DLK1
Encyclopedia
Protein delta homolog 1 is a protein
that in humans is encoded by the DLK1 gene
.
It is expressed as a transmembrane protein
, but a soluble form cleaved off by ADAM17
is active in inhibiting adipogenesis
, the differentiation of pre-adipocytes into adipocytes.
It is a member of the EGF-like
family of homeotic
proteins.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the DLK1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is expressed as a transmembrane protein
Transmembrane protein
A transmembrane protein is a protein that goes from one side of a membrane through to the other side of the membrane. Many TPs function as gateways or "loading docks" to deny or permit the transport of specific substances across the biological membrane, to get into the cell, or out of the cell as...
, but a soluble form cleaved off by ADAM17
ADAM17
ADAM metallopeptidase domain 17 , also called TACE , is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.- Chemical characteristics :...
is active in inhibiting adipogenesis
Adipogenesis
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes.. Adipogenesishas been one of the most intensively studied model of cellular differentiation.-References:...
, the differentiation of pre-adipocytes into adipocytes.
It is a member of the EGF-like
EGF-like domain
EGF-like domain is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted...
family of homeotic
Homeosis
Homeosis is the transformation of one body part into another, arising from mutation in or misexpression of specific developmentally critical genes. It may be caused by mutations in Hox genes, found in animals, or others such as the MADS-box family in plants...
proteins.