EGF-like domain
Encyclopedia
EGF-like domain
is an evolutionary conserved protein domain
, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase
). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.
family is very similar, but has 8 instead of 6
conserved cysteines.
This family includes some cytokine receptor
s.
is an evolutionary conserved protein domain
Protein domain
A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...
, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase
PTGS2
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.- History :...
). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.
family is very similar, but has 8 instead of 6
conserved cysteines.
This family includes some cytokine receptor
Cytokine receptor
Cytokine receptors are receptors that bind cytokines.In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been...
s.
Proteins containing this domain
Below is a list of human proteins containing the EGF-like domain:- AGC1; AGRINAgrinAgrin is a large proteoglycan whose best characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN...
; AREGAmphiregulinAmphiregulin, also known as AREG, is a protein which in humans is encoded by the AREG gene.- Function:The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts...
; ATRNATRNAttractin is a protein that in humans is encoded by the ATRN gene.Attractin is a Group XI C-type lectin.-Further reading:...
; ATRNL1; - BCAN; BMP1Bone morphogenetic protein 1Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven isoforms of the protein created by alternate splicing.-Function:...
; BTC; - C1SC1SComplement C1s subcomponent is a protein that in humans is encoded by the C1S gene.-Interactions:C1S has been shown to interact with C1R.-Further reading:...
; CASPR4; CD248CD248Endosialin is a protein that in humans is encoded by the CD248 gene.-External links:...
; CD93CD93CD93 is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence.- Family :...
; CELSR1CELSR1Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.- Function :...
; CELSR2CELSR2Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.-Further reading:...
; CELSR3CELSR3Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.- Further reading :...
; CNTNAP1; CNTNAP2CNTNAP2Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene.This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal...
; CNTNAP3; CNTNAP4CNTNAP4Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.-Further reading:...
; CNTNAP5; COMPCartilage oligomeric matrix proteinCartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene.COMP is a marker of cartilage turnover.-Further reading:-External links:* *...
; COX-2PTGS2Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.- History :...
; CRB1CRB1Crumbs homolog 1 is a protein that in humans is encoded by the CRB1 gene.This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors...
; CRB2; CSPG3; CUBN; - DLK1DLK1Protein delta homolog 1 is a protein that in humans is encoded by the DLK1 gene.It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, the differentiation of pre-adipocytes into adipocytes.It is a member of the EGF-like family of...
; DLL1Delta-like 1Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.-Interactions:Delta-like 1 has been shown to interact with NOTCH2.-Further reading:...
; DLL3DLL3Delta-like 3 , also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms have been identified for this gene.- Function :...
; DLL4DLL4Delta like ligand 4 is a protein that in humans is encoded by the DLL4 gene.-Further reading:...
; DNERDNERDelta and Notch-like epidermal growth factor-related receptor is a protein that in humans is encoded by the DNER gene.-Further reading:...
; - EDIL3; EGFEpidermal growth factorEpidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR...
; EGFL11; EGFL8; EGFL9; EGFLAM; EPGNEpigenEpigen is a member of the epidermal growth factor family....
; EREGEpiregulinEpiregulin is a protein that in humans is encoded by the EREG gene.- Structure :Epiregulin consists of 46 amino acid residues. Its secondary structure contains approximately 30 percent of β-sheet in the strand. Some of the residues form loops and turns due to the hydrogen bonding...
; - F7Factor VIIFactor VII is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa has U.S. Food and Drug Administration approval for uncontrolled bleeding in hemophilia patients...
; F9Factor IXFactor IX is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to...
; F10Factor XFactor X, also known by the eponym Stuart-Prower factor or as prothrombinase, is an enzyme of the coagulation cascade. It is a serine endopeptidase .-Physiology:...
; F12Factor XIICoagulation factor XII also known as Hageman factor is a plasma protein. It is the zymogen form of factor XIIa, an enzyme of the serine protease class. In humans, factor XII is encoded by the F12 gene.- Function :...
; FATFAT (gene)Protocadherin Fat 1 is a protein that in humans is encoded by the FAT1 gene.-Further reading:...
; FAT2; FAT4FAT4Protocadherin Fat 4, also known as cadherin family member 14 or FAT tumor suppressor homolog 4 , is a protein that in humans is encoded by the FAT4 gene.FAT4 is associated with the Hippo signaling pathway....
; FBN1FBN1Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene.This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils...
