TOP1
Encyclopedia
DNA topoisomerase 1 is an enzyme
that in humans is encoded by the TOP1 gene
.
with BTBD1
, P53
, Nucleolin
, BTBD2
, ASF/SF2
and UBE2I
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the TOP1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
TOP1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with BTBD1
BTBD1
BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.-Further reading:...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
, Nucleolin
Nucleolin
Nucleolin is a protein that in humans is encoded by the NCL gene.- Gene :The human NCL gene is located on chromosome 2 and consists of 14 exons with 13 introns and spans approximately 11kb...
, BTBD2
BTBD2
BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.-Further reading:...
, ASF/SF2
ASF/SF2
ASF/SF2 also known as splicing factor, arginine/serine-rich 1 or SFRS1, is a protein which in humans is encoded by the SFRS1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SFRS1 is the gene that codes for ASF/SF2 and is found on chromosome 17...
and UBE2I
UBE2I
SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene.-Interactions:UBE2I has been shown to interact with WT1, TOP1, RAD51, Activating transcription factor 2, PIAS1, SALL1, FHIT, RANBP2, Protein inhibitor of activated STAT2, DNMT3A, DNMT3B, Small ubiquitin-related...
.