GAS6
Encyclopedia
Growth arrest-specific 6, also known as GAS6, is a human gene
coding for the Gas6 protein. It is similar to the Protein S
with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
with AXL receptor tyrosine kinase
, MerTK and TYRO3
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
coding for the Gas6 protein. It is similar to the Protein S
Protein S
Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. In humans, protein S is encoded by the PROS1 gene...
with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Interactions
GAS6 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with AXL receptor tyrosine kinase
AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.-Interactions:AXL receptor tyrosine kinase has been shown to interact with TENC1.-Further reading:...
, MerTK and TYRO3
TYRO3
Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.-Interactions:TYRO3 has been shown to interact with PIK3R1 and GAS6.-Further reading:...
.