Cytauxzoonosis
Encyclopedia
Cytauxzoonosis is a mostly fatal tick-borne disease
Tick-borne disease
Tick-borne diseases are diseases or illnesses transmitted by ticks. As the incidence of tick-borne illnesses increases and the geographic areas in which they are found expand, it becomes increasingly important that health professionals be able to distinguish the diverse, and often overlapping,...

 of domestic cats. It is identified as the blood parasite Cytauxzoon felis.

In Africa, this disease is carried by ungulate
Ungulate
Ungulates are several groups of mammals, most of which use the tips of their toes, usually hoofed, to sustain their whole body weight while moving. They make up several orders of mammals, of which six to eight survive...

s, but in North America
North America
North America is a continent wholly within the Northern Hemisphere and almost wholly within the Western Hemisphere. It is also considered a northern subcontinent of the Americas...

, it is carried by bobcat
Bobcat
The bobcat is a North American mammal of the cat family Felidae, appearing during the Irvingtonian stage of around 1.8 million years ago . With twelve recognized subspecies, it ranges from southern Canada to northern Mexico, including most of the continental United States...

s, particularly in the South
Southern United States
The Southern United States—commonly referred to as the American South, Dixie, or simply the South—constitutes a large distinctive area in the southeastern and south-central United States...

. As of four years ago, the disease was only reported in Texas
Texas
Texas is the second largest U.S. state by both area and population, and the largest state by area in the contiguous United States.The name, based on the Caddo word "Tejas" meaning "friends" or "allies", was applied by the Spanish to the Caddo themselves and to the region of their settlement in...

, Oklahoma
Oklahoma
Oklahoma is a state located in the South Central region of the United States of America. With an estimated 3,751,351 residents as of the 2010 census and a land area of 68,667 square miles , Oklahoma is the 28th most populous and 20th-largest state...

, Missouri
Missouri
Missouri is a US state located in the Midwestern United States, bordered by Iowa, Illinois, Kentucky, Tennessee, Arkansas, Oklahoma, Kansas and Nebraska. With a 2010 population of 5,988,927, Missouri is the 18th most populous state in the nation and the fifth most populous in the Midwest. It...

, Louisiana
Louisiana
Louisiana is a state located in the southern region of the United States of America. Its capital is Baton Rouge and largest city is New Orleans. Louisiana is the only state in the U.S. with political subdivisions termed parishes, which are local governments equivalent to counties...

, Mississippi
Mississippi
Mississippi is a U.S. state located in the Southern United States. Jackson is the state capital and largest city. The name of the state derives from the Mississippi River, which flows along its western boundary, whose name comes from the Ojibwe word misi-ziibi...

, Georgia
Georgia (U.S. state)
Georgia is a state located in the southeastern United States. It was established in 1732, the last of the original Thirteen Colonies. The state is named after King George II of Great Britain. Georgia was the fourth state to ratify the United States Constitution, on January 2, 1788...

, Florida
Florida
Florida is a state in the southeastern United States, located on the nation's Atlantic and Gulf coasts. It is bordered to the west by the Gulf of Mexico, to the north by Alabama and Georgia and to the east by the Atlantic Ocean. With a population of 18,801,310 as measured by the 2010 census, it...

, and especially Arkansas
Arkansas
Arkansas is a state located in the southern region of the United States. Its name is an Algonquian name of the Quapaw Indians. Arkansas shares borders with six states , and its eastern border is largely defined by the Mississippi River...

, but in May 2006 alone, at least six fatal cases were reported in the Tennessee
Tennessee
Tennessee is a U.S. state located in the Southeastern United States. It has a population of 6,346,105, making it the nation's 17th-largest state by population, and covers , making it the 36th-largest by total land area...

 communities of Franklin
Franklin, Tennessee
Franklin is a city within and the county seat of Williamson County, Tennessee, United States. The population was 62,487 as of the 2010 census Franklin is located approximately south of downtown Nashville.-History:...

 and Brentwood
Brentwood, Tennessee
-Demographics:As of the census of 2000, there were 23,445 people, 7,693 households, and 6,808 families residing in the city. The population density was . There were 7,889 housing units at an average density of . The racial makeup of the city was 94.63% European American, 1.89% African American,...

 just at the clinic of Dr. Charles O. Beauchamp. In 2007 there was at least one fatal case in Rutherford County, Tennessee at the clinic of Dr. Randy Rickets, and another in 2008 at the clinic of Dr. John E. Brunner. Furthermore, veterinarians in Marion County, Tennessee
Marion County, Tennessee
Marion County is a county located in the U.S. state of Tennessee. As of 2000, the population was 27,776. Its county seat is Jasper.Marion County is part of the Chattanooga, TN–GA Metropolitan Statistical Area.-Geography:According to the U.S...

 have found additional cases of Cytauxzoonosis in that locale. Although the pathogen lies dormant in wild cats, when transmitted to domestic cats
Cat
The cat , also known as the domestic cat or housecat to distinguish it from other felids and felines, is a small, usually furry, domesticated, carnivorous mammal that is valued by humans for its companionship and for its ability to hunt vermin and household pests...