; FBN2FibrillinFibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue.Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffoldfor deposition of elastin.It...
; FBN3FibrillinFibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue.Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffoldfor deposition of elastin.It...
; - GAS6GAS6Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity...
; - HABP2HABP2Hyaluronan-binding protein 2 is a protein that in humans is encoded by the HABP2 gene.-Further reading:...
; HBEGFHeparin-binding EGF-like growth factorHeparin-binding EGF-like growth factor is a member of the EGF family of proteins. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.-Interactions:...
; HEG1; HGFACHGFACHepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.-Further reading:...
; HMCN1HMCN1Hemicentin-1 is a protein that in humans is encoded by the HMCN1 gene.-Further reading:...
; HSPG2PerlecanPerlecan also known as basement membrane-specific heparan sulfate proteoglycan core protein or heparan sulfate proteoglycan 2 , is a protein that in humans is encoded by the HSPG2 gene....
; - ITGB5Integrin, beta 5Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.-Interactions:Integrin, beta 5 has been shown to interact with PTK2, Annexin A5 and PAK4.-External links:* Info with links in the...
; - JAG1JAG1JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 .-External links:* *...
; JAG2JAG2Protein jagged-2 is a protein that in humans is encoded by the JAG2 gene.-Further reading:...
; - LDLRLDL receptorThe Low-Density Lipoprotein Receptor is a mosaic protein of ~840 amino acids that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles...
; LRP1LRP1Low density lipoprotein receptor-related protein 1 , also known as alpha-2-macroglobulin receptor , apolipoprotein E receptor or cluster of differentiation 91 , is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis...
; LRP10LRP10Low-density lipoprotein receptor-related protein 10 is a protein that in humans is encoded by the LRP10 gene....
; LRP1BLRP1BLow-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.- Function :LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands....
; LRP2LRP2Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.-Function:...
; LRP4CORINAtrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.-Further reading:...
; LRP5LRP5Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene.- Function :LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis...
; LRP6LRP6Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene....
; LRP8Low density lipoprotein receptor-related protein 8Low-density lipoprotein receptor-related protein 8 is a protein that in humans is encoded by the LRP8 gene.Low density lipoprotein receptor-related protein 8, or LRP8 is a member of the LDL receptor family that plays a role in endocytosis and signal transduction...
; LTBP1; LTBP2LTBP2Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.-External links:*...
; LTBP3LTBP3Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.-Further reading:...
; LTBP4; - MATN1MATN1Matrilin 1, cartilage matrix protein, also known as MATN1, is a protein which in humans is encoded by the MATN1 gene.- Function :This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous...
; MATN2MATN2Matrilin-2 is a protein that in humans is encoded by the MATN2 gene.-Further reading:...
; MATN3MATN3Matrilin-3 is a protein that in humans is encoded by the MATN3 gene.-External links:* -Further reading:...
; MATN4; MEGF12; MEGF6; MEP1AMEP1AMeprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene...
; MEP1BMEP1BMeprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.-Further reading:...
; MFGE8MFGE8Milk fat globule-EGF factor 8 protein Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.- Species distribution :Mfge8 is secreted protein found in vertebrates, including mammals as well as birds....
; MMRN1MMRN1Multimerin-1 is a protein that in humans is encoded by the MMRN1 gene.-Further reading:...
; MMRN1MMRN1Multimerin-1 is a protein that in humans is encoded by the MMRN1 gene.-Further reading:...
; MUC4MUC4Mucin-4 is a protein that in humans is encoded by the MUC4 gene.-Further reading:...
; - NAGPANAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase is an enzyme that in humans is encoded by the NAGPA gene.-Further reading:...
; NID1EntactinEntactin also known as nidogen-1 is a protein that in humans is encoded by the NID1 gene. Entactin is a component of the basement membrane alongside other components such as collagen type IV, proteoglycans , laminin and fibronectin.- Function :Entactin is a member of the nidogen family of basement...
; NID2NID2Nidogen-2 is a protein that in humans is encoded by the NID2 gene.-Further reading:...
; NOTCH1NOTCH1Notch homolog 1, translocation-associated , also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.A deficiency can be associated with bicuspid aortic valve....
; NOTCH2NOTCH2Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene.NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.- Function :Notch 2 a member of the notch family...
; NOTCH2NL; NOTCH3Notch 3Neurogenic locus notch homolog protein 3 is a protein that in humans is encoded by the NOTCH3 gene.-External links:...
