TAL1
Encyclopedia
T-cell acute lymphocytic leukemia protein 1 is a protein
that in humans is encoded by the TAL1 gene
.
The protein encoded by TAL1 is a basic-helix-loop-helix
transcription factor
.
with LMO1
, LDB1
, SIN3A
, LMO2
, Sp1 transcription factor, TCF3
, CBFA2T3
, EP300
and GATA1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the TAL1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The protein encoded by TAL1 is a basic-helix-loop-helix
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
.
Interactions
TAL1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with LMO1
LMO1
Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.-Interactions:LMO1 has been shown to interact with GATA3 and TAL1.-Further reading:...
, LDB1
LDB1
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.-Interactions:LDB1 has been shown to interact with LMO4, TCF3, TAL1 and CBFA2T3.-Further reading:...
, SIN3A
SIN3A
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.-Interactions:SIN3A has been shown to interact with HDAC9, OGT, RBBP7, RBBP4, Host cell factor C1, MXD1, IKZF1, Nuclear receptor co-repressor 2, SAP130, KLF11, Methyl-CpG-binding domain protein 2, HDAC1,...
, LMO2
LMO2
LIM domain only 2 , also known as LMO2, is a protein which in humans is encoded by the LMO2 gene.- Function :LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly...
, Sp1 transcription factor, TCF3
TCF3
Transcription factor 3 , also known as TCF3, is a protein that in humans is encoded by the TCF3 gene...
, CBFA2T3
CBFA2T3
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.-Interactions:CBFA2T3 has been shown to interact with HDAC1, HDAC3, TCF3, LDB1, TAL1, RUNX1T1 and PRKAR2A.-Further reading:...
, EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
and GATA1
GATA1
Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene....
.