NKX2-2
Encyclopedia
Homeobox protein Nkx-2.2 is a protein
that in humans is encoded by the NKX2-2 gene
.
Homeobox protein Nkx-2.2 contains a homeobox
domain and may be involved in the morphogenesis
of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor
.
The expression
of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NKX2-2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Homeobox protein Nkx-2.2 contains a homeobox
Homeobox
A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development in animals, fungi and plants.- Discovery :...
domain and may be involved in the morphogenesis
Morphogenesis
Morphogenesis , is the biological process that causes an organism to develop its shape...
of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
.
The expression
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA...
of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as
Nkx2-2as
Nkx2-2as is a long non-coding RNA. It is located in the cytoplasm of the cell. Nkx2-2as is involved in Neural development. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox gene Nkx2-2 and enhances induction of the differentiation of oligodendrocytes. Besides...
.