; NOTCH4NOTCH4Neurogenic locus notch homolog protein 4 is a protein that in humans is encoded by the NOTCH4 gene.-Further reading:...
; NRG1Neuregulin 1Neuregulin 1 or NRG1 is a protein which in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions...
; NRG2NRG2Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.- Function :Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation...
; NRG3NRG3Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.- Function :...
; NRG4NRG4Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.-Function:...
; NRXN1NRXN1Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.-Genomics:The gene is found in a single copy on the short arm of chromosome 2 . The gene is 1,112,187 bases in length, is located on the Crick strand and encodes a protein of 1,477 amino acids .-Further reading:...
; NRXN2NRXN2Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.-Further reading:...
; NRXN3NRXN3Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.-Further reading:...
; NTNG2NTNG2Netrin-G2 is a protein that in humans is encoded by the NTNG2 gene.-Further reading:...
; - ODZ1ODZ1Teneurin-1 is a protein that in humans is encoded by the ODZ1 gene.-Further reading:...
; ODZ2ODZ2Teneurin-2 is a protein that in humans is encoded by the ODZ2 gene.-Further reading:...
; OIT3; - PLATTissue plasminogen activatorTissue plasminogen activator is a protein involved in the breakdown of blood clots. It is a serine protease found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown...
; PP187; PROC; PROS1Protein SProtein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. In humans, protein S is encoded by the PROS1 gene...
; PROZProtein ZProtein Z also known as PROZ is a protein which in humans is encoded by the PROZ gene.Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy...
; PTGS1PTGS1Cyclooxygenase-1 , also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene.- History :...
; PTGS2PTGS2Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.- History :...
; - RAMPReceptor activity-modifying proteinReceptor activity-modifying proteins are a class of protein which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin , glucagon, and vasoactive intestinal peptide...
; - SCUBE1; SCUBE2; SCUBE3; SEL-OB; SELEE-selectinE-selectin, also known as CD62 antigen-like family member E , endothelial-leukocyte adhesion molecule 1 , or leukocyte-endothelial cell adhesion molecule 2 , is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in...
; SELLL-selectinL-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups...
; SELPP-selectinP-selectin is a cell adhesion molecule on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets...
; SLIT1SLIT1Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.-Further reading:...
; SLIT2SLIT2Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.-Interactions:SLIT2 has been shown to interact with Glypican 1.-Further reading:...
; SLIT3SLIT3Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.-Further reading:...
; SNED1; STAB1STAB1Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.-Further reading:...
; STAB2STAB2Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.-Further reading:...
; SVEP1; - TECTATECTAAlpha-tectorin is a protein that in humans is encoded by the TECTA gene.-Further reading:...
; TGFATGF alphaTransforming growth factor alpha is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects...
; THBDThrombomodulinThrombomodulin, CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells. In humans, thrombomodulin is encoded by the THBD gene...
; THBS1Thrombospondin 1Thrombospondin 1, also known as THBS1, is a protein that in humans in encoded by the THBS1 gene.Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to...
; THBS2THBS2Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.-Further reading:...
; THBS4THBS4Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.-Further reading:...
; TIE1TIE1Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.- Function :...
; TLL1TLL1Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.-Further reading:...
; TLL2TLL2Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.-Further reading:...
; TMEFF1; TMEFF2TMEFF2Tomoregulin-2 is a protein that in humans is encoded by the TMEFF2 gene.-Further reading:...
; TNCTenascin CTenascin is a protein that in humans is encoded by the TNC gene.-Interactions:Tenascin C has been shown to interact with fibronectin.-Further reading:...
; TNXBTenascin XA member of the tenascin family, tenascin X also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB gene.- Gene :...
; - UMODTamm-Horsfall proteinThe Tamm-Horsfall glycoprotein also known as uromodulin is a glycoprotein that in humans is encoded by the UMOD gene. Up to 150 mg/dl of uromodulin may be excreted in the urine, making it the most abundant protein in normal urine.- Gene :...
; - VASN; VCANVersicanVersican, also known as VCAN, is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene....
; VLDLRVLDL receptorThe very-low-density-lipoprotein receptor is a lipoprotein receptor that shows considerable similarity to the low-density-lipoprotein receptor...
; VWA2VWA2von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen is a protein that in humans is encoded by the VWA2 gene....
; - WIF1WIF1Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.-Further reading:...
; - ZAN;