HLA-B38
Encyclopedia
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| HLA-B (alpha)-β2MG with bound peptide | ||
| Alleles | B*3801, 3802, . . | |
| Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... ) |
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| Shared data | ||
| Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map... |
chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells... 6p21.31 |
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HLA-B38 (B38) is an HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...
serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...
. The serotype identifies the B*38 allele
Allele
An allele is one of two or more forms of a gene or a genetic locus . "Allel" is an abbreviation of allelomorph. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation...
products of the HLA-B gene-locus
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...
.
B38 is a split antigen of the broad antigen B16
HLA-B16
HLA-B16 is an HLA - B serotype. B16 is a broad antigen serotype that recognizes the B38 and B39 split antigen serotypes....
, and is a sister type of B39
HLA-B39
HLA-B39 is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.B39 is a split antigen of the broad antigen B16, and is a sister type of B38. B39 is most commonly found on the west pacific rim, in Japan and highest frequency in the new world...
. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East
Far East
The Far East is an English term mostly describing East Asia and Southeast Asia, with South Asia sometimes also included for economic and cultural reasons.The term came into use in European geopolitical discourse in the 19th century,...
.
Serotype
| B*38 | B38 | B16 | B39 | Sample | |
| allele | % | % | % | size (N) | |
| 94 | 1 | 1 | 2317 | ||
| 87 | 2 | 2 | 788 | ||
| Alleles link-out to IMGT/HLA Human leukocyte antigen The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and... Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
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Alleles
| freq | ||
| ref. | Population | (%) |
| Israel Ashk. and Non Ashk. Jews | 6.9 | |
| Croatia | 6.7 | |
| Italy North | 6.7 | |
| Azores Central Islands | 5.4 | |
| Sudanese | 5.3 | |
| Czech Republic | 4.7 | |
| Georgia Tibilisi Georgians | 4.6 | |
| Macedonia (4) | 4.6 | |
| Spain Eastern Andalusia | 4.1 | |
| Georgia Svaneti Svans | 3.8 | |
| New Mexico Canoncito Navajo | 3.7 | |
| Bulgaria | 3.6 | |
| Brazil Belo Horizonte | 3.2 | |
| Romanian | 3.2 | |
| Tunisia | 3.0 | |
| Thailand | 2.8 | |
| Israel Arab Druse | 2.5 | |
| USA Caucasian (2) | 2.5 | |
| Tunisia Tunis | 2.3 | |
| Brazil | 2.2 | |
| Indig. Australian Cape York Penin. | 2.0 | |
| France South East | 1.9 | |
| Georgia Tibilisi Kurds | 1.7 | |
| Australia New South Wales | 1.5 | |
| China Guangzhou | 1.5 | |
| Mexico Guadalajara Mestizos (2) | 1.5 | |
| China Yunnan Lisu | 1.4 | |
| Jordan Amman | 1.4 | |
| Morocco Nador Metalsa Class I | 1.4 | |
| China South Han | 1.2 | |
| Mexico Mestizos | 1.2 | |
| Saudi Arabia Guraiat and Hail | 1.2 | |
| Finland | 1.1 | |
| USA North American Natives | 1.1 | |
| American Samoa | 1.0 | |
| China North Han | 1.0 | |
| India North Hindus | 1.0 | |
| Mexico Mixtec Oaxaca | 1.0 | |
| Hong Kong Chinese | 0.9 | |
| Ireland Northern | 0.9 | |
| Cape Verde Southeastern Islands | 0.8 | |
| China Beijing | 0.8 | |
| Ireland South | 0.8 |
Disease
A higher frequency of HLA-B38 was noted psoriatic arthritisPsoriatic arthritis
Psoriatic arthritis is a type of inflammatory arthritis that, according to the National Psoriasis Foundation, will develop in up to 30 percent of people who have the chronic skin condition psoriasis...
patients with erythroderma
Erythroderma
Erythroderma is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface....
. Psoriatic arthritis is linked to MICA and/or B39
HLA-B39
HLA-B39 is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.B39 is a split antigen of the broad antigen B16, and is a sister type of B38. B39 is most commonly found on the west pacific rim, in Japan and highest frequency in the new world...
in other peoples. In Pemphigus vulgaris
Pemphigus vulgaris
Pemphigus vulgaris is a chronic blistering skin disease with skin lesions that are rarely pruritic, but which are often painful.-Pathophysiology:...
a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients. Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele
| freq | ||
| ref. | Population | (%) |
| Taiwan Tao | 11.0 | |
| China Guangxi Maonan | 8.3 | |
| China South Han | 7.1 | |
| Singapore Javan. Indonesians | 7.1 | |
| Singapore Chinese Han | 6.4 | |
| Taiwan Minnan pop 1 | 6.4 | |
| China Guangzhou | 6.0 | |
| Philippines Ivatan | 6.0 | |
| Hong Kong Chinese | 5.4 | |
| Singapore Chinese | 4.7 | |
| Singapore Riau Malay | 4.5 | |
| China Guangzhou Han | 4.3 | |
| India West Bhils | 4.0 | |
| Taiwan Hakka | 3.6 | |
| Singapore Thai | 3.5 | |
| Taiwan Siraya | 2.9 | |
| Taiwan Pazeh | 1.8 | |
| India Mumbai Marathas | 1.2 | |
| South Korea pop 3 | 1.1 | |
| Taiwan Puyuma | 1.0 | |
| Taiwan Saisiat | 1.0 | |
| China Beijing | 0.8 | |
| Brazil | 0.7 |