, it is ultimately fatal. The pathogen is spread to domestic cats through the American Dog Tick
Tick
Ticks are small arachnids in the order Ixodida, along with mites, constitute the subclass Acarina. Ticks are ectoparasites , living by hematophagy on the blood of mammals, birds, and sometimes reptiles and amphibians...

 (Dermacentor variabilis), which can be found in heavily wooded areas and fields. Because of the route of infection, it is most likely that outdoor cats develop the disease. The biggest risk of infection occurs in May through September, but even during that time, it is a very rare disease.

Symptoms usually occur within six days of infection. These include depression
Depression (mood)
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behaviour, feelings and physical well-being. Depressed people may feel sad, anxious, empty, hopeless, helpless, worthless, guilty, irritable, or restless...

, lethargy, anorexia
Anorexia (symptom)
Anorexia is the decreased sensation of appetite...

, dehydration
Dehydration
In physiology and medicine, dehydration is defined as the excessive loss of body fluid. It is literally the removal of water from an object; however, in physiological terms, it entails a deficiency of fluid within an organism...

, fever
Fever
Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...

, and enlarged lymph node
Lymph node
A lymph node is a small ball or an oval-shaped organ of the immune system, distributed widely throughout the body including the armpit and stomach/gut and linked by lymphatic vessels. Lymph nodes are garrisons of B, T, and other immune cells. Lymph nodes are found all through the body, and act as...

s, shrunken kidneys, spleen and liver. Unlike a good deal of other cat diseases, when the cat is in the throes of the fever, it may cry loudly. Due to the anorexia, cats infected with the disease tend to lose liver function within a few days and become jaundiced
Jaundice
Jaundice is a yellowish pigmentation of the skin, the conjunctival membranes over the sclerae , and other mucous membranes caused by hyperbilirubinemia . This hyperbilirubinemia subsequently causes increased levels of bilirubin in the extracellular fluid...

, losing colour in the gums and nose
Nose
Anatomically, a nose is a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the...

. Symptoms that may not be apparent to the owner include the haemorrhaging of the spleen
Spleen
The spleen is an organ found in virtually all vertebrate animals with important roles in regard to red blood cells and the immune system. In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve of blood in case of hemorrhagic shock...

, anaemia, heart murmur
Heart murmur
Murmurs are extra heart sounds that are produced as a result of turbulent blood flow that is sufficient to produce audible noise. Most murmurs can only be heard with the assistance of a stethoscope ....

 and leukopanomenia.
The vast majority, approximately 95%, of patients succumb to this disease within the time period of one week. Historically, the treatments available for the disease include human blood transfusion
Blood transfusion
Blood transfusion is the process of receiving blood products into one's circulation intravenously. Transfusions are used in a variety of medical conditions to replace lost components of the blood...

s and intravenous fluids. Currently, imidocarb dipropionate is being used to battle the infection, but it has not so far worked well enough for mass usage and tends to cause pain to the animal when injected.

Although it can be prevented in most cases by use of medicines such as those containing Fipronil
Fipronil
Fipronil is a broad spectrum insecticide that disrupts the insect central nervous system by blocking the passage of chloride ions through the GABA receptor and glutamate-gated chloride channels, components of the central nervous system. This causes hyperexcitation of contaminated insects' nerves...

 there have been cases of cats treated with this medication that have died of Cytauxzoonosis because of the delay between application and absorption into the hair follicle of the feline. In the end, the best way to avoid infection is to disallow access of the outside to domestic felines.

Dr. Faith Hughes in Crawfordville, FL, has had a 50% to 75% success rate treating Cytauxzoonosis cases using imidocarb, enrofloxacin
Enrofloxacin
Enrofloxacin is a fluoroquinolone antibiotic sold by the Bayer Corporation under the trade name Baytril. Enrofloxacin is currently FDA-approved for treatment of individual pets and domestic animals in the United States...

, fever meds, appetite stimulants, iron supplements, force feeding and fluids. This has been her protocol for 15 years. Atropine is used prior to Imidocarb to prevent serious side effects.

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