HLA-DR13
Encyclopedia
Haplotypes groups DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 ....
Structure (See HLA-DR)
Identifiers
Symbol(s)
Human Genome Organisation
The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...

HLA-DRA
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRA*0101
Identifiers
Symbol(s)
Human Genome Organisation
The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...

HLA-DRB1
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1301
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1302
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1304
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1306
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1307
EBI-HLA
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

DRB1*1310
Shared data
Locus
Locus (genetics)
In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...

chr.6
Chromosome 6 (human)
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...

 6p21.31


HLA-DR13(DR13) is a HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6
HLA-DR6
HLA-DR6 is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.-Serology:DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7....

 serotype group which also contains the similar HLA-DR14
HLA-DR14
HLA-DR14 is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.-Alleles:...

 antigens.

Alleles

DR13, DR6 and other serotype recognition of some DRB1*13 alleles
DRB1* DR13 DR6 DR14 Sample
allele % % % size (N)
1301 81 14 1 3788
1302 74 17 2 3081
1303 69 10 2 948
1304 87 127
1305 54 12 305
1306 78 9
1307 >50 1
1308 45 55 9
1310 >75 5


Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379
DRB1*13 allele group
  • 81 Alleles: 74 proteins
  • DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
  • DR6 (weak DR13) Serotype: *1308
  • DR13&Other serotypes: *1303, *1305, *1311,
  • Serotype unknown: *1309, *1315 to *1374

Disease associations

DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

Genetic Linkage

DRA DRB1 | DRB3
DR13(6)-DR52 *0101 *1301 *0101
*0101 *1301 *0201
*0101 *1302 *0301
DQA1 DQB1 | DRB1
DR13(6)-DQ6(6.3, 1) *0103 *0603 *1301
DR13(6)-DQ6(6.4, 1) *0102 *0604 *1302
DR13(6)-DQ6(6.5, 1) *0102 *0605 *1302
DR13(6)-DQ6(6.9, 1) *0102 *0609 *1302
HLA-A HLA-B | DRB1
A2-Cw5-B44(16)-DR13 *02 *4402 *1301


HLA-DR13 is genetically linked to DR52 and HLA-DQ6
HLA-DQ6
HLA-DQ6 is a human leukocyte antigen serotype within HLA-DQ  serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently...

 (HLA-DQ1
HLA-DQ1
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...

) serotypes.
The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
x
OK