Table of genes

Gênes

Gênes is the name of a département of the First French Empire in present Italy, named after the city of Genoa. It was formed in 1805, when Napoleon Bonaparte occupied the Republic of Genoa. Its capital was Genoa, and it was divided in the arrondissements of Genoa, Bobbio, Novi Ligure, Tortona and...

 implicated in development

Development

-Land use:*Green development, a concept that includes consideration of community-wide or regional environmental implications*Land development, altering the landscape in any number of ways...

 and differentiation

Cellular differentiation

In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...

 of the intestinal epithelium

Intestinal epithelium

The intestinal epithelium is the epithelium that covers the small and large intestine. It is simple columnar and nonciliated.They primarily take part in the digestive system. However, they also express TLR 4 receptors, and are thus a part of the immune system, both as a barrier and as a first-line...

 

The table listed below is a running comprehensive list of all intestinal differential genes that have been reported in the literature. The PMID is the pubmed identification number of the papers that support the summerized information in the table corresponding to each row.

Official	Common	Function/phenotype	PMID
APC APC -Biology:* Adenomatous polyposis coli, a type of colon cancer caused by a defect APC-protein due to mutations in the APC-gene* Antigen-presenting cell in medicine/immunology* Activated protein C, an anti-coagulant and anti-inflammatory protein...		Conditional deletion promotes Paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  at the expense of enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal... , goblet and enteroendocrine cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science... . Negative regulator of beta-catenin Beta-catenin Beta-catenin is a protein that in humans is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo...	15716339
ATOH1 ATOH1 Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.- External links :*...	Math1, HATH1	Commitment to secretory lineage	20691176 17570220 11739954
BMPR1A BMPR1A The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 .- Function :...		Involved in terminal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of secretory cells	17678919
CBFA2T2 CBFA2T2 Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.-Interactions:CBFA2T2 has been shown to interact with RUNX1T1....	Mtgr1	Required for maintenance of secretory lineage	16227606
CDH1 CDH1 CDH1 may refer to:* Huntsville/Deerhurst Resort Airport* CDH1 classical cadherin from the cadherin superfamily* APC/C activator protein CDH1 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome...	E-cadherin	Required for maturation/localization of Paneth and goblet cells	21179475
CDX1 CDX1 Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene....	Cdx1	Induced expression promoted enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal...  differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  in IEC6 cells	19059241 10579974
CDX2 CDX2 Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The protein encoded by this gene is a homeobox transcription factor.-Function:...	Cdx2	Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science... . Required for the small intestinal identity during development Developmental biology Developmental biology is the study of the process by which organisms grow and develop. Modern developmental biology studies the genetic control of cell growth, differentiation and "morphogenesis", which is the process that gives rise to tissues, organs and anatomy.- Related fields of study... . In IEC-6 cells, conditional expression induced enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal...  and goblet like cells	21081128 19386267 8552090
CTNNB1	Catenin Catenin Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of... , beta	Paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science... . Essential for stem cell Stem cell This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells... /crypt Crypt In architecture, a crypt is a stone chamber or vault beneath the floor of a burial vault possibly containing sarcophagi, coffins or relics....  maintenance. Villus Villus Intestinal villi are tiny, finger-like projections that protrude from the epithelial lining of the intestinal wall. Each villus is approximately 0.5-1.6 mm in length and has many microvilli , each of which are much smaller than a single villus...  and crypt Crypts of Lieberkühn In histology, an intestinal crypt is a gland found in the epithelial lining of the small intestine and colon...  morphogenesis Morphogenesis Morphogenesis , is the biological process that causes an organism to develop its shape...  with Tcf3 via c-Myc	18948094 17785439 17681174
