses. These centres endeavour to create substitutes for imports, improve and update technologies, develop new drugs and formulations, and create high-yielding strains for antibiotics. Vitamin B6 was produced in India for the first time because of IDPL’s technology. It has also succeeded in developing and implementing technologies for production of Methyl-DOPA
Dopa
Dopa or DOPA can refer to:* L-DOPA , used in the treatment of Parkinson's disease* D-DOPA, a chemical compound related to L-DOPA* Dopa, an angel in Enochian* Deleting Online Predators Act of 2006...
and Chloroquine Phosphate
Chloroquine
Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of malaria.-History:Chloroquine , N'--N,N-diethyl-pentane-1,4-diamine, was discovered in 1934 by Hans Andersag and co-workers at the Bayer laboratories who named it "Resochin". It was ignored for a decade because it was...
. Three compounds having promising therapeutic value are in advanced stage of biological evaluation. A non-steroidal anti-inflammatory and anti-arthritic
Rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...
compound has completed Phase-III clinical trials.
IDPL has a Formulations Development Research Laboratory at the Rishikesh plant. A number of the company’s formulations have been developed through in-house research.
See also
- Ministry of Chemicals and Fertilizers (India)
- Bengal Chemicals and Pharmaceuticals
- Pharmaceuticals in India
- Dr. Reddy's LaboratoriesDr. Reddy's LaboratoriesDr. Reddy's Laboratories Ltd. is an integrated pharmaceutical company focused on providing medicines through its three business segments: Global Generics segment, Pharmaceutical Services and Active Ingredients segment and Proprietary Products segment. The company was founded by Dr...
- CiplaCiplaCipla Limited is a prominent Indian pharmaceutical company, best-known outside its home country for manufacturing low-cost anti-AIDS drugs for HIV-positive patients in developing countries...
External Links=
- http://www.hinduonnet.com/thehindu/2004/07/06/stories/2004070615150500.htm
- http://www.pharmaceuticalsinsight.com/file/99425/idpl-introduces-three-new-otc-drugs.html
- http://chemicals.nic.in/pharma_idpl.htm
- http://blogs.timesofindia.indiatimes.com/Swaminomics/entry/let-air-india-fade-away