Hsp90 co-chaperone Cdc37 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the CDC37 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

 control protein of Saccharomyces cerevisiae

Saccharomyces cerevisiae

Saccharomyces cerevisiae is a species of yeast. It is perhaps the most useful yeast, having been instrumental to baking and brewing since ancient times. It is believed that it was originally isolated from the skin of grapes...

. This protein is a molecular chaperone with specific function in cell signal transduction

Signal transduction

Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...

. It has been shown to form complex with Hsp90

Hsp90

Hsp90 is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family, which is upregulated in response to stress...

 and a variety of protein kinase

Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...

s including CDK4, CDK6, SRC

Src (gene)

Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene.Src is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a...

, RAF1, MOK

RAGE (gene)

MAPK/MAK/MRK overlapping kinase is an enzyme that in humans is encoded by the RAGE gene.-Further reading:...

, as well as eIF-2

EIF-2 kinase

eIF-2 is a kinase enzyme that phosphorylates eIF-2.There are four forms in mammals:* EIF2AK1: heme-regulated inhibitor kinase * EIF2AK2: the double-stranded RNA-dependent kinase * EIF2AK3: PEK/PERK* EIF2AK4: GCN2...

 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Interactions

CDC37 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with IKBKG

IKBKG

NF-kappa-B essential modulator also known as inhibitor of nuclear factor kappa-B kinase subunit gamma is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase that activates NF-κB. The human gene for IKBKG is located on chromosome Xq28...

, IKK2

IKK2

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB gene.- Function :...

, Cyclin-dependent kinase 4

Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:...

, Heat shock protein 90kDa alpha (cytosolic), member A1 and STK11

STK11

Serine/threonine kinase 11 also known as liver kinase B1 or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene.-Expression:...

.

Domain architecture

CDC37 consists of three structural domains. The N-terminal domain binds to protein kinases. The central domain is the Hsp90

Hsp90

Hsp90 is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family, which is upregulated in response to stress...

 chaperone (heat shock protein 90) binding domain. The function of the C-terminal domain is unclear.

Further reading