LIM domain only 2, also known as LMO2, is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the LMO2 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

LMO2 encodes a cysteine-rich, two LIM domain

LIM domain

LIM domains are protein structural domains, composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. They are named after their initial discovery in the proteins Lin11, Isl-1 & Mec-3. LIM-domain containing proteins have been shown to play roles in...

 protein that is required for yolk sac erythropoiesis

Erythropoiesis

Erythropoiesis is the process by which red blood cells are produced. It is stimulated by decreased O2 in circulation, which is detected by the kidneys, which then secrete the hormone erythropoietin...

. The LMO2 protein has a central and crucial role in hematopoietic

Haematopoiesis

Haematopoiesis is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells...

 development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia can refer to:* Precursor T acute lymphoblastic leukemia/lymphoma* Adult T-cell leukemia/lymphoma...

-specific translocations occur.

Interactions

LMO2 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with JARID1A

JARID1A

Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.The Drosophila homolog, LID, was found to be an H3K4 histone demethylase that binds to c-Myc. It was recently renamed to Lysine Demethylase 5A ....

, GATA1

GATA1

Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene....

, GATA2

GATA2

GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells...

, TAL1

TAL1

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.The protein encoded by TAL1 is a basic-helix-loop-helix transcription factor.-Interactions:...

 and MLLT4

MLLT4

Afadin is a protein that in humans is encoded by the MLLT4 gene.-Interactions:MLLT4 has been shown to interact with F11 receptor, RAP1A, LMO2, EPHB3, RAP1GAP, PVRL1, PVRL3, USP9X, SORBS1, BCR gene, Tight junction protein 1, Profilin 1, HRAS and SSX2IP.-Further reading:...

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Further reading