Small ubiquitin-related modifier 1 - AbsoluteAstronomy.com

Small ubiquitin-related modifier 1 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

that in humans is encoded by the SUMO1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
Most cleft genes have a sumoylation component .

Interactions

Small ubiquitin-related modifier 1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with SAE2, Death associated protein 6

Death associated protein 6

Death-associated protein 6 also known as DAXX is a protein that in humans is encoded by the DAXX gene.- Function :DAXX, a death-domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas...

, Fas receptor

Fas receptor

The FAS receptor also known as apoptosis antigen 1 , cluster of differentiation 95 or tumor necrosis factor receptor superfamily member 6 is a protein that in humans is encoded by the TNFRSF6 gene....

, Sp1 transcription factor, PIAS1

PIAS1

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.-Interactions:PIAS1 has been shown to interact with DNMT3A, STAT1, Small ubiquitin-related modifier 1, Sp3 transcription factor, UBE2I and P53.-Further reading:...

, Thymine-DNA glycosylase

Thymine-DNA glycosylase

G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene.-Interactions:Thymine-DNA glycosylase has been shown to interact with Estrogen receptor alpha, SUMO3, CREB-binding protein, Promyelocytic leukemia protein and Small ubiquitin-related modifier...

, UBE2I

UBE2I

SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene.-Interactions:UBE2I has been shown to interact with WT1, TOP1, RAD51, Activating transcription factor 2, PIAS1, SALL1, FHIT, RANBP2, Protein inhibitor of activated STAT2, DNMT3A, DNMT3B, Small ubiquitin-related...

, TNFRSF1A

TNFRSF1A

Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...

, P53

P53

p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...

, TOP2B

TOP2B

DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.-Interactions:TOP2B has been shown to interact with BAZ1B, HDAC1, Histone deacetylase 2, T-cell surface glycoprotein CD3 epsilon chain, Small ubiquitin-related modifier 1 and P53.-Further reading:...

, TOP2A

TOP2A

DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.-Interactions:TOP2A has been shown to interact with HDAC1, CDC5L, Small ubiquitin-related modifier 1 and P53.-Further reading:...

, DNMT3B

DNMT3B

DNA -methyltransferase 3 beta, also known as DNMT3B, is a protein associated with immunodeficiency, centromere instability and facial anomalies syndrome.-Interactions:...

and Promyelocytic leukemia protein

Promyelocytic leukemia protein

Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...