TCF3
Encyclopedia
Transcription factor 3, also known as TCF3, is a protein
that in humans is encoded by the TCF3 gene
. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling
) expression.
with ID3
, LYL1
, Twist transcription factor
, PCAF
, LMX1A
, LDB1
, ELK3
, CBFA2T3
, MyoD
, EP300
, CREB-binding protein, MAPKAPK3
, Myogenin
, TAL1
and UBE2I
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the TCF3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling
Notch signaling
The notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass...
) expression.
Interactions
TCF3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with ID3
ID3 (gene)
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.-Interactions:ID3 has been shown to interact with TCF3.-Repressors of ID3:...
, LYL1
LYL1
Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.-Interactions:LYL1 has been shown to interact with TCF3 and NFKB1....
, Twist transcription factor
Twist transcription factor
Twist transcription factor is a basic-helix-loop-helix transcription factor associated with Saethre-Chotzen syndrome.-Interactions:Twist transcription factor has been shown to interact with EP300, TCF3 and PCAF.-External links:*...
, PCAF
PCAF
P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...
, LMX1A
LMX1A
LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.- Function :Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas...
, LDB1
LDB1
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.-Interactions:LDB1 has been shown to interact with LMO4, TCF3, TAL1 and CBFA2T3.-Further reading:...
, ELK3
ELK3
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene....
, CBFA2T3
CBFA2T3
Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.-Interactions:CBFA2T3 has been shown to interact with HDAC1, HDAC3, TCF3, LDB1, TAL1, RUNX1T1 and PRKAR2A.-Further reading:...
, MyoD
MyoD
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
, EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
, CREB-binding protein, MAPKAPK3
MAPKAPK3
MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.-Interactions:MAPKAPK3 has been shown to interact with MAPK14 and TCF3.-Further reading:...
, Myogenin
Myogenin
Myogenin , also known as MYOG, is a gene.Myogenin is a muscle-specific basic-helix-loop-helix transcription factor involved in the coordination of skeletal muscle development and repair...
, TAL1
TAL1
T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.The protein encoded by TAL1 is a basic-helix-loop-helix transcription factor.-Interactions:...
and UBE2I
UBE2I
SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene.-Interactions:UBE2I has been shown to interact with WT1, TOP1, RAD51, Activating transcription factor 2, PIAS1, SALL1, FHIT, RANBP2, Protein inhibitor of activated STAT2, DNMT3A, DNMT3B, Small ubiquitin-related...
.