Low density lipoprotein receptor-related protein 8
Encyclopedia
Low-density lipoprotein receptor-related protein 8 is a protein
that in humans is encoded by the LRP8 gene
.
Low density lipoprotein receptor-related protein 8, or LRP8 (also Apolipoprotein E Receptor 2; ApoER2) is a member of the LDL receptor family
that plays a role in endocytosis
and signal transduction. Together with VLDLR it is able to bind reelin
, leading to the phosphorylation of DAB1
, which binds on its cytosolic tail.
ApoER2 also regulates selenium
intake into cells through endocytosis of SEPP1
.
with SNX17
and Reelin
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the LRP8 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Low density lipoprotein receptor-related protein 8, or LRP8 (also Apolipoprotein E Receptor 2; ApoER2) is a member of the LDL receptor family
Low density lipoprotein receptor gene family
The low density lipoprotein receptor gene family code for a class of structurally closely related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types. The role that is most commonly associated with this evolutionarily ancient family is...
that plays a role in endocytosis
Endocytosis
Endocytosis is a process by which cells absorb molecules by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane...
and signal transduction. Together with VLDLR it is able to bind reelin
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
, leading to the phosphorylation of DAB1
DAB1
The Disabled-1 gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathway...
, which binds on its cytosolic tail.
ApoER2 also regulates selenium
Selenium
Selenium is a chemical element with atomic number 34, chemical symbol Se, and an atomic mass of 78.96. It is a nonmetal, whose properties are intermediate between those of adjacent chalcogen elements sulfur and tellurium...
intake into cells through endocytosis of SEPP1
SEPP1
Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.-Further reading:...
.
Interactions
Low density lipoprotein receptor-related protein 8 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with SNX17
SNX17
Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.-Interactions:SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8 and LDL receptor.-Further reading:...
and Reelin
Reelin
Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...
.