DLL1		Functions as a cis Cis Cis may have the following meanings:* "Cis-" as a prefix of Latin origin, meaning "on the same side [as]" or "on this side [of]", with several derived usages:** In chemistry, cis- refers to cis-trans isomerism...  acting element and required for goblet cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  in the Notch Notch Notch may refer to:* The nock of an arrow* Notch , a Hip hop, R&B, reggae, dancehall and reggaeton artist* Notch signaling pathway, a cell signaling system present in most multicellular organisms...  inactive colonic epithelia. Notch Notch Notch may refer to:* The nock of an arrow* Notch , a Hip hop, R&B, reggae, dancehall and reggaeton artist* Notch signaling pathway, a cell signaling system present in most multicellular organisms...  ligand in intestine Intestine In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine... . Required for the maintenance of stem and progenitors	20170633 21238454
DLL4 DLL4 Delta like ligand 4 is a protein that in humans is encoded by the DLL4 gene.-Further reading:...		Notch Notch Notch may refer to:* The nock of an arrow* Notch , a Hip hop, R&B, reggae, dancehall and reggaeton artist* Notch signaling pathway, a cell signaling system present in most multicellular organisms...  ligand in intestine Intestine In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine... . Required for the maintenance of stem and progenitors	21238454
ELF3	ESE-1	Terminal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of absorptive enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal... s	19801644
EPHB3 EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.-Interactions:EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.-Further reading:...		Localization of Paneth cells to crypt Crypt In architecture, a crypt is a stone chamber or vault beneath the floor of a burial vault possibly containing sarcophagi, coffins or relics....  base	12408869
FGF7 FGF7 Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.-Further reading:...	KGF	Regulate epithelial growth and promote differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	19326389
FGFR3 FGFR3 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 .-Structure and function:-Disease linkage:...		Paneth cell specification through beta-catenin Beta-catenin Beta-catenin is a protein that in humans is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo... /Tcf4 dependent and independent pathway. Significant reduction in Paneth cell in knockout Knockout A knockout is a fight-ending, winning criterion in several full-contact combat sports, such as boxing, kickboxing, Muay Thai, mixed martial arts, Karate and others sports involving striking...  mice. Involved in crypt Crypt In architecture, a crypt is a stone chamber or vault beneath the floor of a burial vault possibly containing sarcophagi, coffins or relics....  development and stem cell Stem cell This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells...  expansion	19407216
FOXA1 FOXA1 Forkhead box protein A1 , also known as hepatocyte nuclear factor 3-alpha , is a protein that in humans is encoded by the FOXA1 gene.- Function :FOXA1 is a member of the forkhead class of DNA-binding proteins...	HNF3A	Involved in goblet cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  and enteroendocrine differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	19737569
FOXA2 FOXA2 Hepatocyte nuclear factor 3-beta , also known as forkhead box protein A2 or transcription factor 3B is a protein that in humans is encoded by the FOXA2 gene.- Function :...	HNF3B	Involved in goblet cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  and enteroendocrine differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	19737569
FZD5 FZD5 Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.-Further reading:...		Required for Paneth cell maturation. Loss of Paneth cell genes after conditional deletion	15778706
GADD45GIP1 GADD45GIP1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene.-Interactions:GADD45GIP1 has been shown to interact with GADD45G, GADD45B and GADD45A.-Further reading:...	Crif1	Essential Elf3 coactivator in differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of absorptive enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal... s	19801644
GATA6 GATA6 Transcription factor GATA-6, also known as GATA-binding factor 6 , is protein that in humans is encoded by the GATA6 gene. The gene product preferentially binds GAT of the consensus binding sequence. It is also linked with embryonic cardiac development....		Regulates proximal-distal identity in the intestine Intestine In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine... s	21262227
GATA4 GATA4 Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.-Interactions:GATA4 has been shown to interact with NKX2-5, TBX5, ZFPM2, Serum response factor and HAND2.HDAC2- External links :...		Required for proximal intestinal identity	16940177 18812176
GFI1 GFI1 Zinc finger protein Gfi-1 is a protein that in humans is encoded by the GFI1 gene.-Interactions:GFI1 has been shown to interact with PIAS3 and RUNX1T1.- External links :...		Required for proper allocation of secretory lineage	16230531
HES1 HES1 Transcription factor HES-1 is a protein that in humans is encoded by the HES1 gene.-Interactions:HES1 has been shown to interact with TLE2 and Sirtuin 1.- External links :...	Hes1	Commitment to absorptive lineage	10615124
