Cyclin-dependent kinase 4
Encyclopedia
Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase
family.
It is regulated by Cyclin D
.
with SERTAD1
, CDC37
, CEBPA
, PCNA
, Cyclin D3, Cyclin D1
, CDKN2C
, MyoD
, P16
, CDKN2B
, Drebrin-like
and CDKN1B
.
Cyclin-dependent kinase
thumb|350px|Schematic of the cell cycle. outer ring: I=[[Interphase]], M=[[Mitosis]]; inner ring: M=Mitosis; G1=[[G1 phase|Gap phase 1]]; S=[[S phase|Synthesis]]; G2=[[G2 phase|Gap phase 2]]...
family.
It is regulated by Cyclin D
Cyclin D
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition...
.
Interactions
Cyclin-dependent kinase 4 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with SERTAD1
SERTAD1
SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.-Interactions:SERTAD1 has been shown to interact with P16, Cyclin-dependent kinase 4 and CREB-binding protein.-Further reading:...
, CDC37
CDC37
Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction...
, CEBPA
CEBPA
CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene.-Interactions:CEBPA has been shown to interact with Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4.- External links :*...
, PCNA
PCNA
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...
, Cyclin D3, Cyclin D1
Cyclin D1
G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene.Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma.-Interactions:...
, CDKN2C
CDKN2C
Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.-Interactions:CDKN2C has been shown to interact with Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6.-Further reading:...
, MyoD
MyoD
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
, P16
P16 (gene)
Cyclin-dependent kinase inhibitor 2A, also known as multiple tumor suppressor 1 , is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene...
, CDKN2B
CDKN2B
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 or p15INK4B is a protein that is encoded by the CDKN2B gene in humans.- Function :...
, Drebrin-like
Drebrin-like
Drebrin-like protein is a protein that in humans is encoded by the DBNL gene.-Interactions:Drebrin-like has been shown to interact with Cyclin-dependent kinase 4, MAP4K1 and ZAP-70.-Further reading:...
and CDKN1B
CDKN1B
Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4...
.