MEP1A
Encyclopedia
Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A
enzyme
that in humans is encoded by the MEP1A gene
. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.
during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B
, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A
.
Meprin A
Meprin A also known as endopeptidase-2 is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.Meprin A is a dimer composed of the products transcribed from the following two genes:...
enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the MEP1A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.
Function
The meprin alpha subunit product of the MEP1A gene is processed in the endoplasmic reticulumEndoplasmic reticulum
The endoplasmic reticulum is an organelle of cells in eukaryotic organisms that forms an interconnected network of tubules, vesicles, and cisternae...
during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing MEP1B
MEP1B
Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.-Further reading:...
, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric meprin A
Meprin A
Meprin A also known as endopeptidase-2 is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.Meprin A is a dimer composed of the products transcribed from the following two genes:...
.