HNF1A HNF1A HNF1 homeobox A , also known as HNF1A, is a human gene.The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.-Interactions:HNF1A has been shown to interact with PCAF, Src,...	HNF1-α	Regulates terminal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of enterocytes and secretory cells potentially by direct regulation of Atoh1	20133952 20388655
HNF1B HNF1B HNF1 homeobox B , also known as HNF1B or transcription factor 2 , is a human gene.-Further reading:...	HNF1-β	Regulates terminal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of enterocytes and secretory cells potentially by direct regulation of Atoh1	20133952 20388655
IHH IHH Indian hedgehog homolog , also known as IHH, is a protein which in humans is encoded by the IHH gene.-Function:The Indian Hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog and Sonic hedgehog...		Colonocytes differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	14770182
KLF4 KLF4 Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells , KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells ....	GKLF	Promotes goblet cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  in colon Colón Colón is a Spanish and Portuguese surname, comparable to the Italian and Portuguese Colombo . It may refer to:People:* Cristóbal Colón, the Spanish language name for the explorer Christopher Columbus...	21070761 12015290
LGR4 LGR4 Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.-Further reading:...	GPR48	Promotes Paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  and crypt cell proliferation. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling	21508962 21909076
LGR5 LGR5 Leucine-rich repeat-containing G-protein coupled receptor 5 is a protein that in humans is encoded by the LGR5 gene. It is also known as GPR49....	GPR49	Premature paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  in fetal intestine Intestine In human anatomy, the intestine is the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine... . Intestinal stem cell Stem cell This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells...  marker. Along with LGR5, acts as the receptor for R-Spondin, a WNT co-ligand that amplifies WNT signaling	19394326 21727895
MMP9 MMP9 Matrix metallopeptidase 9 , also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B , is an enzyme that in humans is encoded by the MMP9 gene.- Function :...		Negatively regulates terminal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of goblet cells in colon Colón Colón is a Spanish and Portuguese surname, comparable to the Italian and Portuguese Colombo . It may refer to:People:* Cristóbal Colón, the Spanish language name for the explorer Christopher Columbus...	17484881
MSI1 MSI1 RNA-binding protein Musashi homolog 1 is a protein that in humans is encoded by the MSI1 gene.-Further reading:...		Suppress paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  independent of Notch Notch Notch may refer to:* The nock of an arrow* Notch , a Hip hop, R&B, reggae, dancehall and reggaeton artist* Notch signaling pathway, a cell signaling system present in most multicellular organisms...  and Wnt WNT WNT is a three-letter abbreviation with multiple meanings, as described below:*Windows NT*WNT *Wnt signaling pathway, a complex protein network...  signaling pathways	19214660
MYBL2 MYBL2 Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.-Interactions:MYBL2 has been shown to interact with Retinoblastoma-like protein 1, Cyclin A1, EP300, CREB-binding protein, CDK9, Cyclin-dependent kinase inhibitor 1C and PARP1.-Further reading:...		Regulates commitment of colon Colón Colón is a Spanish and Portuguese surname, comparable to the Italian and Portuguese Colombo . It may refer to:People:* Cristóbal Colón, the Spanish language name for the explorer Christopher Columbus...  stem cells to differentiate	20857481; 20133952
MYC Myc Myc is a regulator gene that codes for a transcription factor. In the human genome, Myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences and recruiting histone acetyltransferases...		Crypt Crypt In architecture, a crypt is a stone chamber or vault beneath the floor of a burial vault possibly containing sarcophagi, coffins or relics....  loss upon conditional deletion in the adult	16954380
NEUROD1 NEUROD1 Neurogenic differentiation 1 , also called β2 is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.It is a member of the NeuroD family of basic-helix-loop-helix transcription factors...	BETA2	Differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of Ngn3 enteroendocrine cells into CCK and secretin cells	18022152; 15044355
NEUROG3 NEUROG3 Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine...		Commitment to the enteroendocrine cell lineage	17706959; 12456641
NKX2-2 NKX2-2 Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated...	Nkx2.2	Required for a subset of enteroendocrine cells differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	18022152
NOTCH1 NOTCH1 Notch homolog 1, translocation-associated , also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.A deficiency can be associated with bicuspid aortic valve....		Regulates absorptive cells vs secretory cells	15959516; 18274550
