UBE2I
Encyclopedia
SUMO-conjugating enzyme UBC9 is a protein
that in humans is encoded by the UBE2I gene
.
with WT1
, TOP1
, RAD51
, Activating transcription factor 2
, PIAS1
, SALL1
, FHIT
, RANBP2
, Protein inhibitor of activated STAT2
, DNMT3A
, DNMT3B
, Small ubiquitin-related modifier 1
, SAE2, RANGAP1
, Death associated protein 6
, Androgen receptor
, ETS1
, IPO13
, TCF3
, TNFRSF1A
, DACH1
, P53
, BLMH
, MAP3K1
and Microphthalmia-associated transcription factor
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the UBE2I gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
UBE2I has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with WT1
WT1
Wilms tumor protein is a protein that in humans is encoded by the WT1 gene.- Function :This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine-rich DNA-binding domain at the N-terminus...
, TOP1
TOP1
DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.-Interactions:TOP1 has been shown to interact with BTBD1, P53, Nucleolin, BTBD2, ASF/SF2 and UBE2I.-Further reading:...
, RAD51
RAD51
RAD51 is a human gene. The protein encoded by this gene is a member of the RAD51 protein family which assist in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA and yeast Rad51...
, Activating transcription factor 2
Activating transcription factor 2
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.-Function:This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element , an octameric...
, PIAS1
PIAS1
E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.-Interactions:PIAS1 has been shown to interact with DNMT3A, STAT1, Small ubiquitin-related modifier 1, Sp3 transcription factor, UBE2I and P53.-Further reading:...
, SALL1
SALL1
Sal-like 1 , also known as SALL1, is a protein which in humans is encoded by the SALL1 gene. As the full name suggests, it is one of the human versions of the spalt gene known in Drosophila.- Function :...
, FHIT
FHIT
Bis-triphosphatase also known as fragile histidine triad protein is an enzyme that in humans is encoded by the FHIT gene.- Function :FHIT is also known as human accelerated region 10...
, RANBP2
RANBP2
RAN binding protein 2, also known as RANBP2 is protein which in humans is encoded by the RANBP2 gene.RanBP2 is also known as Nup358 since it is a member nucleoporin family that makes-up the nuclear pore complex. RanBP2 has a 358 KDa molecular weight.- Function :RAN is a small GTP-binding protein of...
, Protein inhibitor of activated STAT2
Protein inhibitor of activated STAT2
E3 SUMO-protein ligase PIAS2 is an enzyme that in humans is encoded by the PIAS2 gene.-Interactions:Protein inhibitor of activated STAT2 has been shown to interact with Androgen receptor, DNMT3A, PARK7 and UBE2I.-Further reading:...
, DNMT3A
DNMT3A
DNA -methyltransferase 3A is an enzyme that in humans is encoded by the DNMT3A gene.-Interactions:DNMT3A has been shown to interact with ZNF238, HDAC1, Myc, Protein inhibitor of activated STAT2, DNMT1, DNMT3B, PIAS1, UBE2I and SUV39H1....
, DNMT3B
DNMT3B
DNA -methyltransferase 3 beta, also known as DNMT3B, is a protein associated with immunodeficiency, centromere instability and facial anomalies syndrome.-Interactions:...
, Small ubiquitin-related modifier 1
Small ubiquitin-related modifier 1
Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.Most cleft genes have a sumoylation component .-Interactions:...
, SAE2, RANGAP1
RANGAP1
Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.-Interactions:RANGAP1 has been shown to interact with Ran and UBE2I.-Further reading:...
, Death associated protein 6
Death associated protein 6
Death-associated protein 6 also known as DAXX is a protein that in humans is encoded by the DAXX gene.- Function :DAXX, a death-domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas...
, Androgen receptor
Androgen receptor
The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...
, ETS1
ETS1
Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.-Interactions:ETS1 has been shown to interact with TTRAP, UBE2I and Death associated protein 6....
, IPO13
IPO13
Importin-13 is a protein that in humans is encoded by the IPO13 gene.-Interactions:IPO13 has been shown to interact with RBM8A, PAX6, ALX1, EIF1AX and UBE2I.-Further reading:...
, TCF3
TCF3
Transcription factor 3 , also known as TCF3, is a protein that in humans is encoded by the TCF3 gene...
, TNFRSF1A
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...
, DACH1
DACH1
Dachshund homolog 1 , also known as DACH1, is a protein which in humans is encoded by the DACH1 gene.- Function :This gene is similar to the D. melanogaster dachshund gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
, BLMH
BLMH
Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.-Interactions:BLMH has been shown to interact with RPL29, RPL11, UBE2I and Amyloid precursor protein.-Further reading:...
, MAP3K1
MAP3K1
Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.-Interactions:MAP3K1 has...
and Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development.-Clinical significance:...
.