ATF5
Encyclopedia
Activating transcription factor 5, also known as ATF5, is a protein
that, in humans, is encoded by the ATF5 gene
.
)/cAMP response-element binding protein (CREB
) family.
ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.
ATF5 expression is regulated at the transcriptional and translational level.
ATF5 is expressed in VZ and SVZ during brain development.
Human ATF5 has 282 amino acid.
ATF5 has b-Zip domain.
with DISC1
and TRIB3
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that, in humans, is encoded by the ATF5 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor (ATFActivating transcription factor
In molecular biology, activating transcription factor, ATF, is a class of AP-1 transcription factor dimers.Genes include ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7....
)/cAMP response-element binding protein (CREB
CREB
CREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements , thereby increasing or decreasing the transcription of the downstream genes....
) family.
ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.
ATF5 expression is regulated at the transcriptional and translational level.
ATF5 is expressed in VZ and SVZ during brain development.
Human ATF5 has 282 amino acid.
ATF5 has b-Zip domain.
Interactions
ATF5 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with DISC1
DISC1
Disrupted in schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth,...
and TRIB3
TRIB3
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.-Interactions:TRIB3 has been shown to interact with CSNK2B, TIAF1, RELA, MCM3AP, ATF5, Granulin, ATF4, AKT1, Fibronectin and SIAH1.-Further reading:...
.