NOTCH2 NOTCH2 Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene.NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.- Function :Notch 2 a member of the notch family...		Regulates absorptive]] cells vs secretory cells	15959516; 18274550
NOX1 NOX1 NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.-Further reading:...		Regulate ROS Ros -People and groups:* ROS,Video Director / Producer - Matatabi Records Tokyo Japan* Raggruppamento Operativo Speciale, the Anti-organized Crime Branch of the Italian Carabinieri* Reparti i Operacioneve Speciale, a former Albanian special forces unit...  to activate Notch Notch Notch may refer to:* The nock of an arrow* Notch , a Hip hop, R&B, reggae, dancehall and reggaeton artist* Notch signaling pathway, a cell signaling system present in most multicellular organisms... 1 signaling and indirectly promote absorptive cell lineage in the colon Colón Colón is a Spanish and Portuguese surname, comparable to the Italian and Portuguese Colombo . It may refer to:People:* Cristóbal Colón, the Spanish language name for the explorer Christopher Columbus...	20351171
PAX6 PAX6 Paired box protein Pax-6 also known as aniridia type II protein or oculorhombin is a protein that in humans is encoded by the PAX6 gene.- Function :PAX6 is a member of the Pax gene family...		Differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of GIP in enteroendocrine lineage	18022152; 10478839
PDX1 Pdx1 Pdx1 , also known as insulin promoter factor 1, is a transcription factor necessary for pancreatic development and β-cell maturation...	IPF1	Overexpression causes differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of immature intestinal epithelia to enteroendocrine cells. Conditional deletion alters enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal...  and enteroendocrine gene expression	11408276  ; 19808654
PPARD	PPAR-δ/β	Involves in Paneth cell maturation Maturation Maturation could refer to any of the following:* Fetal development* Developmental biology* Emotional development* Or physical maturation of any biological life form - see individual articles for maturation of different life forms....  by modulating IHH expression	16890607
PTK6 PTK6 Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.- Function :Tyrosine-protein kinase 6 is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues...	BRK	Promote cell cycle Cell cycle The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...  exit in Wnt WNT WNT is a three-letter abbreviation with multiple meanings, as described below:*Windows NT*WNT *Wnt signaling pathway, a complex protein network...  independent pathway and promote enterocyte Enterocyte Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestines and colon. A glycocalyx surface coat contains digestive enzymes. Microvilli on the apical surface increase surface area for the digestion and transport of molecules from the intestinal...  differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	16782882
RB1	pRB	Required for enterocyte terminal differentiation in small intestine	18981186
RBPJ RBPJ Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.RBPJ, also named as CBF1, is a human homolog for the Drosophila gene Suppressor of Hairless...	CBF1	Conversion of progenitors and differentiated cells into goblet cells by conditional deletion	15959515
SOX9 SOX9 Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.- Function :SOX-9 recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins...		Required for paneth cell differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	17698607; 17681175
SPDEF SPDEF SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.-Further reading:...	PDEF	Regulates terminal differentiation of goblet cells and Paneth cells	19786015; 19549527
STK11 STK11 Serine/threonine kinase 11 also known as liver kinase B1 or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.-Expression:...	LKB1	Required for normal differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  of goblet and Paneth cells	19165340
TGFBR2	Tgf-βRII	The critical downstream target of Elf3 for enterocyte differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...	17408644
VAV Vav VAV as a three-letter abbreviation may refer to* A Volcanic Ash Victim meaning someone who has been left stranded by a volcanic ash cloud that is hindering air travel.* A variable air volume device, used in HVAC systems to control the flow of air...		Required for enterocyte differentiation Differentiation Differentiation may refer to:* Differentiation , the process of finding a derivative* Differentiated instruction in education* Cellular differentiation in biology* Planetary differentiation in planetary science...  in mouse cecum Cecum The cecum or caecum is a pouch, connecting the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve or Bauhin's valve, and is considered to be the beginning of the large intestine. It is also separated from the colon by the cecocolic...  and colon Colón Colón is a Spanish and Portuguese surname, comparable to the Italian and Portuguese Colombo . It may refer to:People:* Cristóbal Colón, the Spanish language name for the explorer Christopher Columbus...	19139088